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Waters New Bioseparations Tools Accelerate and Improve Development of RNA-based Vaccines and Therapies Using LC-MS Analysis

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Waters new LC-MS grade reagents, enzymes, and software simplify large molecule RNA analysis to accelerate and improve development of mRNA vaccines, personalized cancer therapies, and innovative drugs for genetic disorders.Novel digestion enzymes deliver complete RNA sequence coveragei for more confident characterization, while new LC-MS-grade reagents increase sensitivity and improve detection accuracy of RNA components.iiNew waters_connect™ MAP Sequence software accelerates RNA oligonucleotide mapping using semi-automated workflows that reduce data processing time over manual techniques, enabling routine monitoring of key product attributes.

MILFORD, Mass., Oct. 14, 2024 /PRNewswire/ — Waters Corporation (NYSE: WAT) today introduced a comprehensive set of sample preparation enzymes, reagents, and waters_connect software that simplify sequence and modification confirmation of large molecule RNA therapeutics using liquid chromatography-mass spectrometry (LC-MS) analysis. When used together in a workflow, these bioseparations tools help accelerate and improve the development of innovative large molecule RNA-based pharmaceuticals, such as CRISPR sgRNA and mRNA therapeutics.

Large molecule RNA (ribonucleic acid) therapeutics represent some of the most exciting and potentially life-saving developments in pharmaceuticals today. They include new and more effective vaccines for diseases like COVID-19, personalized cancer treatments, as well as emerging CRISPR RNA therapies that address challenging genetic conditions, such as sickle cell anemia.

“As RNA-based therapies are prepared for widespread use, more direct composition measurements are needed to ensure stability, safety, and effectiveness for patients,” said Erin Chambers, Vice President, Consumables and Lab Automation at Waters Corporation. “The combination of Waters enzymes, reagents, and software are specially designed to simplify the confirmation of sequence and modifications of complex molecules. These analytical tools can accelerate RNA therapeutic development and lower barriers for use by LC-MS non-experts.”

“As innovators looking to help our customers advance nucleic acid-based therapies and reduce the burden of serious diseases, we are always seeking new technologies to improve characterization and accelerate development,” said Arnaud Delobel, PhD, R&D and Innovation Director at Quality Assistance S.A. and beta tester of the Waters RNA analytical tools. “Waters new enzymes efficiently digest mRNA and sgRNA with short incubation times and data processing in MAP Sequence allows the user to obtain reproducible results quickly with confidence.”

The Waters RNA analytical tools include:

Enzymes: Two novel enzymes, RapiZyme™ MC1 and RapiZyme Cusativin, are used in a simplified three-step protocol that provides complete LC-MS sequence coverage over traditional digestion methods enabling more confident characterization of RNA molecules.iiiReagents: IonHance™ HFIP, an LC-MS-grade reagent, is formulated to improve ionization and delivers increased spectral clarity and detection accuracy of RNA components.Software: New MAP Sequence application on the waters_connect software platform simplifies RNA LC-MS oligo mapping workflows to accelerate analysis and data processing time over manual techniques using spreadsheets.

Used together within a workflow, the tools generate an LC-MS fingerprint to confirm product identity, purity, and efficacy. The tools improve sequence coverage, LC-MS spectral data quality, and data interpretation. Supported by the compliance-ready waters_connect software platform, these tools help transition LC and LC-MS-based digestion analysis from discovery and development to release and at-line process analytical testing.

Waters RapiZyme RNAses and IonHance HFIP are now available. The new MAP Sequence App on waters_connect software will be available on October 18, 2024.

Additional Resources

Learn more about the Waters RNA Analytical ToolsListen to our webinar “Cracking the Code: Analyzing mRNA and sgRNA with Advanced Enzymes, Mass Spectrometry, and Informatics on Oct. 16 at 11:00am ETJoin Waters at the PharmSci 360 conference for an expert session on “Oligo Mapping of Large RNA Therapeutics by Novel Enzyme Specificities” with Dr. Bala Addepalli, Waters Director, R&D New Modalities Portfolio on Oct. 21, at 11:00am ETFollow and connect with Waters via LinkedIn, Twitter, and Facebook

About Waters Corporation (www.waters.com)

Waters Corporation (NYSE: WAT), a global leader in analytical instruments and software, has pioneered chromatography, mass spectrometry, and thermal analysis innovations serving the life, materials, food, and environmental sciences for more than 65 years. With approximately 7,500 employees worldwide, Waters operates directly in 35 countries, including 14 manufacturing facilities, and with products available in more than 100 countries.

Waters, Rapizyme, IonHance, and waters_connect are trademarks of Waters Technologies Corporation.

