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Frost & Sullivan Released Report: “BiBo Pharma: A Global CDMO Leading in Advanced Biopharmaceutical Manufacturing Technologies”

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SHANGHAI, Sept. 2, 2024 /PRNewswire/ — Frost & Sullivan released a report, titled “BiBo Pharma: A Global CDMO Leading in Advanced Biopharmaceutical Manufacturing Technologies”. The report explores a global CDMO leading the “The Fourth Revolutionary Wave of Biologics Manufacturing” and pioneering the next generation of CDMO models.

The global biomanufacturing capacity gap and budget constraints have ignited the “The Fourth Revolutionary Wave of Biologics Manufacturing”, with production sites expanding towards million-liter scales. In this context, Contract Development and Manufacturing Organizations (CDMOs) have become key players in global biomanufacturing. In 2023, BiBo Pharma, founded in Boston, USA, introduced a new generation of ultra-large production platforms, marking a new era in biomanufacturing. BiBo Pharma is breaking capacity barriers and reducing antibody drug production costs from the international average of hundreds of dollars to just $10 per gram, offering disruptive solutions to global biopharmaceutical companies.

Part I: BiBo Pharma 1.0 : Reflecting on the Past – Originating in Boston, USA, and Navigating through the Global CDMO development Journey

In the increasingly competitive CDMO industry, BiBo Pharma continues to advance. This success is due not only to their precise grasp of market opportunities but also to their breakthroughs in core biopharmaceutical industrialization technologies. Sailing from Boston, BiBo Pharma has been committed to the commercial production of biologics since its inception. The company independently designed and manufactured the ultra-large stainless steel bioreactors and pioneers a new generation of production models. In 2023, BiBo Pharma successfully completed the construction of a 30,000L single-tank ultra-large-production line, and in March 2024, it successfully commenced operations.

BiBo Pharma developed a comprehensive technology platform for microbial fermentation, mammalian cell culture, gene therapy, and antibody-drug conjugates (ADC). This platform offers one-stop services from DNA to IND/BLA and large-scale commercial production. To date, BiBo Pharma has offered CDMO services for more than 130 large molecule projects. Their operations adhere to international quality and management standards, solidifying BiBo Pharma’s position on the global CDMO stage after a decade of dedicated effort, and pioneering the next generation of CDMO models.

Part II: BiBo Pharma 2.0: Current Focus – Upgrading Strategies and Expanding Capabilities

//30,000L Capacity Advantage and Global First Delivery Advantage as an Industry Pioneer//

Major global CDMOs are expanding their large-scale commercial production capacities by focusing on the construction of large-scale stainless steel bioreactors. The future direction involves advancing from the current 15,000L reactors to fourth-generation ultra-large-scale production technologies.

BiBo Pharma is the first and only CDMO to deliver a new generation of ultra-large stainless steel bioreactors with a maximum working volume of 30,000L per tank. This is an engineering scale-up of over 2.5 times compared to the current 15,000L (total volume) standard in large-scale biopharmaceutical production. BiBo Pharma leverages economies of scale and cost-sharing to offer a potential solution to reduce costs on the basis of ensuring independently designed core equipment and a controllable supply chain.

PanFlex®-Engineering: Breaking Through the “Quality-Cost-Efficiency” Triangle  

The conventional factory construction process adopts an engineering design model that proceeds from the top level down to the lower levels. PanFlex®-Engineering employs a “Process is King” strategy, using standardized units to reverse-engineer a complete factory. As a result, PanFlex®-Engineering system transcends the impossible triangle of “quality-cost-efficiency.” Remarkably, it took less than 18 months to deliver a 30,000L ultra-large production platform, roughly half the time and cost of similar projects worldwide. In addition, the 30,000L platform passed quality audits from the U.S., EU, and Chinese clients. Leveraging its PanFlex®-Operation system, Bibo Pharma achieved a “Right on First Time” in March 2024 when the platform was put into operation with a 100% success rate in subsequent production.

Grand-CHO Platform: A “Three-in-one” Approach to Innovation

A “Three-in-One” approach to innovation——Grand-CHO Platform involves advances in cell line development, process research, and production technology for ultra-large-scale platforms.

