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IRBM Expands Functional Genomics Platform to Strengthen Early Drug Discovery

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De-Risking Target Validation with Data-Driven Genomic Insights

ROME, April 3, 2025 /PRNewswire/ — IRBM, an integrated Contract Research Organization (CRO) specializing in preclinical drug discovery, has established a comprehensive Functional Genomics Platform to support genetic target identification and validation, and generation of disease-relevant cellular models. The platform integrates CRISPR-based methodologies, screening capabilities, cell engineering, and advanced molecular and cellular analysis to drive both target discovery and validation.

To further enhance target validation, IRBM is expanding its genome editing toolkit with CRISPR tiling to systematically map functional domains within coding and regulatory regions, along with base and prime editing to introduce precise nucleotide modifications. These next-generation approaches—combined with the platform’s high-throughput CRISPR screening, including stem cell engineering—are instrumental in building robust disease models and improving the reliability of target validation.

“Understanding which targets are truly viable for drug development is a complex challenge,” said Sara Tomaselli, PhD, Head of Functional Genomics at IRBM. “With this in-house platform, we’re strengthening our ability to systematically evaluate gene function, de-risk early discovery, and support our partners in making well-informed decisions.”

The platform’s screening capabilities include genome-wide and targeted CRISPR libraries for knockout (CRISPR KO), inhibition (CRISPRi), and activation (CRISPRa), enabling in-depth exploration of gene function and associated pathways. In parallel, IRBM’s cell engineering expertise—spanning patient-relevant models and iPSC-derived systems—supports disease modeling across oncology, neurodegeneration, and rare disorders. Multi-omics integration, including high-content imaging, single-cell transcriptomics, and proteomics, provides deeper functional characterization of drug targets.

IRBM’s Functional Genomics Platform is part of a broader, fully integrated drug discovery ecosystem, ensuring that genetic insights translate into meaningful preclinical models and drug development strategies. By combining functional genomics with expertise in medicinal chemistry, biomarker discovery, and preclinical pharmacology, IRBM enables biopharma innovators to approach target validation with greater confidence.

“We take a careful, methodical approach to functional genomics—one that integrates well with the complexities of drug discovery,” said Carlo Toniatti, MD, PhD, Chief Scientific Officer at IRBM. “Our goal is to help our partners uncover high-quality targets and generate data that can guide and inform decision making throughout the entire drug discovery process.”

IRBM’s collaborative approach allows biotech startups, pharmaceutical companies, and venture-backed teams to access functional genomics expertise without the need for in-house infrastructure. With customized solutions spanning genetic screening, engineered cell models, and mechanistic studies, IRBM provides practical, scientifically rigorous support at key points in drug discovery.

To learn more about IRBM’s Functional Genomics Platform and collaboration opportunities, visit www.irbm.com.

About IRBM

IRBM is a contract research organization (CRO) focused on early-stage drug discovery. With a track record of delivering preclinical candidates across oncology, neurodegeneration, and infectious diseases, IRBM partners with biotech and pharmaceutical innovators to advance therapeutic development with scientific precision and transparency.

 

SOURCE IRBM S.p.A.

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Spectrum Joins Meyer Shank Racing for the 109th Running of the Indianapolis 500

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INDIANAPOLIS, May 13, 2025 /PRNewswire/ — Meyer Shank Racing (MSR) today announced that Spectrum, one of the nation’s leading broadband connectivity providers, will be the primary sponsor for the No. 66 Honda Indy car driven by Marcus Armstrong for the 109th Indianapolis 500 on Sunday, May 25th.

Spectrum will also have placements on the No. 60 Honda Indy car driven by Felix Rosenqvist and the No. 06 Honda Indy car driven by four-time Indianapolis 500 winner Helio Castroneves.

Armstrong will head into Indianapolis 500 practice this week with a striking Spectrum blue livery on his car. With more than 31 million customers across 41 states, Spectrum is the #1 TV provider in the nation¹, with video packages geared towards sports fans and the top streaming apps included at no extra cost. Spectrum’s focus on providing seamless entertainment and connectivity products – including the nation’s fastest and most reliable internet² – works hand-in-hand with MSR’s goals on and off track during the Month of May.

“We’re really excited to have Spectrum onboard with us for the Indianapolis 500,” said Mike Shank, MSR Team Co-Owner. “It’s always special to align with a brand that shares our passion for performance, precision, and pushing the limits. Having Spectrum adds real momentum to our effort with Marcus [Armstrong], and we’re proud to represent their colors on the biggest stage in racing.”

The collaboration will not only see Spectrum enter the motorsports realm, but the national brand will be centerstage for the country’s largest attended single day sporting event, with 350,000 race fans present. Just like the Indy 500 tradition of drinking milk in Victory Lane, Spectrum brings its own time-honored tradition of exceptional service, speed, and reliability to Indianapolis Motor Speedway.

