Technology

Currax Pharmaceuticals: CONTRAVE®/MYSIMBA® Demonstrates Positive Cardiovascular Safety in a Large, Real-World Evidence Study

Published

4 weeks ago

August 27, 2024

BRENTWOOD, Tenn., Aug. 27, 2024 /PRNewswire/ — Currax Pharmaceuticals LLC (“Currax”) today announced the results of a Cardiovascular Health Outcomes Analysis (HOA). The results showed there is no evidence of excess cardiovascular risk and no statistically significant difference in major adverse cardiovascular events (MACE) between CONTRAVE®/MYSIMBA® and the comparator group.1 The study, presented by Dr. Dustin Burns at the International Society for Pharmacoepidemiology (ISPE) conference, held August 24-28th in Berlin, Germany, included more than 24,600 people with an average follow-up of four and a half years.

“The study’s results found no evidence of increase in cardiovascular risk among initiators of CONTRAVE, which is informative for healthcare providers and patients considering this treatment option for obesity,” said Dustin Burns, Ph.D., GStat, the presenting author and Senior Managing Scientist at Exponent who led the analysis.

These results are consistent with the four previous randomized clinical trials, the previous LIGHT Trial, and more than ten years of post-marketing safety surveillance data with over 700,000 patient years of product usage. These study results help to substantiate the cardiovascular safety profile of CONTRAVE/MYSIMBA and the ongoing INFORMUS trial.

In addition, the ongoing INFORMUS trial will address the regulatory post-marketing commitments and further characterize the long-term cardiovascular safety for patients taking CONTRAVE/MYSIMBA. In January 2024, the first patient was enrolled in the INFORMUS trial, and to date there are over 1,800 patients randomized.

“We are honored to have Dr. Burns present these favorable findings at ISPE,” Michael Kyle, M.D., SVP Chief Medical Officer of Currax Pharmaceuticals said. “Achieving this milestone and the affirmation of the cardiovascular safety of CONTRAVE is gratifying. Over the past four years, we worked exhaustively with regulatory agencies to fully characterize the cardiovascular safety of the product and these results are another proof-point of the positive benefit-risk of CONTRAVE/MYSIMBA.”

About CONTRAVE/MYSIMBA
CONTRAVE, also marketed as MYSIMBA in the European Union and European Economic Area, is an extended release fixed dose combination of naltrexone and bupropion (naltrexone HCL/bupropion HCL) indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of 30 kg/m2 or greater (obese), or adults with a BMI of 27 kg/m2 or greater (overweight) with at least one weight-related medical problem such as high blood pressure, high cholesterol, or type 2 diabetes.

About the INFORMUS Trial
The INFORMUS Trial (NB-CVOT3) is a Phase IV, multi-center, prospective, randomized, pragmatic, double-blinded, placebo-controlled study intended to capture cardiovascular (CV) outcomes during real-world use of naltrexone/bupropion (CONTRAVE). Randomization will occur 1:1 between CONTRAVE and placebo. The primary endpoint includes comparison of major adverse cardiovascular events (MACE) between study subjects receiving CONTRAVE and subjects receiving placebo.

About Currax Pharmaceuticals LLC
Currax Pharmaceuticals LLC is a specialty pharmaceutical business focused on addressing the #1 and #2 causes of preventable death in the United States, smoking and obesity. Currax distributes a range of both branded and generic pharmaceutical products, including CONTRAVE® (naltrexone HCl/bupropion HCl), ONZETRA® Xsail® (sumatriptan nasal powder), Silenor® (doxepin), Treximet®, (sumatriptan/naproxen sodium), and the authorized generic of Treximet®.

Media Contact
Hope Mueller
SVP, Strategy and Corporate Development
hmueller@curraxpharma.com

1 D. Burns, et al. Evaluating the Cardiovascular Safety of Naltrexone/Bupropion in the United States. Abstract submitted for presentation at the 2024 International Society for Pharmacoepidemiology (ISPE) conference.

