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Pusan National University Researchers Explore the Interplay Between High-Affinity DNA and Carbon Nanotubes

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Researchers demonstrate the intricate interactions between single-stranded DNA sequences and carbon nanotubes

BUSAN, South Korea, July 26, 2024 /PRNewswire/ — Single-walled carbon nanotubes (SWCNTs) have emerged as promising candidates for applications in biotechnology and nanoelectronics due to their exceptional physical and chemical properties. Despite their potential, challenges like insolubility and toxicity have hindered their widespread use. Prior studies have been investigating diverse strategies to functionalize and modify the surfaces of SWCNTs to overcome these challenges.

In a recent study, researchers from the Pusan National University led by Professor Sanghwa Jeong, Assistant Professor in the School of Biomedical Convergence Engineering, have attempted to fill this gap. This study has gone beyond conventional techniques by employing high-throughput screening methods to elucidate the relationship between DNA sequences and their binding affinity to carbon nanotubes. It focused on optimizing the binding affinity and stability of these constructs through advanced sequence design and molecular dynamics simulations. This recent study was published in the journal of Advanced Science on 25th June 2024. Discussing the background of their study Dr. Jeong explains, “Researchers have been exploring various strategies to engineer SWCNT surfaces to overcome the challenges of limited applications owing to insolubility and potential toxicity. One promising approach is the use of single-stranded DNA (ssDNA) as a wrapping surfactant for SWCNTs.”

The researchers employed a rigorous methodology to ensure precise characterization and optimization of single-stranded DNA (ssDNA)-SWCNT complexes. Initially, a diverse random 30-nucleotide (nt) ssDNA library underwent iterative rounds of screening to identify high-affinity sequences.

Computational modeling, particularly molecular dynamics simulations, provided insights into the structural dynamics of the SWCNT constructs. Furthermore, the researchers used several machine-learning models to understand the pattern of sequences that affect binding affinity. They have successfully created a freely accessible online service that predicts the binding affinity of ssDNA sequences to SWCNTs. These integrated approaches not only validated the experimental findings but also guided the design of high-performance ssDNA-SWCNT constructs.

The findings revealed significant advancements in the stability and functionality of ssDNA-SWCNT complexes. High-affinity 30-nt ssDNA sequences, rich in adenine and cytosine, exhibited superior binding strength, validated through surfactant displacement experiments. Molecular dynamics simulations highlighted the formation of stable intramolecular hydrogen bonds near the SWCNT surface, underscoring their enhanced structural integrity. The machine-learning models effectively predicted the binding affinities of ssDNA sequences, further supporting the design of the tailored ssDNA-SWCNT constructs.

Moreover, the study demonstrated notable improvements in the resistance of these complexes to enzymatic degradation compared to free ssDNA, making them highly suitable for long-term biological applications.

In conclusion, the development of high-affinity ssDNA-SWCNT constructs marks a significant advancement in nanobiotechnology. The exceptional characteristics of ssDNA-SWCNTs make them ideal candidates for cell or tissue-specific drug delivery systems as well as the development of high-performance nano electronic devices.

Dr. Jeong concludes, “Our study not only makes a substantial contribution to our understanding of the interplay between ssDNA and SWCNTs but also offers practical avenues for harnessing these interactions in a wide range of advanced technologies. In the future, developing nanomaterials and devices with enhanced stability will show promise in driving innovation in nanoelectronics and biotechnology.”

Reference
Title of original paper: Systematic Selection of High Affinity ssDNA Sequences to Carbon Nanotubes
Journal: Advanced Science

DOI: https://doi.org/10.1002/advs.202308915

About the institute
Website: https://www.pusan.ac.kr/eng/Main.do

Contact:
Jae-Eun Lee
82 51 510 7928
380885@email4r.com

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Summit of Whose Future? Girls Have the Answers: Leaders Must Listen

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Young Women Activists Launch “What Girls Want,” Demand World Leaders Put Girls at the Center of Summit of the Future 

NEW YORK, Sept. 21, 2024 /PRNewswire/ — Today in New York, more than 50 young women from around the world – including Nobel Prize Laureate Malala Yousafzai – gathered to take government to task for failing to prioritize girls and young women in the upcoming Summit of the Future. The group is backed by acoalition of girl-centered non-profit organizations, institutions, and funds who synthesized the demands of girls at www.whatgirlswant.com.

