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Menarini’s cell based non-invasive prenatal technology demonstrates high resolution detection of fetal genomic abnormalities from a simple maternal blood draw

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Data presented at the 2024 FMF (Fetal Medicine Foundation) World Congress in Lisbon, Portugal shows the potential for an automated system to deliver genomic profiles of fetal cells that is highly concordant with the genomic analysis obtained from invasive procedures. Results of a large clinical validation study show that Menarini Silicon Biosystems’ fetal cell based noninvasive prenatal screening (NIPT) technology can accurately detect both fetal genome-wide pathogenic copy number variants greater than 600Kb in size and the commonly screened trisomy conditions.

BOLOGNA, Italy and HUNTINGDON VALLEY, Pa., July 2, 2024 /PRNewswire/ –The Reproductive Precision Medicine Unit of Menarini Silicon Biosystems (MSB) presented last week, at the 21st World Congress of the Fetal Medicine Foundation meeting in Lisbon, Portugal, results of a large multicenter study describing their next generation non-invasive prenatal testing technology using fetal cells isolated from maternal blood. The genomic analysis of these fetal cells showed a high concordance with the analysis of fetal cells obtained from invasive diagnostic procedures. Moreover, MSB’s cell-based test, under development, demonstrated its potential validity for screening genomic conditions not easily found with currently available, state of the art, non-invasive screening technologies based on cell-free DNA (cfDNA) analysis.

This large study, which enrolled over 1,000 women, was centered on isolating individual fetal (trophoblast) cells from maternal blood and analyzing them for both common trisomic conditions and genome-wide microdeletions and microduplications, called pathogenic copy number variants (pCNVs), that account for significant perinatal morbidity and mortality. The results presented showed that MSB’s fetal cell based NIPT could deliver information beyond core “common” trisomies detected by standard non-invasive cfDNA analysis, as well as detect with a high level of accuracy and granularity genome-wide microdeletions and microduplications down to a size of at least 600Kb. The cell-based test was compared with chromosomal microarray analysis (CMA) and karyotype from chorionic villus sampling (CVS) or amniocentesis, the clinical gold – standard fetal diagnostic methodologies to detect genomic chromosomal abnormalities in the prenatal setting.

According to Professor Jon Hyett, Head of Maternal and Fetal Medicine at Liverpool Hospital and Professor of Obstetrics and Gynaecology at Western Sydney University, who looks after pregnancies that have a high risk of complication – either for the mother, or for the fetus: “This data is exciting because it shows the potential to deliver clinically relevant and actionable information about fetal genomic abnormalities  at higher resolution and accuracy than existing screening tests and at an early gestational age when almost no pCNVs are currently detected.” Menarini’s new study thereby opens the door to a whole new paradigm in prenatal screening.

For Thomas Musci, MD, Chief Medical Officer, Head of Menarini Silicon Biosystems’ Reproductive Precision Medicine Business Unit, who presented the results of the study, “Isolating intact fetal cells from maternal blood for prenatal screening has  long been perceived as an extremely challenging goal. Our highly automated system for the isolation and single–cell analysis of circulating extravillous trophoblasts (cEVTs) supports the feasibility of a cell–based NIPT for fetal genomic profiling that can lead to more informed decision-making at all levels.”

Menarini has been actively investing to advance single cell analysis and sequencing in the field of reproductive care. For Fabio Piazzalunga, President of Menarini Silicon Biosystems, “The results of this study, which confirmed the potential ability of our cell based NIPT to identify fetal abnormalities with high sensitivity, accuracy, and specificity, show the potential of Menarini to significantly impact women’s health. Our continuous commitment and efforts to advance our scientific findings in this field aim to provide, in the future, a potentially revolutionary solution that brings more information to women and their doctors”. These new activities fully support the company’s vision to become a leader in minimally invasive cell-based applications that can allow for easier, faster, and more precise diagnostic and therapeutic approaches in multiple therapeutic areas.

About Menarini Silicon Biosystems (MSB)

MSB offers unique rare cell technologies and solutions that provide clinical researchers with access to unparalleled resolution in the study of cells and their molecular characterization.

Menarini Silicon Biosystems, based in Castel Maggiore (Bologna, Italy), and Huntingdon Valley, PA., U.S., is a wholly owned subsidiary of the Menarini Group, a multinational pharmaceutical, biotechnology and diagnostics company headquartered in Florence, Italy, with more than 17,000 employees in 140 countries.

