Technology

DP Technology and Lepu Biopharma Announce Milestone Collaboration: Leveraging Advanced Computational Methods to Accelerate ADC Drug Innovation

Published

4 hours ago

November 21, 2024

This partnership has effectively integrated DP’s ADC Linker-Payload design platform with Lepu’s ADC technology development platform, capitalizing on their respective strengths. The overall optimization of the ADC drug has been achieved in a relatively short time.

BEIJING, Nov. 20, 2024 /PRNewswire/ — Lepu Biopharma Co., Ltd. (Lepu Biopharma) and Beijing DP Tech Co., Ltd. (DP Technology) have recently announced a significant milestone in their Antibody-Drug Conjugate (ADC) drug collaboration. This partnership has effectively integrated DP’s ADC Linker-Payload design platform with Lepu’s ADC technology development platform, capitalizing on their respective strengths. The overall optimization of the ADC drug has been achieved in a relatively short time. This project has reached an important milestone, further validating the approach of accelerating ADC innovative drug development through computational design. Moving forward, both parties will continue to deepen their R&D collaboration in this field, jointly committed to promoting the continuous optimization and advancement of innovative drug development processes.

The ADC Linker Payload design platform, meticulously crafted by DP Technology, utilizes “RiDYMO®”, an AI-for-Science driven hit discovery platform. Furthermore, “AI + first principles” based computational methods are employed to predict linker cleavage sites and ensure the correct payload release, achieving outstanding cell-killing and bystander effects. Additionally, the designed antibody-drug conjugates (ADCs) maintain excellent hydrophilicity and plasma stability. Leveraging Lepu’s mature and complete ADC development system, candidates developed by the new ADC platform have demonstrated significant efficacy in CDX models targeting multiple targets. This project has been successfully validated in animal models and is currently advancing the candidate ADC to the clinical stage.

Lei Fang, Ph.D., Vice President of Lepu Biopharma and CEO of CtM Bio Co., Ltd., expressed high appreciation for this cooperation: “Introducing advanced computational methods to solve scientific problems and jointly pioneering breakthrough explorations is our goal in the ADC project collaboration. As a leader in ‘AI for Science’, DP Technology has played a crucial role in this project with its newly developed ADC design platform. By integrating Lepu Biopharma’s advanced ADC development platform with AI-driven design, we proposed novel perspectives on ADC development while significantly expediting the process. By complementing each other’s strengths, we jointly provide new inspiration and ideas for innovative ADC drug design.”

Weijie Sun, CEO of DP Technology, expressed great anticipation for future collaboration: “Lepu Biopharma, as an innovative biopharmaceutical company focused on cancer treatment, particularly in the areas of targeted therapy and immunotherapy, has extensive experience and a long-standing track record in developing innovative ADC drugs. We firmly believe that our close cooperation will significantly accelerate the design and development of ADC drugs, and we are optimistic about the potential to develop innovative, highly effective, and differentiated new ADC therapies. I am eagerly anticipating the ongoing and deepened collaboration between both companies in the field of pharmaceutical innovation!”

Concerning the various demands from industry partners in the ADC field, DP Technology’s ADC platform has successfully empowered various scenarios and projects. For instance, it utilizes AI combined with first-principles calculations to predict linker cleavage sites and improve attachment stability. By integrating pre-trained models with fine-tuning strategies and expert insights, the platform can predict and modify physicochemical properties such as payload efflux and bystander effects. Additionally, there is ongoing exploration and collaboration in the overall evaluation of properties like aggregation effects in ADCs.

About Lepu Biopharma

Lepu Biopharma Co., Ltd. is an innovation-driven biopharmaceutical company focusing on oncology therapeutics, in particular, targeted therapy and oncology immunotherapy, with a strong China foundation and global vision. We are dedicated to developing innovative ADCs through an advanced ADC technology development platform. We aim to develop more optimal and innovative drugs to better serve the unmet medical needs of cancer patients. We endeavor to continuously develop a market-differentiating pipeline by combining in-house research and development as well as strategic collaborations, strengthen our in-house manufacturing capabilities and commercialize our pipeline products in China through dedicated sales and marketing forces, and internationally via partnerships. We have an integrated end-to-end capability across drug discovery, clinical development, CMC and GMP-compliant manufacturing, encompassing critical functions of the biopharmaceutical value chain, and are building dedicated sales and marketing forces.

About DP Technology

At DP Technology, we’re at the forefront of integrating artificial intelligence into scientific research and industrial R&D. Our “AI for Science” initiative is redefining how we tackle complex scientific challenges, making groundbreaking discoveries more accessible and actionable.

We’ve developed the “DP Particle Universe,” a suite of advanced pre-trained models that seamlessly connect cutting-edge research with real-world industrial applications. Our software suite includes: Bohrium® Scientific Computing Space Station, Hermite® Computational Drug Design Platform, RiDYMO® Hit Discovery Platform, Piloteye® Battery Design Automation Platform. Together, these platforms form a robust foundation for industrial innovation and an open ecosystem for AI in science, fostering advancements in key areas such as drug discovery, energy, materials science and information technology.