At a demonstration near the UN, alongside life-size cutouts of world leaders dressed ironically as “girl experts”, the activists delivered a strong message: world leaders aren’t the experts on what girls want for their futures – girls are. 

Eylül Erçin, 19, from Türkiye, shared: “The time has passed for girls and young women to be treated as mere afterthoughts. Leaders must include us in the foundational design of these processes, ensuring that our priorities are integrated into shaping the future we will inherit. Anything less is unacceptable.”

Today’s event is about more than calling out a process failure. Girls i from around the world delivered a forward-looking call to action this week. They expect governments, institutions, and community leaders to step up and help shape a more equitable future.

Alongside fellow activists, Malala said: “Even at 27, I know better than to assume I understand best what girls want. Everywhere I go, girls are eager to share their vision for their futures. As adults, it is our job to listen, fund their work and follow their lead. It is not too late for world leaders to do right by girls. They can start by prioritizing their demands in tomorrow’s final Summit deliberations and by investing resources to match their words.”

The evidence is clear: investing in girls and delivering on their rights transforms economies, societies, and the environment, advancing the SDGs and building a future that girls deserve.

About What Girls Want 

This effort was produced by a collaboration of girl-centered organizations, institutions, funders, and allies. The campaign is anchored around work to collate insights, data, and stories from 20+ public consultations with girls and young women over the past decade, driven by a shared desire to center girls’ demands in spaces where they are being ignored. 

Contact:

whatgirlswantpress@gmail.com

nate.powers@edelman.com

Logo – https://mma.prnewswire.com/media/2384993/Women_Deliver_Logo.jpg 

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48-Hour Saudi Visa Processing, Major Discounts and Unmissable Giveaways – Only at ‘Spectacular Saudi’ in Mumbai

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NEW DELHI, Sept. 21, 2024 /PRNewswire/ — Saudi’s national tourism brand, ‘Saudi Welcome to Arabia’ is hosting its first-ever immersive consumer event ‘Spectacular Saudi’, from September 25 to October 2,  from 2:00 p.m. – 10:30 p.m. at R2 Ground in BKC, Mumbai.

Slated to transport visitors straight to the Heart of Arabia; the 8-day immersive experience will give visitors a glimpse into Saudi’s many wonders and iconic experiences – all while extending the warm Saudi welcome. To give consumers a truly memorable experience Saudi is offering exclusive giveaways and discounts specially curated for Indian travellers.

What’s more, Indian travellers can fast-track their Saudi visas exclusively at the event. All you need is a valid Visa or Mastercard credit card! Head on over to one of eight dedicated Tasheer kiosks, ensure the name on the credit card matches the passport, and have sufficient funds available on the card. After that, sit back and relax as your visa will be in hand within 48 hours!

It has never been easier to visit Saudi. With the most seamless visa process offered to date, the excitement doesn’t end there. On the travel front, SAUDIA Airlines is offering special deals, including a buy one get 50% off on the second ticket if travelling business class. Additionally, all economy class tickets will be 15% off. Attendees will also have the chance to participate in daily giveaways for free flight tickets for two to Saudi. With over 50+ travel trade offers, visitors can access incredible cashback and discounts on Saudi travel packages. Additionally, those booking Saudi packages will enjoy complimentary cultural city tours. Group tour packages to Riyadh, Jeddah, and Dammam will be available exclusively at the event, starting at INR 99,999 for 5 nights.

Visitors can expect unique immersive experiences–including exhibits, culinary delights, Ardah dancers, Saudi coffee, traditional scents, and fashion–all under one roof. So don’t miss out and register here to experience a piece of Saudi, right in the heart of Mumbai.

