Technology

Children’s Hospital of Philadelphia Researchers Develop New Tool with Potential to Advance Precision Medicine Treatment for Cancer

Published

2 days ago

January 3, 2025

Technology Discovers Antigen-Reactive T Cell Receptors with High Efficiency

PHILADELPHIA, Jan. 3, 2025 /PRNewswire/ — Researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania developed a new screening technology, Aptamer-based T Lymphocyte Activity Screening and SEQuencing (ATLAS-seq), to better identify antigen-reactive T cells that are more likely to offer greater immune responses against cancer cells. The findings were reported this week in the journal Nature Communications.

Researchers continuously work to develop immunotherapy treatments that help the immune system recognize and attack specific protein targets on cancer cells, also known as tumor antigens, thereby training the body to fight cancer more effectively and precisely. Discovering antigen-reactive T cell receptors (TCRs) is essential to this precision medicine approach.

TCRs are protein complexes located on the surface of T cells that recognize and bind to antigen peptides presented by major histocompatibility complex (MHC) molecules, triggering a cascade of cellular responses that lead to T cell activation. However, standard methods for isolating antigen-reactive TCRs often fail to identify TCRs that effectively activate T cells.

“TCRs identified by ATLAS-seq tend to be more efficient in target cell killing than those identified by conventional technologies,” said Lan Lin, PhD, senior author of the study and Assistant Professor in Pathology and Laboratory Medicine at Children’s Hospital of Philadelphia and Penn Medicine. “Overall, ATLAS-seq improves TCR screening to more effectively identify antigen-reactive TCRs with high functional activity.”

The ATLAS-seq technology combines a single-cell approach with an aptamer-based fluorescent molecular sensor that emits a fluorescence signal when a T cell is activated. In the study, the researchers designed a microfluidic system to isolate individual T cells that react to stimulation by an antigen peptide of interest and determined their unique TCR sequences using single-cell sequencing.

“We envision that ATLAS-seq can play a pivotal role in identifying TCRs targeting tumor antigens, driving the development of novel T cell immunotherapies for a broad range of hard-to-treat cancers,” said Lin, who is also a researcher in the Raymond G. Perelman Center for Cellular and Molecular Therapeutics and the Center for Computational and Genomic Medicine at CHOP.

This work was supported by National Institutes of Health grant R01GM121827, W.W. Smith Charitable Trust grant C2004 and a CHOP Research Institute Cell & Gene Therapy Collaborative seed grant.

Luo et al. “ATLAS-seq: a microfluidic single-cell TCR screen for antigen-reactive TCRs.” Nat Commun. January 2, 2025. DOI:10.1038/s41467-024-54675-3.

About Children’s Hospital of Philadelphia:
A non-profit, charitable organization, Children’s Hospital of Philadelphia was founded in 1855 as the nation’s first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals, and pioneering major research initiatives, the hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country. The institution has a well-established history of providing advanced pediatric care close to home through its CHOP Care Network, which includes more than 50 primary care practices, specialty care and surgical centers, urgent care centers, and community hospital alliances throughout Pennsylvania and New Jersey, as well as the Middleman Family Pavilion and its dedicated pediatric emergency department in King of Prussia. In addition, its unique family-centered care and public service programs have brought Children’s Hospital of Philadelphia recognition as a leading advocate for children and adolescents. For more information, visit https://www.chop.edu .

Contact: Jennifer Lee
Children’s Hospital of Philadelphia
(267) 426-6084
leej41@chop.edu

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SOURCE Children’s Hospital of Philadelphia

Technology

STRADVISION to Showcase Groundbreaking ADAS Innovations at CES 2025 featuring Texas Instruments technology

Published

16 minutes ago

January 5, 2025

Demonstration of the new TI TDA4VPE-Q1 automotive system-on-chip with STRADVISION’s production-ready SVNet 3D perception network for ADAS and autonomous driving

LAS VEGAS, Jan. 5, 2025 /PRNewswire/ — STRADVISION, a leader in deep learning-based vision perception technology is set to showcase their latest innovations featuring Texas Instruments (TI) processors at CES 2025. The collaboration highlights the integration of TI’s TDA4VPE-Q1 system-on-a-chip (SoC) for L2 domain controllers and STRADVISION’s SVNet 3D Perception Network, a production-ready, deep learning-powered solution that redefines ADAS and autonomous driving capabilities.

A Fusion of Cutting-Edge Technologies: SVNet 3D Perception Network based on the TDA4VPE-Q1 SoC

The TI TDA4VPE-Q1 automotive SoC, designed for multi-camera ADAS applications, integrates advanced sensor fusion, edge AI, graphics, and video co-processing. With 16 TOPS of AI performance, 4x Arm® Cortex®-A72 cores, optimized memory architecture, and a heterogeneous design, it delivers unparalleled efficiency while lowering system costs. This platform supports diverse imaging solutions, including Level 2 and Level 2+ ADAS, auto valet parking, 3D surround view, and more making it a versatile and cost-effective choice for next-generation automotive applications.

