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Inductive Bio Announces Publication of Successful Drug Optimization Collaboration with Nested Therapeutics

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NEW YORK, July 29, 2024 /PRNewswire/ — Inductive Bio, a leader in leveraging machine learning (ML) to accelerate compound optimization for small molecule drug discovery, announces the publication of the approach and findings from their recent collaboration with Nested Therapeutics, a biotechnology company pioneering a next-generation precision medicine platform to address hard-to-treat cancers. The publication in ACS Medicinal Chemistry Letters highlights the pivotal role of ML models for ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) alongside computational potency predictions for prioritizing synthetic targets and enhancing design quality.

“Integrating Inductive Bio’s ADMET models into Nested’s predictive platforms helped us to prioritize designs with optimal drug like properties.” 
Yongxin Han, EVP and Head of Drug Discovery at Nested Therapeutics

Multi-parameter optimization of small molecules is an expensive, time-intensive, and high-stakes process in which potency must be balanced with ADMET properties to achieve a viable drug candidate. The two companies combined Inductive’s ADMET foundation models, which leverage state-of-the-art deep learning methods trained on proprietary ADMET datasets, with Nested’s computational platform for predicting the potency of compounds in cryptic pockets. This collaborative approach allowed Nested to reduce the number of compounds synthesized and accelerate the lead optimization process.

“Integrating Inductive Bio’s ADMET models into Nested’s predictive platforms helped us to prioritize designs with optimal drug like properties,” said Yongxin Han, EVP and Head of Drug Discovery at Nested Therapeutics. “This allowed us to rapidly iterate and optimize lead compounds and address critical ADMET challenges.”

“We are very proud of the outcome from our collaboration with Nested Therapeutics,” said Josh Haimson, co-founder and CEO of Inductive Bio. “This publication underscores the impact of ML models for ADMET in accelerating drug optimization and offers a practical framework for others aiming to undertake similar approaches. We look forward to continuing to support our partners in achieving their drug discovery goals.”

For more information on this collaboration, read the full publication here: pubs.acs.org/doi/10.1021/acsmedchemlett.4c00290 

About Inductive Bio

Inductive Bio is a technology company with a machine learning (ML) platform that dramatically accelerates the compound optimization process, a critical and time-consuming step in developing new therapeutics. By building datasets and state-of-the-art ML models designed to map the drivers of small molecule Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET), Inductive’s platform allows scientists to optimize initial compounds into leads and development candidates faster and with a better balance of ADMET properties. For more information, please visit www.inductive.bio.

Contact
media@inductive.bio 

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SOURCE Inductive Bio, Inc.

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STEM Exploration Day Ignite Girls Passion for Careers in STEM

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Professional women with careers in science, technology, engineering and math make a world of difference in inspiring young girls to show them they can achieve anyything they want to with hard work and believing n themselves.

INDIANAPOLIS, Sept. 29, 2024 /PRNewswire-PRWeb/ — The Children’s Museum of Indianapolis is proud to help ignite a passion in science, technology, engineering and mathematics (STEM) for girls of all ages. The STEM Exploration Day took place on Saturday, September 28, 2024 with professional women sharing their experience and advice.

There’s something about a robot that can feed into that interest in science, technology, engineering and math. Touch sensors, buttons and sonar show them how to control different actions and that’s fascinating.

Young girls met with women in various STEM professions including coding, physics, astronomy, robotics and engineering just to name a few. Hands-on activities and demonstrations served as great learning opportunities as visitors received special giveaways.

