Connect with us

Technology

DP Technology and Lepu Biopharma Announce Milestone Collaboration: Leveraging Advanced Computational Methods to Accelerate ADC Drug Innovation

Published

2 months ago

on

This partnership has effectively integrated DP’s ADC Linker-Payload design platform with Lepu’s ADC technology development platform, capitalizing on their respective strengths. The overall optimization of the ADC drug has been achieved in a relatively short time.

BEIJING, Nov. 20, 2024 /PRNewswire/ — Lepu Biopharma Co., Ltd. (Lepu Biopharma) and Beijing DP Tech Co., Ltd. (DP Technology) have recently announced a significant milestone in their Antibody-Drug Conjugate (ADC) drug collaboration. This partnership has effectively integrated DP’s ADC Linker-Payload design platform with Lepu’s ADC technology development platform, capitalizing on their respective strengths. The overall optimization of the ADC drug has been achieved in a relatively short time. This project has reached an important milestone, further validating the approach of accelerating ADC innovative drug development through computational design. Moving forward, both parties will continue to deepen their R&D collaboration in this field, jointly committed to promoting the continuous optimization and advancement of innovative drug development processes.

The ADC Linker Payload design platform, meticulously crafted by DP Technology, utilizes “RiDYMO®”, an AI-for-Science driven hit discovery platform. Furthermore, “AI + first principles” based computational methods are employed to predict linker cleavage sites and ensure the correct payload release, achieving outstanding cell-killing and bystander effects. Additionally, the designed antibody-drug conjugates (ADCs) maintain excellent hydrophilicity and plasma stability. Leveraging Lepu’s mature and complete ADC development system, candidates developed by the new ADC platform have demonstrated significant efficacy in CDX models targeting multiple targets. This project has been successfully validated in animal models and is currently advancing the candidate ADC to the clinical stage.

Lei Fang, Ph.D., Vice President of Lepu Biopharma and CEO of CtM Bio Co., Ltd., expressed high appreciation for this cooperation: “Introducing advanced computational methods to solve scientific problems and jointly pioneering breakthrough explorations is our goal in the ADC project collaboration. As a leader in ‘AI for Science’, DP Technology has played a crucial role in this project with its newly developed ADC design platform. By integrating Lepu Biopharma’s advanced ADC development platform with AI-driven design, we proposed novel perspectives on ADC development while significantly expediting the process. By complementing each other’s strengths, we jointly provide new inspiration and ideas for innovative ADC drug design.”

Weijie Sun, CEO of DP Technology, expressed great anticipation for future collaboration: “Lepu Biopharma, as an innovative biopharmaceutical company focused on cancer treatment, particularly in the areas of targeted therapy and immunotherapy, has extensive experience and a long-standing track record in developing innovative ADC drugs. We firmly believe that our close cooperation will significantly accelerate the design and development of ADC drugs, and we are optimistic about the potential to develop innovative, highly effective, and differentiated new ADC therapies. I am eagerly anticipating the ongoing and deepened collaboration between both companies in the field of pharmaceutical innovation!”

Concerning the various demands from industry partners in the ADC field, DP Technology’s ADC platform has successfully empowered various scenarios and projects. For instance, it utilizes AI combined with first-principles calculations to predict linker cleavage sites and improve attachment stability. By integrating pre-trained models with fine-tuning strategies and expert insights, the platform can predict and modify physicochemical properties such as payload efflux and bystander effects. Additionally, there is ongoing exploration and collaboration in the overall evaluation of properties like aggregation effects in ADCs.

About Lepu Biopharma

Lepu Biopharma Co., Ltd. is an innovation-driven biopharmaceutical company focusing on oncology therapeutics, in particular, targeted therapy and oncology immunotherapy, with a strong China foundation and global vision. We are dedicated to developing innovative ADCs through an advanced ADC technology development platform. We aim to develop more optimal and innovative drugs to better serve the unmet medical needs of cancer patients. We endeavor to continuously develop a market-differentiating pipeline by combining in-house research and development as well as strategic collaborations, strengthen our in-house manufacturing capabilities and commercialize our pipeline products in China through dedicated sales and marketing forces, and internationally via partnerships. We have an integrated end-to-end capability across drug discovery, clinical development, CMC and GMP-compliant manufacturing, encompassing critical functions of the biopharmaceutical value chain, and are building dedicated sales and marketing forces.

About DP Technology

At DP Technology, we’re at the forefront of integrating artificial intelligence into scientific research and industrial R&D. Our “AI for Science” initiative is redefining how we tackle complex scientific challenges, making groundbreaking discoveries more accessible and actionable.

We’ve developed the “DP Particle Universe,” a suite of advanced pre-trained models that seamlessly connect cutting-edge research with real-world industrial applications. Our software suite includes: Bohrium® Scientific Computing Space Station, Hermite® Computational Drug Design Platform, RiDYMO® Hit Discovery Platform, Piloteye® Battery Design Automation Platform. Together, these platforms form a robust foundation for industrial innovation and an open ecosystem for AI in science, fostering advancements in key areas such as drug discovery, energy, materials science and information technology.

