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Expert Systems Celebrates Completion of Single Dose Studies and Start of Multiple Human Dosing for Lomonitinib, a Selective Pan-FLT3/IRAK4 Inhibitor, Achieved in Just 3 Years

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ROCKVILLE, Md., Feb. 23, 2024 /PRNewswire/ — Expert Systems, a leader in AI-enabled drug discovery, proudly announces a significant milestone in partnership with Eilean Therapeutics LLC: the successful completion of a single ascending dose Phase 1 clinical trial for lomonitinib, a selective pan-FLT3/IRAK4 inhibitor, alongside the launch of a multiple ascending dose Phase 1 study.

“Lomonitinib has demonstrated an exceptional safety profile, with no significant adverse events reported at doses achieving robust target engagement. This positions it as a leading best-in-class candidate for the treatment of FLT3-mutated AML,” commented Bill Farley, CBO at Expert Systems. “We are proud that our comprehensive hybrid AI-based platform has helped advance a new treatment like lomonitinib to clinical trials in just 3 years.”

Supported by Orbimed, Torrey Pines Investment, and Dr. John C. Byrd, Eilean Therapeutics is committed to leading the development of innovative therapies that significantly enhance treatment outcomes in both hematologic and solid malignancies. This effort is bolstered by leveraging Expert Systems’ cutting-edge AI platform to speed up the discovery and development process.

About Lomonitinib

Lomonitinib is a highly potent and selective inhibitor of FLT3 ITD (internal tandem duplications), tyrosine kinase domain (TKD), and other clinically significant FLT3 mutations, and an IRAK4 inhibitor. FLT3 mutations are the most frequently identified mutations in AML. There are two main mechanisms of resistance to FLT3 inhibitors: the FLT3-ITD-F691L mutation – deemed the “gatekeeper” mutation that confers resistance to all currently approved FLT3 inhibitors; and the activation of the IRAK4 escape pathway. Lomonitinib effectively inhibits both of these resistance pathways, promising a new treatment for patients with FLT3-mutated AML.

About Expert Systems, Inc.

Expert Systems, Inc., an advanced accelerator platform, is equipped with a comprehensive, hybrid AI-based system that covers the entire spectrum of preclinical drug discovery and early development phases. This includes target identification, virtual screening, non-clinical and clinical pharmacology, chemical liability assessment, and toxicology. Utilizing a unique combination of proprietary and public databases, Expert Systems employs specialized software tools to evaluate the intellectual property landscape and construct a competitive drug intelligence strategy to de-risk candidate selection for rapid transition from in silico to first-in-human trials. Expert Systems has been pivotal in establishing seed and Series A companies, organizing and managing over 30 research and development programs across various financial investors and strategic partners in North America, Europe, and Australia. To learn more, visit www.expertsystems.inc

About Eilean Therapeutics

Eilean Therapeutics LLC is a cutting-edge biopharmaceutical company, established through a collaboration between Orbimed, Torrey Pines Investment, and Dr. John C. Byrd, dedicated to the identification of both best-in-class and first-in-class small molecule inhibitors targeting escape mutations in both hematologic and solid cancers. The company harnesses the Expert Systems Inc. hybrid AI platform alongside its key partners’ exclusive data, chem-bio platforms, knowledge, and expertise. This enables Eilean Therapeutics to select molecular mechanisms of pathology with high clinical relevance, precisely designing and expediting the discovery and development processes for leading-edge therapies. Eilean Therapeutics is committed to leveraging its unique capabilities and platform to create novel, groundbreaking medicines for patients with hematologic and solid malignancies, marking a new era in targeted cancer therapy. For more information, visit www.eileanther.com

Media Contact:

Bill Farley

CBO

bfarley@expertsystems.inc

View original content:https://www.prnewswire.com/news-releases/expert-systems-celebrates-completion-of-single-dose-studies-and-start-of-multiple-human-dosing-for-lomonitinib-a-selective-pan-flt3irak4-inhibitor-achieved-in-just-3-years-302069988.html

SOURCE Expert Systems, Inc.

