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Ariceum Therapeutics Presents Outstanding Data on its First-in-Class Radiopharmaceutical Drug 225Ac-Satoreotide at the European Association of Nuclear Medicine 2024

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225Ac-Satoreotide is a first-in-class somatostatin receptor 2 antagonist targeting extensive stage small cell lung cancer and is the first antagonist labelled with 225Ac to enter clinical developmentSatoreotide expressed a superior pharmacokinetic profile relative to DOTA-TATE with a higher pre-clinical anti-tumour efficacy, irrespective of radionuclide used100% survival with a single dose of 30 kBq 225Ac-satoreotide but not with 225Ac-DOTA-TATE

BERLIN, Oct. 22, 2024 /PRNewswire/ — Ariceum Therapeutics (Ariceum), a private biotech company developing radiopharmaceutical products for the diagnosis and treatment of certain hard-to-treat cancers, today announces that it presented data on its proprietary radiolabelled peptide SS0110 (satoreotide), a first-in-class antagonist of the somatostatin receptor 2 (SSTR2), at this year’s European Association of Nuclear Medicine (EANM) Annual Conference, held in Hamburg, Germany from 19-23 October 2024.

The Top-Rated Oral Presentation (TROP) entitled ‘225Ac-SSO110 induces long-lasting anti-tumour responses in contrast to 225Ac-DOTA-TATE and 161Tb-DOTA-TATE in the treatment of SSTR2-positive tumour xenografts’, details the anti-tumour efficacy of different radiolabelled satoreotide antagonists (225Ac, 161Tb, 177Lu-labelled SSO110) versus respective DOTA-TATE agonists (225Ac- and 161Tb-labelled DOTA-TATE) in mice engrafted with SSTR2 positive xenografts of small cell lung cancer (SCLC) and pancreatic cancer using clinically relevant associated dose ranges.  

Results demonstrate that 225Ac-satoreotide shows the strongest anti-tumoural effect in vivo at a low single dose when evaluating satoreotide and DOTA-TATE radiolabelled with different radionuclides. Irrespective of the radionuclides used, satoreotide demonstrated a higher pre-clinical anti-tumour efficacy when compared to DOTA-TATE which was less potent and required increased dose levels. Satoreotide was well tolerated across all dose levels and with all used radionuclides. These comparisons between satoreotide and DOTA-TATE will facilitate and guide further clinical development of satoreotide across multiple indications expressing SSTR2, such as SCLC, pancreatic cancers and Merkel Cell Carcinoma (MCC).

Previous comparisons between satoreotide and DOTA-TATE demonstrated that antagonist, 225Ac-satoreotide, is multiple times more potent than SSTR2 agonist, 225Ac-DOTA-TATE, signifying a durable complete response in standard murine xenograft models of SCLC in animal models, versus tumour growth delay.

Ariceum had previously shown at the Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting 2024 that 212Pb was not seen to be more potent than Lutetium or Terbium but caused more side effects and hence was not further pursued.

Manfred Rüdiger, Chief Executive Officer at Ariceum Therapeutics, said: “These results provide strong evidence for satoreotide and its potential to clinically outperform SSTR2 targeting agonists, by demonstrating significantly better efficacy in tumour growth control, up to complete tumour eradication depending on isotope used. In addition, when a single dose of 30 kBq 225Ac-satoreotide was administered, we observed high frequency of complete durable responses and 100% survival which strongly supports further clinical development for the treatment of SCLC, MCC and other cancers.”

Details of the oral presentation are as follow:

Title: 225Ac-SSO110 induces long-lasting anti-tumour responses in contrast to 225Ac-DOTA-TATE and 161Tb-DOTA-TATE in the treatment of SSTR2-positive tumour xenografts

Presenting Author: Prachi Desai, Scientist at Ariceum Therapeutics

Session Number: 1204
Session Title: M2M Track – TROP Session: Radiopharmaceutical Sciences + Translational Molecular Imaging & Therapy Committee: From Radionuclide to Clinical Translation

Oral Presentation Date & Time: Tuesday 22 October 2024, 09:00 AM09:10 AM CEST

Abstract Authors: Prachi Desai, Manuel Sturzbecher
–  Hoehne,
Dennis Mewis, Manfred Ruediger & Anika Jaekel  of Ariceum Therapeutics

Abstracts are available in the September edition of Springer’s European Journal of Nuclear Medicine and Molecular Imaging (EJNMMI) abstract book here and on the Ariceum website here.

About Ariceum Therapeutics

Ariceum Therapeutics (Ariceum) is a private, clinical stage radiopharmaceutical company focused on the diagnosis and precision treatment of certain neuroendocrine and other aggressive, hard-to-treat cancers. The name Ariceum is an anagram of ‘Marie Curie’ whose discovery of radium and polonium have been huge contributions to finding treatments for cancer.