Grand-CHO platform improves cell line expression and stability, optimizes commercial production processes of different scales, and offers other benefits. The second-generation Epic-CHO cell line achieves a high expression level of 10 g/L at the mini-pool stage and offers more than double the stability of leading international cell lines, laying a solid foundation for large-scale production.

Grand-CHO technology enables high-density and large-scale cell storage, while seamlessly integrating a 3,000L N-1 perfusion process and a 30,000L intensified Fed-batch production process. Compared to traditional methods, Grand-CHO technology reduces production cycle time by 30%, doubles the yield per fermentation volume, and cuts restart time for 30,000L projects from 60 days to 30 days. Grand-CHO technology, integrated with the 30,000L ultra-large-scale production line, is fundamentally transforming the overall production efficiency of biopharmaceuticals.  

Pulse Continuous Manufacturing (PCM)

The combination of BiBo Pharma’s PanFlex®-Engineering and Grand-CHO technology has led to a groundbreaking production model — Pulse Continuous Manufacturing (PCM). PCM releases a single high-volume batch upstream, such as 60,000 liters per pulse (60kL/P). It then processes multiple downstream batches continuously based on each unit’s operation time. PCM significantly improves production efficiency, boosting overall line efficiency by 50% to 300%. PCM’s success is driven by the interconnected equipment enabled by PanFlex®-Engineering. Additionally, BiBo’s P03 plant has implemented an automated process control system (PAS) that enables full digital integration across the facility, making the execution of the PCM model more efficient and seamless. 

Technology Integration Drives Reduction of Antibody Drug Production Cost to $10 per Gram

The primary initiative to solve the constraints of production costs, is the international breakthrough of the first-ever 30,000L single-tank ultra-large-scale production line. Integrating PanFlex®-Engineering, Grand-CHO technology, and a pulse continuous production mode, BiBo Pharma reduce antibody drug production cost from hundreds of dollars to $10 per gram.

An Engineering and Technical Service Provider

BiBo Pharma has launched the pioneering “Blue Whale Program,” a financial risk-free manufacturing solution powered by the PanFlex® system. This program offers tailored production line construction services to global clients, which reduces the construction costs and timelines by 50%. This allows clients to postpone capital expenditure decisions from Phase I/II to Phase III of clinical trials, giving them more time to make informed investment choices. Additionally, the program provides a risk reduction feature: fees paid by clients are refundable regardless of whether the product succeeds in the market. This effectively offers additional insurance for commercialization and mitigates risks in the R&D and production phases.

Part III: BiBo Pharma 3.0: Shaping the Future – Establishing Comprehensive Technology Industry Advantages and Leading the Next Chapter

BiBo Pharma establishes an intensive production model, which underpins the company a diversified, full-technology platform offering one-stop CDMO services. With its Boston R&D center and global production capabilities, BiBo Pharma delivers high-quality services adhering to international standards. BiBo Pharma utilizes its unparalleled industry advantages to empower the global biopharmaceutical companies by reshaping the cost structure of biologics.

Additionally, the “Blue Whale Program” expands BiBo Pharma’s established engineering solutions, reaching more clients with commercial production needs. Frost & Sullivan expects that these capabilities and advantages will position BiBo Pharma as the best solution for global pharmaceutical companies in the future.

To read the full content, go here: https://www.frost.com/news/press-releases/bibo-pharma-a-global-cdmo-leading-in-advanced-biopharmaceutical-manufacturing-technologies/

Media Contact
Contact: Qian Li
Company Name: Frost & Sullivan
Website: http://www.frostchina.com
Email: qian.li@frostchina.com 

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SOURCE Frost & Sullivan

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TTA and O-RAN ALLIANCE Signed Agreement to Cooperate on Standardization of Open RAN Technology

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WASHINGTON and BONN, Germany, Nov. 25, 2024 /PRNewswire/ — TTA and O-RAN ALLIANCE have officially announced the signing of a Cooperation Agreement (CA) that enables the adoption of O-RAN ALLIANCE specifications to TTA standards.