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Mach7 Technologies introduces UnityVue, a next-generation radiology reading solution with groundbreaking capabilities

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Mach7 Technologies unveils UnityVue, an innovative AI-driven workflow orchestration solution developed to improve patient care, reduce radiologist burnout, and streamline diagnostic workflows.

SOUTH BURLINGTON, Vt., Nov. 11, 2024 /PRNewswire/ — Mach7 Technologies, a company specializing in innovative medical imaging and data management solutions today announced the formal launch of UnityVue, a landmark radiology software platform developed in partnership with NewVue.

UnityVue is a pioneering solution which integrates Mach7’s well-renown eUnity Enterprise Diagnostic Viewer (eUnity) with NewVue’s revolutionary EmpowerSuite Workflow Orchestrator, delivering a comprehensive software platform designed to improve radiology reading workflows.

UnityVue consolidates radiology workflows by seamlessly integrating image viewing and worklist management. This cloud-based solution offers radiologists a powerful platform for task prioritization, AI-driven data aggregation, and enhanced diagnostic workflow—all from a single interface.  UnityVue’s ability to dynamically curate worklists and automate data normalization enhances productivity while reducing administrative burden.

Mike Lampron, CEO of Mach7, said, “UnityVue is the future of radiology imaging that gives healthcare providers capabilities that look far over the horizon of a traditional PACS. We are proud to unveil this new groundbreaking solution that will deliver immediate value to our customers in improving workflow efficiency, reducing administrative burden, enhancing productivity, and elevating patient care.”

UnityVue’s key features include cloud-based image access, real-time AI-driven workflow orchestration, automated data normalization, and a unified interface for radiologists to perform their tasks efficiently. With its zero-footprint design, UnityVue allows radiologists to access critical information from any location, enhancing productivity while reducing administrative complexity.

Through the launch of UnityVue, Mach7 customers have a future proof, all-in-one solution that not only meets the current demands of radiologists but also anticipates future needs. By solving these critical challenges, healthcare organizations can deploy a platform that enhances job satisfaction for radiologists, improves patient care, and drives better business outcomes.

Key Benefits

For Independent Delivery Networks:

Unifying PACS: Integrates multiple PACS systems into a single platform, simplifying workflows and reducing inefficiencies.Gradual Cloud Migration: IDNs can migrate to the cloud incrementally, preserving existing systems while modernizing infrastructure.Disaster Recovery: Cloud-based continuity ensures radiologists can continue working during local system outages.Reduced IT Complexity: The zero-footprint design eliminates on-site server requirements and minimizes maintenance.

For Radiology Groups:

AI-Driven Workflows: Intelligently prioritizes cases, improving turnaround times and reducing administrative burdens.Remote Access: Radiologists can access the platform from anywhere, enhancing flexibility and productivity.Cost-Effective Cloud Solutions: Targeted data migration reduces costs while maintaining performance.Integrated AI and Peer Review: AI tools and peer review functions streamline compliance and support interpretive workflows.

Said Lampron. “UnityVue is a transformative software application that offers radiologists a comprehensive platform that streamlines workflows, supports decision making, and modernizes the entire study interpretation process. It provides a fully integrated environment where radiologists can access what they need in one place— from advanced image viewing and interpretation to AI-driven workflow management— all within a cloud-enabled, zero-footprint solution. UnityVue provides a future-ready solution for radiology departments, addressing today’s needs while anticipating tomorrow’s challenges.”

Join Mach7 at RSNA 2024 [South Hall, Booth # 3953] for the official unveiling of UnityVue.

Schedule a demo at Mach7t.com to see how UnityVue addresses the evolving needs of radiology practices and large integrated delivery networks (IDNs) across the healthcare spectrum.

About Mach7 Technologies:

Mach7 Technologies (ASX:M7T) is a medical imaging technology provider that develops innovative data management and image viewing solutions for healthcare organizations. Its core offering is the Mach7 Enterprise Imaging Solution (EIS), a next-generation platform built for the future of healthcare, comprised of a Vendor Neutral Archive (VNA), eUnity Enterprise Diagnostic Viewer, and Diagnostic Workflow Applications. Designed to maximize flexibility and scalability, Mach7 gives customers the independence to deploy a full enterprise solution or individual components. Mach7 serves a global network of customers, ranging from expansive IDNs and National Health Systems to small, independent provider groups and private radiology practices. Visit Mach7t.com for more information.

