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Decentralized science meets AI — legacy institutions aren’t ready

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Opinion by: Sasha Shilina, PhD, founder of Episteme and researcher at Paradigm Research Institute

Science has always been about pushing boundaries, yet today, many of those boundaries are artificial — walled-off journals, slow-moving institutions and research funding locked behind bureaucratic doors. The system is designed for gatekeepers, not explorers. But what if we could tear down those walls? What if science could be set free?

Over the past few years, we’ve watched decentralized science (DeSci) morph from a radical experiment into one of crypto’s most electrifying frontiers. Once dismissed as a niche idea, DeSci is now a billion-dollar movement. As of early 2025, the top DeSci tokens collectively boast a market capitalization of around $1 billion. Momentum is undeniable: Half of the top 10 projects in the space launched just last year, according to Messari. What started as a whisper is now a roar, echoing across the halls of academia, biotech labs and decentralized autonomous organizations alike.

Raw energy isn’t enough. DeSci still faces formidable challenges: scalability, quality control, reproducibility and real-world adoption. It’s a vision in motion, not a finished revolution. And that’s where artificial intelligence steps in — not just as a tool but as the missing puzzle that could propel DeSci from a bold experiment to an unstoppable force.

AI is already reshaping the traditional science (TradSci) landscape: sifts through massive data sets, spots hidden patterns, cracks problems that once took decades to solve, ventures into longevity research, and accelerates drug development, materials science and computational biology. Yet, for all its promise, access to AI remains tightly controlled and monopolized by a handful of corporations, elite universities and government-backed institutions. AI’s vast potential is shackled by centralization.

What if these two forces — the decentralized infrastructure of DeSci and the power of AI — merged into one system? A system where science is decentralized, intelligent, autonomous and radically open?

Let’s call it DeScAI. 

Science, but unstoppable

Imagine a world where every experiment, every data set and every discovery isn’t buried in paywalled journals or trapped in proprietary vaults but flows seamlessly across a decentralized, living network. This is the vision of DeScAI, where blockchain and AI unite to build an open, intelligent and self-sustaining ecosystem. Knowledge isn’t just stored — it breathes, evolves and connects. AI curators scour vast data sets, linking research across disciplines, uncovering hidden insights and transforming isolated findings into a shared intellectual bloodstream.

Recent: DeFi can help us choose the best robots for the job

For too long, independent researchers have struggled to access the AI tools they need for research and massive data analysis. DeScAI could rewrite this equation by turning the world into a vast, decentralized supercomputer. Every idle processor, every surplus server and every untapped resource can contribute to a global grid where computing power is not a commodity but a shared asset. Need to map the human brain or train a biodiversity model? There is no need to beg a tech giant — just tap into the collective machine. Smart incentives ensure fairness; AI optimizes distribution; and science advances at a speed never seen before.

What about funding? Today’s grant system is a labyrinth of delays, favoritism and opaque decision-making. DeScAI could replace this outdated model with a marketplace of ideas where anyone — researchers, enthusiasts even curious citizens — can directly support groundbreaking projects. No elite panels, no endless bureaucracy. AI-assisted platforms analyze proposals, suggest collaborations, and help communities vote with their resources. If an idea has merit, it gets the backing it deserves — whether from one person or 10,000.

Peer review, once the bedrock of scientific integrity, has become a bottleneck. Papers languish in submission queues for months, sometimes years, subjected to a process that is as unpredictable as it is biased. DeScAI can potentially turn peer review into a dynamic, real-time process. Research is uploaded to an immutable ledger, where AI immediately verifies data integrity and flags potential conflicts of interest. Expert reviewers — who are no longer anonymous gatekeepers but active, rewarded participants — provide transparent, constructive and traceable feedback. Reputations are built on contributions, not credentials. Science becomes an ongoing conversation, not a waiting game.

Perhaps the most revolutionary aspect of DeScAI is its ability to turn isolated curiosity into collective intelligence. What if an AI could help a marine biologist in Argentina and a quantum physicist in Germany stumble upon a connection neither would have made alone? What if an engineer working on renewable energy models could instantly access simulations run by climate scientists in a different hemisphere? DeScAI makes these moments of serendipity not just possible but inevitable.