SOURCE Currax Pharmaceuticals LLC

Technology

The Ar-King of Spirits: Ed Arking’s Impact on the Liquor Industry

Published

14 mins ago

September 21, 2024

In the interest of providing luxury liquors in a convenient and stress-free format, Served Neat was born. When asked about his intentions for the company, Ed states, “My goal with Served Neat is to create a one-stop shop where customers can easily discover these rare gems.”

MOORESTOWN, N.J., Sept. 21, 2024 /PRNewswire-PRWeb/ — Served Neat is an emerging online platform with a curated selection of some of the world’s most popular luxury spirits. The website offers daily flash deals that highlight a variety of high-end international brands including Pappy Van Winkle, Buffalo Trace, Clase Azul, and more.

“While there are websites selling spirits, none have the decades of experience that we bring from WTSO. Served Neat will offer not only incredible bottles but also the best customer service in the industry.”

Ed and Joe Arking, the father-son team behind the concept of Served Neat, have decades of experience hand-selecting and supplying sought-after liquors. Ed Arking, CEO of New Jersey’s Roger Wilco, grew up in the world of wine and spirits and formed his own business aspirations.

“Growing up, I watched my father navigate and succeed in the ever-evolving wine and spirits industry,” Ed explains. “While I always aspired to create something similar, I knew I needed to wait for the right moment.” Ed has gone on to manage his own liquor store and lead projects for up-and-coming brands, such as the vodka-infused and non-carbonated Smooth Water.

As he evolved in his career, Ed discovered the perfect time to make his lifelong vision a reality. He recalls, “I noticed a gap in the market—especially for whiskey and tequila. These categories have surged in popularity, making it difficult for the everyday consumer to find those elusive sought-after allocated bottles.”

When it comes to Served Neat, quality and knowledge is key. Ed adds, “While there are websites selling spirits, none have the decades of experience that we bring from WTSO. Served Neat will offer not only incredible bottles but also the best customer service in the industry.”

Served Neat is the sister company to WTSO and The Wine Market, two online platforms dedicated to sourcing and distributing top-notch wines from every corner of the globe.

At The Wine Market, an online marketplace for the world’s most popular wine brands, convenience and quality are key. Each bottle in their curated collection is a testament to exceptional flavor and craftsmanship.

Since 2006, WTSO has enjoyed creating a unique wine experience and sharing it with new beginners and seasoned connoisseurs alike. Using an extensive network of wineries and wine makers, WTSO connects customers to thousands of brands from top wine appellations around the globe. The strong relationships they’ve formed within the wine world allow the business to deliver authentic and high-quality bottles to homes across the United States.

Wine and spirits lovers alike are invited to explore Served Neat, WTSO, and The Wine Market to find their next favorite bottle. Visit their websites to learn more about these one-of-a-kind online marketplaces!

Media Contact

Julie Blount, WTSO, 1 8669572795, marketing@wtso.com

View original content to download multimedia:https://www.prweb.com/releases/the-ar-king-of-spirits-ed-arkings-impact-on-the-liquor-industry-302254517.html

SOURCE WTSO

Technology

Compete for $150K Prizes: Join Spatial Joy 2024 The Global AR Application Development Championship

Published

1 hour ago

September 21, 2024

HANGZHOU, China, Sept. 21, 2024 /PRNewswire/ — Spatial Joy 2024 The Global AR Application Development Championship is now open for registration! Organized by Rokid, a global leader in human-computer interaction through augmented reality, this championship invites AR developers globally to harness voice, gesture, and visual AI technologies to create groundbreaking AR experiences. Powered by the self-developed YodaOS-Master operating system, Rokid AR glasses deliver exceptional spatial computing performance.

What is Spatial Joy 2024 about？
In September 2022, Rokid kicked off its first AR Application Development Championship. The second championship, held last year in collaboration with Unity and Agora, quickly established itself as the largest AR application development event in China. As Rokid celebrates its 10th anniversary this year, we are excited to present “Spatial Joy,” our newly branded global championship, open to developers worldwide for the first time, and positioned as the flagship event in the AR industry.

