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Simcere Zaiming collaborates with TargetRx to introduce a third-generation ALK inhibitor

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NANJING, China, Sept. 2, 2024 /PRNewswire/ — On September 02, 2024, Simcere Zaiming, an innovative oncology company under Simcere Pharmaceutical Group (2096.HK), announced a collaboration agreement with Shenzhen TargetRx Inc. The partnership focuses on the ALK/ROS1 dual receptor tyrosine kinase inhibitor TGRX-326, a clinical-stage anti-tumor candidate.

According to the terms of the agreement, Simcere Zaiming will acquire exclusive commercial rights to TGRX-326 in Mainland China. These rights encompass but are not limited to marketing promotion, strategy formulation and adjustment, and the right to obtain relevant benefits from TGRX-326. TargetRx will receive an initial payment exceeding $20 million. Additionally, TargetRx will compensate Simcere Zaiming for promotional services.

TGRX-326 is a third-generation anaplastic lymphoma kinase (ALK) inhibitor independently developed by TargetRx. It is a potent and highly selective small molecule inhibitor that targets ALK and c-ROS proto-oncogene 1 (ROS1) receptor tyrosine kinases (RTKs). This inhibitor holds significant therapeutic potential for ALK/ROS1 fusion gene-positive non-small cell lung cancer (NSCLC) patients, especially those with multiple ALK-resistant mutations, including G1202R.

In preclinical studies and a Phase 1 clinical trial, TGRX-326 demonstrated robust anti-tumor activity and a favorable safety profile. Moreover, the molecule effectively crosses the blood-brain barrier, exhibiting exceptional efficacy in NSCLC patients with brain metastases.

Dr. Renhong Tang, Chairman of Simcere Zaiming, said, “We are pleased to collaborate with TargetRx on novel dual-targeted therapy for lung cancer, a major malignancy that Simcere Zaiming strategically focuses on. This partnership will further enhance our innovative product portfolio. ALK/ROS1 fusion is a critical genetic mutation in non-small cell lung cancer. The advancement of targeted therapies has significantly improved survival rates for these patients. However, there remains a substantial need for new treatments with better efficacy and the ability to overcome drug resistance. We look forward to working closely with TargetRx to provide Chinese lung cancer patients with more effective treatment options as soon as possible.”

Dr. Yihan Wang, Chairman of TargetRx, said, “TGRX-326 is a potentially best-in-class novel anti-tumor molecule independently developed by TargetRx. It is a third-generation ALK inhibitor in late-stage clinical development which may bring a better option for patients. We believe that with the support of Simcere Zaiming, we will be able to bring this product quickly to the market. TargetRx aims to continuously deliver innovative therapies that will transform the lives of cancer patients.”

About Simcere Zaiming

Simcere Zaiming, an oncology-centric biopharmaceutical subsidiary of Simcere Pharmaceutical Group Limited (HKEX: 2096), was established in 2023. The company is dedicated to developing groundbreaking therapies to meet the unmet clinical needs of cancer patients globally. With a robust and innovative R&D pipeline featuring distinct clinical assets, Simcere Zaiming has successfully launched several products in China, including COSELA®, Endostar®, Enweida®, and Enlituo®. The company is determined to deliver potentially transformative treatment options to cancer patients worldwide through its internal R&D, manufacturing, and commercialization capabilities, complemented by strategic collaborations with leading partners in cancer therapeutics. 

About TargetRx

TargetRx is a clinical stage, high-tech pharmaceutical R&D company focused on developing next-generation targeted therapies for cancer patients, particularly those who are resistant or refractory to current treatments. TargetRx has developed a series of cutting-edge and efficient small molecule drug discovery platforms, which combine innovative research and development capabilities for drug design, screening, evaluation and optimization. Since its establishment, TargetRx has been granted over 170 patents from authorities in China, the US, Europe, Japan and other regions. Several potential best-in-class compounds are at different stages of multi-national clinical trials.

