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Zapping the right brain cells: The path to improved stimulation

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New findings could help scientists develop better ways to treat brain disorders with electrical stimulation.

SEATTLE, June 4, 2024 /PRNewswire/ — New research by scientists at the Allen Institute’s Brain and Consciousness group and Cedars-Sinai offers an unprecedented look at how neurons respond to ES. Far from being uniform, different types of neurons showed distinct patterns of ‘syncing up’ with electrical fields. These patterns varied depending on the rate at which the ES was delivered.

The findings, published today in Neuron, could help doctors fine tune where, when, and how to apply ES to the brain, said Soo Yeun Lee, Ph.D., the paper’s first author and a Senior Scientist at the Allen Institute. 

“With this study, we now have a much better idea of what types of stimulation work for specific cell classes,” she said. “We can use that knowledge to develop more efficient ways of using electrical stimulation to treat disorders.” 

Using tissue samples from mice and humans, the research team delivered oscillating waves of ES within tens of micrometers of individual neurons. This extraordinary precision enabled an unprecedented look at electrical stimulation’s impact at a single-cell level. They observed strong, cell-class-specific responses. Excitatory neurons synchronized firing with both slow and fast stimulation frequencies, while inhibitory neurons primarily responded to fast frequencies. These class-specific responses are significant, Lee said, because they reveal that adjusting the stimulation frequency allows for the selective targeting of different neurons. That discovery could lead to more precise therapies to modulate neural activity. 

For example, inhibitory neurons that express a protein called parvalbumin are implicated in epilepsy and in cognitive dysfunctions, she noted. This study shows that these cell classes are most responsive to certain frequencies. Future treatments could tailor ES to the most effective frequency, potentially improving outcomes and limiting side effects. 

Beyond its clinical implications, the study also revealed a universal truth about how neurons function, Lee added. Regardless of cell class, cortical areas, or species, neurons exhibit a remarkable ability to synchronize with an external electric field. 

This general property is superimposed on the brain’s dazzling cellular diversity, Lee said—and the newfound understanding of these underlying mechanisms could transform our approach to treating complex brain disorders. 

Research described in this article was supported by award numbers R01NS120300 and R01NS130126 from the National Institute of Neurological Disorders and Stroke of the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH and its subsidiary institutes.  

About the Allen Institute
The Allen Institute is an independent, 501(c)(3) nonprofit research organization founded by philanthropist and visionary, the late Paul G. Allen. The Allen Institute is dedicated to answering some of the biggest questions in bioscience and accelerating research worldwide. The Institute is a recognized leader in large-scale research with a commitment to an open science model. Its research institutes and programs include the Allen Institute for Brain Science, launched in 2003; the Allen Institute for Cell Science, launched in 2014; the Allen Institute for Immunology, launched in 2018; and the Allen Institute for Neural Dynamics, launched in 2021. In 2016, the Allen Institute expanded its reach with the launch of The Paul G. Allen Frontiers Group, which identifies pioneers with new ideas to expand the boundaries of knowledge and make the world better. For more information, visit alleninstitute.org.

Media Contact
Peter Kim, Sr. Manager, Media Relations
206-605-9884 | peter.kim@alleninstitute.org 

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SOURCE Allen Institute

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BOAT ROCKER MEDIA ANNOUNCES FILING OF MANAGEMENT INFORMATION CIRCULAR FOR SPECIAL MEETING OF SHAREHOLDERS

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TORONTO, May 9, 2025 /CNW/ – Boat  Rocker Media Inc. (“BRMI” or the “Company”) (TSX: BRMI) announced today that it has filed its notice of meeting, management information circular and related documents (collectively, the “Meeting Materials”) with securities regulators in connection with the special meeting (the “Meeting”) of the holders (the “Shareholders”) of subordinate voting shares and multiple voting shares of the Company. The Meeting Materials can be accessed either on the Company’s website at www.boatrocker.com or under the Company’s SEDAR+ profile at www.sedarplus.ca.

The Meeting is to be held on June 17, 2025, at 10:00 a.m. (Toronto time) at the offices of Stikeman Elliott LLP, 5300 Commerce Court West, 199 Bay Street, Toronto, Ontario, M5L 1B5, Canada. Only Shareholders whose names have been entered in the register of the Company as at the close of business on April 21, 2025, the record date for the Meeting, or their duly appointed proxyholders, will be entitled to receive notice of and vote at the Meeting or any adjournment(s) or postponement(s) thereof.

