De-Risking Target Validation with Data-Driven Genomic Insights

ROME, April 3, 2025 /PRNewswire/ — IRBM, an integrated Contract Research Organization (CRO) specializing in preclinical drug discovery, has established a comprehensive Functional Genomics Platform to support genetic target identification and validation, and generation of disease-relevant cellular models. The platform integrates CRISPR-based methodologies, screening capabilities, cell engineering, and advanced molecular and cellular analysis to drive both target discovery and validation.

To further enhance target validation, IRBM is expanding its genome editing toolkit with CRISPR tiling to systematically map functional domains within coding and regulatory regions, along with base and prime editing to introduce precise nucleotide modifications. These next-generation approaches—combined with the platform’s high-throughput CRISPR screening, including stem cell engineering—are instrumental in building robust disease models and improving the reliability of target validation.

“Understanding which targets are truly viable for drug development is a complex challenge,” said Sara Tomaselli, PhD, Head of Functional Genomics at IRBM. “With this in-house platform, we’re strengthening our ability to systematically evaluate gene function, de-risk early discovery, and support our partners in making well-informed decisions.”

The platform’s screening capabilities include genome-wide and targeted CRISPR libraries for knockout (CRISPR KO), inhibition (CRISPRi), and activation (CRISPRa), enabling in-depth exploration of gene function and associated pathways. In parallel, IRBM’s cell engineering expertise—spanning patient-relevant models and iPSC-derived systems—supports disease modeling across oncology, neurodegeneration, and rare disorders. Multi-omics integration, including high-content imaging, single-cell transcriptomics, and proteomics, provides deeper functional characterization of drug targets.

IRBM’s Functional Genomics Platform is part of a broader, fully integrated drug discovery ecosystem, ensuring that genetic insights translate into meaningful preclinical models and drug development strategies. By combining functional genomics with expertise in medicinal chemistry, biomarker discovery, and preclinical pharmacology, IRBM enables biopharma innovators to approach target validation with greater confidence.

“We take a careful, methodical approach to functional genomics—one that integrates well with the complexities of drug discovery,” said Carlo Toniatti, MD, PhD, Chief Scientific Officer at IRBM. “Our goal is to help our partners uncover high-quality targets and generate data that can guide and inform decision making throughout the entire drug discovery process.”

IRBM’s collaborative approach allows biotech startups, pharmaceutical companies, and venture-backed teams to access functional genomics expertise without the need for in-house infrastructure. With customized solutions spanning genetic screening, engineered cell models, and mechanistic studies, IRBM provides practical, scientifically rigorous support at key points in drug discovery.

To learn more about IRBM’s Functional Genomics Platform and collaboration opportunities, visit www.irbm.com.

About IRBM

IRBM is a contract research organization (CRO) focused on early-stage drug discovery. With a track record of delivering preclinical candidates across oncology, neurodegeneration, and infectious diseases, IRBM partners with biotech and pharmaceutical innovators to advance therapeutic development with scientific precision and transparency.

SOURCE IRBM S.p.A.

WASHINGTON, April 2, 2025 /PRNewswire/ — The National Electrical Contractors Association (NECA) applauds President Donald J. Trump’s strong leadership in addressing critical national priorities, including strengthening American manufacturing, securing our borders, and revitalizing our economy. As an association representing thousands of electrical contractors nationwide, we share his vision for a more resilient domestic supply chain and a thriving workforce.

At the same time, NECA remains mindful of the potential impacts that the newly announced tariffs may have on the electrical construction industry. With a global supply chain integral to our work, increased costs on key materials such as copper wiring, transformers, work vehicles and electrical products could pose challenges for contractors, project timelines, and infrastructure development.

That said, we appreciate the Administration’s efforts to support American businesses and are encouraged that several key materials critical to the electrical construction industry—such as copper, semiconductors, steel, and aluminum—are not subject to these new reciprocal tariffs. Ensuring access to these essential goods at competitive prices is vital to the success of our contractors and the broader economy.

“President Trump has consistently prioritized policies that put the electrical industry as a priority, and we recognize his commitment to strengthening our nation’s economy,” said David Long, NECA’s Chief Executive Officer.

NECA encourages its members to proactively prepare for potential shifts in pricing and availability by:

Strengthening Supplier Partnerships – Exploring new domestic sourcing opportunities while reinforcing existing relationships to maintain project efficiency.Adapting Contract Strategies – Reviewing and adjusting contracts to accommodate material cost fluctuations and ensure long-term project sustainability.Engaging in Policy Dialogue – Collaborating with industry leaders and policymakers to support a balanced approach that protects American businesses and workers.

The electrical construction industry plays a vital role in America’s infrastructure and economic growth. NECA is committed to working alongside the administration and industry stakeholders to uphold the strength, innovation, and competitiveness of U.S. electrical contractors.

