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Study Uncovers How Much of Biological Aging is Driven by Random Noise Versus Dynamic Biologic Change

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LEXINGTON, Ky., May 23, 2024 /PRNewswire/ — A new groundbreaking study, recently published in *Nature Aging*, by researchers from the University of Chinese Academy of Sciences, TruDiagnostic, and Harvard, has unveiled significant insights into the mechanisms of epigenetic clocks, which are widely used to predict biological age. The study’s findings suggest that a large portion of the predictive accuracy of chronological clocks can be attributed to stochastic, or random, DNA methylation (DNAm) changes rather than deterministic biological aging processes.

Epigenetic clocks, such as those developed by Horvath and Zhang, have gained prominence for their ability to estimate an individual’s biological age with remarkable accuracy, based solely on patterns of DNA methylation. However, the precise mechanisms by which these changes in DNAm occur has remained largely unexplored until now.

The research team, led by Dr. Andrew Teschendorff, utilized sophisticated simulation models and extensive DNAm data from over 25 independent cohorts totaling 22,770 samples. Their analysis revealed that between 66% to 90% of the accuracy of various epigenetic clocks could be explained by stochastic processes. This finding was particularly pronounced in Zhang’s clock, which showed that up to 90% of its predictive capability could be attributed to these random changes.

Dr. Andrew E. Teschendorff, a senior author of the study, noted, “Our results further indicate that biological age-acceleration is unlikely to be the result of an increased rate of stochastic change, but instead being driven by non-stochastic processes. However, one exception to this seems to be mitotic age-acceleration in precancerous lesions.”

Furthermore, the study distinguished between different types of epigenetic clocks, finding that those more predictive of chronological age, like Zhang’s clock, were largely influenced by stochastic DNAm changes. In contrast, clocks like PhenoAge, which are more reflective of biological age, showed a lower degree of stochastic influence. This suggests that first generation clocks, trained to predict chronological age, have less utility in predicting outcomes of aging than clocks trained on other phenotypes of aging or biomarkers.

These insights are vital for the future development and refinement of epigenetic clocks, potentially guiding medical professionals towards more accurate assessments of biological aging and associated health risks.

“One trend we have seen in recent years is that clocks trained to predict chronological age have lower predictive power than newer clocks trained on biological information. Additionally, chronological clocks can sometimes increase with known lifespan extension interventions. This is counter intuitive. This study might explain why. Clocks trained to predict chronological age are driven by random variation over time while clocks which are predictive of lifespan seem to be much more dynamic and responsive to the ways we live our life” added Dr. Varun Dwaraka, a co-author of the study. 

The full study is available in the latest issue of *Nature Aging* and provides a comprehensive view of the stochastic components influencing epigenetic aging. This research not only advances our understanding of genetic aging mechanisms but also enhances the potential for personalized medical strategies based on more accurate DNA methylation profiling.

For further information, access the full paper here.

About TruDiagnostic

Home to the largest, private DNA methylation database in the world, TruDiagnostic is a leading health data company and CLIA-certified laboratory that specializes in epigenetic testing and research. In partnership with notable biotech developers, researchers, and academic institutions, we are transforming the healthcare potential of epigenetic data into actionable applications. We aim to improve people’s lives by arming patients and physicians with novel biological insights; enabling them to make the right lifestyle and medical decisions through information found in the fluid epigenome. With the ability to analyze more than 1,000,000 locations on one’s DNA, our TruAge biological aging tests provide the most in-depth results, and multi-omic correlations to accelerated aging.

Additional Contacts

Hannah Went, Director of Operations

General Inquiries  

(937) 570-0471  

(833) 963-1700

hannah@trudiagnostic.com

support@trudiagnostic.com

www.trudiagnostic.com

www.trudiagnostic.com

**Contact:**
Dr. Andrew E. Teschendorff
Email: andrew@sinh.ac.cn
University of Chinese Academy of Sciences, Shanghai, China

Emilie Arroyo, Media Relations
(786) 247-4579
emilie@trudiagnostic.com  
www.trudiagnostic.com

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Omdia: Small medium OLED shipment to hit 1 billion units for the first time in 2025

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LONDON, Dec. 4, 2024 /PRNewswire/ — New data from Omdia has revealed that OLED (Organic Light-Emitting Diode) technology, which began with small displays under 10 inches two decades ago, is set to reach new heights in 2025. With advancements in technology, capacity and cost, OLED is poised for significant growth. Over the years, OLED has outperformed LCD displays in key areas such as color saturation, slimness, weight, flexibility and contrast. These advantages have accelerated the transition from LCD to OLED, particularly as production scales expand, especially in China.