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SOURCE DP Technology

Technology

Cangzhou Hosts Premiere Chinese Cultural Showcase

Published

49 minutes ago

November 21, 2024

The Fifth China (Cangzhou) Fine Traditional Chinese Culture Network Film Festival Excellent Films Promotion Evening Celebrates Cinematic Excellence

CANGZHOU, China, Nov. 21, 2024 /PRNewswire/ — A news report from xinhuanet:

The Fifth China (Cangzhou) Fine Traditional Chinese Culture Network Film Festival Excellent Films Promotion Evening was held at Cangzhou Stadium on the evening of November 18. The event highlighted 52 outstanding film and television productions, offering insights into the creative processes behind each work. The evening was not only a showcase of cinematic excellence but also marked the launch of a new initiative: the roll-out of the first batch of dedicated film sets and locations specifically designed for the production of online films and series.

The festival, centered on the preservation and promotion of China’s traditional culture, has become a significant cultural institution in Cangzhou. Since its initiation on June 20, 2024, it has amassed an impressive array of 3,136 works, including 80 streaming movies, 2,989 short films, 53 digital shorts, and The Lion City Impressions Series, a collection of 14 films that together offer a vivid portrayal of the vibrant city of Cangzhou. The collection not only highlights the diversity but also the enhanced quality of submissions compared to previous years.

Traditional culture is akin to a pearl in the sea, with online films and TV shows acting as the vessels that navigate these valuable traditions into the future. Culture only becomes impactful when it is deeply rooted and gains momentum. The films and TV shows selected for this initiative are deeply entrenched in real life, engaging viewers and fostering the creative evolution and innovative growth of China’s traditional culture. This strategic approach not only highlights cultural significance but also positions Cangzhou as an emerging economic powerhouse.

The rising tides of the Bohai Sea have shaped a vast and dramatic landscape, while the convergence of nine rivers fosters a fertile land of prosperity. The masterfully crafted Grand Canal has nourished this ancient city, enriching it with a deep cultural heritage. During the promotional event, several sites were designated as the first batch of film locations – Nanchuan Old Street, Cangzhou Garden Expo Park, the China Grand Canal Intangible Cultural Heritage Exhibition Hall, Cangzhou Dahua Industrial Heritage Cultural Area, Nandagang Migratory Bird Habitat, Cangzhou Iron Lion and the Ancient City Ruins Park, Wuqiao Acrobatics World, Xianxian Danqiao, Ancient Government Office of Hejian, MengCun Bajiquan International Training Center, and Huanghua Port Industrial Tourism Scenic Area.

Cangzhou, a city with a cultural lineage that stretches back thousands of years, is rich in historical significance. In recent years, the city has succeeded in transforming its vast cultural resources into high-quality business ventures, converting cultural ‘soft power’ into robust ‘hard support’ for economic growth. Since its launch in 2018, the China (Cangzhou) Fine Traditional Chinese Culture Network Film Festival has continually enhanced its offerings and embraced cutting-edge formats. It has earned accolades and widespread acclaim from industry experts and the public alike, significantly boosting its visibility, influence, and appeal as a premier cultural brand.

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SOURCE xinhuanet

Technology

Gravity Announces Global Launch of Idle Mobile RPG “Poring Rush”

Published

49 minutes ago

November 21, 2024

– Various types of Porings emerge at different levels. Enjoy the Fun of Creating Custom Poring Combinations to Enhance Combat

– “Poring Rush” is available for download and play in global markets, excluding Korea, Japan, China, Vietnam, Netherlands, Belgium, Russia, Iran, and Cuba.

SEOUL, South Korea, Nov. 21, 2024 /CNW/ — Gravity, a global gaming company, officially launched the idle mobile RPG “Poring Rush” on November 21 across global markets.

The mobile RPG can be accessed in multiple regions through the Google Play Store and Apple App Store, except in Korea, Japan, China, Vietnam, Netherlands, Belgium, Russia, Iran, and Cuba. The game supports ten languages, including Korean, English, Simplified and Traditional Chinese, Thai, Indonesian, and Portuguese.

As the title suggests, “Poring Rush” is an adventure game featuring a variety of Porings. Players can create their own cute Poring combinations to enhance attributes like HP, attack, and defense, which can then be used in battle. Higher-tier Porings become more accessible as summoning levels increase, while frequent summons improve the chances of obtaining Porings with powerful skills.

Character customization, inspired by the signature charm of Ragnarok IP characters, includes various costumes and mounts for personalization. As summoning levels increase, the probability of summoning higher-tier Porings grows, and the more summons performed, the greater the chance to obtain Porings with powerful skills.