What about the raw material of modern science — data? Today, data is hoarded, exploited and sold without the consent of those who generate it. DeScAI shifts power back to the people. Data contributors retain ownership and are compensated when their information is used to train AI or develop new models. Blockchain solutions ensure privacy; smart contracts enforce fairness; and the age of data colonialism ends.

Science should be borderless, but for too long, geography, institutions and economics have dictated who gets to participate. DeScAI erases those barriers. A young coder in Nairobi can collaborate with a neuroscientist in Seoul, not because an institution promotes it but because the infrastructure allows it. AI-driven translation tools dissolve language barriers, decentralized data sharing enables seamless collaboration, and research teams form organically around ideas, not affiliations.

The resistance will be fierce

Academic publishers, government agencies and corporate research labs have built their influence on exclusivity. They will not willingly embrace an open system where knowledge flows freely, research is verifiable in real-time and funding no longer depends on institutional decisions. 

Some projects in this space will stumble, giving critics ammunition to dismiss the movement as they may argue that decentralized oversight cannot maintain the same level of quality control, and it is unrealistic to expect cohesive governance from a patchwork of tokenholders and autonomous agents. Yet the success of DeScAI does not hinge on dismantling the existing research order outright — it hinges on demonstrating superior efficiency, fairness and innovation. Ultimately, it offers a parallel ecosystem that anyone can join, building trust through open ledgers, cryptographic proofs and AI-verified methodologies. The direction is clear: Just as DeFi forced the banking sector to acknowledge new economic models, DeScAI will force research institutions to do the same.

This is not a slow evolution — it is a shift in scientific power. The old system, built on secrecy and hierarchy, collides with an emerging model of openness and decentralization. The question for those still embedded in traditional academia is whether they will adapt or be left behind as knowledge production moves into a future they can no longer control.

Opinion by: Sasha Shilina, PhD, founder of Episteme and researcher at Paradigm Research Institute.

This article is for general information purposes and is not intended to be and should not be taken as legal or investment advice. The views, thoughts, and opinions expressed here are the author’s alone and do not necessarily reflect or represent the views and opinions of Cointelegraph.

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Trump exempts select tech products from tariffs, crypto to benefit?

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United States President Donald Trump has exempted an array of tech products including, smartphones, chips, computers, and select electronics from tariffs, giving the tech industry a much-needed respite from trade pressures.

According to the US Customs and Border Protection, storage cards, modems, diodes, semiconductors, and other electronics were also excluded from the ongoing trade tariffs.

“Large-cap technology companies will ultimately come out ahead when this is all said and done,” The Kobeissi letter wrote in an April 12 X post.

US Customs and Border Protection announces tariff exemptions on select tech products. Source: US Customs and Border Protection

The tariff relief will take the pressure off of tech stocks, which were one of the biggest casualties of the trade war. Crypto markets are correlated with tech stocks and could also rally as risk appetite increases on positive trade war headlines.

Following news of the tariff exemptions, the price of Bitcoin (BTC) broke past $85,000 on April 12, a signal that crypto markets are already responding to the latest macroeconomic development.

Related: Billionaire investor would ‘not be surprised’ if Trump postpones tariffs

Markets hinge on Trump’s every word during macroeconomic uncertainty

President Trump walked back the sweeping tariff policies on April 9 by initiating a 90-day pause on the reciprocal tariffs and lowering tariff rates to 10% for countries that did not respond with counter-tariffs on US goods.

Bitcoin surged by 9% and the S&P 500 surged by over 10% on the same day that Trump issued the tariff pause.

Macroeconomic trader Raoul Pal said the tariff policies were a negotiation tool to establish a US-China trade deal and characterized the US administration’s trade rhetoric as “posturing.”

Bitcoin advocate Max Keiser argued that exempting select tech products from import tariffs would not reduce bond yields or further the Trump administration’s goal of lowering interest rates.

Yield on the 10-year US government bond spikes following sweeping trade policies from the Trump administration. Source: TradingView

The yield on the 10-year US Treasury Bond shot up to a local high of approximately 4.5% on April 11 as bond investors reacted to the macroeconomic uncertainty of a protracted trade war.