According to Omdia’s latest OLED Display Market Tracker, small to medium OLED shipments are expected to surpass one billion units for the first time. The milestone includes displays ranging from 1-inch to 8-inch, covering a wide array of applications such as game consoles, AR/VR/MR headsets, near eyeglasses and head-mount displays, automotive displays, smartphones, sub displays, smartwatches and industrial displays.

OLED technology has seen significant growth in the smartphone market, driven by China OLED makers such as BOE, ChinaStar, EverDisplay, Visionox and Tianma as along with the vast technological advancements from Korean giants Samsung Display and LG Display. Additionally, OLED displays are expanding into the new applications including AR/VR and automotive displays.

David Hsieh, Senior Research Director, Displays in Omdia highlights, “Despite its higher cost and more complex manufacturing, OLED has proven ideal for small to medium displays due to its slim design, lightweight, excellent picture quality, efficient power consumption and flexibility. Beyond replacing TFT LCDs in these applications, OLED enables  innovative form factors like ultra-lightweight and foldable designs. Shipments of small to medium OLED display are projected to peak 1 billion units in 2025.”

Conversely, display manufacturers are refining OLED production processes while scaling up capacity scale with innovations such as Gen8.6 fabs, LTPO+ backplane, COE, fingerprint-on-display technology, under display cameras, hybrid OLEDs, Tandem RGB OLEDs, mask-less OLED photolithographic deposition and ink jet printing. These new developments aim to elevate OLED’s value proposition beyond mere volume growth.

Hsieh added, “However, new players are beginning to challenge the dominance of OLED. Samsung Display and LG Display have introduced stretchable Micro LED displays, while display manufacturers like AUO and Tianma are initiating mass production of small to medium Micro LED displays, supported by gradual improvements in cost and product readiness. After reaching its peak, small to medium OLED displays are expected to enjoy a golden era lasting for decades, though they may eventually be overshadowed by the emergence of Micro LED Display.”

ABOUT OMDIA
Omdia, part of Informa TechTarget, Inc. (Nasdaq: TTGT), is a technology research and advisory group. Our deep knowledge of tech markets combined with our actionable insights empower organizations to make smart growth decisions.

Contact: Fasiha Khan / fasiha.khan@omdia.com

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Delta Force New First-Person Shooter from the Team Behind Call of Duty: Mobile Now Available

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Free to Play PC Multiplayer Campaign Now Available on Steam; iOS, Android and Google Play Games on PC Launches Jan. 20; Black Hawk Down Campaign Follows Shortly After  

LOS ANGELES, Dec. 5, 2024 /PRNewswire/ — Mission launch! Team Jade today released their highly-anticipated multiplayer Open Beta for first-person tactical shooter Delta Force. Following a successful Steam Next Fest reception, where Delta Force was the 4th most wishlisted title and topped all three Steam Next Fest charts, Team Jade is excited to bring more expanded content such as new weapons and Operators, unique maps, engaging missions and more to the multiplayer campaign. 

 

Watch the Black Hawk Down Teaser Now

“The entire team at Team Jade is proud to release our vision for Delta Force upon the world,” said Shadow Guo, Game Director of Delta Force. “We’re truly excited to jump in with gamers across the globe in this exciting new shooter, who we hope will have as much fun playing the game as we had making it.”

Available at launch with Season Genesis, Delta Force will feature a diverse roster of multiplayer modes, a deep and customizable weapons arsenal, top notch graphics and more. An action-packed single-player/co-op campaign will be arriving in January of 2025. Furthermore, Delta Force will be available on the App Store, Google Play Store, and Google Play Games on PC January 20, 2025 with pre-registration begins today.