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Contact:
PAVY Consulting
Linda PAVY
lipavy@pavyconsulting.com 

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Experts from SPS North America to share Best Practices at BFSI Conference Expo

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September 20, 2024

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Business Process Outsourcing experts from SPS, a leading provider of Technology Business Solutions, will share best practices related to business transformation and process automation at the Digital Transformation in BFSI Conference Expo in New York on September 26, 2024

NEW YORK, Sept. 20, 2024 /PRNewswire-PRWeb/ — Business Process Outsourcing experts from SPS will be on hand to share best practices at the Digital Transformation in BFSI Conference Expo in New York on September 26, 2024. SPS is a leading innovative outsourcing provider of Technology Business Solutions that help companies automate workflows, streamline processes, and elevate the customer experience.

Through our Lean Six-Sigma methodologies, SPS helps our banking, financial services and insurance clients analyze workflows and build solutions that leverage automation to reduce cycle time, improve quality, and enhance compliance measures.

The Digital Transformation in BFSI Conference Expo is a focused event that unites professionals, experts, and stakeholders from the banking, financial services, and insurance sectors. Its purpose is to discuss, demonstrate, and examine digital innovations and their impact. The event offers a valuable platform for knowledge exchange, networking, and collaboration between industry leaders and technology providers.

SPS is a technology-driven partner, specializing in transforming back-office operations and enhancing client-focused services for leading organizations with 45% of its current clients in the BFSI sectors. The organization offers tailored Technology Business Solutions, focusing on Data & Business Process Management and providing custom solutions for the Health and BFSI sectors to address their specific challenges.

“At SPS, we understand that digital transformation is a never-ending process,” stated Pamela Tom, Vice President, Solution Design, SPS North America. “Through our Lean Six-Sigma methodologies, we help our banking, financial services and insurance clients analyze workflows and build solutions that leverage automation to reduce cycle time, improve quality, and enhance compliance measures. We look forward to connecting and sharing best practices with attendees of the BFSI Conference.”

With a global network of delivery centers, SPS stands out as a trusted outsourcing partner, offering flexible processing options for onshore, nearshore, and offshore delivery. The team of SPS experts utilize industry best practices and cutting-edge automation technologies to elevate business processes all within a certified high-security environment that safeguards sensitive data.

Explore how SPS can drive growth by implementing innovative, tech-enabled solutions at http://www.spsglobal.com.

About SPS
SPS is a leading technology-driven business transformation company. Our Technology Business Solutions bring together cutting-edge technology, deep vertical process expertise, and a diverse global workforce to support clients in their digital transformation journey and efficiently tackle their most complex challenges. With our innovative Enterprise Workplace Solutions, we empower organizations to adopt hybrid work programs to enhance productivity and flexibility.

Headquartered in Zurich, Switzerland, SPS operates in more than 20 countries and focuses on clients in banking, insurance and health. SPS has more than 8,500 employees and is recognized with a world-class NPS by its global client base.

We act with precision, connect people to the right information, and turn data into insights for better outcomes.

Discover how our dedicated team at SPS makes an impact that matters by visiting http://www.spsglobal.com.
SPS. The Power of Possibility.

Media Contact

Janet Tarzia, SPS North America, 1-212-204-0900, janet.tarzia@spsglobal.com, https://www.spsglobal.com

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INGEEK Recognized in 2024 Gartner Market Guide for Fleet Telematics and 2024 China Hype Cycle for Security

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September 20, 2024

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SHANGHAI, Sept. 20, 2024 /PRNewswire/ — INGEEK, a leading provider of innovative intelligent connected vehicle (ICV) technologies, and its Intelligent Connected System (ICS) and Automotive Digital Key have been featured in Gartner’s Market Guide for Fleet Telematics. This recognition highlights INGEEK’s capability to boost efficiency, ensure safety, and enable sustainability in fleet operations and management.

Revolutionizing Fleet Management with INGEEK ICS/Digital Key
INGEEK’s digital key solution establishes connection between the people and vehicle by digitalizing conventional car key into digital twin, which seamlessly integrates with the broader mobility ecosystem and diverse business scenarios.

Business Process Automation with online key sharing, such as contactless pick-up and return.Digital Key Management simplifies key management, reduces administrative overhead, and mitigates the risk of lost or stolen keys.Data Tracking provides insights to fleet performance and health.Enhanced Driver Satisfaction: Convenient features such as proximity lock/unlock provide a seamless driving experience.