“The Indy 500 represents the pinnacle of speed and performance, and that makes it the perfect stage for our brand,” said Sharon Peters, Executive Vice President, Chief Marketing Officer for Spectrum. “As the provider of the nation’s fastest internet, we know what it takes to always deliver at full throttle. Sponsoring these incredible race cars is our way of showing up where speed matters most, and we cannot wait to cheer MSR on at the Brickyard.”

MSR will begin Indianapolis 500 practice starting on Tuesday, May 13th which will see the No. 66 Spectrum Honda take to the track for the first time. The 109th Running of the Indianapolis 500 is set for Sunday, May 25th with live coverage on FOX.

¹Based on earnings results of paid TV video providers with linear programming.

²Fastest Speeds claim based on Broadband Download Speed among the top 5 national providers in Opensignal USA: Fixed Broadband Experience Report – National View, May 2024. Based on Opensignal independent analysis of mean download speed. © 2024 Opensignal Limited.

About Spectrum 
Spectrum is a suite of advanced communications services offered by Charter Communications, Inc. (NASDAQ:CHTR), a leading broadband connectivity company and cable operator with services available to more than 57 million homes and businesses in 41 states. Over an advanced communications network, supported by a 100% U.S.-based workforce, the Company offers a full range of state-of-the-art residential and business services including Spectrum Internet®, TV, Mobile and Voice.

More information can be found at corporate.charter.com

About MSR
Meyer Shank Racing (MSR) is a championship-winning motorsports team competing in the NTT INDYCAR SERIES and IMSA WeatherTech SportsCar Championship. Founded by Mike Shank and headquartered in Pataskala, Ohio, MSR has established itself as a premier team with a reputation for innovation, perseverance, and performance. The team is a three-time overall winner at the prestigious Rolex 24 at Daytona and is a multi-IMSA championship winning team. In addition to its sports car racing success, MSR is the 2021 Indianapolis 500 winner in NTT INDYCAR SERIES competition with the team debuting in the series in 2017. With a focus on engineering excellence and driver development, Meyer Shank Racing continues to push the boundaries of motorsport in North America.

For more information visit www.meyershankracing.com

 

View original content to download multimedia:https://www.prnewswire.com/news-releases/spectrum-joins-meyer-shank-racing-for-the-109th-running-of-the-indianapolis-500-302454069.html

SOURCE Charter Communications, Inc.

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RS and ebm-papst enable renewable energy infrastructure

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ebm-papst leveraged its 60+ years of rigorous R&D experience in air-moving technologies to launch two fan series engineered to help customers solve critical cooling challenges in the renewable energy industry. Both are now in stock at RS, providing customers with quick and easy access and proven technical support.

FORT WORTH, Texas, May 13, 2025 /PRNewswire/ — RS, a global product and service solutions provider for industrial customers, offers an extensive portfolio of ebm-papst fans engineered to maximize efficiency, significantly reduce power consumption, and minimize noise, including two new series optimized to help customers solve critical cooling challenges in the renewable energy industry.

ebm-papst’s economical, high-efficiency, low-noise fans solve tough cooling challenges in the renewable energy industry.

The renewable energy industry is experiencing significant growth fueled by a combination of customer demands, climate concerns, and government initiatives. Electric vehicle (EV) sales, for instance, have soared, creating an increased need for the infrastructure required to support them. The number of EV charging ports in the U.S. grew from around 184,000 in 2023 to around 204,000 in 2024, representing a roughly 11% increase in publicly accessible medium-power and fast-charging technologies. In addition, the cumulative storage capacity of large-scale lithium-ion battery energy storage systems (BESS) in the U.S. surged from just 16 gigawatts (GW) in 2023 to a record-breaking 26.3GW in 2024, representing a roughly 64% increase.

EV charging stations and BESS generate a significant amount of heat and are continually evolving, incorporating new, more advanced components to drive increased performance. Unfortunately, the more electronic components there are in a system, the more heat those systems generate, and heat is the mortal enemy of electronics — slashing efficiencies, shortening product lifespans, and increasing the risk of failure.

As such, these systems rely on an assortment of thermal management technologies, including fans, a comparatively simple and cost-effective active cooling technology, to dissipate heat and maintain a safe operating temperature. A typical DC fast charger, for example, can contain as many as 20–25 small- to medium-sized axial fans in addition to higher pressure fans with backward curved impellers.

To satisfy the challenging thermal management demands of these and other densely populated electronic systems, ebm-papst leveraged its more than 60 years of rigorous research, design, and development experience in air-moving technologies to launch the high-performance AxiForce and W3G300–ME46 series fans — both of which are engineered to deliver high efficiency, low noise, and low vibration while remaining economically competitive.

ebm-papst AxiForce series fans have an innovative, aerodynamic housing and fan blade design that makes them both quieter and more energy efficient than their predecessors and competitors. Their steep air performance curve delivers maximum efficiency, which reduces power requirements and heat generation and extends their lifespan, and their small form factors support installation flexibility and broad application suitability. In addition to a high cooling capacity, AxiForce series compact tubeaxial fans provide an acoustic noise advantage of up to 6dB(A), environmental protection up to IP68, and the ability to network with device logic. They also achieve pressures of up to 4.8 inches of water gauge (in. WG) or 1,200 Pascals. This series is currently available in 80, 120, and 172mm models, with additional sizes to come later this year, and ideal applications include EV chargers, industrial control cabinets, and applications with high back pressure.

