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Inductive Bio Announces Publication of Successful Drug Optimization Collaboration with Nested Therapeutics

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NEW YORK, July 29, 2024 /PRNewswire/ — Inductive Bio, a leader in leveraging machine learning (ML) to accelerate compound optimization for small molecule drug discovery, announces the publication of the approach and findings from their recent collaboration with Nested Therapeutics, a biotechnology company pioneering a next-generation precision medicine platform to address hard-to-treat cancers. The publication in ACS Medicinal Chemistry Letters highlights the pivotal role of ML models for ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) alongside computational potency predictions for prioritizing synthetic targets and enhancing design quality.

“Integrating Inductive Bio’s ADMET models into Nested’s predictive platforms helped us to prioritize designs with optimal drug like properties.” 
Yongxin Han, EVP and Head of Drug Discovery at Nested Therapeutics

Multi-parameter optimization of small molecules is an expensive, time-intensive, and high-stakes process in which potency must be balanced with ADMET properties to achieve a viable drug candidate. The two companies combined Inductive’s ADMET foundation models, which leverage state-of-the-art deep learning methods trained on proprietary ADMET datasets, with Nested’s computational platform for predicting the potency of compounds in cryptic pockets. This collaborative approach allowed Nested to reduce the number of compounds synthesized and accelerate the lead optimization process.

“Integrating Inductive Bio’s ADMET models into Nested’s predictive platforms helped us to prioritize designs with optimal drug like properties,” said Yongxin Han, EVP and Head of Drug Discovery at Nested Therapeutics. “This allowed us to rapidly iterate and optimize lead compounds and address critical ADMET challenges.”

“We are very proud of the outcome from our collaboration with Nested Therapeutics,” said Josh Haimson, co-founder and CEO of Inductive Bio. “This publication underscores the impact of ML models for ADMET in accelerating drug optimization and offers a practical framework for others aiming to undertake similar approaches. We look forward to continuing to support our partners in achieving their drug discovery goals.”

For more information on this collaboration, read the full publication here: pubs.acs.org/doi/10.1021/acsmedchemlett.4c00290 

About Inductive Bio

Inductive Bio is a technology company with a machine learning (ML) platform that dramatically accelerates the compound optimization process, a critical and time-consuming step in developing new therapeutics. By building datasets and state-of-the-art ML models designed to map the drivers of small molecule Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET), Inductive’s platform allows scientists to optimize initial compounds into leads and development candidates faster and with a better balance of ADMET properties. For more information, please visit www.inductive.bio.

Contact
media@inductive.bio 

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SOURCE Inductive Bio, Inc.

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ResumeTemplates.com Survey Reveals 3 in 10 Gen Zers Believe CEOs Are Evil; Many Support Release of Mangione

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The majority of Gen Zers feel CEOs wield excessive power, with some expressing extreme views about corporate accountability

SEATTLE, Dec. 27, 2024 /PRNewswire-PRWeb/ — ResumeTemplates.com, the leading platform for professional resume templates and career advice, has released findings from a recent survey revealing critical attitudes among Gen Z toward corporate leaders. Conducted in December 2024, the survey of 1,200 U.S.-based Gen Zers highlights the sentiment that CEOs hold excessive power and are overcompensated, with some respondents expressing extreme views about corporate accountability.

According to the survey, more than half of Gen Zers (55%) believe CEOs wield excessive power in society, particularly influencing elections, the economy, and policymaking. Additionally, 59% of respondents believe CEOs are overpaid, with most saying total annual compensation should not exceed $750,000. Only 7% of respondents support unlimited earning potential for CEOs. The survey also found that 39% of Gen Zers believe all levels of a workforce equally contribute to a company’s success, while only 20% think CEOs create the most value within an organization.

The survey also explored Gen Z’s perceptions of corporate leadership. More than half believe CEOs are responsible for driving corporate greed, and 30% of respondents view CEOs as “evil,” reflecting deep skepticism toward corporate leadership.

Additionally, the survey examined opinions on high-profile cases like Brian Thompson’s killing. Among respondents, 21% agreed that “CEOs deserve to lose their lives for their professional actions,” including 7% who strongly agreed. When asked specifically about Brian Thompson’s killing, 22% of respondents believe he definitely (10%) or probably (12%) deserved what happened to him. Regarding Luigi Mangione, Thompson’s accused killer, 21% supported his release, while 51% opposed it.

This survey, conducted December 18, 2024, via Pollfish, gathered responses from 1,200 U.S.-based 18 to 27 year olds. The full report can be viewed here: https://www.resumetemplates.com/3-in-10-gen-zers-say-ceos-are-evil-many-believe-mangione-should-go-free/

ABOUT RESUMETEMPLATES.COM
ResumeTemplates.com offers a comprehensive selection of free, industry-specific resume templates, tailored to meet the needs of various job seekers. The website also provides extensive resources to help facilitate the job application process, including expert advice, resume examples, and tips and tricks for creating impactful resumes. For more information, please visit: https://www.resumetemplates.com/.

Media Contact

Abigail Davis, ResumeTemplates, 000-0000, abigail@resumetemplates.com

View original content:https://www.prweb.com/releases/resumetemplatescom-survey-reveals-3-in-10-gen-zers-believe-ceos-are-evil-many-support-release-of-mangione-302338434.html

SOURCE ResumeTemplates

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Founder Shares Unforgettable Lessons After Spending $1 Million on a Domain Name

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ATLANTA, Dec. 27, 2024 /PRNewswire/ — VPN.com CEO Michael Gargiulo recently shared invaluable insights with Entrepreneur on the unforgettable lessons he learned while spending $1 million to acquire the premium domain VPN.com.

