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Kanazawa University research: Sensing a biomarker

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KANAZAWA, Japan, June 7, 2024 /PRNewswire/ — Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Biosensors and Bioelectronics: X a novel approach for detecting a particular biomolecule associated with several diseases. The results show good sensitivity and selectivity, and may lead to the development of a low-cost, rapid detection device useful in cancer prognosis.

Human diseases are often the result of DNA transcriptions gone wrong. Transcription refers to the copying of parts of a DNA molecule — the ‘genetic code’ — into an RNA molecule, which in turn is required for converting the encoded information into proteins. The latter play crucial roles in various biochemical processes taking place in the human body. One transcriptional modification mechanism is adenosine-to-inosine editing, in which adenosine (one of four RNA building blocks) is chemically modified, resulting in an altered RNA molecule. This type of modification is facilitated by catalyst proteins called ADARs (adenosine deaminases acting on RNA). Three such ADARs have been identified in humans. One of them, ADAR1, has been found to be more abundant in the presence of several kinds of chronic diseases, including neurological disorders and cancer. ADAR1 is therefore considered a biomarker — a ‘signature molecule’ — for assessing a patient’s condition and chances of survival. Madhu Biyani from Kanazawa University and colleagues have now developed a new, electrochemical biosensor for detecting ADAR1, offering a low-cost, rapid tool for measuring ADAR1 concentrations in cells. The detector is expected to be useful for monitoring cancer progression.

The procedure presented by Biyani and colleagues is new in two ways. The first is that it uses newly identified aptamers as molecules that can recognize and capture ADAR1. Aptamers are molecules consisting of sequences of (synthetic) DNA, RNA or other biomolecules that bind to a particular target molecule, in this case ADAR1. The second novelty lies in the use of a field-deployable electrochemical sensor DEPSOR (BioSeeds Corp.), which has the advantages of, apart from being fast and non-expensive, requiring only small samples.

In order to find the optimal aptamer — that is, the one that chemically binds easiest to ADAR1 — the researchers screened a large set of DNA sequences and narrowed it down to 15 candidate aptamers. Each of these candidates was then tested in an electrochemical sensing platform: the amount of ADAR1 is ‘sensed’ through chemical reactions that result in an electrical current. The latter can be easily detected. The more ADAR1 in a sample, the higher the measured current.

The candidate aptamer resulting in the highest electrochemical current, called Apt38483, was then checked further. Its electrochemical response to ‘false’ proteins was very low, confirming it to be the optimal aptamer in terms of both sensitivity and selectivity. The scientists then tested an Apt38483-based prototype device on diluted cell samples. They found that even in a 625-fold diluted sample, ADAR1 could still be detected, highlighting the high sensitivity of the device.

The electrochemical biosensor developed by Biyani and colleagues for the detection of ADAR1 in cell samples is a promising platform for monitoring cancer progression in clinical samples. Quoting the scientists: “In the future, it will be promising to evaluate the system for the identification of low to high levels of ADAR1 expression in a cancer cell line sample for clinical prognosis.”

Figure

https://nanolsi.kanazawa-u.ac.jp/wp/wp-content/uploads/Figure1-6.png

Caption

A novel electrochemical biosensor for the detection of ADAR1 in cells is expected to be useful in cancer prognosis. © 2024 Biyani, et al. Published by Elsevier B.V.

Background

Electrochemical biosensors

Electrochemical biosensors are devices that convert biological information, such as the presence of a particular molecule (called the analyte), into a measurable signal. Essentially, biosensors consist of a bioreceptor, an interface and a transducer element. The bioreceptor binds to the analyte at the interface, which results in a signal that is picked up and converted by the transducer into an electric signal. The electric signal is processed through a computer; for example, the signal can be converted into an analyte concentration reading. Electrochemical biosensors are normally robust, low-cost and easy to miniaturize.

Madhu Biyani from Kanazawa University and colleagues have now developed an electrochemical biosensor for the detection of ADAR1, an RNA-editing enzyme associated with cancer progression. They identified a particular biomolecule as the optimal bioreceptor, showing good sensitivity and selectivity for ADAR1. The developed device is expected to be useful for monitoring cancer progression.

Reference

Madhu Biyani, Kirti Sharma, Maeda Shoei, Hinako Akashi, Masataka Nakano, Miki Nakajima, and Manish Biyani. A novel aptamer-antibody sandwich electrochemical sensor for detecting ADAR1 in complex biological samples, Biosensors and Bioelectronics: 19, 100491 (2024).