The new ebm-papst W3G300–ME46 series fans are larger than AxiForce fans at 300mm in diameter and are specifically designed to meet the needs of outdoor renewable energy applications, like high-power EV chargers and BESS. These electronically commutated (EC) fans combine AC and DC voltages to provide very high power densities and don’t need to be connected to the grid, which protects them from exposure to voltage fluctuations and frequency deviations. They also offer thermal overload protections, locked rotor detection, and motor current limiting and can be built locally in the U.S., which helps minimize delivery timelines. In addition, since they’re often mounted at the top of renewable energy devices, where exposure to moisture and direct sunlight is greatest, they’re qualified using the ISO16750 harsh environment automotive standard, which exposes the fans to ice, rain, sun, wind, and washing substances to ensure safe and reliable operation in even the most extreme conditions.

To learn more about the vast selection of ebm-papst fan and thermal management products available at RS, including the AxiForce series fans and the new W3G300–ME46 series fans, visit the links embedded here and check out the company’s most recent RS Expert Advice article, “Cooling eMobility and renewable energy infrastructure,” an interview with Todd Cardillo, the Director of Renewable and Industrial Markets at ebm-papst.

To view the complete RS portfolio of ebm-papst products or the company’s other contributions to the RS Expert Advice series, visit the links embedded here. For assistance identifying, procuring, deploying, and maintaining ebm-papst air-moving solutions optimized to solve critical cooling challenges in the renewable energy industry and beyond, please contact your local RS representative at 1.866.433.5722 or reach out to the RS technical support team.

About RS 
RS is a global product and service solutions provider for industrial customers, enabling them to operate efficiently and sustainably. 

We operate in 36 markets, stock over 800,000 industrial and specialist products, and list an additional five million relevant for our industrial customers, sourced from over 2,500 suppliers. This extensive range supports our customers across the industrial lifecycle of designing, building, and maintaining equipment and operations. We enhance their experience through a tailored service model, leveraging our efficient physical, digital, and process infrastructure sustainably. We combine a technically led and digitally enabled approach with an exceptional team of experts; ultimately, it’s our people that make the difference.

Our purpose, making amazing happen for a better world, reflects our focus on delivering results for people, planet, and profit. 

RS Group plc is listed on the London Stock Exchange with stock ticker RS1 and in the year ended 31 March 2024 reported revenue of £2,942 million.

For more information, please visit https://www.rsgroup.com/ or connect with us on LinkedIn or X (Twitter).

About RS in the Americas
In the Americas region, RS stocks more than 250,000 industrial and electronic products from more than 700 trusted suppliers. These solutions cover categories extending from automation and control equipment to interconnect, passive, active, and electromechanical components and include more than 80,000 high-quality, competitively priced RS PRO products. For more information, please visit https://us.rs-online.com or connect with us via social media on FacebookX (Twitter), LinkedIn, and YouTube.

Image Download:
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Editorial Contact & Media Inquiries:
Erica Goode, RS Director of Marketing – U.S. and Canada
Erica.Goode@rsgroup.com

View original content to download multimedia:https://www.prnewswire.com/news-releases/rs-and-ebm-papst-enable-renewable-energy-infrastructure-302454068.html

SOURCE RS

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Broadridge Declares Quarterly Dividend of $0.88 Per Share

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NEW YORK, May 13, 2025 /PRNewswire/ — Broadridge Financial Solutions, Inc. (NYSE:BR) announced that its Board of Directors has declared a quarterly cash dividend of $0.88 per share. The dividend is payable on July 2, 2025 to stockholders of record at the close of business on June 12, 2025.

About Broadridge

Broadridge Financial Solutions (NYSE: BR), a global Fintech leader with over $6 billion in revenues, provides the critical infrastructure that powers investing, corporate governance and communications to enable better financial lives. We deliver technology-driven solutions to banks, broker-dealers, asset and wealth managers and public companies. Broadridge’s infrastructure serves as a global communications hub enabling corporate governance by linking thousands of public companies and mutual funds to tens of millions of individual and institutional investors around the world. In addition, Broadridge’s technology and operations platforms underpin the daily trading of on average more than U.S. $10 trillion of equities, fixed income and other securities globally. A certified Great Place to Work®, Broadridge is a part of the S&P 500® Index, employing over 14,000 associates in 21 countries. For more information about Broadridge, please visit www.broadridge.com.           

Contact Information 

Investors
broadridgeir@broadridge.com

Media
Gregg.rosenberg@broadridge.com

 

View original content:https://www.prnewswire.com/news-releases/broadridge-declares-quarterly-dividend-of-0-88-per-share-302454076.html

SOURCE Broadridge Financial Solutions, Inc.

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