View original content:https://www.prnewswire.com/news-releases/dp-technology-and-lepu-biopharma-announce-milestone-collaboration-leveraging-advanced-computational-methods-to-accelerate-adc-drug-innovation-302312430.html

SOURCE DP Technology

Related Topics:
Continue Reading
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Technology

Thinkpal learning tablet from Think Academy wins TechRadar Pro Picks and Trusted Reviews Best in Show awards at CES 2025

Published

20 minutes ago

on

January 11, 2025

By

LAS VEGAS, Jan. 11, 2025 /PRNewswire/ — Think Academy debuted its Thinkpal tablet at CES 2025 and has won a TechRadar Pro Picks and Trusted Reviews Best in Show awards for this innovative new product.

Both awards are given to innovative products and solutions at CES that stand out from a packed crowd. Think Academy President, Alex Peng, was presented the awards at CES, noting the awards were given to Thinkpal because it is both a wholly unique product in the education technology market and also provides such value to parents and educators.

Designed to transform the way kids learn, explore, and thrive in an ever-evolving world, the Thinkpal is powered by cutting-edge AI that serves as a guide and tutor for young learners. With significant learning loss experienced in recent years, families and educators have faced unprecedented challenges as test scores in reading and math have seen steady declines. Parents have expressed their struggles in reigniting their children’s passion for learning, while educators grapple with the complexities of bridging diverse learning gaps.

To meet these challenges, the Thinkpal tablet offers a tailored, AI-powered solution that provides step-by-step writing guidance and real-time math support, making learning more intuitive and enjoyable.

Alex Peng introduced several key features of the Thinkpal during a press event. He showed the audience how Thinkpal’s “GeniusTutor,” an AI-powered system that transforms learning into an interactive and engaging experience, is the heart of this product’s features. Built on the Microsoft Azure OpenAI GPT-4o model, GeniusTutor provides real-time guidance and feedback, empowering students to:

Conquer complex math problems through logic-driven, step-by-step explanationsMaster writing with interactive prompts and instant feedback that build confidence and creativityEnhance vocabulary and reading skills with innovative tools like “Point-and-Discover,” where children can point to words in a physical book, and the tablet’s camera instantly provides explanations, along with guided reading exercises

Adding a touch of fun and companionship, “Thinkie,” an advanced AI-powered learning companion, engages children through voice-based natural language interactions. Thinkie chats, answers questions, and fosters curiosity, making the learning process enjoyable and dynamic.

With an extensive library of ebooks, gamified coursework, and compatibility with popular applications like Google Classroom, the Thinkpal Tablet is a versatile tool for modern families. The 11-inch TÜV Rheinland-certified eye-care screen also safeguards children’s vision during extended use, while the optional keyboard transforms the tablet into a Chromebook-like device, enhancing productivity and usability.

“Our mission is to provide every child with a personalized, world-class tutor that inspires confidence and a lifelong love for learning”, noted Alex Peng during a media interview Q&A. “We’re honored that TechRadar and Trusted Reviews recognize the potential of the Thinkpal to improve learning through advanced and accessible technology.”

The Thinkpal Tablet will be available for $249 ($339 including keyboard) at shop.thethinkacademy.com. Pre-orders open today.

About Think Academy

Think Academy, a subsidiary of TAL Education Group (NYSE: TAL), has been at the forefront of education innovation for over two decades. Serving more than 5 million K-12 students across 10+ countries, Think Academy is dedicated to creating fair and comprehensive educational opportunities. By integrating advanced technology with expert curriculum design, Think Academy is shaping the future of learning to be more accessible, engaging, and impactful.

For media inquiries, contact:
Cecilia Qian
cecilia@impact5r.com

View original content to download multimedia:https://www.prnewswire.com/news-releases/thinkpal-learning-tablet-from-think-academy-wins-techradar-pro-picks-and-trusted-reviews-best-in-show-awards-at-ces-2025-302348472.html

SOURCE Think Academy

Continue Reading

Technology

MLVision M5 Unveiled at CES 2025: Pioneering Innovation in Wearable Technology with the World’s Lightest AI-Powered AR Glasses

Published

20 minutes ago

on

January 11, 2025

By

LAS VEGAS, Jan. 11, 2025 /PRNewswire/ — At CES 2025, MLVision has officially launched its groundbreaking MLVision M5, setting a new global standard for wearable technology. Weighing a mere 25.8 grams, the MLVision M5 is the world’s lightest AI-powered AR glasses. The device combines cutting-edge artificial intelligence, precision engineering, and a commitment to privacy and accessibility.

“MLVision M5 is more than just a wearable device; it represents a significant breakthrough in both weight and product design,” said CEO Zhaoen Dai. “Our goal is to create smart AR glasses that feel effortless to wear, leveraging cutting-edge AR display technology and advanced AI models to genuinely help users work and live more efficiently and conveniently.”

Crafted with aviation-grade titanium and ultra-lightweight floating plastic, this device achieves an unprecedented balance between durability and comfort. Weighing only 25.8g, 40% less than traditional AR glasses, it ensures an effortless, all-day wearing experience that feels almost weightless. The ergonomic design caters to users’ needs, making it a perfect companion for both work and leisure.

