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Differentia Biotech Launches Cutting-Edge Autoimmune Disorder Platform Combining AI/ML with QSP

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Groundbreaking Platform First Applied to Rare Autoimmune Disorder, IgG4-RD to Uncover New Treatment Targets

SOUTH SAN FRANCISCO, Calif., Aug. 22, 2024 /PRNewswire-PRWeb/ — Differentia Biotech, a leader in model-informed drug development, is proud to announce the launch of its innovative autoimmune disease platform. This platform integrates Artificial Intelligence and Machine Learning (AI/ML) with Quantitative Systems Pharmacology (QSP) extracting disease understanding by combining insights from patient-specific multiomics datasets and literature. This pioneering platform marks a significant advancement in the understanding and treatment of autoimmune diseases, enabling target identification and validation, lead optimization, biomarker discovery and clinical trial design.

The first application of Differentia Biotech’s platform focuses on IgG4-Related Disease (IgG4-RD), a rare and often misdiagnosed autoimmune disorder, for which specific treatments are currently missing due to insufficient understanding of its underlying mechanisms. Differentia Biotech has successfully developed a comprehensive disease model of IgG4-RD that maps the inter-cellular communication network among key immune cells. This model elucidates the dynamic interactions in healthy homeostasis and in the context of IgG4-RD, revealing the distinctive immune system characteristics associated with the disease state. Differentia Biotech utilized this platform to evaluate various therapeutic interventions via fast and scalable simulations and has identified targets that effectively shift the disease state towards healthy homeostasis. This innovative approach promises to transform the landscape of autoimmune disease treatment by providing deeper insights into disease mechanisms and accelerating the discovery of effective therapies.

Key Features of the Differentia Biotech’s Autoimmune Disorder Platform:

Advanced AI/ML Integration: Utilizes state-of-the-art machine learning algorithms to analyze complex multi-omics biological data, uncovering patterns and insights that are not discernible through traditional methods.Quantitative Systems Pharmacology (QSP): Employs sophisticated mathematical models to simulate disease processes and drug interactions at a systems level, enabling precise identification of potential therapeutic targets.First Application – IgG4-RD: The platform’s success with IgG4-RD underscores its potential to tackle other challenging autoimmune diseases. The IgG4-RD model has already started yielding promising targets for new treatments.

“Differentia’s modeling platform was instrumental in our study of IgG4-RD patients for clinical insights,” said Dr Hui Gao from Department of Rheumatology, Peking University International Hospital and Dr. Cuiping Pan from the Center for Intelligent Medicine Research. “It helped to uncover complex immune interactions in the patients, revealing enhanced B-cell proliferation and differential regulation of cytokines in T-cell subsets. Furthermore, we utilized Differentia’s platform to model treatment effects of numerous immune therapies, e.g., anti-CD20 B cells, anti-IL4, and anti-IL6, which had been previously shown beneficial in treating other autoimmune diseases. We are now designing clinical trials to validate the off-label use of these drugs for treating IgG4-RD. The collaboration with Differentia helped us to prioritize drug candidates with a mechanistic understanding, which accelerated the development of treatment strategies for the patients. We are hopeful that these prioritized drugs will have a therapeutic impact in this field.”

“We are thrilled to introduce this groundbreaking platform, which represents a new era in the fight against autoimmune disorders,” said Kas Subramanian, CEO of Differentia Biotech. “By combining the predictive power of AI/ML with the robust analytical capabilities of QSP, we are not only enhancing our understanding of these complex diseases but also paving the way for the development of more effective treatments.”

Differentia Biotech invites biotech and pharmaceutical companies and research organizations with a focus on autoimmune diseases to explore the potential applications of this platform to their specific areas of interest. By partnering with Differentia Biotech, stakeholders can leverage this powerful tool to drive their research and development efforts towards groundbreaking discoveries and innovative therapies.

For partnership inquiries and more information about Differentia Biotech’s autoimmune disorder platform, please contact:

Lorenz Huebner

V.P. Customer Solutions

Differentia Biotech

lorenz.huebner@differentiabio.com

Ph: +49 151 290 35213

www.differentiabio.com

About Differentia Biotech:

Differentia provides modeling and simulation services to biopharmaceutical companies delivering knowledge-based insights to improve drug development outcomes. Backed by Differentia’s proprietary data pool and cutting-edge AI/ML analytics, we empower biopharmaceutical companies to accelerate drug development and shape the future of healthcare.