Ariceum’s lead targeted systemic radiopharmaceutical product, 177Lu-satoreotide tetraxetan (“Satoreotide”), is an antagonist of the somatostatin type 2 (SSTR2) receptor which is overexpressed in neuroendocrine tumours (NETs) and some aggressive cancers such as small cell lung cancer (SCLC), or Merkel Cell Carcinoma (MCC), all of which have few treatment options and poor prognosis. Satoreotide is being developed as a ‘theranostic’ pair for the combined diagnosis and targeted radionuclide treatment of these tumours. Ariceum is also developing a radiolabelled PARP-inhibitor (ATT001), currently in Phase 1 clinical development under the trial name CITADEL-123. ATT001 was part of the acquisition of Theragnostics Ltd which was closed in June 2023.

Ariceum Therapeutics, launched in 2021, acquired all rights to Satoreotide from Ipsen. Ipsen remains a shareholder in the Company. Ariceum is headquartered in Berlin, with operations in Germany, Switzerland, Australia, United Kingdom and United States of America and with activities currently across the globe.

Ariceum is led by a highly experienced management team and supported by specialist investors including EQT Life Sciences (formerly LSP), HealthCap, Pureos Bioventures, Andera Partners and Earlybird Venture Capital. For further information, please visit www.ariceum-therapeutics.com.

About European Association of Nuclear Medicine (EANM)

The European Association of Nuclear Medicine (EANM) is a non-profit organization that promotes nuclear medicine and aims to improve public health. The EANM’s mission is to advance nuclear medicine through personalized healthcare, innovation in diagnosis and treatment, and raising awareness of nuclear medicine

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Finzly Launches FedNow Service through Finzly BankOS Platform in AWS Marketplace

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The modern banking platform eliminates the need for complex connection builds and maintenance, allowing financial institutions to connect to FedNow in an accelerated manner.

CHARLOTTE, N.C., Oct. 22, 2024 /PRNewswire-PRWeb/ — Finzly, an early participant in the FedNow™ pilot and a leading service provider for financial institutions (FIs) to send and receive payments on the FedNow network, announced today that its instant payment service is now available in AWS Marketplace, a digital catalog with thousands of software listings from independent software vendors that make it easy to find, test, buy, and deploy software that runs on Amazon Web Services (AWS).

“By partnering with Finzly to deliver FedNow and RTP instant payments solutions, we can provide our customers with more options beyond traditional payments methods, enabling them to move money at the speed they need, when they need it,” said Aaron Wiatrek, Senior Vice President at Frost Bank.

Powered by AWS, the Finzly BankOS platform integrates the FedNow service seamlessly with FIs’ core and digital banking systems. Finzly’s Digital Galaxy enhances this offering by providing a comprehensive digital banking experience, enabling businesses and consumers to send, receive, and request instant payments.

Finzly’s modern payment hub on the BankOS platform enables financial institutions to connect effortlessly to traditional rails like Automated Clearing House (ACH) and Fedwire, as well as modern networks such as FedNow and Real Time Payments (RTP), all with just a few clicks and independent of their core systems.

A recent US Faster Payments Council survey found that nearly 75% of financial institutions see legacy systems as a barrier to using FedNow. Finzly’s BankOS platform addresses this with Application Programming Interface (API)-driven solutions for quick FedNow deployment, removing the need for complex builds and making instant payments more accessible.

“Adding Finzly’s instant payments solution to the AWS Marketplace is a significant step forward. For financial institutions that are ready to offer instant payments to their customers scalability, real-time processing, and the ability to easily send and receive payments across networks are critical for keeping up with increasing customer demands and regulatory standards,” remarked Reed Luhtanen, Executive Director of the U.S. Faster Payments Council (FPC).

Booshan Rengachari, founder and CEO of Finzly said, “We are excited that our BankOS solution powered by AWS is now available in AWS Marketplace helping eliminate technology barriers to FedNow adoption for even more financial institutions. Our AWS-powered platform enables financial institutions to transform into digital enterprises by optimizing speed, quality, and security for the demands of a real-time environment.”

Frost Bank recently selected Finzly’s BankOS to modernize its payment operations. “At Frost, we work hard to make our customers’ lives easier and better,” said Aaron Wiatrek, a senior vice president at Frost Bank. “By partnering with Finzly to deliver FedNow and RTP instant payments solutions, we can provide our customers with more options beyond traditional payments methods, enabling them to move money at the speed they need, when they need it.”

Finzly’s BankOS Platform Key Benefits:

Rapid FedNow Launch: Connect to FedNow in just a few clicks via our AWS-powered, scalable platform, available 24/7/365.

