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Gabather reports initial positive results from the EEG/fMRI target engagement study

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STOCKHOLM, March 7, 2024 /PRNewswire/ — Gabather AB (Nasdaq First North Growth Market: GABA) today reports initial positive results from the EEG/fMRI target engagement study, a double-blinded placebo-controlled, cross-over phase Ib study of Gabather’s GABAA-receptor positive allosteric modulator, GT-002, in healthy volunteers.

The study met the primary objective to confirm a favourable safety and tolerability profile of GT-002. The secondary objective to demonstrate target engagement in human brain was also met. The study clearly demonstrated that GT-002 is safe and well tolerated at dose levels expected to be effective for treatment of patients with neuropsychiatric disorders.

Clinically relevant effects of GT-002 were observed on modulation of EEG frequency band power with a significant increase in alpha band power, compared to Lorazepam at the 2-hour after treatment. This effect spanned various brain regions, including frontal and occipital areas. No significant effect of Lorazepam on EEG alpha band power compared to placebo was observed. The results suggest a distinct effect of GT-002 to modulate alpha band power across specific cortical regions.

EEG alpha band power is recognized as a marker of cognitive activity such as attention and associated with relaxation and less anxiety, an increase in alpha band may be beneficial for a number of different neuropsychiatric conditions. Of particular clinical interest are the reports that negative symptoms in schizophrenia patients are associated with reduced EEG alpha band power.

“We have now proven clinically relevant target engagement in the human brain following oral administration of GT-002 showing that EEG and neuroimaging techniques can indeed open ‘a window into the brain’ and drive the drug development process of our candidate drugs. The next data to be presented will be a refined analysis of the EEG data during task performance and the fMRI neuroimaging data. With these results at hand, we will move forward into clinical trials in patients and identify the right partner for the continued development of GT-002,” says Michael-Robin Witt, CEO of Gabather AB.

 GT-002 Background

GT-002 is a small molecule GABAA receptor Positive Allosteric Modulator (PAM) eliciting both tonic and phasic inhibitory currents. GT-002 improves learning and memory in preclinical models. It restores ketamine induced cognitive deficits in the discrimination learning task model, and inhibits the behavioural effects induced by phencyclidine in the in-vivo model of schizophrenia. GT-002 has been shown to be anxiolytic and to promote social interaction in rats. GT-002 targets a novel binding site on GABAA receptors, different from benzodiazepines (BZD), and has not shown any of the side effects known for BZD. Long-term treatment (28 days) with GT-002 has not shown any withdrawal symptoms upon cessation of treatment both in mice and dogs, indicating no drug abuse liability associated with this drug candidate. GT-002 has successfully completed three phase I clinical trials in healthy volunteers. Both single ascending dose (SAD) and multiple ascending dose (MAD) studies have been completed. The results from these studies show that GT-002 is safe and well tolerated and that it has excellent pharmacokinetic properties, allowing for once-a-day oral dosing.

Contact Information

Michael-Robin Witt, CEO
Phone: 073-687 28 39
E-mail: mrw@gabather.com

About Gabather

Gabather is a clinical-stage pharmaceutical company aiming to transform the treatment of neuropsychiatric disorders. The Company was founded as a response to the significant unmet need and lack of innovative therapeutics in the mental health treatment landscape. Gabather is dedicated to developing innovative therapeutics for the treatment of a broad range of neuropsychiatric disorders. The goal is to accelerate the development of new groundbreaking medicines to achieve clinically meaningful therapies for the patients.

For more information, please visit: www.gabather.com

Certified Adviser

Corpura Fondkommission AB
Phone: +4672-252 34 51
Email: ca@corpura.se 
www.corpura.se

Forward-looking statement

This press release contains forward-looking statements that constitute subjective estimates and forecasts about the future. Assessments about the future are only valid on the date they are made and are, by their nature, similar to research and development work in the biotech field, associated with risk and uncertainty. In light of this, actual outcomes may differ substantially from what is described in this press release. Gabather is listed on First North Growth Market and Corpura Fondkommission AB is Certified Advisor.

The following files are available for download:

https://mb.cision.com/Public/11735/3942198/9693ab2d0c4c3557.pdf

PM positive clinical data GT-002 2024-03-07

 

View original content:https://www.prnewswire.co.uk/news-releases/gabather-reports-initial-positive-results-from-the-eegfmri-target-engagement-study-302082662.html

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Enverus releases Investor Analytics: Refined, actionable financial insights at your fingertips

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New generative AI tool harnesses insights from earnings, investment power, oil and gas M&A, and what’s driving the energy transition

AUSTIN, Texas, April 25, 2025 /PRNewswire/ — Enverus, the most trusted energy-dedicated SaaS company that leverages generative AI across its solutions, announced it has added Investor Analytics to its suite of offerings. This cutting-edge solution stemming from Enverus’ flagship AI tool, Instant Analyst™, is designed to provide investors with a comprehensive view of key market dynamics. Investor Analytics delivers refined and actionable insights into financials, investor behavior, private equity trends and performance metrics, all vetted by Enverus experts.