Photo – https://mma.prnewswire.com/media/2511104/Spectacular_Saudi.jpg

 

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Indian Cancer Genome Atlas Launches the Country’s First Comprehensive Cancer Multi-Omics Data Portal

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Offers open access to cancer data for research

NEW DELHI, Sept. 21, 2024 /PRNewswire/ — The Indian Cancer Genome Atlas (ICGA) has launched India’s first comprehensive cancer multi-omics data portal. This pioneering platform provides open access to clinically correlated data from Indian cancer patients, aimed at transforming cancer research and treatment for Indian populations.

Historically, cancer treatments in India have been based on Western data sets. However, cancers in Indian patients can differ significantly at the molecular level. ICGA’s mission is to create Indian-specific datasets to help researchers and clinicians develop personalized treatment protocols. This new open-access portal represents a monumental step in revolutionizing cancer research, specifically for Indian patients.

The ICGA cancer multi-omics portal is the first in India to offer data that includes DNA, RNA, and protein profiles of breast cancer patients, integrated with clinical outcomes. Currently, the platform consists of data from 50 breast cancer patients, with plans to expand to over 500 patients in the coming year. This data is freely accessible to the global research community under India’s PRIDE guidelines, which promote ethical sharing and collaboration in cancer research.

Key Highlights of this portal include:

India’s First Cancer Multi-Omics Data Portal: A comprehensive resource that offers detailed multi-omics data for breast cancer patients, including genomic and proteomic information.Based on cBioPortal Platform: Derived from the internationally recognized cBioPortal, this platform ensures seamless integration with global cancer research efforts.Initial Dataset from 50 Indian Patients: Provides clinically annotated DNA, RNA, and protein profiles, along with treatment histories and patient outcomes, with an aim to scale up to 500 in a year.Free Access Under PRIDE Guidelines: Adhering to responsible and ethical data-sharing practices, the portal is freely accessible to the scientific community.A Step Toward Precision Oncology for Indian Patients: This initiative is designed to enable the development of personalized cancer treatments tailored to Indian patients.Call for Collaboration:  ICGA invites researchers worldwide to contribute and expand the platform, fostering global collaboration in cancer research.

Professor Shekhar C. Mande, Former DG-CSIR, Currently Senior Professor at Savitribai Phule Pune University
“Making this invaluable cancer data publicly accessible marks a pivotal step in accelerating scientific discoveries and enhancing patient outcomes. By openly sharing this data, we are empowering researchers, clinicians, and innovators to collaborate, explore new frontiers, and drive transformative breakthroughs in cancer treatment.”

Joint Statement from Dr JC Zenklusen – Director of The Cancer Genome Atlas (TCGA) at the NCI, NIH, USA, and Prof Sunil Badve – Vice Chair, Pathology Cancer Programs, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
“Fifteen years ago, when we launched TCGA, we could not have foreseen the remarkable progress cancer research would make. It is incredibly exciting to see ICGA advancing so rapidly and taking bold steps in revolutionizing cancer research. Understanding the genome of cancer patients will improve the treatment of Indians not only in India but also worldwide. We, both, encourage others with similar data to actively contribute to ICGA, so this initiative can grow even faster and drive greater breakthroughs.”

Dr. Anand Deshpande, Chairman and Managing Director at Persistent, and Non-Executive Director at ICGA
“We have made an excellent start with this groundbreaking multi-omics cancer portal. Cancer touches all of us, and the need for more effective, personalized treatments—especially tailored to the unique genetic and environmental factors in India—is urgent. This portal will empower researchers with crucial data to advance customized cancer research for better treatment outcomes. I encourage everyone to contribute and support this vital cause, helping us accelerate progress in the fight against cancer.”

About Indian Cancer Genome Atlas (ICGA):
The Indian Cancer Genome Atlas (ICGA) is a national initiative focused on mapping the genomic, transcriptomic, and proteomic landscapes of cancers across India. As a section 8 not-for-profit organization, the ICGA Foundation, operates through a public-private-philanthropic partnership, with active support from over 50 clinicians, researchers, and data analysts. Its mission is to enhance cancer diagnosis and treatment for Indian patients and contribute to the global understanding of cancer biology. The foundation’s first project focuses on the multi-omics profiling of breast cancer, with plans to extend this effort to other types of cancer in the future.

https://www.icga.in/

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