Gargiulo’s journey to acquiring VPN.com wasn’t just about landing a high-value web address. In the Entrepreneur.com article titled “5 Unforgettable Lessons I Learned Spending $1 Million on a Domain Name”, Gargiulo emphasizes the long-term value a premium domain brings to brand trust, visibility, and scalability.

Investing in a Domain: More Than Just a Name

Gargiulo’s $1 million purchase of VPN.com was more than a simple transaction—it was an investment in the future of his business and the value of owning a recognizable, exact-match domain. “The right domain can change everything for a brand. It immediately creates trust and credibility with customers, and it sets your company apart from the competition,” said Gargiulo.

In the article, he shares five critical lessons learned during his experience, including the importance of patience, timing, and the negotiating power of a premium domain. “A domain isn’t just a digital asset—it’s a business strategy. Acquiring VPN.com helped us stand out in the crowded cybersecurity market and continues to drive our success.”

Brand Trust and Global Recognition

Since acquiring VPN.com, Gargiulo has expanded his company’s mission to help hundreds of millions of people secure a private internet experience. The premium domain has played a pivotal role in building trust with customers, partners, and investors. “A premium domain acts as an instant signal of authority,” Gargiulo noted. “It makes a lasting impression, and in today’s fast-moving digital world, that’s invaluable.”

A Vision for the Future

Gargiulo’s vision for VPN.com extends beyond the domain. With a mission to provide a secure internet experience for one billion people by 2030, VPN.com is at the forefront of internet privacy, security, and premium domain brokerage. Gargiulo’s experience acquiring VPN.com has equipped him with unique insights into the premium domain marketplace, helping businesses recognize the value of digital branding in today’s world.

Read More About Michael Gargiulo’s Insights

To read Gargiulo’s full breakdown of the lessons learned from his $1 million domain purchase, visit the Entrepreneur article here.

In addition, Gargiulo also contributed to the Entrepreneur article “Getting a Divorce With a Six-Figure Domain Portfolio”, where he shares insights on the unique challenges of managing and valuing a high-profile domain portfolio in complex personal and financial situations.

For media inquiries or interviews, please contact:

Michael Gargiulo
855-VPN-FAST
388102@email4pr.com

Visit: vpn.com for more information.

About VPN.com
VPN.com is a global leader in internet security and premium domain brokerage, dedicated to helping entrepreneurs, businesses, and individuals protect their brands and secure their online presence. With a $1 million domain name and a mission to serve one billion people by 2030, VPN.com is at the cutting edge of internet privacy, security, and digital branding.

Learn more about VPN.com’s work:

Michael Gargiulo Shares Insider Secrets on Premium Domain ValuationHow to Acquire a Premium Domain Via Stealth AcquisitionVPN.com Renews Commitment to Freedom, Digital Liberties, and Brand Protection

For more insights on digital brand protection and domain name acquisition, visit: vpn.com/domains.

View original content:https://www.prnewswire.com/news-releases/founder-shares-unforgettable-lessons-after-spending-1-million-on-a-domain-name-302339666.html

SOURCE VPN.com

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OCR Canada Rebrands to Levata

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TORONTO, Dec. 27, 2024 /CNW/ — OCR Canada Ltd., Canada’s leading solutions provider of automated identification data capture (AIDC) products, software, and services for businesses across industries and government organizations, is pleased to announce its rebrand to Levata as of January 1, 2025. This transition unites Canada’s operations with Levata’s global identity, streamlining the company’s messaging while honoring OCR Canada’s more than 40-year legacy of trusted service and expertise.

The name OCR, which originally stood for Optical Character Recognition, reflects a technology that no longer represents the company’s comprehensive offerings. Rebranding to Levata supports the broader strategic vision of uniting Levata across markets under one multinational brand to better communicate the full value Levata delivers to its customers.

“This rebrand is an exciting milestone for Canada,” said Tony Mastrangeli, Executive Vice President & GM of Canada. “While our name is changing, the exceptional service, expertise, and relationships our customers rely on remain the same. Levata will continue to empower businesses with tailored solutions, just as OCR Canada has for more than 40 years.”

The transition follows a successful history of growth in Canada, with OCR Canada joining Levata in 2014. Since then, the Canadian arm has expanded its expertise through strategic acquisitions and established itself as a leading provider of AIDC solutions across industries.

“This rebrand marks the next step in Levata’s long-term vision,” said Dan Nettesheim, CEO of Levata. “By uniting under a single, global identity, we are amplifying our global message that we enable our customers to elevate their potential. Today, we provide solutions beyond OCR and barcoding, we also offer leading technology and services for enterprise mobility, RFID, networking, IT infrastructure, and more to help customers succeed in a competitive and rapidly evolving market.”

To complement this transformation, Levata Canada will launch a French-enabled eCommerce platform in January 2025, further enhancing customer access and experience.

For more information about the rebranding, visit www.Levata.com/en-ca/news/ocr-canada-rebrands-to-levata.

About Levata
Levata enables customers to elevate their potential by providing strategies, solutions, and services that power modern environments. With a broad suite of technology products to enable enterprise mobility, a digital supply chain, a secure workplace, and an elevated customer experience, and the services to move businesses forward, Levata unlocks the power of thousands of organizations worldwide. Levata has operated as a market leader in full-stack technology solutions for over 40 years. Learn more at www.levata.com.

Alana Tufford, Director, Enterprise Marketing
Levata
905-475-5505 x242
branding@levata.com

SOURCE Levata

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