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Vitamin K supplement slows prostate cancer in mice

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COLD SPRING HARBOR, N.Y., Oct. 24, 2024 /PRNewswire/ — Prostate cancer is a quiet killer. In most men, it’s treatable. However, in some cases, it resists all known therapies and turns extremely deadly. A new discovery at Cold Spring Harbor Laboratory (CSHL) points to a potentially groundbreaking solution. CSHL Professor Lloyd Trotman‘s lab has found that the pro-oxidant supplement menadione slows prostate cancer progression in mice. The supplement is a precursor to vitamin K, commonly found in leafy greens. The story begins more than two decades ago.

In 2001, the National Cancer Institute’s SELECT trial sought to determine if an antioxidant vitamin E supplement could successfully treat or prevent prostate cancer. The trial involving 35,000 men was planned to last up to 12 years. However, after just three years, participants were told to stop taking their supplements. Not only had vitamin E failed to slow or prevent prostate cancer—more men taking the supplement started to get the disease. Seeing these results, Trotman thought, ‘If an antioxidant failed, maybe a pro-oxidant would work.’ His new findings in mice show just that.

When mice with prostate cancer are given menadione, it messes with the cancer’s survival processes. Trotman’s team has discovered that menadione kills prostate cancer cells by depleting a lipid called PI(3)P, which works like an ID tag. Without it, the cells stop recycling incoming materials and eventually explode. Trotman explains:

“It’s like a transport hub, like JFK. If everything that goes in is immediately de-identified, nobody knows where the airplanes should go next. New stuff keeps coming in, and the hub starts to swell. This ultimately leads to the cell bursting.”

This causes the cancer’s progression to slow significantly in mice. Trotman now hopes to see the experiment translated to pilot studies in human prostate cancer patients:

“Our target group would be men who get biopsies and have an early form of the disease diagnosed. We wonder if they start to take the supplement, whether we would be able to slow that disease down.”

Amazingly, Trotman’s research suggests menadione may also prove effective against myotubular myopathy, a rare condition that prevents muscle growth in infant boys. Those diagnosed rarely live beyond early childhood. Trotman’s lab has found that depleting PI(3)P with menadione can double the lifespan of mice with this condition.

If the results hold up in humans, it would mean that men with prostate cancer can enjoy a better quality of life and more time with their families. It could also mean more precious time for children born with an incurable disease.

About Cold Spring Harbor Laboratory
Founded in 1890, Cold Spring Harbor Laboratory has shaped contemporary biomedical research and education with programs in cancer, neuroscience, plant biology and quantitative biology. Home to eight Nobel Prize winners, the private, not-for-profit Laboratory employs 1,000 people including 600 scientists, students and technicians. For more information, visit www.cshl.edu

View original content to download multimedia:https://www.prnewswire.com/news-releases/vitamin-k-supplement-slows-prostate-cancer-in-mice-302286057.html

SOURCE Cold Spring Harbor Laboratory

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CoinEx Expands Global Reach with Italian and Polish Language Launches

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HONG KONG, Oct. 24, 2024 /PRNewswire/ — CoinEx, a global cryptocurrency exchange dedicated to putting users first, will officially launch its Italian and Polish language platforms on October 24. This strategic step underscores CoinEx’s commitment to expanding its presence in these fast-growing markets, offering a secure trading environment, a wide variety of cryptocurrencies, rapid coin listings, and a diverse range of trading tools to meet user needs.

Both Italy and Poland hold immense growth potential in the cryptocurrency space. Italian and Polish users are increasingly seeking platforms that provide accessibility, reliability, and strong community engagement. In response, CoinEx will focus on building local communities, strengthening partnerships, and participating in key events to deepen its local footprint in both countries.

In Poland, CoinEx has already made its mark as a golden sponsor of Cryptosphere and through participation in Web3 Student Expo x PlanetaNFT. CoinEx is also preparing for its 7th-anniversary meetup in Warsaw. In Italy, CoinEx will run engaging activities on Telegram and other social media channels to keep users connected and rewarded. Italian and Polish users will also enjoy exclusive benefits, including social media campaigns, newcomer promotions, trading competitions, and special events on CoinEx Brand Day.

Additionally, the Italian and Polish websites will feature CoinEx Insight for market analysis and CoinEx Academy for crypto market education. Official Italian and Polish websites will offer localized support, urging users to connect via social media and Telegram.

Official Website in Poland: https://www.coinex.com/pl
Official Website in Italy: https://www.coinex.com/it

Polish Instagram: https://www.instagram.com/coinexpolska
Polish X: https://x.com/CoinExPolska
Polish Telegram: https://t.me/CoinEx_Polska
Italian Telegram: https://t.me/coinex_italian
Italian X: https://x.com/CoinEx_Italian

About CoinEx

Established in 2017, CoinEx is a global cryptocurrency exchange committed to making trading easier. The platform provides a range of services, including spot and futures trading, margin trading, swaps, automated market makers (AMM), and financial management services for over 10 million users across 200+ countries and regions. Since its establishment, CoinEx has steadfastly adhered to a “user-first” service principle. With the sincere intention of nurturing an equitable, respectful, and secure crypto trading environment, CoinEx enables individuals with varying levels of experience to effortlessly access the world of cryptocurrency by offering easy-to-use products.

To learn more about CoinEx, visit: Website | Twitter | Telegram | LinkedIn | Facebook | Instagram  | YouTube

View original content:https://www.prnewswire.com/news-releases/coinex-expands-global-reach-with-italian-and-polish-language-launches-302286816.html

SOURCE CoinEx Global

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HSG Laser Opens New Showroom in Busan, Expanding Its Commitment to Localize Services in South Korea

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BUSAN, South Korea, Oct. 25, 2024 /PRNewswire/ — On October 23rd, HSG Laser, a global leader in metal shaping equipment and automation solutions, celebrated the grand opening of their new showroom in Busan, South Korea. This strategic expansion underscores the company’s dedication to enhancing service offerings and supporting international client growth at high speed.