Contact:
Janice Foley
Senior Public Relations Manager, Corporate Communications
Waters Corporation
janice_foley@waters.com
+1.617.823.5555

i 100% RNA sequence coverage achieved for HPRT sgRNA digested with RapiZyme MC1 and RapiZyme Cusativin compared to traditional digestion methods such as RNase T1. Waters Application Note 720008539EN: “Tunable Digestions of RNA Using RapiZyme RNases to Confirm Sequence and Map Modifications” .

ii IonHance HFIP reagents are certified to contain less than 100 ppb sodium and less than 100 ppb potassium content, resulting in reduced adduct formation and improved sensitivity of RNA detection compared to commercially available HFIP. Waters Application Note 720008540EN: “Evaluating IonHance Hexafluoroisopropanol (HFIP) for Enhanced LC-MS Oligonucleotide Analysis”

iii Waters RapiZyme RNase protocol simplifies sample preparation with three steps including reagent preparation, RNA digestion, and heat inactivation without the need to add chemical denaturants and enzyme inhibitors.

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SolaX Power Wins SMM Global Tier 1 Award for Battery Energy Storage Systems (BESS)

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HANGZHOU, China, Oct. 13, 2024 /CNW/ — SolaX Power, the leading solar energy storage solution provider, is proud to announce that it has been awarded the prestigious SMM Global Tier 1 Award for Battery Energy Storage Systems (BESS). This accolade recognizes SolaX’s commitment to innovation, sustainability, and excellence in the energy storage industry, placing the company among the top global manufacturers of advanced energy storage solutions.

A Milestone for SolaX Power

The SMM Global Tier 1 Award is one of the most respected awards in the renewable energy sector, honoring companies that demonstrate leadership, technological advancement, and a significant contribution to the clean energy transition. Receiving this award underscores SolaX Power’s dedication to providing high-quality, reliable, and innovative energy storage solutions for both residential and commercial applications worldwide.

Winning the SMM Global Tier 1 Award is a testament to SolaX Power’s continuous efforts in revolutionizing the energy storage landscape with its cutting-edge Battery Energy Storage Systems (BESS). SolaX’s comprehensive BESS product range offers solutions that not only improve energy efficiency but also enhance the way households and businesses manage and store renewable energy.

Innovating for a Greener Future

SolaX Power’s achievement of the SMM Global Tier 1 Award solidifies its position as a global leader in the battery energy storage market. The company’s innovative solutions are helping to accelerate the adoption of renewable energy by providing dependable, high-performing systems that empower consumers and businesses to make sustainable energy choices.

The global demand for BESS solutions continues to rise as more countries and regions set ambitious targets for renewable energy and carbon neutrality. SolaX’s ability to deliver efficient, scalable, and cost-effective energy storage products positions it as a trusted partner in the global clean energy transition.

As SolaX continues to grow, we remain focused on pushing the boundaries of what’s possible with battery energy storage technology. SolaX’s BESS solutions are designed to address the growing global demand for more resilient, reliable, and eco-friendly energy storage systems, which in the long term, helps play a crucial role in reducing reliance on fossil fuels and promotes a sustainable future.

View original content to download multimedia:https://www.prnewswire.com/news-releases/solax-power-wins-smm-global-tier-1-award-for-battery-energy-storage-systems-bess-302274741.html

SOURCE SolaX Power

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SUS ENVIRONMENT formally signed EPC contract for the Tam Sinh Nghia Waste-to-Energy project in Ho Chi Minh City, Vietnam

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HO CHI MINH CITY, Vietnam, Oct. 14, 2024 /PRNewswire/ — On October 9th, Shanghai SUS Environment Co., Ltd., POWERCHINA, and Bamboo Capital Group (BCG) officially signed the EPC contract for the Tam Sinh Nghia Waste-to-Energy Project in Ho Chi Minh City, Vietnam. Mr. Zhu Xiaoping, COO of SUS ENVIRONMENT, Mr. Chen Guanfu, Chairman of Power China International, and Mr. Pham Minh Tuan, Vice Chairman of BCG, among other leaders, attended the ceremony to witness the signing ceremony.

Mr. Zhu Xiaoping, COO of SUS ENVIRONMENT, expressed, “The signing of the Tam Sinh Nghia Waste-to-Energy project marks another significant collaboration between SUS ENVIRONMENT and its industry partners in jointly addressing environmental challenges. With extensive experience and professional expertise of SUS ENVIRONMENT in the EPC field of waste-to-energy, and through dedicated cooperation with all parties, we are confident that we can make a significant contribution to Vietnam’s environmental protection and energy transition, jointly creating a cleaner and greener future!”

