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Allelica Presents New Method to Model Human Genetic Diversity Without Labels, Driving Increased Equity in Precision Medicine

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DENVER, Nov. 13, 2024 /PRNewswire/ — Last week at the American Society of Human Genetics (ASHG) Annual Meeting, the leaders in clinical polygenic risk score (PRS) analysis at Allelica unveiled a groundbreaking approach to modeling human genetic diversity without predefined labels. This new method called “8 Billion” generates 8 billion unique risk models,  to represent each individual on the planet, marking a significant milestone in the company’s mission to make PRS more accurate and predictive across all varieties of human genetic diversity. Allelica’s innovative method is a big step forward to transform the traditional, restrictive “bucket” approach to genetic ancestry, which has long fallen short in capturing the genuine diversity of human beings.

“Up until now, risk models in genomics have relied on broad categories that overlook the specific and unique genetic makeup of each individual,” said Giordano Bottà, CEO of Allelica. “This innovation is a transformative step towards reducing disparities in healthcare, enabling a more precise and equitable approach to precision medicine.”

Current methods force each individual into a bucket defined by continental borders, even when the individual is admixed or originates from a place that does not clearly align with these constructed geographies. As a result, these misaligned individuals can experience exacerbated health inequities. The 8 Billion model’s 81% improvement in estimated risk probability (Brier score) compared to the bucket approach means far more accurate predictions, leading to 24% fewer misclassifications (as measured by net reclassification improvement) and more reliably identifying patients who need intervention as a result.

By further enhancing the predictive power of Allelica’s multi-ancestry PRS for individuals of diverse backgrounds, Allelica’s method once again raises the standard for addressing human genetic diversity in the implementation of polygenic risk scores. As part of the company’s ongoing commitment to advancing equity in healthcare, the 8 Billion method will be integrated with existing products, in parallel with continuous improvements to risk models for diverse populations.

The method was presented by Allelica scientists at the ASHG Meeting with a poster titled 8 billion risk models: modelling human genetic diversity without labels improves risk model performance. The work generated significant interest among attendees, leading to numerous requests for additional presentation sessions. The presentation also covered how Allelica scientists are integrating the new method into the company’s proprietary clinical PRS tests and software, allowing third-party labs to develop their own clinical PRS tests. The ability to model individual genetic diversity through scalable solutions like Allelica’s software tools opens up vast potential for improved health outcomes, particularly for populations historically underrepresented in genomic research. A pending patent application protects the 8 Billion method, reinforcing Allelica’s position at the forefront of precision medicine innovation.

In addition to this presentation, Allelica showcased two other major findings in presentations titled: Integrating APOE haplotype and PRS to improve Alzheimer’s disease genetic risk prediction and a new method to identify drug targets using multi-omics and causal inference: Refraction of Causal Analyses upon Proteomics Data Into Bands of Efficacious Drug Targets. These results further highlight Allelica’s dedication to addressing complex genetic risk factors in healthcare and working to improve preventive medicine for all.

About Allelica
Allelica is the leading platform enabling precision medicine for common disease. Allelica’s technology combines world-class datasets with the most advanced algorithms to build polygenic risk scores (PRS) with the highest predictive power for estimating disease risk in diverse populations. Allelica’s tools translate the enormous potential of genomic data into practical tools that physicians can use to identify individuals with a high genetic susceptibility for life-threatening diseases. Through the incorporation of genetics into disease risk assessments, Allelica is building the foundations of precision medicine for common disease. To learn more, visit allelica.com.

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SOURCE Allelica, Inc.

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State Grid Zhenjiang Power Supply Company Establishes the Province’s First Integrated Station for Green Electricity, Green Certificates, and Carbon Electricity Services

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ZHENJIANG, China, Nov. 26, 2024 /PRNewswire/ — Recently, the first integrated station for green electricity, green certificates, and carbon electricity services in Jiangsu was officially inaugurated at the State Grid Zhenjiang Power Supply Company’s Danyang City district service hall.

