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KOLON TISSUEGENE COMPLETES PATIENT DOSING IN TWO PIVOTAL US PHASE III CLINICAL TRIALS FOR TG-C

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Completed patient dosing in US Phase 3 clinical trials.There will be a two-year follow-up period, followed by submission of the Biologics License Application (BLA) to permit marketing of TG-C once approved.

ROCKVILLE, Md., July 11, 2024 /PRNewswire/ — Kolon TissueGene, Inc. (‘the Company”) announced today that patient dosing has been completed on the US Phase 3 clinical trials for Knee Osteoarthritis. Since resuming patient recruitment in November 2021, the Company has completed 2 large clinical trials involving 1,066 patients in about 30 months.

Completion of patient dosing is a big milestone which enabled the Company to complete the pivotal Phase 3 clinical trials. The Company worked diligently with the US Food and Drug Administration (FDA) to get the clinical hold lifted in April 2020, which allowed resumption of the Phase 3 clinical trials in the US. The clinical hold was successfully lifted through extensive research based on scientific data on TG-C and an intensive regulatory review process.

Even though there were difficulties in the Phase 3 clinical trial process such as significant delays of the clinical studies in the US due to the global pandemic, the Company was able to complete patient dosing in the Phase 3 clinical trials with the determination and conviction to succeed in developing the world’s first and only cell and gene therapy for osteoarthritis of the knee.

During the patient recruitment process, approximately 6,700 patients signed up to participate in the Phase 3 clinical trials. Among them, more than 1,000 patients met eligibility criteria and were enrolled in the Phase 3 clinical trials.

In accordance with the protocol, the Company will continue a two-year follow-up on all dosed patients to assess the safety and efficacy after TG-C administration. The results of the Phase 3 clinical trials will be published at the end of the two-year follow-up period.

During the follow-up period, the Company will prepare the BLA submission package for the US FDA in order to obtain marketing authorization of TG-C in the US. The Company has already begun preparations related to commercial production (manufacturing) and is collaborating with Lonza, the world’s largest pharmaceutical CDMO.

“We expect the Phase 3 clinical trials to provide positive results, similar to the successfully completed Phase 2 clinical trial in the US” said Moon Jong Noh, PhD, CEO of the Company, adding, “When the Phase 3 clinical trials are successfully completed, we will start discussions with potential partners for commercial sales and marketing along with completion and submission of the BLA for product approval.” In addition, he said, “All executives and employees will do their best to repay all customers, shareholders, and others who have trusted and waited for the Company for a long time with meaningful results.”

About Kolon TissueGene, Inc. 
Kolon TissueGene, Inc., is an advanced cell therapies company that has developed a first-in-class cell and gene therapy targeting OA of the knee. The Company’s lead product, TG-C, is an allogeneic cell and gene therapy. The Company is conducting Phase 3 clinical trials in the US under a Special Protocol Assessment (SPA) agreement reached with the US FDA. Information about the trials can be found at the National Institutes of Health registry, www.clinicaltrials.gov.  For additional information about Kolon TissueGene, Inc., please visit www.tissuegene.com.

About TG-C
TG-C is a first-in-class cell and gene therapy targeting OA of the knee through a single intra-articular injection. Clinical trials held in the US and abroad have demonstrated pain relief and increased mobility, as well indicators towards decreased progression of OA and improvements in joint structure. The allogeneic (off-the-shelf) drug could provide an alternative to traditional treatment and surgery, or delay the progression of OA to minimize the need for multiple surgical interventions. In a concluded US Phase 2 clinical trial, Kolon TissueGene demonstrated a two-year improvement of pain and function. The Company seeks to continue to support these results through its Phase 3 clinical trials. In addition, the Company has designed the trials to seek a disease-modifying osteoarthritis drug (DMOAD) designation for TG-C from the US FDA—potentially making TG-C the first therapy to receive such a DMOAD label.

View original content:https://www.prnewswire.com/news-releases/kolon-tissuegene-completes-patient-dosing-in-two-pivotal-us-phase-iii-clinical-trials-for-tg-c-302195060.html

SOURCE Kolon TissueGene, Inc.