About NewVue:

Based in Tampa, Florida, NewVue is a leader in cloud-based radiology solutions. Their flagship platform, EmpowerSuite, optimizes radiology workflows using AI to curate worklists tailored dynamically to the practices and each radiologist’s needs. The platform’s AI-driven data normalization facilitates seamless site onboarding and volume expansion. This approach boosts productivity, enhances job satisfaction, and supports scalable growth for radiology practices, improving patient care through increased professional fulfillment. www.newvue.ai

CONTACT:

Mach7 Technologies
Bob Tranchida
VP of Marketing, Mach7 Technologies
802-861-7745
bob.tranchida@mach7t.com

View original content to download multimedia:https://www.prnewswire.com/news-releases/mach7-technologies-introduces-unityvue-a-next-generation-radiology-reading-solution-with-groundbreaking-capabilities-302300204.html

SOURCE Mach7 Technologies

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Trimble Expands Access to Advanced Construction Project Management Capabilities with Free Version of ProjectSight Software

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Increased accessibility through a no-cost option enables all contractors to take advantage of Trimble ProjectSight with a new AI feature that supports greater automation and efficiency

LAS VEGAS, Nov. 11, 2024 /PRNewswire/ — Trimble® (Nasdaq: TRMB) is unveiling a free version of Trimble ProjectSight®, featuring AI and advanced tools that were previously inaccessible to many in the construction industry. This initiative underscores Trimble’s strategy to empower contractors of all sizes with connected data and workflows. ProjectSight provides a centralized, real-time solution for managing and sharing project information, including documents and drawings. Contractors use the application to collaborate within their teams and with other contractors, architects, engineers and project owners to gain efficiency and minimize risk.

Trimble is highlighting ProjectSight’s new, AI-driven feature to automate tasks, save time and increase accuracy at the annual Trimble Dimensions User Conference.

Extending Advanced Collaboration Tools to Everyone
Trimble ProjectSight empowers contractors to connect construction teams by capturing, organizing and sharing critical project data, such as drawings, requests for information (RFIs), submittals and photos. Jon Fingland, vice president and general manager for Trimble construction software solutions, said, “A no-cost version of ProjectSight removes barriers to entry and presents a simple way to experience the project management benefits.”

“Some contractors have viewed powerful construction management tools like ProjectSight as too expensive or complicated,” explained Fingland. “We envision a future where all contractors use this type of solution to access up-to-date information, collaborate, streamline workflows and make critical business and project decisions more effectively.”

Contractors can now access and install the software themselves by creating an account on the ProjectSight website.

AI Feature Ushers in a New Era of Automation
Trimble’s ProjectSight AI-driven capabilities were developed in collaboration with Microsoft. Trimble integrates Microsoft Azure OpenAI Service to add automation to project management workflows, improve efficiency and accuracy, and free up construction professionals to spend more time on critical tasks rather than administrative work.

A new ProjectSight drawing import feature uses AI to read and extract critical drawing information. “The specialized drawing tool goes beyond standard optical character recognition with an engine that can read the name, revision number and content more holistically,” Fingland explained. “This makes it much faster to upload, validate and publish drawing sets without re-keying information.”

ProjectSight Options
The new, free version of Trimble ProjectSight provides a centralized environment to manage and share drawings, photos, specifications, submittals, punchlists and RFIs. Contractors can also create customized dashboards to view and organize upcoming document-related tasks.

Additional versions of ProjectSight — available with paid subscriptions — allow for unlimited projects and data, and provide advanced cost management, field management, workflow connectivity and integrations with Trimble Viewpoint® Vista™ and Spectrum® construction management software.

Trimble hardware and software solutions for architecture, engineering and construction — including ProjectSight — elevate performance, efficiency, coordination and data-driven decision making across workflows and project phases. With Trimble Construction One™, customers can purchase, manage and use multiple Trimble solutions cohesively. This connected construction approach enhances collaboration and visibility by linking people, processes, data and the physical and digital aspects of planning, designing and building.