This new solution, combined with other offerings like Enverus M&A Analytics for oil and gas deals or Energy Transition M&A, which provides guidance and analytics for navigating energy transition transactions, covers 30 asset types including established power generation assets, CCUS, hydrogen and emerging technologies. Together, these generative AI tools offer comprehensive M&A coverage and knowledge for a vast range of energy deal teams, executives and investors.

Investor Analytics empowers users with timely and actionable insights, enabling them to find answers faster, sharpen their competitive edge and navigate opportunities and risks with greater precision. Investor Analytics will be on full display at EVOLVE 2025, Enverus’ upcoming three-day conference held May 12-15, 2025, at the Hilton Americas in downtown Houston, where visionaries converge to shape the future of energy. EVOLVE will feature more than 65 sessions with 130 speakers focused on technology and energy innovation and exclusive insights from the Enverus Intelligence® Research team. This powerhouse symposium offers unmatched market insights, cutting-edge technological know-how and the chance to connect with industry leaders across the entire energy spectrum.

Continue reading our extended Investor Analytics announcement and EVOLVE 2025

About Enverus
Enverus is the most trusted energy-dedicated SaaS company, with a platform built to maximize value from generative AI, offering anytime, anywhere access to analytics and insights. These include benchmark cost and revenue data sourced from more than 95% of U.S. energy producers and more than 40,000 suppliers. Our platform, with intelligent connections, drives more efficient production and distribution, capital allocation, renewable energy development, investment and sourcing. Our experienced industry experts support our customers through thought leadership, consulting and technology innovations. We provide intelligence across the energy ecosystem: renewables, oil and gas, financial institutions, and power and utilities, with more than 7,700 customers in 50 countries. Learn more at Enverus.com.

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Goodwin Partners with Cincinnati Bengals to Power “Meet the Draft Picks” Event for Bengals Premium Suite Holders

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COLUMBUS, Ohio, April 25, 2025 /PRNewswire/ — Goodwin, an Ohio-based software company built for charter aviation brokers, is proud to announce its official sponsorship of the Cincinnati Bengals’ “Meet the Draft Picks” event for Bengals Premium Suite Holders, taking place this Saturday, April 26.

As a part of its broader partnership with the Bengals’ Suite Program, Goodwin is bringing its spirit of Ohio ingenuity and seamless connectivity to this exclusive event, where the Bengals Premium Suite Holders will get a first look at the Bengals’ 2nd and 3rd round draft picks.

The event timeline includes:

Player introductions and fan meet-and-greetsLive draft insights from Bengals broadcasters Dan Hoard and Dave LaphamBehind-the-scenes tours of the state-of-the-art Kettering Health Performance CenterPhoto ops with Who Dey and the Ben-GalsComplimentary beverages and hors d’oeuvresLive Day 3 NFL Draft coverage

“As a company born and built in Ohio, we’re thrilled to partner with a team that represents the heart of this community,” said Tolga Demirel, Co-Founder of Goodwin. “Our technology is designed to make every connection—from brokers to operators to aircraft—as smooth and intuitive as possible. When things just work, that’s Goodwin Generated.”

Goodwin’s platform is quickly becoming the go-to solution in the charter aviation space, offering a seamless booking and backend support for brokers and operators. By empowering aviation professionals with tools that work smarter, faster and more transparently, Goodwin is helping reshape what modern air travel looks like—starting right here in the Midwest.

The Bengals’ “Meet the Draft Picks” event is the perfect kickoff to a partnership grounded in performance, innovation and Ohio pride.

For more information about Goodwin and its mission, visit www.teamgoodwin.com

About Goodwin

Founded in 2022, Goodwin is headquartered in Ohio with technical talent across the U.S. The company is revolutionizing the charter aviation industry with innovative technology that streamlines charter operations. Goodwin acts solely in a B2B capacity, supporting brokers and operators in digitizing and elevating their workflows, ensuring charter aviation professionals can focus on building meaningful client relationships and scaling their businesses. For more information about how Goodwin is reshaping the charter landscape, please visit www.teamgoodwin.com or follow us on LinkedIn to stay updated.