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Learnologyworld Unveils New Domain and Partnerships for Enhanced IT Training

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Discover Learnologyworld’s new domain, learnologyworld.net, and exciting partnerships with Phoenix Computer Academy and WiFi Training Voucher. Expand your IT skills today!

LOS ANGELES, Sept. 28, 2024 /PRNewswire/ — Learnologyworld, the premier resource for online IT training and certification, is proud to announce two exciting new developments. This includes a brand new website domain, learnologyworld.net, and partnerships with key players in the IT training space.

Learnologyworld’s new website is available now at learnologyworld.net. The old domain, learnologyworld.com, will remain live until October 18, 2024, but visitors are encouraged to update their bookmarks to the new official home of Learnologyworld. The new domain’s launch represents Learnologyworld’s ongoing growth and innovation and its dedication to providing enhanced online experiences.

Manuel End, Co-Founder and CEO of Learnologyworld, said of the new domain, “This transition marks a significant milestone in Learnologyworld’s development, and I couldn’t be more excited.”

Learnologyworld has also teamed up with Phoenix Computer Academy (phxcomputeracademyshop.com) and WiFi Training Voucher (wifitrainingvouchers.com), two established names in online IT training and certification. This strategic expansion of Learnologyworld’s certification offerings will enhance the educational journey for both IT newcomers and experienced pros looking to add new skills.

“These exciting collaborations allow us to offer an expanded product selection, adding industry-recognized training and certification programs that our customers have long asked for,” End said. Phoenix Computer Academy offers a broad range of IT certifications, and WiFi Training Voucher specializes in real-world network training.

Learnologyworld is a leading provider of online IT training and certification programs. The company’s international presence provides learners with a global perspective on the latest trends in information technology.

IT professionals who want to add new certifications to their resumes and beginners in the field can find out more about Learnologyworld’s training programs online at https://learnologyworld.net.

About Learnologyworld

Learnology World is an online platform that provides IT professionals with the necessary expertise to succeed in the digital age. With years of experience, the platform offers a variety of certification materials, including exam vouchers for DevOps, Autodesk, and Linux users.

For media inquiries or to learn more about Learnology World’s latest discounted materials and certifications for advancing your IT career, visit learnologyworld.com.

Press Contact

Bella Rose
7402177670
https://www.learnologyworld.net/

View original content:https://www.prnewswire.com/news-releases/learnologyworld-unveils-new-domain-and-partnerships-for-enhanced-it-training-302261594.html

SOURCE Learnologyworld

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CGTN: Why has China’s nature reserve network proved invaluable?

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BEIJING, Sept. 28, 2024 /PRNewswire/ — Summer is the busiest season at Qinghai Lake, the largest saline lake in China.

Birds feed and nurture their young, herders drive yaks to the alpine pastures. Meanwhile, an army of naked carp, a species unique to the lake, gather to start their annual migration.

The fish swim in the lake, which lies in northwest China’s Qinghai Province, at an average depth of 18 meters. But the high saline and alkaline content of the lake water inhibits their gonad development, so every year from May to August the mature naked carp head to the fresh waters of the Buha River and Shaliu River, that flow into the lake, to spawn. This forms one of the great wonders of Qinghai Lake – the migration of the naked carp.

The ‘lost and found’ naked carp

The naked carp has a special place in the hearts of people in Qinghai, because it once helped save countless lives. In the 1950s and 1960s, food shortages led locals to rely on the fish for survival. The large-scale development of Qinghai Lake’s naked carp population began.

But in just a few decades, the “gift of the divine lake,” as the fish was known, was in danger of extinction due to overfishing and habitat loss. By the early 21st century, the number of naked carp in Qinghai Lake had fallen to less than 1 percent of the historical peak.

The local government implemented fishing bans and cracked down hard on illegal fishing and trading. Combined with artificial breeding and the improvement of the ecology of the lake, the carp population bounced back despite a low fertility rate.

Over time, the efforts have paid off. As of 2023, the total tonnage of naked carp in the lake had reached about 120,300 – about 44 times that of 2002. The fish’s protection status has since been downgraded from “endangered” to “vulnerable.”

The protection of the naked carp is just one example of the success of China’s conservation efforts. From giant pandas and crested ibises to golden snub-nosed monkeys, the populations of rare species have gradually grown as the country’s system of nature reserves has developed.