DOI: 10.1016/j.biosx.2024.100491

https://doi.org/10.1016/j.biosx.2024.100491

Contact
Hiroe Yoneda
Senior Specialist in Project Planning and Outreach
NanoLSI Administration Office, Nano Life Science Institute (WPI-NanoLSI)
Kanazawa University
Kakuma-machi, Kanazawa 920-1192, Japan
Email: nanolsi-office@adm.kanazawa-u.ac.jp
Tel: +81 (76) 234-4555

About Nano Life Science Institute (WPI-NanoLSI), Kanazawa University

Understanding nanoscale mechanisms of life phenomena by exploring “uncharted nano-realms”.

Cells are the basic units of almost all life forms. We are developing nanoprobe technologies that allow direct imaging, analysis, and manipulation of the behavior and dynamics of important macromolecules in living organisms, such as proteins and nucleic acids, at the surface and interior of cells. We aim at acquiring a fundamental understanding of the various life phenomena at the nanoscale.

https://nanolsi.kanazawa-u.ac.jp/en/

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Huawei Peer-Recognized as a 2024 Gartner® Peer Insights™ Customers’ Choice for Enterprise Wired and Wireless LAN Infrastructure

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September 29, 2024

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SHENZHEN, China, Sept. 29, 2024 /PRNewswire/ — On September 24, 2024, Huawei announced that it has been peer-recognized a 2024 Gartner® Peer Insights™ Customers’ Choice in the Voice of the Customer for Enterprise Wired and Wireless LAN Infrastructure thanks to its Xinghe Intelligent Campus offerings. This marks the fifth year in a row that Huawei has received this distinction. Notably, Huawei receives Customers’ Choice distinctions in four of the six customer segments: Midsize Enterprise (50M – 1B USD); Public Sector, Government and Education; Asia/Pacific; and Europe, the Middle East and Africa.

As of June 30, 2024, customers across diverse sectors — including manufacturing, IT services, education, and telecommunication — have reviewed Huawei’s complete Xinghe Intelligent Campus offerings on the Gartner Peer Insights platform. We believe their impressive feedback showed global recognition of Huawei from the industry influence, deployment scales, and mature commercial use perspectives.

“We’re thrilled to be named a Gartner® Peer Insights™ Customers’ Choice for Enterprise Wired and Wireless LAN Infrastructure again,” said Shawn Zhao, President of Huawei’s Campus Network Domain. “Recently, Huawei launched the newly upgraded Xinghe Intelligent Campus that takes wireless, application, and O&M experience to new levels with AI technologies, ultimately accelerating the digital transformation of enterprises.”

Looking ahead, Huawei will further innovate Xinghe Intelligent Campus offerings from wireless, application, and O&M experience upgrade perspectives, helping all industries stride to the future of experience-centric intelligent campus networks.

For more about Gartner® Peer Insights™ Customers’ Choice, visit: https://www.gartner.com/reviews/market/enterprise-wired-wireless-lan-access-infrastructure 

Disclaimer:

Gartner, Voice of the Customer for Enterprise Wired and Wireless LAN Infrastructure, Peer Contributors, 12 September 2024

Gartner, Peer Insights, Magic Quadrant and Customers’ Choice badge are trademarks of Gartner, Inc. and/or its affiliates. All rights reserved. Gartner Peer Insights content consists of the opinions of individual end users based on their own experiences, and should not be construed as statements of fact, nor do they represent the views of Gartner or its affiliates. Gartner does not endorse any vendor, product or service depicted in its research publications, and does not advise technology users to select only those vendors with the highest ratings or other designation. Gartner research publications consist of the opinions of Gartner’s research organization and should not be construed as statements of fact. Gartner disclaims all warranties, expressed or implied, with respect to this research, including any warranties of merchantability or fitness for a particular purpose.

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“MLOVE” Rangers Speakers to be unveiled at Global Sources Consumer Electronics Show 2024.10

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4 hours ago

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September 29, 2024

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SHENZHEN, China, Sept. 29, 2024 /PRNewswire/ — MLOVE, announces its participation in the Global Sources Consumer Electronics Show during October 11 to 14, 2024 in Hong Kong. We look very much forward to offering 7 original and pioneering Busking Speakers from MLOVE Rangers Series.

To further expand MLOVE on the global market and have more face-to-face communications with our customers and agents, we are scheduled to attend the Global Sources Consumer Electronics Show.