Media Contact: Clara Armagast
clara@teamgoodwin.com
304-688-5179

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Precision for Medicine and PathAI Announce Strategic Collaboration to Advance AI-Powered Clinical Trial Services and Biospecimen Products

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Collaboration will deliver innovative AI-powered pathology tools and quality control enhancements to accelerate clinical trials and biomarker discovery

BOSTON and FREDERICK, Md., April 25, 2025 /PRNewswire/ — Precision for Medicine, a leading provider of next generation drug development research and services, and PathAI, a global leader in digital pathology, today announced a strategic collaboration to partner on developing novel AI-based technologies and to integrate PathAI’s advanced digital pathology and analysis capabilities across Precision for Medicine’s clinical trial and biospecimen operations.

The collaboration’s innovative tools will provide a level of integration and customization not available elsewhere.

This collaboration includes use of several PathAI technologies and establishes an agreement to offer novel tools and analytical services that address emerging needs in biomarker discovery, spatial biology, and tissue-based clinical research. Through this collaboration PathAI’s tools and services will help augment Precision for Medicine’s proprietary pipeline providing biopharma clients with access to imaging workflows offered through Precision for Medicine’s integrated laboratory and clinical trial services.

“Together, we’re deploying tools that add critical quality control steps to tumor biopsy workflows and apply machine-based learning and unsupervised algorithms early in the development cycle to help identify which biomarkers are most relevant for clinical efficacy,” said Darren Davis, PhD, Senior Vice President Global Digital Pathology, Genomics and Liquid Biopsy Solutions. “Precision for Medicine’s CLIA compliant laboratory enables precise patient stratification and accelerate decision-making in clinical trials, ultimately supporting success in areas of high unmet need.”

As part of the agreement, Precision for Medicine will deploy select tools from PathAI, including AISight®, a digital pathology image management system, and other AI-powered algorithms to enhance biospecimen and clinical trial services. These tools will enable the application of validated, algorithm-based quality control steps to biospecimen analysis, improving consistency and data reliability.

The collaboration will also support the use of PathAI’s leading AI capabilities leveraging best in class machine learning based models to enhance Precision for Medicine multi-modal datasets. The technology reduces large, complex biomarker panels to scalable, and actionable, biomarkers to help interpret complex tissue biology to complement translational research programs. Additionally, the companies will work together to analyze complex tissue biology empowering biopharma clients to understand and identify the right patients for the right therapies, faster.

“At PathAI, our mission is to harness the power of artificial intelligence to improve the accuracy, depth, and efficiency of pathology-driven insights,” said Andy Beck, MD, PhD, Co-founder and CEO of PathAI. “We are thrilled to collaborate with Precision for Medicine to help advance our mission and deliver differentiated value to our mutual customers.”

Precision’s collaboration with PathAI brings unique value to biopharma clients by combining these AI tools with proprietary wet lab infrastructure, centralized clinical trial operations, and scientific oversight. The innovative tools generated through this collaboration will only be available through Precision for Medicine’s services, providing a level of integration and customization not offered elsewhere in the industry.

“This collaboration enhances how we’re using our biospecimen business by enabling deeper, more informative analyses of the tissue samples we provide to our clients,” said Cullen Taylor, MD, Medical Director at Precision for Medicine. “We’re adding an entirely new layer of cellular-level insight on top of already well-annotated sequenced samples, going far beyond what traditional pathology assessments can offer. It’s a meaningful step forward in how we support biomarker discovery, enhancing datasets for diagnostic validation and therapeutic development.”

About Precision for Medicine
Precision for Medicine is the first biomarker-driven clinical research and development services organization supporting life sciences companies in the use of biomarkers essential to targeting patient treatments more precisely and effectively. Precision applies a transformational approach to clinical research that integrates clinical trial design and execution with deep scientific knowledge, laboratory expertise, data sciences and advanced manufacturing solutions. This convergence is driving faster clinical development and approval. Precision for Medicine is part of Precision Medicine Group, with 3,500 people in 40 locations globally across North America, Europe and Asia-Pacific. For more information, visit precisionformedicine.com

Contact
Andie Lunkenheimer
andie.lunkenheimer@gcihealth.com

About PathAI
PathAI is a leading provider of integrated AI and digital pathology solutions dedicated to transforming diagnostic accuracy and operational efficiency in pathology labs worldwide. Through innovative technologies and strategic partnerships, PathAI aims to enhance patient outcomes and drive the future of medical diagnostics. For more information, please visit pathai.com

Contact
Owen Blaschak
oblaschak@lifescicomms.com

Footnote

1AISight is for Research Use Only in the US; AISight Dx is CE-IVDR in Europe and UKCA in UK

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