“The concession just given to China for tech exports won’t reverse the trend of rates going higher. Confidence in US bonds and the US Dollar has been eroding for years and won’t stop now,” Keiser wrote on April 12.

This article does not contain investment advice or recommendations. Every investment and trading move involves risk, and readers should conduct their own research when making a decision.

Magazine: Trump’s crypto ventures raise conflict of interest, insider trading questions

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Asia holds crypto liquidity, but US Treasurys will unlock institutional funds

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Opinion by: Jack Lu, CEO of BounceBit

For years, crypto has promised a more open and efficient financial system. A fundamental inefficiency remains: the disconnect between US capital markets and Asia’s liquidity hubs.

The United States dominates capital formation, and its recent embrace of tokenized treasuries and real-world assets signals a significant step toward blockchain-based finance. Meanwhile, Asia has historically been a global crypto trading and liquidity hub despite evolving regulatory shifts. These two economies operate, however, in silos, limiting how capital can move seamlessly into digital assets.

This isn’t just an inconvenience — it’s a structural weakness preventing crypto from becoming a true institutional asset class. Solving it will cause a new era of structured liquidity, making digital assets more efficient and attractive to institutional investors.

The capital bottleneck holding crypto back

Inefficiency between US capital markets and Asian crypto hubs stems from regulatory fragmentation and a lack of institutional-grade financial instruments.

US firms hesitate to bring tokenized treasuries onchain because of evolving regulations and compliance burdens. Meanwhile, Asian trading platforms operate in a different regulatory paradigm, with fewer barriers to trading but limited access to US-based capital. Without a unified framework, cross-border capital flow remains inefficient.

Stablecoins bridge traditional finance and crypto by providing a blockchain-based alternative to fiat. They are not enough. Markets require more than just fiat equivalents. To function efficiently, they need yield-bearing, institutionally trusted assets like US Treasurys and bonds. Without these, institutional capital remains largely absent from crypto markets.

Crypto needs a universal collateral standard

Crypto must evolve beyond simple tokenized dollars and develop structured, yield-bearing instruments that institutions can trust. Crypto needs a global collateral standard that links traditional finance with digital assets. This standard must meet three core criteria.

First, it must offer stability. Institutions will not allocate meaningful capital to an asset class that lacks a robust foundation. Therefore, collateral must be backed by real-world financial instruments that provide consistent yield and security.

Recent: Hong Kong crypto payment firm RedotPay wraps $40M Series A funding round

Second, it must be widely adopted. Just as Tether’s USDt (USDT) and USDC (USDC) became de facto standards for fiat-backed stablecoins, widely accepted yield-bearing assets are necessary for institutional liquidity. Market fragmentation will persist without standardization, limiting crypto’s ability to integrate with broader financial systems.

Third, it must be DeFi-native. These assets must be composable and interoperable across blockchains and exchanges, allowing capital to move freely. Digital assets will remain locked in separate liquidity pools without onchain integration, preventing efficient market growth.

Without this infrastructure, crypto will continue to operate as a fragmented financial system. To ensure that both US and Asian investors can access tokenized financial instruments under the same security and governance standard, institutions require a seamless, compliant pathway for capital deployment. 

Establishing a structured framework that aligns crypto liquidity with institutional financial principles will determine whether digital assets can truly scale beyond their current limitations.

The rise of institutional-grade crypto liquidity

A new generation of financial products is beginning to solve this issue. Tokenized treasuries, like BUIDL and USYC, function as stable-value, yield-generating assets, offering investors an onchain version of traditional fixed-income products. These instruments provide an alternative to traditional stablecoins, enabling a more capital-efficient system that mimics traditional money markets.

Asian exchanges are beginning to incorporate these tokens, providing users access to yields from US capital markets. Beyond mere access, however, a more significant opportunity lies in packaging crypto exposure alongside tokenized US capital market assets in a way that meets institutional standards while remaining accessible in Asia. This will allow for a more robust, compliant and scalable system that connects traditional and digital finance.