The agreement establishes a collaborative process through which individual O-RAN specifications will be selected and adopted by TTA, strengthening the framework for Open RAN development and deployment in the Republic of Korea. By enabling O-RAN ALLIANCE specifications to be adopted as TTA standards, the agreement provides the basis for accelerated progress in mobile network innovation and supports the creation of a more competitive and diverse telecommunications ecosystem.

This agreement aligns with the shared vision of TTA and the O-RAN ALLIANCE to drive the industry towards the development of more intelligent, open, and virtualized mobile networks that comply with global standards. Both organizations are committed to fostering a robust framework that facilitates the adoption of Open RAN technology, ensuring that mobile networks meet evolving technical and architectural requirements in the future.

“TTA and O-RAN ALLIANCE share a commitment to the advancement of Open RAN and recognize the important role it plays in fostering an ecosystem of trusted vendors capable of delivering cost-effective, high-performance mobile network platforms.” said Seung-Hyun Son, President of TTA. “The Cooperation Agreement we have signed will combine the expertise and influence of both organizations to ensure interoperability in the open RAN market and the deployment of systems based on integrated, standards-based technologies.”

“O-RAN ALLIANCE specifications set the global foundation for open, intelligent, virtualized and interoperable Radio Access Networks, building on common RAN standards,” said Abdurazak Mudesir, Chair of the Board of O-RAN ALLIANCE and Group CTO, Deutsche Telekom. “O-RAN ALLIANCE welcomes TTA’s transposition of O-RAN specifications to TTA standards. As with other national SDO’s, this MoU ensures technical alignment and supports mutual efforts to enable truly open RAN ecosystem.”

About TTA

The Telecommunications Technology Association (TTA) is a leading organization in the Republic of Korea dedicated to develop ICT standardization and provide testing and certification services. It plays a key role in setting and promoting high-quality ICT standards that enable the development and adoption of innovative communication technologies, ICT convergence, security, software, broadcasting, radio/wireless communications, 5G/B5G, etc. TTA’s extensive range of services includes testing and certification for software and network systems, ensuring that they meet global industry standards. By supporting international cooperation and developing specialized training programs, TTA contributes to the growth and competitiveness of Korea’s digital and telecommunications industries.

For more information, visit www.tta.or.kr

About O-RAN ALLIANCE

The O-RAN ALLIANCE is a worldwide community of more than 300 mobile operators, vendors, and research & academic institutions operating in the Radio Access Network (RAN) industry. As the RAN is an essential part of any mobile network, the O-RAN ALLIANCE’s mission is to re-shape the industry towards more intelligent, open, virtualized and fully interoperable mobile networks. The new O-RAN specifications enable a more competitive and vibrant RAN supplier ecosystem with faster innovation to improve user experience. O-RAN based mobile networks at the same time improve the efficiency of RAN deployments as well as operations by the mobile operators. To achieve this, the O-RAN ALLIANCE publishes new RAN specifications, releases open software for the RAN, and supports its members in integration and testing of their implementations.

For more information, please visit www.o-ran.org.

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SOURCE O-RAN Alliance

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The vegetable greenhouse at the foot of the Turpan Flame Mountain ushered in a new era of electrification

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TURPAN, China, Nov. 25, 2024 /PRNewswire/ — On November 20, in the 10,000-mu vegetable greenhouse base in Sanbao Township, under Huoshan Mountain, Turpan City, Xinjiang, there was a busy and warm scene. Power supply personnel are shuttling between greenhouses, helping growers to debug electric heaters and other electrical equipment to ensure a stable supply of vegetables this winter. Despite the cold wind, the greenhouses are full of greenery, and growers are busy planting fruits and vegetables such as peppers and bok choy in preparation for the upcoming harvest season.

In recent years, with the in-depth promotion of smart greenhouse technology, the electrification of greenhouses has become a common trend in Turpan. Growers have adopted modern equipment such as electric roller shutters, electric heating equipment, temperature and humidity control devices, which not only improve production efficiency, but also greatly improve the quality of fruits and vegetables.