Long concluded, “As these new tariffs take effect, we look forward to working with the Administration to ensure that electrical contractors and the entire electrical industry can continue powering America efficiently while navigating potential cost and supply chain challenges.”

ABOUT THE NATIONAL ELECTRICAL CONTRACTORS ASSOCIATION
NECA is the voice of the $255 billion electrical construction industry that brings power, light, and communication technology to buildings and communities across North America. NECA’s national office and 118 local chapters advance the industry through advocacy, education, research, and standards development. Go to www.necanet.org for more information.

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SOURCE National Electrical Contractors Assoc Inc.

PHOENIX, April 2, 2025 /PRNewswire/ — Blackpearl Group Limited (NZX:BPG) has appointed Christie Kerner as its Chief Operating Officer (COO) to support the company’s strategic go-to-market (GTM) strategy and drive its next phase of growth in the US market. With over 30 years of experience scaling companies of all sizes, leading global teams and driving operational excellence, Kerner will play a pivotal role in strengthening Blackpearl Group’s leadership team as it accelerates expansion.

“The US is our primary market and local expertise is key to our success. To do this, we need to secure world-class talent with the chops, experience and proven ability to align company operations with trajectory,” comments Nick Lissette, Founder and Chief Executive Officer of Blackpearl Group.

With extensive experience in both high-growth startups and profitable, long-term businesses, Kerner brings a rare ability to balance ambition with structure. “Her leadership will be instrumental in ensuring Blackpearl Group scales effectively while preserving the ingenuity and agility that set us apart,” adds Lissette.

Leading from the US – scaling with vision

Kerner will be based in the US and will work to closely align the company’s US and NZ teams. Her focus will be on building the infrastructure needed to support long-term success. “We’re sitting on a launchpad right now – our trajectory is set and my role is to refine our strategies, remove barriers and shape the rocketship for sustainable growth,” she says.

“Scaling isn’t just about growth though – it’s about ensuring the right people are in the right seats, that priorities are aligned and that we’re disciplined in execution,” explains Kerner. “I focus on creating an environment where people thrive – because when they do, the businesses will thrive.”

A track record of leadership and impact

With a Master’s in Management and Leadership, Kerner’s career spans senior leadership roles across startups, corporates and academia where she is renowned for her ability to balance aggressive growth with sound fiscal strategy, ensuring businesses scale effectively while maintaining strong foundations.

Kerner has been instrumental in shaping the growth-stage startup ecosystem in the US, helping companies as they scale toward $200M+ in revenue. As a board member of StartupAZ and Founder of the Founders Collective, she has championed high-growth founders navigating this critical phase and has scaled international programs with Startup Grind.

Kerner has also built and exited multiple companies and served as an Entrepreneur in Residence advising founders on growth, leadership and decision-making. Previously, she led the Center for Entrepreneurship at Arizona State University’s W. P. Carey School of Business (the largest public university in the US) and was Executive Director of Student Entrepreneurship across ASU.

“This experience aligns seamlessly with Blackpearl Group’s trajectory as it moves beyond $11M in ARR and into its next stage of growth,” adds Lissette.

A billion-dollar vision

“AI and emerging technologies can disrupt markets overnight,” notes Kerner, adding that “Success lies in building resilience and that’s rooted in an ability to innovate on an ongoing basis.”

Blackpearl Group leverages a portfolio approach to product development within a rapidly evolving tech landscape, reflected in the development of Bebop, the company’s AI-powered sales intelligence tool, in a single quarter. Bebop is a game-changer for SMEs, offering powerful sales intelligence at a fraction of the cost of competitors like ZoomInfo, Kaspr and Apollo. The beta launch of Bebop follows the success of Pearl Diver, Blackpearl Group’s flagship prospect identification platform. Pearl Diver is a marketing intelligence platform which offers businesses a way of off-setting their reliance on traditional pay-to-play ad platforms.

“Under Nick’s progressive leadership, we have the potential to be a billion-dollar company. Importantly, we’re not building that success around a single product – we’re creating a portfolio of solutions that balance high-risk innovation with consistent, long-term performance,” she adds.

“Christie shares a belief that’s been fundamental to our success so far: it’s time to stop playing small. This appointment brings together ambition, strategy and the discipline to execute at scale and I’m excited to see its effects,” concludes Lissette.

About Blackpearl Group (NZX: BPG)

Blackpearl Group is a market-leading data technology company that pioneers AI-driven, sales and marketing solutions for the US market. 

Specifically engineered for small-medium-sized businesses (SMEs), Blackpearl Group consistently delivers exceptional value to its customers. Our mantra is simple: ‘Creating Motivating Opportunities.’ 

Blackpearl creates the opportunities that motivate action. We create high-impact products that pivot at speed to serve what businesses really need, kick-starting action – turning data into dollars. 

Founded in 2012, Blackpearl Group is based in Wellington, New Zealand, and Phoenix, Arizona. blackpearl.com 

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SOURCE Blackpearl Group Limited