View original content:https://www.prnewswire.com/news-releases/simcere-zaiming-collaborates-with-targetrx-to-introduce-a-third-generation-alk-inhibitor-302235944.html

SOURCE Simcere Pharmaceutical Group Limited

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Matrixdock Partners with Brink’s for Global RWA Custody, Starting with Gold

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Partnership Enhances Security for XAUm, Matrixdock’s Gold-Backed Digital Asset, with a Focus on Key Asian Financial Hubs

SINGAPORE, Nov. 25, 2024 /PRNewswire/ — Matrixdock, a leading platform for tokenized real-world assets (RWA), is pleased to announce a strategic partnership with Brink’s, a global leader in secure logistics and asset protection. This partnership ensures the secure transportation and vaulting of LBMA-certified gold, which underpins Matrixdock’s recently launched XAUm token, with a focus on vaults located in Singapore and Hong Kong, two of Asia’s premier financial hubs.

XAUm, an ERC-20 token fully backed by physical gold, offers investors a trusted and transparent digital asset tied to London Bullion Market Association (LBMA) accredited gold. The partnership with Brink’s guarantees that the gold reserves backing XAUm are securely held in high-security, fully insured vaults in Singapore and Hong Kong, enhancing the credibility and security of the token for investors across the globe, particularly in the Asia-Pacific region.

“Brink’s reputation for excellence in secure logistics, combined with the strategic location of vaults in Singapore and Hong Kong, provides unparalleled security and confidence for our XAUm investors,” said Eva Meng, Head of Matrixdock. “This partnership underscores our commitment to maintaining the highest standards of trust and transparency for our tokenized real-world assets.”

Zac McKenna, Head of Digital Assets at Brink’s, emphasized the importance of secure custody solutions in the growing RWA tokenization space: “At Brink’s, we are proud to support the tokenization of real-world assets by providing the secure infrastructure that makes these digital products credible and reliable. Our collaboration with Matrixdock enables us to bring our extensive expertise in secure logistics to the forefront of the blockchain ecosystem.”

Brink’s, with its extensive experience in secure asset management and its well-established presence in Asia, will ensure that the LBMA gold backing XAUm is safely transported, stored, and protected in its world-class vaults. Ben Van Kerkwijk, Vice President of Brink’s Global Services – Asia Pacific, added: “Our premier vaulting facilities in Singapore and Hong Kong are trusted by top-tier clients around the world. We are pleased to provide the same world-class protection for the physical gold that backs Matrixdock’s XAUm token, further enhancing the security and trust for investors in the region.”

This partnership allows Matrixdock to offer a robust gold-backed digital asset that aligns with the security and regulatory requirements of global investors.

XAUm provides investors with seamless access to the value of physical gold while benefiting from the efficiency, liquidity, and transparency of blockchain technology. By focusing on secure vaulting in Singapore and Hong Kong, Matrixdock strengthens its offering in the growing Asian market for tokenized assets.

For more information, please visit www.matrixdock.com.

About Matrixdock

Founded in February 2023 by Matrixport, Matrixdock is a premier platform that offers access to high-quality Real World Assets (RWA) through advanced tokenization technology. As the first in Asia to introduce a tokenized short-term treasury bill product, STBT, Matrixdock has rapidly emerged as an industry leader, earning the Ecosystem Excellence TADS Award in 2023 for Trading & Liquidity Solutions.

Matrixdock is dedicated to becoming the gateway for clients seeking top-tier RWA investments. With a steadfast focus on building a trusted and secure RWA ecosystem for crypto, Matrixdock provides diversified investment opportunities while setting new standards for trust and governance in the digital asset space.

About Brink’s

The Brink’s Company (NYSE:BCO) is a leading global provider of cash and valuables management, digital retail solutions, and ATM managed services. Our customers include financial institutions, retailers, government agencies, mints, jewelers, and other commercial operations. Our network of operations in 52 countries serves customers in more than 100 countries.

Photo – https://mma.prnewswire.com/media/2566272/Matrixdock_Brinks_XAUm_Gold_Partnership.jpg

View original content:https://www.prnewswire.co.uk/news-releases/matrixdock-partners-with-brinks-for-global-rwa-custody-starting-with-gold-302315224.html

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Snag top-notch smart home gadgets at unbeatable prices: EZVIZ drops Black Friday deals on its all-time bestsellers and flagship innovations

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People can score huge savings on EZVIZ’s award-winning security products and robot vacuums, making their homes safe and comfortable before New Year arrives.