In view of the concentrated area of greenhouse planting, the State Grid Turfan Power Supply Company carried out a survey on electricity demand in advance and vigorously implemented the upgrading and transformation project of the rural power grid. By upgrading transformers and rural power lines in a timely manner, the power supply company has effectively improved the stability and reliability of power supply. At the same time, the company also regularly carries out door-to-door services to help growers check the hidden dangers of electricity, ensure the stable operation of greenhouse equipment, and protect the growers’ “money bags”.

Turpan City has 24,000 greenhouses, and the planting area of fruits and vegetables reaches 36,000 mu, forming 15 relatively concentrated development areas. In November this year, the planting of off-season fruits and vegetables in winter has been in full swing, and it is expected that they will be available from January to April next year. These products are mainly shipped to Urumqi and other medium-sized cities, becoming a veritable “vegetable basket” in Xinjiang.

Electrification not only brings about productivity gains, but also significant environmental benefits. Traditional coal-fired heating methods not only pollute the environment, but also have potential safety hazards. Electric heating equipment is not only environmentally friendly, but also easy to control, which can accurately adjust the temperature in the greenhouse and provide the best growing environment for fruit and vegetable growth.

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SOURCE State Grid Turfan Power Supply Company

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Special Envoy of Indonesia, Hashim Djojohadikusumo Attracts EUR 1.2 Billion of Green Financing in Electricity Sector at COP29

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BAKU, Azerbaijan, Nov. 25, 2024 /PRNewswire/ — The Government of Indonesia, represented by the Special Envoy of the President of the Republic of Indonesia, Hashim Djojohadikusumo, has attracted EUR 1.2 billion in green financing for the power sector from Kreditanstalt für Wiederaufbau (KfW). This agreement was finalized during the 29th Conference of the Parties (COP29) in Baku, Azerbaijan, on Wednesday (11/13). The funding will be allocated to the development of various green power infrastructures, supporting the nation’s sustainable energy transition.

The partnership was formalized by the signing of a Memorandum of Understanding (MoU) between PT PLN (Persero) and KfW. This partnership focuses on developing clean energy projects, specifically Pumped Storage Hydropower Plants and transmission network to connect green power plants.

Hashim Djojohadikusumo emphasized that the government of Indonesia is committed to reducing carbon emissions through energy transition by fostering collaborations at the global level, the shift towards renewable energy is expected to support energy self-sufficiency and drive national economic growth. He affirmed, “We have developed a new strategy over the next five years to achieve a minimum of 8% sustainable economic growth.”

He underscored that the development of clean energy sources is crucial for enhancing Indonesia’s industrial competitiveness. Over the next 15 years, the country targets a 75 percent increase in renewable energy generation capacity, contributing to the planned addition of 100 gigawatts (GW) of electricity capacity. “As a major nation, we are committed to fulfilling our responsibility to protect the future of our environment. We deeply appreciate the established international cooperation, which is a testament of our collective efforts in achieving the Net Zero Emissions (NZE) target,”

Darmawan Prasodjo, President Director of PT PLN (Persero) (“PLN”), expressed the corporation’s firm support towards the government’s initiatives in advancing energy transition. Various collaborations and initiatives have been implemented by PLN to ensure the success of sustainable electricity projects.

He noted that KfW’s involvement in PLN’s green projects is expected to drive more international partners to collaborate, cultivating a synergy of sustainable strategic, technical, and investment collaboration to accelerate global climate action. “This collaboration signifies PLN’s proactive steps in expanding international partnerships to enhance national energy self-sufficiency in line with global climate actions.”

Jürgen Kern, Sustainability Officer of KfW Group, explained that KfW’s support for Indonesia demonstrates Germany’s commitment to international cooperation for green transformation. Furthermore, Jürgen highlighted that PLN is at the center of Indonesia’s energy transition, underscoring the company’s unwavering support to greening the energy sector, while maintaining reliable energy access.

“Therefore, we believe that Indonesia and Germany can continue to strengthen partnership in the energy sector, moreover, in clean energy projects, like renewable energy and transmission. Achieving the NZE target requires robust collaboration and partnership,” he concluded.

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SOURCE PT PLN (Persero)

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