China is home to some of the richest biodiversity on Earth and is the only country with nearly all ecosystem types. Its natural protected areas have boosted biodiversity conservation and play a primary role in safeguarding national ecological security.

Nature reserves of various types have been established in the People’s Republic of China since its founding in 1949. Protection of endangered species has been continuously strengthened, international cooperation has grown, and the network of natural protected areas is bearing fruit.

Ecological civilization was incorporated into China’s integrated development plan in 2012, when Xi Jinping became China’s top leader. Since then, greater changes have been seen across the country as Xi emphasized the importance of seeking harmonious coexistence between humanity and nature.

“The Book of Changes (l Ching) says, ‘We should learn about the changes of the season by studying natural phenomena and foster social development by studying human phenomena. Wealth arises from following the way of heaven and earth and assisting the natural order’,” Xi said at the National Conference on Ecological and Environmental Protection on May 18, 2018.

According to the Chinese Ministry of Natural Resources, by June 2024, the country had restored over 100 million mu (about 6.7 million hectares) of ecosystems that include mountains, rivers, forests, farmlands, lakes, grasslands and deserts.

China’s protected areas cover 18 percent of its land area and 4.1 percent of its maritime area, corresponding to 90 percent of its terrestrial ecosystem types, 85 percent of wild animal populations, 65 percent of higher plant communities and nearly 30 percent of important geological relics.

The country’s nature reserves are a solid foundation for ecological environmental protection, and the “China Biodiversity Conservation Strategy and Action Plan (2023-2030)” has clarified priority areas and actions for biodiversity conservation.

China has also shouldered its international responsibilities, participated in global environmental governance and biodiversity conservation cooperation, and been the driving force for the concept of a community with a shared future for mankind, emphasizing the interdependence and common challenges faced by all countries.

https://news.cgtn.com/news/2024-09-27/Why-has-China-s-nature-reserve-network-proved-invaluable–1xezv2eED4c/p.html

View original content:https://www.prnewswire.com/news-releases/cgtn-why-has-chinas-nature-reserve-network-proved-invaluable-302261659.html

SOURCE CGTN

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ChoiceCash publishes two new data studies highlighting title loan application trends

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VAN NUYS, Calif., Sept. 27, 2024 /PRNewswire/ — ChoiceCash, a leading title loan brand offering auto equity loans to subprime borrowers in more than 20 states, has published two new data studies highlighting title loan application trends.

Published on September 10th 2024, the first data study covering average credit scores for title loan applicants reveals that the ChoiceCash product offers consumer credit to applicants with a credit profile that is well below the national average. The product-wide credit score average of 557.6 for year-to-date applications through end of August is largely consistent for applicants from all regions within the United States, ranging from 545.3 in the Northeast to 559.6 in the West.

Published on September 18th 2024, the second data study highlights title loan customer payment trends by payment method, region and loan disbursement method. This study reveals that ChoiceCash title loan customers have a clear preference for making payments using electronic payment channels, accounting for more than 90% of payments. Looking at payment channel preferences based on how the loan proceeds were disbursed at the inception of the loan, the study finds that customers’ preferences for receiving loan funds also reflect in the channels they choose for making loan payments. The study concludes that ChoiceCash’s online title loan product offer, which includes multiple ways to both receive loan proceeds and make loan payments, allows title loan customers to transact consistent with their financial preferences.

About ChoiceCash:

ChoiceCash is a vehicle-secured loan option for borrowers from all walks of life. Serving customers in more than 20 states, ChoiceCash has grown to be a premier funding option, with more than a million loan inquiries processed.

The ChoiceCash loan is made by Capital Community Bank, a Utah Charted bank, located in Provo, Utah, Member FDIC. All loans will be serviced by LoanMart. Loan proceeds are intended primarily for personal, family and household purposes. All loan applications are subject to meeting Capital Community Bank’s credit criteria, which include providing acceptable property as collateral. Customers need to demonstrate ability to repay the loan.

Contact information: media@choicecash.com

View original content:https://www.prnewswire.com/news-releases/choicecash-publishes-two-new-data-studies-highlighting-title-loan-application-trends-302261650.html

SOURCE ChoiceCash Title Loans

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