At the Meeting, Shareholders will be asked to pass resolutions approving, among things, (i) the reverse take-over of BRMI by Blue Ant Media Inc. (“Blue Ant”), a privately owned company controlled by Michael MacMillan, (ii) the management buyout of Boat Rocker Studios by BRMI Co-Founders and Co-Executive Chairmen, David Fortier and Ivan Schneeberg, and BRMI CEO John Young, and (iii) the sale of the Company’s interests in The Initial Group Global, LLC (“The Initial Group”), a U.S. talent management business, to Fairfax Financial Holdings Limited (collectively, the “Transaction”).

Shareholders are encouraged to vote well in advance of the proxy cut-off time of 10:00 a.m. (Toronto time) on June 13, 2025.

If you have any questions regarding the Transaction or how to vote your shares, please contact the Company’s proxy solicitation agent, Carson Proxy Advisors: (i) by telephone at 1-800-530-5189 (North American toll free); or (ii) by email at info@carsonproxy.com.

About Boat Rocker Media Inc.

Boat Rocker (TSX: BRMI) is the home for creative visionaries. An independent, integrated global entertainment company, BRMI’s purpose is to tell stories and build iconic brands across all genres and mediums. With offices around the world, BRMI’s creative and commercial capabilities include Scripted, Unscripted, and Kids and Family television production, distribution, brand & franchise management, a world-class animation studio, and talent management through a minority stake in The Initial Group, a new company launched by TPG. A selection of BRMI’s projects include: Invasion (Apple TV+), Palm Royale (Apple TV+), Video Nasty (BBC Northern Ireland, BBC Three, Virgin Media One, WDR), This Is the Tom Green Documentary (Prime Video), Orphan Black: Echoes (AMC), American Rust: Broken Justice (Prime Video), Beacon 23 (MGM+), Pretty Baby: Brooke Shields (Hulu), Downey’s Dream Cars (Max), BS High (HBO), Orphan Black (BBC AMERICA, CTV Sci-Fi Channel), Billie Eilish: The World’s a Little Blurry (Apple TV+), The Next Step (BBC, Corus, CBC), Daniel Spellbound (Netflix), and Dino Ranch (Disney+, Disney Junior, CBC). For more information, please visit www.boatrocker.com.

Forward-Looking Information / Cautionary Statements

Certain information contained in this news release may be forward-looking statements within the meaning of Canadian securities laws. Forward-looking statements are often, but not always, identified by the use of words such as “expect”, “anticipate”, “believe”, “foresee”, “could”, “estimate”, “goal”, “intend”, “plan”, “seek”, “will”, “may”, “would” and “should” and similar expressions or words suggesting future outcomes. These forward-looking statements reflect material factors and expectations and assumptions of the parties. These forward-looking statements include the assumptions: that the Transaction is able to be completed on the timelines and on the terms currently anticipated; that all regulatory and other required approvals can be obtained on the timelines and in the manner currently anticipated; that the anticipated benefits of the transaction are able to be achieved; that the businesses of both BRMI and Blue Ant will continue to operate in a manner consistent with past practice; and that the parties’ transition plans are effective.

The parties’ estimates, beliefs and assumptions are inherently subject to uncertainties and contingencies regarding future events and, as such, are subject to change. Risks and uncertainties not presently known to the parties or that they presently believe are not material could cause actual results or events to differ materially from those expressed in the forward-looking statements. Additional information on these and other factors that could affect events and results are included in other documents and reports that will be filed by BRMI with applicable securities regulatory authorities and may be accessed through the SEDAR+ website (www.sedarplus.ca). Readers are cautioned not to place undue reliance on these forward-looking statements, which reflect the parties’ expectations only as of the date of this press release. The parties disclaim any obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as expressly required by law.

U.S. Securities Matters

None of the securities to be issued pursuant to the Transaction have been or will be registered under the United States Securities Act of 1933, as amended (the “U.S. Securities Act”), or any state securities laws. The resulting issuer securities to be issued in the Transaction are anticipated to be issued in reliance upon available exemptions from such registration requirements pursuant to section 3(a)(10) of the U.S. Securities Act and applicable exemptions under state securities laws. This press release does not constitute an offer to sell or the solicitation of an offer to buy any securities.