It is reported that the signed waste-to-energy project is located in Cu Chi District, Ho Chi Minh City. The construction capacity of the Phase I project is 2,600 t/d. After the project is put into operation, it will convert 20-25% of the municipal solid waste in Ho Chi Minh City into green electricity.

The project will convert environmental challenges into sustainable solutions through means that better align with Vietnam’s environmental and economic goals, contributing efforts of SUS ENVIRONMENT to Vietnam’s carbon neutrality goals and energy transition.

View original content to download multimedia:https://www.prnewswire.com/apac/news-releases/sus-environment-formally-signed-epc-contract-for-the-tam-sinh-nghia-waste-to-energy-project-in-ho-chi-minh-city-vietnam-302274471.html

SOURCE Shanghai SUS ENVIRONMENT Co.,Ltd.

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21st TAITA Annual Conference Explores Taiwan’s AI Era Strategies in the Global Tech Supply Chain

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TAIPEI, Oct. 13, 2024 /PRNewswire/ — The upcoming 21st TAITA-SV Annual Conference, scheduled for Saturday, October 19, 2024, at the Hyatt Regency Hotel in Santa Clara, California, will focus on the theme “Taiwan’s Strategic Layout in the AI Era.” The conference will explore how Taiwan leverages its leading semiconductor technology advantages to sustain its core position in the global supply chain while addressing the challenges and opportunities brought by the AI revolution.

Colley Hwang, Founder and President of DIGITIMES, will deliver a keynote speech, providing a detailed analysis of the latest advancements in AI technology and their impact on Taiwan’s role in the global technology landscape. With the rapid expansion of AI and the rising demand for high-performance computing (HPC), the global technology industry is undergoing an unprecedented transformation. According to the latest DIGITIMES Research report, global server shipments are projected to grow at a compound annual growth rate (CAGR) of 6% from 2023 to 2028. Colley Hwang highlighted that Taiwan’s share in the high-end AI server market is expected to increase from 74.4% last year to 83.6% this year, and exceed 90.2% by 2025, demonstrating Taiwan’s strong capabilities and growth potential in AI server technology.

Industry Leaders Share Insights: In-depth Exploration of Technology and Future Development

The afternoon forum will bring together multiple industry leaders and experts to delve into the latest AI advancements and their profound impact on Taiwan’s semiconductor supply chain. Colley Hwang, Founder and President of DIGITIMES, will share his insights into the development of AI technology and how it is reshaping the global tech supply chain. Dr. Y.K. Chen, Deputy Chief Technology Officer at Coherent, will explore the prospects of silicon photonics in next-generation semiconductors, while Dr. Kevin Yasumura, Director at Google, will present on the development of optical switches for data centers in the AI era, revealing how AI is driving infrastructure transformation.

In addition to insights from technology experts, the forum will feature four leading venture capitalists discussing the future of hard-tech (Hard-Tech), including Dr. Wen Hsieh, Founding Managing Partner at Matter Venture Partners, Dr. Alex Fang, Managing Partner at Entrada Ventures, Tong Chao, Partner at Tyche Partners, and Dr. Huang Lee, Managing Partner at Taiwania Capital. These experts will analyze how Taiwan can leverage its semiconductor strengths to tackle the challenges brought by the rapid adoption of AI, and ensure supply chain security and stability from multiple perspectives, including technology innovation, policy development, and geopolitics.

Dinner Keynote: Exploring the Future of Biotechnology and Healthcare

The dinner keynote will be delivered by Professor Chi-Huey Wong, with a focus on “Research Toward Healthcare and Biotech Development.” As a pioneer in the biotechnology field, Professor Wong’s research spans several key areas, including chemical synthesis, protein engineering, cancer treatment, vaccine development, and immunotherapy. He will emphasize the importance of STEM (Science, Technology, Engineering, and Mathematics) education for cultivating future innovators and inspiring the next generation to actively engage in scientific research and lead future technological revolutions.

Register Now to Secure Your Spot!

Key topics such as photonics, advanced semiconductor technologies, and the integration of AI with the semiconductor supply chain. Use the promo code “ILOVETAIWAN” to register for the afternoon panel discussions for free. Don’t miss the opportunity to attend the dinner keynote (a paid event) and connect with industry leaders. Spaces are limited, so register now to secure your spot!

Registration link: qr.codes/fh7Vb2

View original content to download multimedia:https://www.prnewswire.com/news-releases/21st-taita-annual-conference-explores-taiwans-ai-era-strategies-in-the-global-tech-supply-chain-302274700.html

SOURCE DIGITIMES ASIA

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