In recent years, green electricity has emerged as a crucial factor influencing foreign trade and the construction of green industrial chains. From January to October this year, Zhenjiang’s total green electricity trading volume reached 113 million kilowatt-hours, marking a 39% increase year-on-year. To address the growing demand for green electricity consumption among enterprises, the State Grid Zhenjiang Power Supply Company utilizes its service hall as a public service window to offer “one-stop” comprehensive services. These include consultations on green electricity and green certificate policies, supply and demand trading, bill interpretation, green electricity consumption and carbon footprint certification, as well as the construction of zero-carbon parks and intelligent microgrids.

Distinguished from other green electricity and green certificate service stations, this company has expanded its services to include carbon electricity. It incorporates the company’s self-developed “Carbon Electricity” management and service platform to facilitate green electricity traceability. Collaborating with domestic and international carbon service organizations such as the CQC, it provides unified certification services for green electricity and green certificates, thereby assisting more local export enterprises and bridging the “last mile” in electricity carbon emission calculations on the user side.

According to statistics, this service station has already enabled the province’s first government park-side photovoltaic project to secure green certificates. It has also launched Zhenjiang’s inaugural “Green Electricity Loan,” aiding entities like Ji Kai En (Danyang) Industrial Co., Ltd. and five other export-oriented enterprises to purchase approximately 340 megawatt-hours of green electricity each month. Moreover, it has supported Danyang City Jinlong Energy Technology Co., Ltd., and other companies, in selling 47 megawatt-hours of distributed photovoltaic green electricity. Through its one-stop, full-chain green and low-carbon services, the station aids enterprises in achieving sustainable, low-carbon, high-quality development.

 

View original content:https://www.prnewswire.com/apac/news-releases/state-grid-zhenjiang-power-supply-company-establishes-the-provinces-first-integrated-station-for-green-electricity-green-certificates-and-carbon-electricity-services-302316265.html

SOURCE State Grid Zhenjiang Power Supply Company

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BNP Paribas, AXA and Bloomberg’s former executive joins fintech Premialab

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Diane Lansard, further expands Premialab’s marketing footprint bringing in her extensive banking and asset management expertise to the fintech dedicated to quantitative investment strategies.

LONDON, Nov. 26, 2024 /PRNewswire/ — Premialab announces the appointment of Diane Lansard, as Head of Marketing. Based in London, Ms. Lansard will lead the marketing strategy of the leading independent platform dedicated to quantitative strategies. Before joining PremiaLab, Ms. Lansard served a wide range of institutional clients in buy-and sell-side leadership roles at BNP Paribas, AXA, Bloomberg, and M&G Investments.

Ms. Lansard has over 15 years’ experience in banking, asset management and fintech solutions. She will be responsible to execute and scale Premialab’s marketing initiatives, providing data and analytics solutions to asset managers, pension funds, insurance companies and sovereign wealth funds globally.

Adrien Geliot, CEO of Premialab, said: “We are thrilled to welcome Diane to our team as we continue to scale our presence globally. Her extensive experience in finance and innovative approach to marketing, will play a pivotal role in driving our growth efforts. Diane’s expertise will further strengthen our position as a leader in data and analytics for institutional investors.”

The announcement follows recent senior appointments at Premialab including John Macpherson, former Managing Director at Goldman Sachs, Citibank, and Nomura; Marc Fisher, former Managing Director at Citibank with a prior position at Deutsche Bank; and Georgios Sittas, former Managing Director at HSBC, Standard Chartered, and previously a director at Lehman Brothers.

Recognized as the leading independent platform for data and analytics on quantitative strategies, Premialab’s capital markets infrastructure is currently used by leading institutional investors, accelerating their digitalization and enhancing performance and risk control while reducing costs. The Platform is already providing data to institutional clients representing over $20 Trillion of assets under management.

Notes to Editors

About PremiaLab

Premialabis the leading independent platform providing data, analytics and risk solutions on quantitative and multi-asset strategies in collaboration with leading investment banks and institutional investors globally. Combining intelligent technology with a unique source of information the platform empowers asset allocators to make better investment decisions whilst achieving utmost time and cost efficiency.