Programs & Activities – Thank you to all participating groups that provided hands-on activities and helped guide STEM career explorations. They included:

Eli Lilly and Company Visiting Scientist Dr. Carlotta Berry
Dr. Berry is an accomplished electrical engineer specializing in controls and robotics. She advocates for the demystification of STEM through innovative strategies, including robot hip-hop slam poetry. She is a professor and endowed department chair at Rose-Hulman Institute of Technology. She’s also an author, researcher, mentor, role model, prolific speaker, and a STEM trailblazer. Dr. Berry engaged visitors in hands-on exploration with robots. You can hear more from her here: https://youtu.be/16smIuetR_w

Indiana Visiting Artist Emily Bennett
If your first thought of “sculpture” is a gleaming marble bust from ancient Greece, just wait until you see the work of Terre Haute artist Emily Bennett! She redefines what sculpture can be, weaving colorful fibers onto metal structures to create bold, vibrant pieces. The results are what she calls “imaginary dreamscapes” that you can hang on the wall or set on a shelf. As programming coordinator for the Community School of the Arts at Indiana State University, Bennett relishes helping people uncover their artistic abilities.

Women in Lilly Discovery and Development (WiLDD) with Eli Lilly and Company (families created their own binary bracelets and lava lamps).

80 Acres Farms

Franklin Pest Solutions

Indiana State Police Crime Laboratory (visitors examined various pieces of evidence with forensic experts to learn how they solve crimes).

Society of Women Engineers (girls explored mechanical engineering and learned how to make their own catapults). UIndy Human Identification Center (families received an interesting introduction to forensic anthropology, learned about radiographs and studied casts of bones from various animals to learn about the different ages and stages of life).

City of Indianapolis—Department of Public Works, Engineering (shared a storm drain model to demonstrate how families can protect stormwater).

IU Astronomy Department (families learned how the same elements that make up our bodies are also present in galaxies billions of light years away and examined the patterns of Hydrogen, Helium, Oxygen and Neon and made bracelets with the same patterns as these elements).

IU Intelligent Systems Engineering (featured robotics and electronics).

IEEE Women in Engineering (helped visitors explore various sensors).

Sycamore School (more than two dozen activities revolving around mechanics, electricity, sound, optics and air pressure made up the activities).

American Council of Engineering Companies (ACEC) (provided a bridge building simulation).

The Gurl Code (provided binary bracelets, 3D Pens, Ozobots and MakeyMakey).

DNA Discovery in Corteva Agriscience STEMLab (families were able to extract real DNA from plant cells, discovered where DNA can be found in nature and learned about how scientists discovered the structure of DNA).

STEM Exploration Day is presented Lilly Girls & Young Women In STEM and supported by Indiana Soybean Alliance.

About The Children’s Museum of Indianapolis
We ignite joy, wonder and curiosity by creating powerful learning experiences for children and adults. For more information about The Children’s Museum, visit http://www.childrensmuseum.org and follow us on social media @childrensmuseum.

Media Contact

Kimberly Harms, The Children’s Museum of Indianapolis, 317-334-4003, kimh@childrensmuseum.org, www.childrensmuseum.org

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View original content to download multimedia:https://www.prweb.com/releases/stem-exploration-day-ignite-girls-passion-for-careers-in-stem-302261817.html

SOURCE The Children’s Museum of Indianapolis

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NECA to Unveil EV Charging Resource Network at NECA 2024 San Diego

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SAN DIEGO, Sept. 29, 2024 /PRNewswire/ — The National Electrical Contractors Association (NECA) today announced the unveiling of its EV Charging Resource Network at NECA 2024 San Diego. Developed in collaboration with Fuser LLC, this platform aims to empower NECA members to capitalize on the rapidly growing EV charging market.

NECA’s new online hub will provide charging news, information and industry networking opportunities.

“We see a critical need to unify the professional community around Electric Vehicle Service Equipment (EVSE),” said Marco Giamberardino, NECA’s Senior Vice President of Government and Public Affairs. “As EV adoption accelerates, we have to ensure our infrastructure keeps pace. This Resource Network will play a crucial role in connecting skilled electrical professionals with the growing demands of the industry.”