Established in 2024, HSG Laser Korea marks a significant investment of over 2 billion Won, demonstrating HSG’s commitment to the region. The subsidiary delivers technical support and after-sales services all over the country. With over 25,000 machines installed in over 100 countries, HSG gained a strong global presence and reputation for high-quality, competitively priced equipment.

“Quality is at the heart of everything we do, from research to customer interactions,” emphasizes Frank Liu, Head of HSG’s New Asia Pacific Region, highlighting the foundational principle that guides every facet of HSG’s operations. This dedication to quality isn’t just about maintaining high standards in products and services, but also extends to the company’s relationship approach. By fostering respectful partnerships that encourage growth for all parties, HSG not only sustains its commitment to quality but also collaboratively tackles challenges and utilizes opportunities alongside its clients and partners.

At the event, 50 agents and clients attended, out of which four groups participated in a contract signing ceremony securing their HSG equipment, such as multiple high-power cutting machines. Visitors explored the showroom and viewed demonstrations of the GFA, GH, and T2 Series. The GFA is a standout for sheet metal, boasting a large-format beveling laser cutter capable of handling sizes up to 13 x 25m and offering bevel angles up to 45 degrees. Next, the GH High-Power Flagship Model features the innovative P30 cutting head and AlphaTplus system, for tasks requiring maximum speed and precision. Completing the trio, the T2 Series specializes in cutting heavy-duty tubes up to 240mm in diameter, with minimal tailing thanks to its efficient three-chuck design.

By inaugurating the showroom, HSG Laser not only reaffirms its dedication to the Korean market but also supports its international clients in achieving their manufacturing objectives. This initiative is part of a broader strategy to ensure accessibility and responsiveness to customer needs worldwide, further solidifying HSG’s role as a key player in the global metal-shaping industry.

View original content:https://www.prnewswire.com/apac/news-releases/hsg-laser-opens-new-showroom-in-busan-expanding-its-commitment-to-localize-services-in-south-korea-302286818.html

SOURCE HSG Laser Co., Ltd

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Pluribus Technologies Corp. Announces Departure of CFO

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TORONTO, Oct. 24, 2024 /CNW/ – Pluribus Technologies Corp. (TSXV: PLRB) (“Pluribus” or the “Company”) announces that Nancy Fahy has resigned as the Chief Financial Officer of the Company, effective December 21, 2024, to pursue other career opportunities. Ms. Fahy will continue to serve as Chief Financial Officer until her departure. The Company thanks Ms. Fahy for her service and wishes her continued success in her future endeavors.

About Pluribus Technologies Corp.

Pluribus is a technology company that is a value-based acquirer and operator of small, profitable business-to-business technology companies in a range of verticals and industries. Pluribus provides its acquisitions access to experienced sales and marketing resources, strategic partnership opportunities, a diverse portfolio of customers in different geographical markets and enabling technologies to create new revenue streams and provide the opportunity for these companies to grow in their respective markets. When market conditions are conducive to raising capital at reasonable costs, Pluribus focuses on rapidly acquiring and integrating new acquisitions to accelerate growth. When the environment does not support this, Pluribus focuses on implementing strategies to maximize organic growth and increase cashflow from operations in its existing portfolio companies. For more information, please visit: pluribustechnologies.com.

Forward-Looking Information

Certain information in this press release constitutes forward-looking statements under applicable securities laws. Any statements that are contained in this press release that are not statements of historical fact may be deemed to be forward-looking statements. Forward-looking statements are often identified by terms such as “may”, “should”, “anticipate”, “expect”, “potential”, “believe”, “intend” or negatives of these terms and similar expressions.

Forward-looking statements are based on certain assumptions, including the Company’s ability to manage a complex portfolio of companies effectively; and the Company’s ability to raise sufficient financing to continue its acquisition strategy. Other assumptions include industry trends, the availability of growth opportunities, and general business, economic, competitive, political, regulatory and social uncertainties will not prevent the Company from conducting its business. While the Company considers these assumptions to be reasonable based on information currently available, they are inherently subject to significant business, economic and competitive uncertainties and contingencies and they may prove to be incorrect. Forward-looking information speaks only to such assumptions as of the date of this press release.

Readers are cautioned that the foregoing is not exhaustive. Readers are further cautioned not to place undue reliance on forward-looking statements as there can be no assurance that the plans, intentions or expectations upon which they are placed will occur. Such information, although considered reasonable by management at the time of preparation, may prove to be incorrect and actual results may differ from those anticipated. Forward-looking statements are not guarantees of future performance. The purpose of forward-looking information is to provide the reader with a description of management’s expectations, and such forward-looking information may not be appropriate for any other purpose. Except as required by law, the Company disclaims any obligation to update or revise any forward-looking statements, whether as a result of new information, events or otherwise. Forward-looking statements contained in this press release are expressly qualified by this cautionary statement.

Neither the TSXV nor its Regulation Services Provider (as that term is defined in the policies of the TSXV) accepts responsibility for the adequacy or accuracy of this press release.

Contact:

Diane Pedreira
Chief Operating Officer
Pluribus Technologies Corp.
1 (800) 851-9383

View original content to download multimedia:https://www.prnewswire.com/news-releases/pluribus-technologies-corp-announces-departure-of-cfo-302286842.html

SOURCE Pluribus Technologies Corp.

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