With offices in London, Paris, New York, Hong Kong, Sydney, and Dubai, its international team is dedicated to supporting a global client base with the most up-to-date QIS dataset, advanced portfolio construction, performance and risk analytics. The firm has established strong partnerships with the top 18 investments banks, global asset managers, pensions funds and insurance companies.

For more information please visit: www.premialab.com

View original content:https://www.prnewswire.co.uk/news-releases/bnp-paribas-axa-and-bloombergs-former-executive-joins-fintech-premialab-302315533.html

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Singapore auto market stays bright with tech injection from Sgcarmart

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SINGAPORE, Nov. 26, 2024 /PRNewswire/ — Sleepy showrooms filled with dubious characters used to be the defining feature of Singapore’s used car trade, but the sector has seen rapid change in the past years.

Founded as an online car classifieds page, Sgcarmart’s arrival brought much needed light to consumers shopping in an otherwise opaque market. Those looking to purchase a used car could now see just what alternatives were available, all at clearly stated prices, with the simple click of a few buttons. The firm had finally corrected the long unaddressed discrepancy of market knowledge back in favour of the everyday consumer, and with this, came fairer prices for all looking to purchase a set of wheels.

But Sgcarmart did not rest content with what it had achieved. As consumer habits and expectations evolved in the rapidly growing city-state, so too did the firm evolve.

On the front-end, the firm has embraced new programming languages, integrating it across its projects even as the dominance of the programming language only started to become apparent. Alongside this, Sgcarmart also made the transition to more modern frameworks, moves that have enabled it to create more efficient and user-friendly applications.

The changes have been a welcome beacon for all in Singapore. Today, the Sgcarmart website and accompanying app is packed with prices and details of new and used cars alike (information that is much needed in this market). Users can also easily obtain information on vehicle care and maintenance, and there’s a host of resources for individuals to obtain parts and accessories for their vehicles.

More recently, Sgcarmart has also taken to integrate AI into its workflows, allowing it to enhance staff productivity while ensuring it remains ready to tackle future challenges with confidence.

Propelling this most recent embrace of technology is Sgcarmart’s GM of Product Development, Mrs. Paustina Chou, who recently won the Tech Talent Assembly award for “Tech Talent Builders”.  Together with the team, she has designed and developed a multifaceted strategy designed to foster tech talent growth at Sgcarmart, building the people that have stood at the centre of the firm’s innovation.

With the goal of ensuring that talents are up to date with the latest emerging market trends including the growth of modern development frameworks, widespread use of generative AI, as well as the maturing of cloud computing and machine learning, she has worked closely with the teams under her care to ensure all within the firm stay updated in a rapidly evolving tech landscape.

Shahrul Tahir, CEO of Sgcarmart, said, “At Sgcarmart, we continue to cement our position as Singapore’s no.1 automotive platform by our continuous pursuit on improvement, both on technology and on talent development.”

There’s still more work to be done, of course. 2024 saw car prices in the country skyrocket, while a multi-day failure of one of the nation’s oldest train lines has led to renewed doubts about how the state ought to manage its public transport infrastructure.

Addressing these will no doubt require clever solutions from the world of public policy and urban planning. But the nation can at least rest easy with the knowledge that when it comes to applying new tech, the (head) lights at Sgcarmart are shining brighter than ever.

About SGCM Pte Ltd

As the first choice car site with over 30,000 listings, Sgcarmart offers the largest database of new and used cars, with an average of 10 cars sold every hour, helping to drive approximately 70% of all second-hand car transactions in Singapore. The platform receives more than 1.6 million users every month, offering the highest level of support for drivers with its suite of value-added car ownership & transactional services.

View original content to download multimedia:https://www.prnewswire.com/apac/news-releases/singapore-auto-market-stays-bright-with-tech-injection-from-sgcarmart-302316211.html

SOURCE Sgcarmart

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