Pete Mastrorocco, NECA’s Senior Vice President of Education, Events and Partnerships, expects the Resource Network to represent NECA’s ongoing commitment to boosting member engagement in lucrative new markets. “EVSE represents a significant opportunity for our members,” said Mastrorocco. “NECA’s Resource Network will be an invaluable tool, helping contractors connect with experienced peers, share knowledge and capitalize on the industry’s rapid growth.”

Key features of NECA’s EV Charging Resource Network will include:

Training resourcesComprehensive EVSE news and informationRegular updates on National Electric Vehicle Infrastructure (NEVI) and Charging and Fueling Infrastructure (CFI) funding opportunitiesCurated links to state and utility grants and rebatesSpecial opportunities for NECA members

The Resource Network also provides access to Fuser, the open marketplace and networking platform devoted to EVSE.

Fuser LLC executive Pat McGinnis has expressed hope to build a stronger, more responsive industry by working with NECA to bring together all EVSE stakeholders. “These initiatives will streamline the service and installation process, create new business opportunities, and support widespread adoption of electric vehicles,” commented McGinnis. “Fuser is working with NECA to integrate their platform and is currently offering an exclusive 4-month free trial of their open marketplace to all NECA members.”

For convention details, visit necaconvention.org.

To explore NECA’s EV Charging Resource Network, visit www.necaev.org.

About NECA

NECA is the voice of the $240 billion electrical construction industry that brings power, light, and communication technology to buildings and communities across North America. NECA’s national office and 118 local chapters advance the industry through advocacy, education, research, and standards development. Go to www.necanet.org for more information. 

View original content to download multimedia:https://www.prnewswire.com/news-releases/neca-to-unveil-ev-charging-resource-network-at-neca-2024-san-diego-302261872.html

SOURCE National Electrical Contractors Assoc Inc.

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CNBM holds promotional conference in Riyadh

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RIYADH, Saudi Arabia, Sept. 29, 2024 /PRNewswire/ — A Report From GLOBAL TIMES ONLINE: 

China National Building Material Group (CNBM) held a promotional conference in Riyadh, capital of Saudi Arabia on Sept. 25.

The event was joint by over 120 guests from the Chinese Embassy in Saudi Arabia, the government of Saudi Arabia, 35 of the group’s global partners, eight investment organizations as well as renowned media outlets.

Chairman of CNBM Zhou Yuxian delivered a keynote speech at the event, stressing the solid foundation and future prospects of CNBM’s cooperation with Saudi Arabia. He said CNBM is committed to promoting international industrial cooperation, and is ready to contribute its wisdom, plans and strength to the development of Saudi Arabia.

Mosleh H. Alemrani, General Manager for Non-Metallic Minerals Development, Ministry of industry & Mineral Resources of Saudi Arabia, remarked that the government of Saudi Arabia supports green development and will promote carbon reduction and the use of new energy in the cement industry.

Mohammed A. Al-Garni, Board Member & CEO of Saudi Cement Company, reviewed the company’s cooperation with CNBM and reiterated the company’s willingness to promote mutually beneficial cooperation between the two sides.

Mohammad N. A-Mulhim, Vice President of Aramco Asia noted that Aramco and CNBM see huge potential of cooperation in advanced non-metal materials, low-carbon construction materials and energy storage solutions. The framework agreement of cooperation signed by the two sides this time marked their continued cooperation and signaled their willingness to keep sharing opportunities, he added.

During the event, the guests jointly inaugurated Sinoma Technical Service Center (KSA), which aims to improve the service capabilities of CNBM in the Middle East. The service center will provide CNBM’s clients in the Middle East with professional equipment, processing, repairment and maintenance, technical upgradation as well as training services.

The promotional conference built a closer bond between CNBM and various sectors in Saudi Arabia, and laid a solid foundation for promoting the synergy between China’s Belt and Road Initiative and Saudi Arabia’s Vision 2030. CNBM looks forward to joining hands with more partners to jointly advance sustainable development.

View original content:https://www.prnewswire.co.uk/news-releases/cnbm-holds-promotional-conference-in-riyadh-302261862.html

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