About Trimble AECO
Trimble is empowering stakeholders through planning, design, construction and the entire asset lifecycle. The company’s innovative and connected ecosystem of solutions improves coordination and collaboration between teams, phases and processes. Automating work and transforming workflows, Trimble is enabling teams to deliver with confidence at every turn. For more information, visit: construction.trimble.com.

About Trimble
Trimble is transforming the ways people move, build and live. Core technologies in positioning, modeling and data analytics connect the digital and physical worlds to improve our customers’ productivity, quality, safety, transparency and sustainability. For more information about Trimble (Nasdaq: TRMB), visit: www.trimble.com.

GTRMB

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SOURCE Trimble

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M4Markets Partners with Swiset to Enhance IB Acquisition and Retention with AI-powered Analytics

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M4Markets has announced a strategic partnership with Swiset, an AI analytics leader, to enhance IB acquisition, retention, and trading experiences globally. Leveraging Swiset’s AI platform, M4Markets aims to expand its network and provide partners with data-driven tools for sustainable growth and improved trader engagement.

MAHE, Seychelles, Nov. 11, 2024 /PRNewswire-PRWeb/ — M4Markets, a global pioneer in offering innovative trading solutions, is happy to announce a strategic relationship with Swiset, a cutting-edge developer of AI analytics solutions that will give brokers with unsurpassed IB acquisition and retention capabilities, as well as an improved experience for Academies and their students. This agreement extends M4Markets’ commitment to creating a world-class trading environment by offering excellent support and robust growth tools.

Swiset’s AI-powered platform, which has a reach of over 150 countries and a growing community of over 70,000 registered traders, provides M4Markets with a distinct advantage in IB engagement. Using Swiset’s strong AI analytics, M4Markets hopes to expand its network by engaging with a larger, data-informed IB audience and offering our partners with a targeted, efficient experience that encourages sustainable growth and trading success.

“Ongoing innovation and strategic partnerships are at the heart of our commitment to providing exceptional experiences for our IBs, Academies and clients,” stated Sam Chaney, the Commercial Director of M4Markets. “With Swiset’s cutting-edge analytics, our partners will have access to deeper insights that empower them to connect more meaningfully with traders, which is a significant advantage for growth in today’s market.”

With over 30 million monitored trades and 250,000 connected accounts, Swiset is well-known for its ability to convert complex trade data into usable insights, which will now enable M4Markets’ partners to make educated decisions that increase engagement and income. This collaboration not only strengthens M4Markets’ value proposition for existing partners, but it also creates new opportunities for attracting top-tier talent from the IB and Academy communities.

“We are thrilled to partner with M4Markets to deliver our AI-powered insights to their network of IBs, Academies and traders,” Santiago Valencia, CSO of Swiset. “This collaboration allows us to enhance M4Markets’ partners program by enabling data-driven strategies that drive performance and retention, benefitting partners and traders alike.”

Swiset’s AI technology will be an important touchpoint in M4Markets’ growth plan, coinciding with its goals of providing a simpler trading experience and improving service offerings in competitive global marketplaces

About M4Markets: The M4Markets Group is a globally recognized and is comprised of multi-licensed entities, which include regulatory licenses from leading authorities, such as the DFSA in the UAE, CySEC in Cyprus, FSA in Seychelles. These licenses allow M4Markets to serve clients across the world, offering a wide range of trading instruments while adhering to the highest industry standards. For more information, please visit http://www.m4markets.com.

About Swiset: At Swiset, we assist brokers in acquiring and retaining more IBs through AI analytics. We currently have a presence in over 150 countries, with 70,000+ registered traders, 30 million+ tracked trades, and 250,000+ connected accounts. For more information visit: https://swiset.com/

Media Contact

Farah Farhat, M4Markets, +2484632013, support@m4markets.com, https://www.m4markets.com/

View original content to download multimedia:https://www.prweb.com/releases/m4markets-partners-with-swiset-to-enhance-ib-acquisition-and-retention-with-ai-powered-analytics-302300833.html

SOURCE M4Markets; M4Markets

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