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Genezen Enters Licensing Agreement with CSL for the Cytegrity™ Stable Lentivirus Production System

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Licensing of a proven stable producer system for lentiviral vector production represents a significant investment in next-generation technology for Genezen, offering its clients immediate access to cutting edge technology for stable and scalable high-titer clinical lentivirus production.   

FISHERS, Ind. and BOSTON, Feb. 21, 2024 /PRNewswire/ — Genezen, a leading cell and gene therapy Contract Development and Manufacturing Organization (CDMO), today announced licensing of the Cytegrity™ proprietary ­­­­stable production system from biotechnology leader CSL.

Cytegrity™ is an advanced inducible stable producer technology designed for the production of lentiviral vectors (LVVs). This cutting-edge technology allows for scalable and cost-effective generation of LVVs at clinically effective titers for both gene and cell therapies. Validated through early clinical testing, Cytegrity™ has demonstrated safety and efficacy. Lentiviral vectors are traditionally produced at limited scale using plasmid-based transient transfection technology. This stable lentiviral producer system is one of the first of its kind to offer continuous production from a stably transfected adherent or suspension cell line. This eliminates the need for costly plasmid, reduces process complexity, and allows for large-scale batch production, multiple harvests, and less batch-to-batch variability, thus significantly lowering production cost for Genezen’s clients.

Steve Favaloro, President and CEO of Genezen, commented, “I am excited that Genezen is the first CDMO to license the Cytegrity™ cell line. We have significant, hands-on experience scaling up and producing LVV using this stable production system at our GMP vector facility in Fishers, Indiana. Stable producer cell lines can be developed for clients in under four months, and this system will help alleviate the current global viral vector shortage by providing customers with a scalable, high quality vector platform. This licensing capability is a significant value-add for our current and future LVV customers, and furthers our collective mission to bring gene and cell therapies more efficiently to patients.”

Pratima Cherukuri, CSO of Genezen, also commented, “I am enthusiastic to drive the field forward by optimizing LVV production for speed, cost-effectiveness, scalability, and reproducibility. Leveraging our experience and expertise with Cytegrity™, I believe that Genezen can truly help customers get to the clinic faster and producer higher quality LVV at scale in the long run.”

Vicky Pirzas, SVP Biopharmaceutical Product Development at CSL, added, “We are excited to share access to the Cytegrity™ cell line with Genezen and the broader cell and gene therapy community including innovators and manufacturers. Following many years of investment in the development of the cell line at CSL in collaboration with our partners, the Cytegrity™ cell line will potentially lower cost of goods and enable quicker scaleup to clinical and commercial manufacture which, in turn, will benefit patients in gaining access to therapies faster.”

Genezen is prepared to begin immediately offering Cytegrity™ to customers at its state-of-the-art GMP facility in Fishers, IN – please contact Jennifer Thiaville at jthiaville@genezen.com.

About Genezen
Genezen is a contract development and manufacturing organization (CDMO) with a decade’s experience at the heart of the rapid growth in the gene and cell therapy market. Genezen is a leader in the supply of retroviral vectors, lentiviral vectors, and AAV. Led by an extremely experienced team, a science-first approach influences continual investment in scalable, high-yield manufacturing processes and best-in-class technologies. For more information about Genezen, please visit genezen.com.

Media Contact
Connor Halverson
That’s Nice LLC
Tel: +1 212-366-4455
Email: connor@thatsnice.com

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Margex Adds RLUSD Stablecoin as Collateral for Trading Crypto Pairs

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Margex announces the listing of RLUSD stablecoin on its platform for all users

VICTORIA, Seychelles, Jan. 1, 2025 /PRNewswire/ — Margex, a cryptocurrency trading platform boasting ultra-convenient and user-friendly copy trading, is excited to announce the listing of RLUSD stablecoin on its platform for all users.

Margex exchange is thrilled to be the first crypto platform to include RLUSD stablecoin as collateral for trading different cryptocurrency pairs. This enables its users to have access to reliable, flexible, and secure trading facilities.

Ripple USD (RLUSD) is a stablecoin designed to provide cross-border payment that is efficient and cost-efficient compared to traditional financial systems when carrying out large transactions. Ripple’s new stablecoin (RLUSD) is developed on the XRP ledger and Ethereum network, offering security, deep liquidity for users, and fast transactions as a competitive player in the stablecoin industry.

The Ripple stablecoin (RLUSD) is pegged 1:1 to the U.S. dollar (USD) to gain stability through a collateralization mechanism using dollar deposits, government bonds, and other cash equivalents to ensure reliable and secure digital currency.

Margex Integrates TradingView to Simplify Market Analysis for Users

Margex exchange also integrates the TradingView charting tool on its platform to elevate users’ trading experience. This tool enables users to access over 100+ technical indicators, 110+ drawing tools, and 17+ chart types without leaving the Margex platform.

About Margex

Margex is a boutique cryptocurrency exchange established in 2019, providing users access to a safe, powerful, and convenient copy trading platform. Margex copy trading makes trading simple yet effective for traders of any experience level. Users of all types can earn a return on their equity by replicating the trades of professional traders with no experience required, while skilled traders can earn income by allowing other users to copy successful strategies.