Media Contact

Lorenz Huebner, Differentia Biotech, 49 151 290 35213, lorenz.huebner@differentiabio.com, www.differentiabio.com 

View original content:https://www.prweb.com/releases/differentia-biotech-launches-cutting-edge-autoimmune-disorder-platform-combining-aiml-with-qsp-302226178.html

SOURCE Differentia Biotech

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DANAconnect and eSource Capital Launch PayrollTrace for Digital Payroll Compliance

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3 hours ago

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September 22, 2024

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PayrollTrace is an innovative, secure platform for paperless payroll receipt delivery, ensuring regulatory compliance and real-time traceability.

FORT LAUDERDALE, Fla., Sept. 22, 2024 /PRNewswire-PRWeb/ — DANAconnect, the leading company in automated business communications, in collaboration with eSource Capital, a prominent Google Cloud Partner in Latin America, announce the launch of PayrollTrace, an innovative platform designed for the secure and efficient digital delivery of payroll receipts, ensuring regulatory compliance and complete traceability in every transaction.

Paul Kienholz, CEO of DANAconnect, highlighted: “PayrollTrace is the next step in automating critical business processes, enabling companies to eliminate paper and manage payroll receipt deliveries with full confidence and transparency, while ensuring regulatory compliance.”

PayrollTrace automates the delivery of payroll receipts through multiple channels, including email and SMS, completely eliminating the use of paper or reliance on email. This solution not only simplifies human resources processes but also ensures regulatory compliance with verifiable technical reports that allow companies to manage and audit receipt deliveries in real time.

Paul Kienholz, CEO of DANAconnect, highlighted: “PayrollTrace is the next step in automating critical business processes, enabling companies to eliminate paper and manage payroll receipt deliveries with full confidence and transparency, while ensuring regulatory compliance.”

Juan Aguilera Franceschi, Managing Partner at eSource Capital, added: “Our partnership with DANAconnect allows us to offer companies in the region a robust solution that optimizes payroll management. PayrollTrace provides the security and flexibility companies need to manage payments efficiently and sustainably.”

The partnership between DANAconnect and eSource Capital combines DANAconnect’s strength in omnichannel business communications with eSource Capital’s expertise in cloud digital transformation. Together, they aim to provide businesses across the Americas with a comprehensive solution that not only optimizes payroll delivery but also ensures compliance with local regulations, guaranteeing that every transaction is backed by complete audits.

About DANAconnect

DANAconnect is a North American company and a leader in communication automation for financial companies through its omnichannel platform. It sends communications to more than 10% of the population of the Americas every month, ensuring secure deliveries, traceability, and large-scale regulatory compliance.

About eSource Capital

eSource Capital is a leading Google Cloud partner in Latin America, specializing in digital transformation and cloud solutions. With a focus on Google Workspace and Google Cloud, eSource Capital helps companies optimize their operations in the digital environment.

Media Contact

Fabiana Arroyo, DANAconnect Corp., 1 8556003262, info@payrolltrace.com, https://www.payrolltrace.com

Twitter, LinkedIn

View original content to download multimedia:https://www.prweb.com/releases/danaconnect-and-esource-capital-launch-payrolltrace-for-digital-payroll-compliance-302254651.html

SOURCE DANAconnect Corp.

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Siemon Announces Optical Patching Solutions for GenAI Networks Using NVIDIA Accelerated Computing

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9 hours ago

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September 22, 2024

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Siemon announces it is offering its full range of optical patching solutions to work specifically with NVIDIA AI infrastructure for generative AI networks.

WATERTOWN, Conn., Sept. 22, 2024 /PRNewswire-PRWeb/ — The Siemon Company, a global leader in network infrastructure solutions, today announced it is offering its full range of optical patching solutions to work specifically with NVIDIA AI infrastructure for generative AI networks. Large complex GPU clusters can benefit from using structured cabling patch panels versus point-to-point cabling. Siemon acts as a trusted advisor to customers by providing expert advice and best practice recommendations for design & deployment of NVIDIA AI Infrastructure.

“Siemon is very familiar with NVIDIA reference architectures and has worked with many customers to design and deploy NVIDIA clusters… Siemon offers a full range of AI-ready fiber cabling, DAC, and AOC solutions that support 400G, 800G, and 1.6T applications.”