Get Delta Force Now

The PC Open Beta includes both multiplayer modes, including:

Warfare: A 32v32 player game mode where teams battle across massive maps of authentic terrain, utilizing a range of authentic and satisfying weapons and equipment, as well as military vehicles such as tanks and aircraft, to take on the enemy across the large objective-laden battlefields.Operations: Form a squad of three to take on rival teams and marauding AI-controlled mercenaries. Random events across huge mission-based maps will keep players on their toes, as they work together through PvE-focused missions full of valuable loot. 

For more information about Delta Force visit our official website and YouTube channel, with additional updates found on X, Facebook, Instagram, and TikTok.

About Delta Force

Delta Force is the upcoming free-to-play tactical shooter that is the next installment of the beloved Delta Force series, which will feature large-scale multiplayer modes, as well as an action-packed single-player/co-op campaign, a deep weapons arsenal for customization, and more. Delta Force PC Open Beta launches on December 5th and players can join the fray by getting the game for free via its website, Steam and Epic Games Store pages. Players can now also pre-register on the App Store, Google Play Store, and Google Play Games on PC for the January 20, 2025 launch.

About Team Jade

Team Jade is a notable branch of TiMi Studio Group renowned for Call of Duty: Mobile and Assault Fire, the latter being the most popular Chinese shooter game on PC for the past decade. With a roster of hundreds of industry veterans, the team has garnered multiple prestigious accolades, including BAFTA and TGA awards.

Video – https://www.youtube.com/watch?v=bLim7pmoAZc 

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Korea Legal Industry Veteran Robert Surh Joins TransPerfect Legal

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NEW YORK and SEOUL, South Korea, Dec. 4, 2024 /PRNewswire/ — TransPerfect Legal, the global leader in legal technology, AI, and advisory services, today announced the hiring of Robert Surh as a Director in the company’s APAC region. Based in Seoul, Surh’s addition strengthens TransPerfect Legal’s presence in Korea and underscores its commitment to the region.

In his new position, Surh will take responsibility for the growth of TransPerfect Legal’s technology, services, and advisory offerings across Asia, with a particular emphasis on South Korea and neighboring markets. With over two decades of experience spanning litigation, corporate law, forensic consulting, and global account management, Surh’s expertise will have an immediate positive impact on clients.

Surh began his career as a US-licensed attorney, where he gained first-hand litigation experience. He honed his skills at prestigious law firms, managing complex federal and state commercial class action and mass tort cases. He later transitioned to corporate law, where he held the role of General Manager of Foreign Litigation at LG Electronics and Chief Legal Counsel of Foreign Legal Affairs at E.Land World Co., Ltd. Surh also served as Head Counsel and Director at Deloitte Anjin, LLC, followed by a Director role at AlixPartners, which further expanded his consulting and advisory skills.

Surh commented, “As a leader in legal technology, digital forensics, and language services, TransPerfect’s cross-border value proposition is the best there is, particularly in APAC where language and regulations can differ dramatically. I am excited to join the growing team and continue TransPerfect Legal’s expansion across the Asia-Pacific region.”

TransPerfect President and Co-CEO Phil Shawe stated, “It is my honor to welcome Robert Surh to the TransPerfect team. Our clients in Korea, and throughout all of APAC, will benefit greatly from his experience and expertise.”

About TransPerfect Legal
TransPerfect Legal is a global leader in legal technology, AI, and advisory services for Am Law 200 and Global 100 law firms as well as corporate legal departments. With offices in more than 140 cities worldwide, solutions include forensic technology and consultingeDiscovery and early data assessmentmanaged review and legal staffinglanguage servicesdeposition and trial support, and paper discovery, all offered alongside the Reef Technology ecosystem, TransPerfect Legal’s suite of proprietary applications that address the needs of legal and regulatory practitioners around the world. For more information, please visit www.transperfectlegal.com.

About TransPerfect
TransPerfect is the world’s largest provider of language services and AI solutions for global business. From offices in over 140 cities on six continents, TransPerfect offers a full range of services in 200+ languages to clients worldwide. More than 6,000 global organizations employ TransPerfect’s GlobalLink® technology to simplify the management of multilingual content. With an unparalleled commitment to quality and client service, TransPerfect is fully ISO 9001 and ISO 17100 certified. TransPerfect has global headquarters in New York, with regional headquarters in London and Hong Kong. For more information, please visit our website at www.transperfect.com.

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