With a minimum deposit of $10, traders can access all of Margex’s copy trading functionality, as it remains the most user-friendly platform in the crypto industry.

Follow Margex on Facebook, Twitter, Telegram, Discord, and YouTube, or join the Margex team.

This press release was issued through 24-7PressRelease.com. For further information, visit http://www.24-7pressrelease.com.

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Rockford Fosgate celebrates its 45th Anniversary and continues to set the standard of excellence in the audio industry

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TEMPE, Ariz., Jan. 1, 2025 /PRNewswire/ — Rockford Fosgate (www.rockfordfosgate.com), a global leader in high-performance audio systems, proudly celebrates its 45th anniversary, marking nearly five decades of groundbreaking innovation, customer dedication, and industry leadership. Since its founding in 1980, the company has been at the forefront of audio advancements across mobile, marine, motorcycle, and motorsports platforms.

“We’re excited to celebrate 45 years of serving our customers and shaping the audio industry,” said Zach Luke, President. “This milestone reflects the passion and hard work of our employees, the loyalty of our customers, and the strong partnerships we’ve built over the years. We look forward to continuing this journey into the future.”

Jim Fosgate, the visionary behind Rockford Fosgate, is widely recognized as the pioneer of the car audio amplifier. In the early 1970s, Fosgate and his fellow audio enthusiasts began experimenting with sound reproduction and automotive acoustics, leading to the debut of the first Fosgate Electronics® product at the 1973 Consumer Electronics Show in Chicago. Soon after, he developed the Punch Equalization circuit and introduced the first car stereo systems to the market. In 1980, with the help of investment partners, Rockford Fosgate officially launched and began revolutionizing the in-car audio experience.

To commemorate this significant milestone, Rockford Fosgate will unveil a series of special collaborations throughout the year. “This anniversary isn’t just about reflecting on our accomplishments; it’s about celebrating the people who’ve been part of our journey,” said Tammy Lowe, Director of Marketing. “We’re thrilled to share our excitement for what lies ahead.”

For more information, please visit rockfordfosgate.com

About Rockford Fosgate
Setting the standard for excellence in the audio industry, Rockford Corporation markets high-performance audio systems under the brand Rockford Fosgate® for the mobile, marine, motorsport, and motorcycle audio aftermarket and OEM market. Headquartered in Tempe, Ariz., Rockford Corporation is a wholly owned subsidiary of Patrick Industries, Inc. (NASDAQ: PATK).

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Oceanfoam Becomes Carbon Positive in 2025: A Huge Milestone for the Sustainable Foam Roller and Workout Mat Brand

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The pioneering brand making foam products with algae and recycled foam has cleaned over 1m+ gallons of water, removed 1.3k+ tons of carbon dioxide from the atmosphere and removed 7.9k+ pounds of plastic from the ocean.

NAPLES, Fla., Jan. 1, 2025 /PRNewswire/ — Oceanfoam, an active lifestyle brand committed to sustainability, announces it has achieved a carbon positive status going into 2025. A newcomer in the fitness and wellness industry, the sustainable company is poised to continue simultaneously revolutionizing the fitness industry and helping the planet, making a significant environmental impact and raising awareness. The company designs fitness products made with Bloom algae and recycled material. In addition to foam rollers, Oceanfoam has released workout and yoga mats, wave ball rollers and workout blocks.

By prioritizing sustainability in the development of each item, Oceanfoam has made a significant environmental impact. The brand has cleaned over 1,026,896 gallons of water, removed 1,319.91 tons of carbon dioxide from the atmosphere and removed 7,947 pounds of plastic from the ocean. The algae used is harvested from North America’s overabundant supply (due to the rise of global temperatures), thus helping to clean the water and reduce the amount of carbon released into the air.

“We’ve been working on this for a year since we launched and Oceanfoam is now officially carbon positive!,” said Founder Zachary Quinn. “We believe products can be more than objects. Foam rollers live in our living rooms, bedrooms, offices, gyms and workout studios; they need to look good and make you feel good. We set out to design a foam roller that you didn’t have to put in your closet, and now we’ve made it one that you can be proud of.”

Oceanfoam achieved its carbon positive status through the following:

Algae-Based Materials: Producing products with Bloom Materials reduces plastic consumption while capturing carbon and cleaning water through removing algae from the environment.Carbon Offsetting: Partnering with Climate Partner, the team offset the remaining carbon emissions from all of its production and shipping to ensure its operations go beyond carbon neutrality.Ocean Plastic Cleanup: Through collaborations with 4Ocean and Ecodrive, the brand actively contributes to cleaning up plastic waste from the world’s oceans, helping to protect marine ecosystems. With every order, one pound of ocean plastic is removed.

This certification and offset will also add a “Climate Pledge Friendly” badge to all of Oceanfoam’s products on Amazon, alerting consumers of products that have sustainability features recognized by trusted certifications. For more information, visit oceanfoam.com.

About Oceanfoam:
Oceanfoam creates high-quality, durable and beautiful active lifestyle products with algae and recycled materials to create a healthier, cleaner environment – where beauty and function meet sustainability.

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