As part of the solution integration, Siemon has joined the NVIDIA Partner Network (NPN) as a Solution Advisor Consultant. NPN Solution Advisor Consultants provide consultation services and expert advice to customers looking to implement NVIDIA-based solutions or technologies. Siemon joins the network to offer its expertise in addressing the unique infrastructure and cabling challenges presented by accelerated computing.

NVIDIA optical reach specifications are calculated assuming two optical patch panels are used in the link and assuming each employ two optical connectors, which makes for a total allowance of four optical connectors in the link. The Siemon optical patching solutions meet NVIDIA requirements and provide customers with flexibility and ease of management.

Media Contact

Brian Baum, Siemon, 1 8609454200, brian_baum@siemon.com

View original content:https://www.prweb.com/releases/siemon-announces-optical-patching-solutions-for-genai-networks-using-nvidia-accelerated-computing-302254640.html

SOURCE Siemon

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AMSimpkins & Associates Awarded Wisconsin Technical Purchasing Consortium Contract RFB 25-002TP – for Identity Verification Solutions

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10 hours ago

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September 22, 2024

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AMSimpkins & Associates has been awarded the Wisconsin Technical Colleges Purchasing Consortium (WTC-PC) contract for Identity Verification Solutions. This partnership includes providing their advanced S.A.F.E. (Student Application Fraudulent Examination) platform to 16 Wisconsin technical colleges, enhancing security and safeguarding against fraudulent student applications. With a focus on higher education, AMSA aims to support these institutions in maintaining the integrity of their admissions processes and preventing identity fraud. This collaboration underscores AMSA’s commitment to delivering innovative solutions tailored for the education sector.

ATLANTA, Sept. 22, 2024 /PRNewswire-PRWeb/ — AMSimpkins & Associates is proud to announce its selection by the Wisconsin Technical College System Purchasing Consortium (WTC-PC) to provide Identity Verification Solutions through the S.A.F.E. platform. The WTC-PC comprises 16 independent, publicly funded two-year technical colleges across Wisconsin, including Blackhawk Technical College, Chippewa Valley Technical College, Fox Valley Technical College, and Milwaukee Area Technical College, among others.

“We are honored by the Wisconsin Technical College Consortium’s trust in AMSA. This partnership further emphasizes our commitment to providing secure, innovative identity verification solutions that support the needs of educational institutions in protecting their students and operations.”

With a focus on preventing identity fraud, AMSimpkins & Associates’ comprehensive solutions will strengthen the security measures across admissions, enrollment, and financial aid processes, ensuring secure verification and compliance with federal and state regulations. S.A.F.E. will now support Wisconsin’s higher education system, offering its cutting-edge technology to streamline operations and safeguard student data.

“We are honored by the Wisconsin Technical College Consortium’s trust in AMSimpkins & Associates,” said Maurice Simpkins, President and Founder. “This partnership further emphasizes our commitment to providing secure, innovative identity verification solutions that support the needs of educational institutions in protecting their students and operations.”

As part of this agreement, AMSimpkins & Associates will deliver comprehensive services, including system integration, training, and ongoing support to ensure seamless implementation. S.A.F.E.’s capabilities are designed to evolve with growing threats of fraudulent activities, keeping institutions one step ahead in securing student identities.

Institutions in the Wisconsin Technical College System:

Blackhawk Technical CollegeChippewa Valley Technical CollegeFox Valley Technical CollegeGateway Technical CollegeLakeshore Technical CollegeMadison Area Technical CollegeMid-State Technical CollegeMilwaukee Area Technical CollegeMoraine Park Technical CollegeNicolet Area Technical CollegeNorthcentral Technical CollegeNortheast Wisconsin Technical CollegeNorthwood Technical CollegeSouthwest Wisconsin Technical CollegeWaukesha County Technical CollegeWestern Technical College

The S.A.F.E. platform’s advanced identity verification services will play a pivotal role in securing sensitive data and ensuring a safe and fraud-free environment for Wisconsin’s technical colleges and their students.

For more information about AMSimpkins & Associates and the S.A.F.E. platform, please visit amsa-highered.com.

Media Contact

LAQWACIA SIMPKINS, AMSimpkins & Associates, 1 6786824193, LSIMPKINS@AMSA-CONSULTING.COM, amsa-highered.com

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View original content:https://www.prweb.com/releases/amsimpkins–associates-awarded-wisconsin-technical-purchasing-consortium-contract-rfb-25-002tp—for-identity-verification-solutions-302253867.html

SOURCE AMSimpkins & Associates

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