Come and Join Us at:
Booth No.: Hall1, 1D26
Time: October 11 – 14, 2024
Address: AsiaWorld-Expo • Hong Kong

About Global Sources Consumer Electronics Show

Global Sources Consumer Electronics show, the world’s largest export-centered electronics sourcing trade show, features over 3,100 booths offering a whole host of industry innovations, which cover 9 major product categories including smart wearables, TWS, AR/VR, energy storage, solar energy, and charging stations — all in high demand for the world’s buyers. Aside from their diversity, what these products share in common are strong branding, intelligence, and innovative design.

Introducing 7 New Masterpieces: Rangers Busking Speakers

MLOVE S3 Pro, S1, S5 ,D5, D4, D6, D8 Pro

Three Main Functions In One Speaker  

Playing Music Speaker
Sound is the soul of the speaker. We are committed to shaping the sound characteristics of our own style with deep and dynamic bass, clean and clear vocal, stable treble, bass, vocal, and treble balance so that every note is full of our persistence and passion, bringing users an unprecedented auditory feast.

Karaoke Speaker
Support 2 wireless UHF microphones,
high quality metal housing and cardioid voice collection Microphone
Multi channels timbre adjustment independently, customized your tone

Musical Instrument Amplifier
This function specially developed for musical instrument lovers
Portable size, you can make a street busk with your friends easily
Different musical instruments assigns independent impedance matching tap
Maximizes the musical instrument’s sound

Other Special Features:
100+ Connections Together
Reverse Charging other devices
Wireless/Wired Recording
OTG playing and charging
Wireless/Wired Live Streaming

About MLOVE

Established in 2008, the MLOVE factory is a national high-tech enterprise that integrates ID design, research and development, production, and sales and after-sales service. It is also a specialized and innovative enterprise in the Guangdong Province. MLOVE factory has a modern independent industrial park of 30,000 square meters, strategically cooperated with SMT and injection molding suppliers.

Currently, MLOVE product line includes Rangers Karaoke and musical instrument speaker series, retro home speaker series, and portable outdoor speaker series.

We will continue to pursue excellence and provide customers with higher quality products and services.

Thank you for your attention. We look forward to establishing a long-term and stable cooperative partnership with customers all over the world.

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Good Media: Two Guinness World Records Set! Shenzhen’s stunning drone show kicks off National Day celebrations

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4 hours ago

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September 29, 2024

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SHENZHEN, China, Sept. 29, 2024 /PRNewswire/ — On the evening of September 26, Shenzhen hosted a spectacular drone show themed “City of Sky, Maybe Shenzhen” above Shenzhen Bay Park. A total of 10,197 drones took to the sky simultaneously, setting two Guinness World Records: “The most multirotor/drones airborne simultaneously from a single computer (outdoors)” and “The largest aerial image formed by multirotors/drones”.

The drone light show was a breathtaking spectacle. A vast array of drones came together to form a stunning starry sky, making the audience feel as though they were floating in an endless universe. What truly amazed the crowd was the sight of a floating “Sky City” materializing in midair, intertwined with iconic Shenzhen elements like the city’s landmarks, light shows, and scenes of Wing Chun, all symbolizing the limitless future of Shenzhen. Following this, dazzling “cyber fireworks” lit up the night, painting a vibrant picture of Shenzhen as a “City of Miracles, City of Innovation, City of Future”. 

The drones’ kaleidoscopic display in the night sky was not just a technological and visual feast but also a vivid demonstration of Shenzhen’s limitless potential as a “Sky City” for global visitors. 

It is worth noting that this drone show was just the beginning. During the National Day Holiday, Shenzhen will continue the drone performances for seven consecutive days. Daily shows will feature 10,000 drones across five districts in a relay format. 

To welcome global tourists to experience low-altitude tourism, starting from September 23, Shenzhen has been offering special holiday packages for seven consecutive days. This includes 10,000 low-altitude flight experience vouchers, allowing visitors to enjoy helicopter rides and take in the stunning urban landscapes, mountains, and coastal vistas of Shenzhen from above. 

In addition, Shenzhen will host over 300 highlight cultural and tourism activities. It will also offer more than 40,000 discounted attraction tickets, 2,000 free admission tickets, and 1,000 Shenzhen Airlines upgrade vouchers, inviting tourists from around the world to join in this grand autumn tourism celebration.

 

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