Versatile Instant Payment Services: Allow a wide range of use cases, including account transfers, bill payments, and mortgage payments.

Extensive Network Access: Tap into FedNow’s network of over 1,000 participating financial institutions and connect with businesses on the AWS Marketplace.

Revenue-Boosting Embedded Banking: Utilize our API catalog to enhance real-time payment revenue opportunities.

AWS customers can access Finzly’s BankOS platform directly within AWS Marketplace, taking advantage of streamlined procurement, consolidated billing, and customized pricing terms, while also retiring their Enterprise Discount Program (EDP) commitment when applicable. Finzly will offer private subscriptions for enterprises seeking tailored commercial solutions, allowing customers to work directly with Finzly while benefiting from centralized invoicing through AWS.

Financial institutions can leverage the AWS Finzly Real Time Payments Workshop Studio to expedite their FedNow adoption, and if interested in accelerating the modernization of ACH, Fedwire, RTP and Swift rails are encouraged to get started by expressing their interest here.

About Finzly:
Finzly helps banks and credit unions thrive in a real-time, connected world with its Finzly BankOS platform. Institutions can quickly launch instant payments on FedNow and RTP, modernize ACH and wire transfers, and orchestrate payments through a unified API and ISO 20022-native payment hub. Finzly, recognized with multiple awards, also offers advanced FX solutions to help banks attract corporate and enterprise treasury customers.

Media Contact

Cognito Media, Finzly, 9176608527, finzly@cognitomedia.com, https://finzly.com

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SOURCE Finzly

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BGC Group announces agreement to acquire OTC Global Holdings

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Acquisition will bolster BGC’s Energy, Commodities, and Shipping business

NEW YORK, Oct. 22, 2024 /PRNewswire/ — BGC Group, Inc. (Nasdaq: BGC), a leading global brokerage and financial technology company, announced today that it has entered into an agreement to acquire OTC Global Holdings, LP (“OTC”), the largest independent institutional energy and commodities brokerage firm. Through this acquisition, BGC Group will further expand and diversify its global Energy, Commodities, and Shipping (“ECS”) business.

OTC is one of the fastest growing energy and commodities brokerage firms, with global operations across North America, Europe, and Asia. Its brokerage services include crude and refined products, petrochemicals, natural gas, ship brokerage, and biofuels, amongst others. OTC’s product suite and client base are highly complementary to BGC’s existing ECS business and will create a comprehensive platform to serve the global energy and commodities market.

“OTC has built a premier global energy, commodities, and shipping business that is supported by world class talent,” said Howard Lutnick, Chairman and CEO of BGC Group. “This acquisition will complement our existing ECS business and will enhance our ability to deliver a comprehensive, best-in-class offering to our global client base. We look forward to welcoming the OTC team onto the BGC platform, combining our innovative solutions to drive greater results for our clients.”

“BGC has an incredible offering with a proven track record of growth and innovation,” said Joe Kelly, CEO of OTC Global Holdings. “We have built something very special and unique at OTC.  We look forward to joining BGC’s platform and believe that together we will become a leading global broker for energy, commodities, and shipping products, delivering unparalleled value to our clients worldwide.”

Under the terms of the agreement, BGC expects to acquire OTC in a substantially all-cash transaction, which is subject to customary closing conditions, including applicable regulatory approvals.

Jefferies LLC is acting as exclusive financial advisor to OTC Global Holdings.

About BGC Group, Inc.

BGC Group, Inc. (Nasdaq: BGC) is a leading global marketplace, data, and financial technology services company for a broad range of products, including fixed income, foreign exchange, energy, commodities, shipping, equities, and now includes the FMX Futures Exchange. BGC’s clients are many of the world’s largest banks, broker-dealers, investment banks, trading firms, hedge funds, governments, corporations, and investment firms.

BGC and leading global investment banks and market making firms have partnered to create FMX, part of the BGC Group of companies, which includes a U.S. interest rate futures exchange, spot foreign exchange platform and the world’s fastest growing U.S. cash treasuries platform.

For more information about BGC, please visit www.bgcg.com.

Discussion of Forward-Looking Statements about BGC

Statements in this document regarding BGC that are not historical facts are “forward-looking statements” that involve risks and uncertainties, which could cause actual results to differ from those contained in the forward-looking statements. These include statements about the Company’s business, results, financial position, liquidity and outlook, as well as about the proposed acquisition of OTC (the “Acquisition”) and the closing thereof, the potential benefits of the Acquisition and the anticipated effect of the Acquisition on BGC’s business, which may constitute forward-looking statements and are subject to the risk that the actual impact may differ, possibly materially, from what is currently expected. Except as required by law, BGC undertakes no obligation to update any forward-looking statements. For a discussion of additional risks and uncertainties, which could cause actual results to differ from those contained in the forward-looking statements, see BGC’s Securities and Exchange Commission (“SEC”) filings, including, but not limited to, the risk factors and Special Note on Forward-Looking Information set forth in these filings and any updates to such risk factors and Special Note on Forward-Looking Information contained in subsequent reports on Form 10-K, Form 10-Q or Form 8-K.