Securing Connected Vehicles with INGEEK’s Trust Center for Automotive
Previously, AUGUST 6, INGEEK’s Trust Center was featured in Gartner’s Hype Cycle for Security’s IoT Authentication technology segment. With IoT connections in China projected to reach 8 billion by 2025, robust IoT authentication is critical to protect connected car business-use cases such as V2X communications, OTA, and Digital Key. The Trust Center leverages PKI to ensure top-tier security.

Remarks from Leadership
“We’re proud to be recognized by Gartner, which is the global authority in providing industry technology advisory and insights to executives,” stated Steven Shan, CEO of INGEEK. “Our intelligent vehicle solutions prompt the next wave of smart mobility transformations, and this inclusion is a signal to how OEMs and automotive players are leveraging advanced digitalization technologies to connect the people and vehicle together.”

“Our Trust Center offers robust and scalable authentication mechanisms to safeguard connected vehicles against security threats,” added Feng Li, INGEEK’s Head of Cybersecurity BU.

“Gartner’s Market Guide coincides with our vision for a more connected, secure, and efficient mobility market,” continued William Yuan, Director of Strategy at INGEEK. “Our solutions are not just about technological advancements; they are strategic initiatives aimed at optimizing operations, reducing costs, and ultimately helping fleet operators to expand their mobility business offerings.”

For more information about INGEEK and its solutions, please visit www.ingeek.com
Media Contact: Ms. Fang at jingneng.fang@ingeek.com
Germany Contact: Professor Sachs at hans-ulrich.sachs@hus-online.com
AP/EMEA Contact: Mr. Yuan at guohao.yuan@ingeek.com

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View original content:https://www.prnewswire.co.uk/news-releases/ingeek-recognized-in-2024-gartner-market-guide-for-fleet-telematics-and-2024-china-hype-cycle-for-security-302253355.html

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Niutech at the Forefront: U.S.-China Circular Economy Forum Tackles “White Pollution”

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55 mins ago

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September 20, 2024

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BEIJING, Sept. 20, 2024 /PRNewswire/ — On September 6, 2024, the inaugural U.S.-China Circular Economy Cooperation Forum was held in Beijing. The forum, guided by the U.S.-China Climate Action Working Group Circular Economy Task Force, was co-organized by the China Circular Economy Association and the US-China Business Council. The forum brought together approximately 460 distinguished guests from the National Development and Reform Commission of China, the U.S. Department of State, the U.S. Department of Energy, and other government departments, as well as industry experts, business representatives and scientific research institutions of the two countries. As the domestic leader in continuous pyrolysis technology, Niutech was invited to attend the forum and gave an insightful speech on the topic of waste plastic recycling, and the issues of ‘white pollution’ that can result from it.

The forum was strategically designed to advance the goals outlined in the U.S.-China “The Sunnylands Statement on Enhancing Cooperation to Address the Climate Crisis”. It aimed to create a collaborative platform for both countries’ business community, social organizations, and research institutions to foster exchanges and drive tangible cooperation in the circular economy. 

Zhao Chenxin, Deputy Director of the National Development and Reform Commission, John Podesta, Senior Advisor to the U.S. President on International Climate Policy, Liu Zhenmin, China’s Special Envoy for Climate Change Affairs, and Nicholas Burns, U.S. Ambassador to China attended the opening ceremony of the Forum and delivered a speech, and Xie Feng, Chinese Ambassador to the U.S., made a video message. Deputy Director Zhao Chenxin said that addressing climate change is a common cause for all mankind and cannot be separated from the cooperation between the two global forces, China and the United States.

At the forum, as the international expert in continuous pyrolysis technology, the corporate representative of Niutech shared the cases of waste plastic chemical recycling projects deployed with international giants BASF and Quantafuel in Denmark, Thailand and other countries. This technology enables the transformation of low-value, mixed, and contaminated waste plastics into high-quality fuel oil. 

The fuel oil derived from this process can undergo further refining into naphtha, a critical raw material in the production of new plastics. This advanced recycling process not only diverts plastics from landfills and the environment but also contributes to a circular economy by turning waste into a valuable resource.

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View original content:https://www.prnewswire.co.uk/news-releases/niutech-at-the-forefront-us-china-circular-economy-forum-tackles-white-pollution-302254026.html

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