Paired with the TI TDA4VPE-Q1 SoC, the SVNet 3D Perception Network solution converts 2D camera data into precise 3D environmental maps, enabling vehicles to perceive their surroundings with exceptional clarity. Designed for adaptability, the SVNet platform supports high-level autonomous driving across various Operational Design Domains (ODD), including complex and challenging conditions.

Showcasing Innovation at CES 2025

At CES 2025, attendees can witness a live demonstration of the SVNet based on TDA4VPE-Q1 automotive SoC. The demo highlights its capabilities in enabling multi-camera inputs for advanced driver assistance systems (ADAS), such as Level 2+ highway driving, auto valet parking, 3D surround view, and memory-based automatic parking.

A Game-Changer for Automotive Applications

STRADVISION’s SVNet, integrated with the TDA4V-Mid Plus Eco SoC, empowers automotive OEMs to deliver scalable ADAS solutions. The SoC’s flexibility accommodates various image sensors and resolutions, supporting ADAS domain controllers, front cameras, surround views, and mirror replacement. This collaboration paves the way for innovation in automotive, robotics, and security systems.

“We are proud to collaborate with Texas Instruments to bring cost-effective yet powerful solutions to the automotive industry,” said Philip Vidal, CBO of STRADVISION. “The TDA4VPE-Q1 automotive SoC, paired with STRADVISION’s SVNet, exemplifies our shared vision for advancing ADAS technologies. With production-ready software development concluding in 2025 and a Start of Production (SoP) targeted for 2026, we are poised to meet the demands of an evolving market. This collaboration also underscores our commitment to global expansion, enabling us to address the rising demand for innovative and scalable solutions worldwide.”

“The TDA4VPE-Q1 automotive system-on-a-chip for L2 domain controllers with graphics, AI, and video co-processing embodies our vision of delivering high-performance, flexible, and efficient solutions for next-generation automotive applications,” said Mike Pienovi, product line manager at Texas Instruments. “Our collaboration with STRADVISION and their SVNet software demonstrates how technology can accelerate the move from 2D to 3D perception networks.”

Event Details:

Date: January 7–10, 2025 Location: Westgate Hotel Hospitality Suite #2951, Las Vegas, Nevada

For more information on STRADVISION and its industry-leading technologies, please visit STRADVISION.

About STRADVISION

Founded in 2014, STRADVISION is an automotive industry pioneer in artificial intelligence-based vision perception technology for ADAS. The company is accelerating the advent of fully autonomous vehicles by making ADAS features available at a fraction of the market cost compared with competitors. STRADVISION’s SVNet is being deployed on various vehicle models in partnership with OEMs; can power ADAS and autonomous vehicles worldwide; and is serviced by over 300 employees in Seoul, San Jose, Detroit, Tokyo, Shanghai, and Dusseldorf. STRADVISION has been honored with Frost & Sullivan’s 2022 Global Technology Innovation Leadership Award, the Gold Award at the 2022 and 2021 AutoSens Awards for Best-in-Class Software for Perception Systems, and the 2020 Autonomous Vehicle Technology ACES Award in Autonomy (software category). In addition, STRADVISION and its software have achieved TISAX’s AL3 standard for information security management, as well as being certified to the ISO 9001:2015 for Quality Management Systems and ISO 26262 for Automotive Functional Safety.

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SOURCE StradVision

Technology

STRADVISION Showcases Collaboration with Renesas at CES 2025

Published

16 minutes ago

January 5, 2025

Highlighting Next-Generation ADAS Innovation with SVNet Integration on Renesas’ R-Car V4H SoC Platform

LAS VEGAS, Jan. 5, 2025 /PRNewswire/ — STRADVISION, a global leader in AI-based vision perception technology, is excited to announce its collaboration with Renesas Electronics Corporation at CES 2025. This collaboration showcases the integration of STRADVISION’s SVNet software into Renesas’ R-Car Open Access (RoX) development platform, a cutting-edge demonstration of advanced driver assistance systems (ADAS).

As part of this collaboration, STRADVISION will present a groundbreaking demo featuring a 3D perception system powered by an 8MP Front View Camera (FVC) based on the Renesas R-CarV4H platform. This demonstration highlights the exceptional efficiency and low computing power of SVNet, providing an optimized, scalable solution for next-generation Software-Defined Vehicles (SDVs). Additionally, the 3DP FVC ADAS solution is set for production in 2026.

Driving Efficiency and Performance in ADAS

STRADVISION’s SVNet software is celebrated for its high efficiency, enabling advanced perception capabilities even on platforms with constrained computing power. By integrating SVNet with Renesas’ RoX platform supporting R-Car SoCs, the demo delivers a pre-validated, high-performance ADAS solution that caters to the growing demand for affordable, reliable, and scalable technologies in the automotive industry.