The official launch version introduces engaging content such as research labs, ruins, farms, altars, and the Magic Castle. In the ruins, players can explore stages with mounts to collect valuable resources. In the farm, they can grow and harvest different crops, earning rewards based on their level. Shrines grant skill effects like increased attack damage based on progression, while the Magic Castle offers a match-3 mini-puzzle game to earn essential resources.

To celebrate the official launch, a variety of exciting in-game events will take place. The ongoing 7-day mission event provides special item rewards for completing daily tasks, with a cute cat mount awarded for finishing all missions. Additional rewards are available during the first launch week, based on the number of skill books used, with exclusive bonuses granted upon completing all missions. Time-limited rewards are also distributed through push notifications during this period. Additionally, the official “Poring Rush” Discord community hosts events such as a sign-up celebration, friend invitation contests, and a creator contest, offering generous rewards for participants.

Kenneth Noh, Head of Gravity’s Global Mobile Business Team, commented, “Poring Rush embraces the cute and familiar charm of Porings, iconic characters from Ragnarok Monsters.” “This game will appeal not only to Ragnarok fans but to anyone who enjoys unique and fun combat with Porings,” he added. “To celebrate the global launch, in-game and community events are being held with plenty of exciting rewards, and we invite everyone to join in!”

For more details on the global launch of Poring Rush, visit the official website at https://poringrush.gnjoy.com.

[Gravity official website] http://www.gravity.co.kr
[Poring Rush website] https://poringrush.gnjoy.com
[Poring Rush Facebook webpage] https://www.facebook.com/PoringRush/
[Poring Rush Discord community] https://discord.gg/JPMBGvxK3c

Contacts
Gravity Co., Ltd.
Kwon Kuk Moon, Gravity Global Mobile Business Unit
moon@gravity.co.kr

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SOURCE Gravity Co., Ltd.

Technology

Hisense Announced the Best Smart Home Offers with the “UNLOCK FOR BLACK FRIDAY” Campaign

Published

49 minutes ago

November 21, 2024

QINGDAO, China, Nov. 21, 2024 /PRNewswire/ — Hisense, a leading brand in global consumer electronics and home appliances, is doubling down on automating your life from better to smarter this Black Friday with its “Unlock for Black Friday” campaign. As technology seamlessly integrates into daily lives, Hisense’s AI-powered appliances offer personalized comfort and convenience. Get ready to embrace the future of home living! Stay ahead of the curve and equip your home, Hisense has it all, and at an unbeatable price!

Optimize your comfort with Hisense Air-conditioner Energy Pro X, driven by AI Smart Eye and TMS Control System technology. Effortlessly detecting your position, it optimizes temperature, humidity, air flow direction, and speed, ensuring customized comfort in every corner of your home. The HI-NANO feature sterilizes germs and bacteria by releasing double ion groups, removing airborne contaminants. Enjoy a friendly environment with high energy efficiency, awarded a top EU energy efficiency rating of A+++.

Experience the smart connected life with the Hisense Refrigerator BCD-522W, serving as the control center to your smart home and featuring a 21-inch TFT bult-in screen for unified control. The Food Inventory feature intelligently manages food storage and expiration reminders, with AI-tech to suggest ideal recipes. Within the large liter-capacity, Triple Temp Zone technology regulates temperature and humidity across all three sections, preventing food odor mixing. The My Fresh Choice feature in the lower right compartment enables conversion from a fridge to freezer with an -18°C~+5°C temperature setting. Synch a smartphone to the fridge touchscreen to copy shopping lists or mirror to play favorite games. As your kitchen companion, an intelligent voice assistant offers hands-free control of home appliances.

Save to sit-back and relax with Hisense Series 7S Washer & Dryer for laundry day with its 6.86-inch TFT touchscreen and seamless integration with ConnectLife app. Features like AI Super Wash automatically matches the perfect washing cycle for your laundry by weighing and sensing what you put in. AI Super Dry cleverly picks the correct drying cycle for each load. With Smart Link, simply pair the dryer with your washing machine, and once your clothes are finished washing, the perfect drying cycle will be already programmed.

Don’t miss the chance to elevate your kitchen with other great campaign deals, including the spacious Hisense Slide-In Electric Range HFE3501CPS with large 5.8 cu. ft. capacity and sleek built-in design; the Hisense 16-place Free Standing Dish Washer HS693C90BXAU featuring versatile wash programs and quiet operation; the Hisense ChefMate Microwave HMAS4211DSV with a generous 42-liter capacity and Smart Inverter Technology; or the Hisense Wine Cabinet JC230W with Dual Temp Zone for the wine connoisseur!

About Hisense

Hisense is a leading global home appliance and consumer electronics brand. According to Omdia, Hisense ranked No. 2 globally for TV shipments and No. 1 in 100″ TVs in both 2023 and H1 2024. The company has expanded quickly to operate in more than 160 countries and specializes in multi-media goods, home appliances, and intelligent IT information.

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SOURCE Hisense