Bitcoin is also evolving beyond its role as a passive store of value. Bitcoin-backed financial instruments enable Bitcoin (BTC) to be restaked as collateral, unlocking liquidity while generating rewards. For Bitcoin to function effectively within institutional markets, however, it must be integrated into a structured financial system that aligns with regulatory standards, making it accessible and compliant for investors across regions.

Centralized decentralized finance (DeFi), or “CeDeFi,” is the hybrid model that integrates centralized liquidity with DeFi’s transparency and composability, and is another key piece of this transition. For this to be widely adopted by institutional players, it must offer standardized risk management, clear regulatory compliance and deep integration with traditional financial markets. Ensuring that CeDeFi-based instruments — e.g., tokenized treasuries, BTC restaking or structured lending — operate within recognized institutional frameworks will be critical for unlocking large-scale liquidity.

The key shift is not just about tokenizing assets. It’s about creating a system where digital assets can serve as effective financial instruments that institutions recognize and trust.

Why this matters now

The next phase of crypto’s evolution depends on its ability to attract institutional capital. The industry is at a turning point: Unless crypto establishes a foundation for seamless capital movement between traditional markets and digital assets, it will struggle to gain long-term institutional adoption.

Bridging US capital with Asian liquidity is not just an opportunity — it is a necessity. The winners in this next phase of digital asset growth will be the projects that solve the fundamental flaws in liquidity and collateral efficiency, laying the groundwork for a truly global, interoperable financial system.

Crypto was designed to be borderless. Now, it’s time to make its liquidity borderless, too.

Opinion by: Jack Lu, CEO of BounceBit.

This article is for general information purposes and is not intended to be and should not be taken as legal or investment advice. The views, thoughts, and opinions expressed here are the author’s alone and do not necessarily reflect or represent the views and opinions of Cointelegraph.

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CZ claps back against ‘baseless’ US plea deal allegations

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Changpeng “CZ” Zhao, former CEO of Binance, has denied claims that he agreed to provide evidence against Tron founder Justin Sun as part of a plea deal with the United States Department of Justice (DOJ).

In an April 11 report, The Wall Street Journal cited unnamed sources alleging that CZ had agreed to testify against Sun under the terms of his settlement with US prosecutors.

“As part of Zhao’s plea deal, he agreed to give evidence on Sun to prosecutors,” an “arrangement” that “hasn’t previously been reported,” the WSJ report stated, citing sources familiar with the matter.

“WSJ is really TRYING here. They seem to have forgotten who went to prison and who didn’t,” Zhao wrote in an April 12 X post. “People who become gov witnesses don’t go to prison. They are protected. I heard someone paid WSJ employees to smear me.”

Source: Changpeng Zhao

CZ was sentenced to four months in prison in April 2024 for Anti-Money Laundering (AML) violations. He walked free from federal prison on Sept. 27 as the wealthiest person to ever serve a US prison sentence, with a $60 billion net worth at the time.

In a separate April 11 post, CZ claimed multiple individuals had warned him about the Journal’s intentions to publish what he described as a “hit piece.”

Source: Justin Sun

Sun said he was “not aware of the circulation rumors,” calling CZ his “mentor and close friend,” Cointelegraph reported on April 11.

Related: Trump kills DeFi broker rule in major crypto win: Finance Redefined

“Some players are lobbying against us again in the US” — CZ

CZ further speculated that the report could be linked to lobbying efforts against him and his former company.

“I also heard some rumors about some players ‘lobbying’ against us again in the US,” CZ said.

Cointelegraph has approached CZ for more details on the lobbying claims.

In November 2023, Zhao said that “FTX sought regulatory ‘crack down’ on Binance to increase market share,” citing a Federal Newswire report.

Related: New York bill proposes legalizing Bitcoin, crypto for state payments

Zhao’s comments come over a month after crypto donations raised influence concerns among industry participants.

Crypto firms spent over $134 million on the 2024 US elections in “unchecked political spending,” which presents some critical challenges, Cointelegraph reported on March 10.

Fairshake donations. Source: politicalaccountability.net

“While the companies making these contributions may be seeking a favorable regulatory environment, these political donations further erode public trust and expose companies to legal, reputational, and business risks that cannot be ignored,” according to a March 7 report by the Center for Political Accountability (CPA).

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