 

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SOURCE BGC Group, Inc.

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ROAM Communications Named as an Inc. 2024 Power Partner

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The annual list recognizes the country’s leading B2B companies that have proven track records of supporting entrepreneurs and helping companies grow

TULSA, Okla., Oct. 22, 2024 /PRNewswire/ — ROAM Communications, a boutique public relations consulting collaborative, has been recognized among 359 companies as part of Inc.’s third annual Power Partner Awards. Inc., the leading media brand and playbook for the entrepreneurs and business leaders shaping our future, announced the prestigious list, which honors B2B organizations across the country that have proven track records supporting entrepreneurs and helping startups grow.

Every company on the Inc. Power Partner award list received top marks from clients for being instrumental in helping leadership navigate the dynamic world of startups. These B2B partners, which cover marketing and advertising, health and wellness, financial services, legal, logistics, public relations, and productivity, support entrepreneurs across various facets of the business, including hiring, compliance, infrastructure development, cloud migration, and fundraising, allowing founders to focus on their core missions.

“This is our definitive listing of vendors and suppliers who have demonstrated excellence in serving small- and midsize customers,” says Inc. editor in chief Mike Hofman. “As part of the vetting process, our team of editors, researchers, and reporters gathered information on companies’ products and services, assessed their reputation as captured in online comments and forums, and collected customer testimonials to ensure that the sales pitch matches the actual client experience. In every case, we spoke to founders like you who were happy to attest to a vendor’s genuine commitment to a mutually beneficial business partnership. We’re happy to be the conduit for that positive word of mouth.”

“Being recognized as a true partner in our clients’ success is what matters most,” said Kat Eller Murray, founder and principal of ROAM Communications. “At ROAM, our mission has always been to empower startups by providing strategic communications that drive business growth. This award is a testament to the trust our clients place in us and the collaborative approach we take in helping them achieve their goals.”

ROAM Communications is a trusted partner for companies, especially startups, that need help developing effective communications strategies, crafting impactful messages, and gaining meaningful media coverage. With a focus on aligning communications efforts with business objectives, ROAM offers tailored solutions to meet each company’s unique needs, goals, and budget. This personalized approach not only increases media coverage but also enhances brand visibility and credibility, making communications a powerful tool for business growth.

Over the past decade, ROAM’s strong results have led to long-lasting client relationships. Nine client points of contact have re-engaged ROAM after moving to new ventures, and nearly two dozen have extended or expanded their projects. In some cases, planned engagements have grown significantly, such as a three-month project that extended to over three years and another that tripled in length to accommodate family leave. By tightly integrating with our clients, ROAM becomes a seamless extension of their organization and team.

The November 2024 Issue of Inc. magazine is available online now at https://www.inc.com/magazine and will be on newsstands beginning October 29, 2024. To view the complete list, go to: https://www.inc.com/power-partner-awards/2024 

About ROAM Communications, Inc.
ROAM Communications is a boutique public relations consulting firm focused on working with technology companies and nonprofits of all sizes on their communications strategy and execution. We are seasoned, independent public relations professionals with a broad network of consultants specializing in technical writing, event management, social media, and more. ROAM Communications is certified as a Women’s Business Enterprise by the Women’s Business Enterprise National Council (WBENC), the nation’s largest third-party certifier of businesses owned and operated by women. For more information, visit www.roamcomms.com

About Inc.
Inc. is the leading media brand and playbook for the entrepreneurs and business leaders shaping our future. Through its journalism, Inc. aims to inform, educate, and elevate the profile of our community: the risk-takers, the innovators, and the ultra-driven go-getters who are creating our future. Inc.’s award-winning work achieves a monthly brand footprint of more than 40 million across a variety of channels, including events, digital, print, video, podcasts, newsletters, and social media. Its proprietary Inc. 5000 list, produced every year since its launch as the Inc. 100 in 1982, analyzes company data to rank the fastest-growing privately held businesses in the United States. The recognition that comes with inclusion on this and other prestigious Inc. lists, such as Female Founders and Power Partners, gives the founders of top businesses the opportunity to engage with an exclusive community of their peers, and credibility that helps them drive sales and recruit talent. For more information, visit www.inc.com.

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SOURCE Roam Communications Inc.

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