SOURCE Boat Rocker Media Inc.

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The Secret to Turning Back Time: DermRays Skincare Device Makes Women Look 10 Years Younger

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PLEASANTON, Calif., May 10, 2025 /PRNewswire/ — Every woman dreams of reversing the clock and reclaiming youthful, radiant skin. This Mother’s Day, make that dream a reality with DermRays Skincare Device-the perfect gift for moms and yourself! From May 1-15, enjoy an exclusive $120 OFF during our Mother’s Day Sale. 

DermRays offers two cutting-edge devices tailored to different skincare needs: 

DermRays Revive: Designed for mature skin, this device combats wrinkles, fine lines, and loss of elasticity with advanced 1064nm laser therapy, restoring a lifted, firmer look. DermRays FusionGlow: Ideal for younger users, it tackles acne, dullness, and uneven texture with red and blue light therapy, promoting clearer, glowing skin. DermRays LED: Your daily skincare companion: blue, red, infrared, and mixed light for every need. FDA-cleared safety with built-in eye cups for added protection. Only 15 minutes a day for youthful and radiant skin.

According to the DermRays R&D team, an exciting 1450nm laser skincare device is currently in development and is expected to launch later this year. “We are committed to continuously innovating to meet women’s skincare needs,” says Dr. Yang Lin, dermatology consultant for DermRays. “Our upcoming laser technology will further enhance skin rejuvenation, offering even more transformative results.

“Looking 10 years younger isn’t just a fantasy-it’s achievable with the right technology,” says Dr. Yang Lin, dermatology consultant for DermRays. “Our devices provide salon-quality results at home, making skincare effortless and effective.” 

Don’t miss this limited-time offer! Visit DermRays.com and use code MOTHER120 at checkout. Give the gift of timeless beauty this Mother’s Day-because every woman deserves to feel her best. Stay tuned for the groundbreaking 1450nm laser device and witness how DermRays continues to revolutionize women’s skincare. 

Video – https://www.youtube.com/watch?v=xs7jnzuQX08

 

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StarCharge Unveils Cutting-Edge BESS Solution at Intersolar 2025

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MUNICH, May 10, 2025 /PRNewswire/ — StarCharge, a global leader in EV charging infrastructure, energy, and digital solutions, has unveiled its latest BESS solution at Intersolar 2025. The launch attracted considerable attention, with a high volume of customers visiting the booth to explore the latest 5MWh BESS solution. Numerous clients showed strong interest and engaged in in-depth consultations, highlighting the market’s enthusiasm for innovative and scalable energy storage solutions.

StarCharge 5MWh Container Energy Storage System

The 5MWh Container Energy Storage System is optimized for utility-scale application, ensuring peak shaving and enhancing grid stability. It features high-performance 314Ah LFP battery cells, BMS, Aerosol Fire Suppression System (FSS) and Environmental Control System, all housed within a 20 feet standardized container. The container is highly corrosion-resistant and complies with global environmental standards, ensuring its resilience in a variety of operating conditions.

Tailored for the European market, the system is well-suited for use as standalone BESS projects, distributed energy storage power stations, industrial and commercial microgrids, EV charging hubs, and renewable energy storage facilities. Its flexible and scalable design addresses the growing demand for reliable energy infrastructure amid Europe’s accelerating transition to renewables and electric mobility.

Future Prospects

Intersolar 2025 marks the international debut for StarCharge 5MWh BESS solution, representing a significant milestone in the company’s global expansion strategy. By leveraging its integrated manufacturing capabilities in ESS containers, battery packs and PCS systems, StarCharge is well-poised to contribute significantly to global energy sustainability efforts.

“As the global energy sector rapidly evolves, StarCharge remains resolutely focused on integrating advanced technologies that support global energy independence,” said a spokesperson for StarCharge. “Our participation at Intersolar 2025 represents a pivotal moment in advancing our strategic initiatives, as we empower businesses, utilities, and communities worldwide with innovative energy solutions.”

About StarCharge

StarCharge, a global leader in EV charging infrastructure and comprehensive energy solutions. It offers a diverse range of intelligent and reliable charging and BESS solutions powered by cutting-edge technology, designed to cater to various scenarios and contribute to building a more efficient and resilient energy future.

For more information, please visit www.starcharge.com or contact BESSinfo@starcharge.com.

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