“This collaboration underscores STRADVISION’s commitment to pioneering AI-based solutions that meet the evolving needs of the automotive market,” said Philip Vidal, Chief Business Officer at STRADVISION. “By working closely with Renesas, we are delivering innovative technologies that redefine safety, efficiency, and performance for automotive manufacturers worldwide.”

A Strategic Partnership for the Future of SDVs

STRADVISION has a longstanding history of collaboration with Renesas, with previous integrations including the SVNet software on Renesas’ R-Car V3x platform. During the week of CES 2025, STRADVISION plans to demonstrate a cohesive solution designed for SDVs that bridges the gap between ADAS and IVI functionalities. This innovation is poised to catalyze broader adoption of advanced safety features and autonomous driving technologies across diverse vehicle segments.

Visit STRADVISION at CES 2025

Attendees at CES 2025 are invited to experience this breakthrough technology firsthand at STRADVISION’s booth. The demo highlights STRADVISION’s strategic role in shaping the future of mobility by providing intelligent, efficient, and scalable solutions that empower Tier-1 suppliers and car OEMs to innovate rapidly and cost-effectively.

Event Details:

Date: January 7–10, 2025Location: Westgate Hotel Hospitality Suite #2951, Las Vegas, Nevada

For more information on STRADVISION and its industry-leading technologies, please visit STRADVISION.

About STRADVISION

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Technology

STRADVISION and AMD Showcase Next-Generation Perception Technology at CES 2025

Published

16 minutes ago

January 5, 2025

First-ever collaboration introduces a robust perception stack for automated drivingSTRADVISION’s 3D Perception SVNet enables deep learning-based embedded perception algorithms using AMD Versal™ AI Edge Series Adaptive SoCSTRADVISION to host AMD Versal SoC-powered demos during CES® 2025 in Las Vegas

LAS VEGAS, Jan. 5, 2025 /PRNewswire/ — STRADVISION, a trailblazer in AI-based vision perception technology, proudly announces a collaboration with AMD for the first time to combine STRADVISION’s cutting-edge 3D Perception SVNet with advanced processing technology from AMD to deliver high-performance perception solutions for automated driving systems.

At CES® 2025, STRADVISION will unveil a joint technology demonstration with AMD that features STRADVISION’s 3D Perception SVNet, powered by the AMD Versal™ AI Edge Series adaptive SoC, utilizing an 8MP front-facing camera. This showcase underscores STRADVISION’s commitment to enhancing ADAS (Advanced Driver Assistance Systems) and autonomous driving technologies with cutting-edge adaptive computing hardware from AMD.

AMD Versal™ AI Edge Series delivers high performance, low latency AI inference for intelligence in automated driving and other demanded AI-driven embedded systems. Designed for sensor fusion and AI algorithm development, the Versal AI Edge series delivers scalable solutions that address diverse performance and power requirements, from edge to endpoint applications.

This collaboration combines AMD adaptive computing hardware with STRADVISION’s industry-leading perception software, offering a comprehensive perception stack tailored for real-world driving conditions and delivering reliable, scalable solutions to automotive manufacturers worldwide.

“Our work with AMD represents a pivotal moment for STRADVISION,” said Philip Vidal, CBO of STRADVISION. “Combining cutting-edge real-time processing technology from AMD with our advanced 3D perception network, ‘SVNet’ enables us to redefine industry standards for performance, reliability, and scalability in automated driving systems.”

“STRADVISION is helping accelerate autonomous vehicles by increasing the access to ADAS technologies by reducing its cost without compromising its capability,” said Wayne Lyons, Senior Director of Marketing, Automotive Segment, AMD. “Together, we’re addressing the growing demand for scalable, high-performance solutions that enhance the safety and functionality of automated driving systems.”

By joining forces, STRADVISION and AMD are poised to address the needs of the evolving mobility landscape, providing a robust, scalable perception stack optimized for ADAS and autonomous driving systems. This relationship reflects both companies’ dedication to shaping the future of automated driving.

For more information on STRADVISION and its industry-leading technologies, please visit STRADVISION.

CES 2025 Demo Details

Attendees of CES 2025 can experience the 3D Perception SVNet demonstration at both STRADVISION’s booth and AMD automotive demo space. This showcase highlights the seamless integration of STRADVISION’s AI-powered vision technology with AMD processors, providing a glimpse into the future of automated driving.

Dates: January 7–10, 2025Locations: STRADVISION booth at Westgate Hotel Hospitality Suite #2951, Las Vegas, and AMD auto demos at the LVCC, West Hall, Room W223

About STRADVISION

AMD, the AMD Arrow logo, Versal, and combinations thereof are trademarks of Advanced Micro Devices, Inc.

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