This device introduces an industry-first modular design, setting a new benchmark for adaptability in AR glasses. This innovation allows users to seamlessly transition between an all-in-one configuration and a clip-on style, accommodating diverse preferences and use cases. For nearsighted users, the M5 eliminates the need for custom prescription lenses—a common limitation in traditional AR glasses. Instead, it can be conveniently clipped onto existing prescription glasses, offering unmatched practicality and cost savings. This thoughtful modularity not only enhances accessibility but also positions the MLVision M5 as a versatile solution for a broad spectrum of users.

One of MLVision M5’s standout features is its immersive visual projection system, which offers an 86-inch private virtual screen. Powered by MLVision’s proprietary Hummingbird Micro-LED light engine and advanced nano-scale diffraction waveguide technology, the glasses create a secure and private viewing experience, ideal for reading confidential documents or browsing personal files. To prioritize eye health, the device utilizes soft green light with a projection distance of 4 meters, reducing strain during extended use.

The MLVision M5 is also equipped with the AIOS platform, delivering unparalleled AI-driven capabilities to enhance user productivity and accessibility. With intelligent tools like document summarization, real-time translation in seven languages, and interactive AI chat for setting reminders and brainstorming ideas, the device seamlessly integrates into the modern workflow. Additionally, its innovative Care Mode provides real-time audio transcription, enabling a more inclusive experience for users with hearing impairments.

The MLVision M5 excels as a navigation powerhouse, offering intuitive, real-time directions to guide users seamlessly through various environments. Whether exploring a new city, finding the fastest route to your destination, or navigating while riding a bike, the M5 ensures you always stay on the right path with ease and confidence.

The MLVision M5 will launch in China at the end of January 2025. Pricing and pre-order details will be announced in the coming weeks.

MLVision, a global innovator in wearable technology, continues to push the boundaries of what is possible by merging innovation, style, and functionality. With the launch of MLVision M5, the company reinforces its commitment to accessibility, sustainability, and creating cutting-edge solutions that redefine how technology is integrated into everyday life.

View original content to download multimedia:https://www.prnewswire.com/news-releases/mlvision-m5-unveiled-at-ces-2025-pioneering-innovation-in-wearable-technology-with-the-worlds-lightest-ai-powered-ar-glasses-302348534.html

SOURCE MLVision

Continue Reading

Technology

Brandivio Launches Advanced Retail Allocation Platform for Inventory Excellence

Published

20 minutes ago

on

January 11, 2025

By

Brandivio’s inventory optimization solutions empower footwear and apparel brands and retailers to buy smarter, allocate & replenish faster, and meet demand with precision.

NEW YORK, Jan. 11, 2025 /PRNewswire-PRWeb/ — Brandivio, a new generation inventory excellence platform for apparel and footwear retailers, announces its expansion into North America, in conjunction with the National Retail Federation’s (NRF) Big Show in New York City.

The Brandivio platform addresses the unique needs of the retail allocation market, ensuring apparel and footwear retailers have innovative tools to grow and thrive,” said Keith Whaley, SVP of Retail Solutions at Brandivio.

Brandivio, already supporting top-tier brands in EMEA, is built by seasoned retail experts to solve critical inventory challenges in fashion and footwear.

Leveraging machine learning, real-time demand signals, and automation, the Brandivio platform optimizes the distribution of products across a retailer’s stores and e-commerce channels ensuring the right products are in the right places at the right times, ultimately improving sales and margin performance, customer satisfaction, and inventory efficiency.

Key Features of Brandivio –

Advanced Demand Sensing: Predict future demand for short lifecycle products using machine learning native algorithms incorporating hyper-local external datasets to map powerful demand drivers.Dynamic Inventory Allocation: Adjust inventory in real time at the SKU/location level based on in-season trends to reduce stockouts and overstock situations.Real-Time Analytics: Drive test and learn strategies, optimize assortment in-season and connect functional teams across the organization with actionable insights for rapid response to market trends.Automation: Reduce up to 80% of existing manual planning efforts and redirect planner focus towards even greater efficiencies.Ease of Use: Intuitive workflows ensure rapid adoption without extensive training.

“Retailers can no longer rely on outdated tools or seasonal strategies,” said James Townsend, CEO of Brandivio.

“Brandivio democratizes retail data science, enabling brands to level the playing field, compete effectively, and maximize profits in today’s fast-paced market.”

This launch underscores Brandivio’s mission to support U.S. retailers facing tighter margins and increasing competition. “Our platform addresses the unique needs of this market, ensuring retailers have the tools to grow and thrive,” added Keith Whaley, SVP of Retail Solutions.

Contact us for a demo at info@brandivio.com or visit Brandivio.com for more.

Media Contact

Keith Whaley, Brandivio, Inc., 1 9494453183, keith.whaley@brandivio.com, https://brandivio.com

View original content to download multimedia:https://www.prweb.com/releases/brandivio-launches-advanced-retail-allocation-platform-for-inventory-excellence-302345595.html

SOURCE Brandivio, Inc.

Continue Reading

Trending