HOOFDDORP, Netherlands, Nov. 25, 2024 /PRNewswire/ — EZVIZ, a leading smart home company known for its high-quality gadgets, is ramping up the thrills of Black Friday shopping by kicking off its special sale into high gear. Simplifying the stressful process of handpicking products and comparing bargains across brands and platforms, EZVIZ adds massive discounts to its extensive product portfolio, helping people build a multi-device smart system from scratch. Even busy but picky homeowners can quickly find essential devices like a garage security camera, a pet monitor or a multi-purpose vacuum cleaner, at hard-to-resist prices with unmatched functionality.

EZVIZ’s Black Friday sale runs from November 22 to December 2 in its official store on Amazon UK. For any family in need of peace of mind or gift ideas for the upcoming holidays, here are some hard-to-miss offers:

H9c Dual Pan & Tilt Wi-Fi Camera (3K) – now£99.99, was£129.99

A star innovation of the year that advances the dual-lens technology to become highly smart and responsive. The H9c Dual combines a 3K wide-angle lens and a pan-tilt 3K telephoto lens in one housing. The duo works independently to secure two directions, or reacts to each other to complete the tracking of a single important activity.

EP3x Pro Dual-Lens Battery Video Doorbell – now£99.99, was£129.99

A truly smart doorkeeper that doubles up your vision with subscription-free detection features, all with easy installation. Seamlessly stitching the view of a main 2K lens and a 1080p down-facing lens, the EP3x Pro sees visitors and delivered packages from top to bottom. Flexible for any home, it uses a large battery and has an included solar panel for additional green power. 

CP2 Peephole Door Viewer – now£49.99, was£69.99

A simple yet reliable option to turn an existing peephole into a smart, sharp camera. The CP2 attaches to most doors and allows real-time viewing via the large indoor screen or remotely via the EZVIZ App. All family members, including seniors and children, can see who’s outside without having to worry about blind spots, and feel protected and safe in a cost-effective way.

Photo – https://mma.prnewswire.com/media/2557647/EZVIZ_2024_Black_Friday_PR_Picture.jpg 

View original content:https://www.prnewswire.co.uk/news-releases/snag-top-notch-smart-home-gadgets-at-unbeatable-prices-ezviz-drops-black-friday-deals-on-its-all-time-bestsellers-and-flagship-innovations-302315226.html

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innDex bolsters team with new COO appointment – their global mission to transform the industry shows no signs of slowing

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LONDON, Nov. 25, 2024 /PRNewswire/ — innDex have announced the strategic appointment of Charlie Versi as Chief Operating Officer, “marking a significant step in the company’s ongoing mission to empower the construction industry with simple and powerful solutions”. Charlie brings 20 years of experience within development and contractor businesses, including 10 years leading in-house software development and procurement. 

innDex have recognised that continuing to build this blend of technology and construction delivery expertise in-house, is vital in navigating today’s construction challenges. 

Reflecting on the move to innDex, Versi shared, “the last 12 months has reinforced the fact that the construction industry continues to face significant challenges and a need to evolve. innDex has positioned itself as a key technology partner, at the forefront of tackling many of these issues  through innovation and strong industry partnerships. I’m thrilled to join a team that’s deeply committed to addressing the underlying inefficiencies that fundamentally impact productivity in  the construction industry.”

innDex Co-Founders George Smithies and Aaron Vousden both saw an opportunity to bring Versi in, to drive multiple positive impacts inside the organisation as well as support their continued efforts to partner closely with the industry that is under increasing pressure to perform in difficult conditions. They believe this strategic hire, coupled with a shared vision for a proactive, technology-led approach, will support innDex’s growth and their continued focus on addressing  the fundamental causes of the sector’s productivity challenges.

Co-Founder George Smithies added, “Our mission to empower construction professionals remains  the core driver of our business. innDex was built by industry experts committed to revolutionising  project delivery—not just through small improvements, but by embracing a forward-thinking, tech driven mindset. Having Charlie join was the obvious next big step for us, we’re excited to strengthen an already incredible team, during a rapid time in our growth.”

Contacts: Marketing and Communications Coordinator – Uyen Danguyen@inndex.co.uk 

Photo – https://mma.prnewswire.com/media/2565698/innDex_COO_Charlie_Versi.jpg

View original content to download multimedia:https://www.prnewswire.co.uk/news-releases/inndex-bolsters-team-with-new-coo-appointment—their-global-mission-to-transform-the-industry-shows-no-signs-of-slowing-302314512.html

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