Why join Spatial Joy 2024?

Compete for a $150,000 prize poolFree access to Rokid AR Lite or Rokid AR studioDiscounted rates on purchasing Rokid productsFree participationTechnical support from Unity and AgoraInternational exposure within the AR industryOpportunity to attend the award ceremony in China

Who can participant?
The championship is open to global AR developers of all levels, including students, independent developers, teams, and professionals across sectors such as healthcare, retail, education, gaming, entertainment, lifestyle, and more.

How to register?
Detailed registration guidelines and requirements are available online at [https://t.rokid.com/iwvwcxkn]. Developers can register and submit their projects through Rokid official website at [www.global.rokid.com].

Spatial Joy 2024 Timeline:

Registration Deadline: October 16, 2024Final Project Submission Deadline: November 15, 2024Finalists Announcement: December 27, 2024Award Ceremony: January 11, 2025

About Organizer
Rokid has expanded its global presence, making notable progress in key markets across North America, Europe, and Asia, including a successful campaign on Kickstarter. With a decade of expertise, Rokid has revolutionized AR technology, transforming how users interact with both digital and physical environments.

Join us in shaping the future of AR with Rokid – enter Spatial Joy 2024 The Global AR Application Development Championship Now!

View original content to download multimedia:https://www.prnewswire.com/news-releases/compete-for-150k-prizes-join-spatial-joy-2024-the-global-ar-application-development-championship-302254807.html

SOURCE Rokid

Technology

Summit of Whose Future? Girls Have the Answers: Leaders Must Listen

Published

3 hours ago

September 21, 2024

Young Women Activists Launch “What Girls Want,” Demand World Leaders Put Girls at the Center of Summit of the Future

NEW YORK, Sept. 21, 2024 /PRNewswire/ — Today in New York, more than 50 young women from around the world – including Nobel Prize Laureate Malala Yousafzai – gathered to take government to task for failing to prioritize girls and young women in the upcoming Summit of the Future. The group is backed by acoalition of girl-centered non-profit organizations, institutions, and funds who synthesized the demands of girls at www.whatgirlswant.com.

At a demonstration near the UN, alongside life-size cutouts of world leaders dressed ironically as “girl experts”, the activists delivered a strong message: world leaders aren’t the experts on what girls want for their futures – girls are.

Eylül Erçin, 19, from Türkiye, shared: “The time has passed for girls and young women to be treated as mere afterthoughts. Leaders must include us in the foundational design of these processes, ensuring that our priorities are integrated into shaping the future we will inherit. Anything less is unacceptable.”

Today’s event is about more than calling out a process failure. Girls i from around the world delivered a forward-looking call to action this week. They expect governments, institutions, and community leaders to step up and help shape a more equitable future.

Alongside fellow activists, Malala said: “Even at 27, I know better than to assume I understand best what girls want. Everywhere I go, girls are eager to share their vision for their futures. As adults, it is our job to listen, fund their work and follow their lead. It is not too late for world leaders to do right by girls. They can start by prioritizing their demands in tomorrow’s final Summit deliberations and by investing resources to match their words.”

The evidence is clear: investing in girls and delivering on their rights transforms economies, societies, and the environment, advancing the SDGs and building a future that girls deserve.

About What Girls Want

This effort was produced by a collaboration of girl-centered organizations, institutions, funders, and allies. The campaign is anchored around work to collate insights, data, and stories from 20+ public consultations with girls and young women over the past decade, driven by a shared desire to center girls’ demands in spaces where they are being ignored.

Contact:

whatgirlswantpress@gmail.com

nate.powers@edelman.com

Logo – https://mma.prnewswire.com/media/2384993/Women_Deliver_Logo.jpg

View original content:https://www.prnewswire.co.uk/news-releases/summit-of-whose-future-girls-have-the-answers-leaders-must-listen-302254570.html