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2024 Tsingke High-Impact Literature Compilation – Gene Synthesis

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2 weeks ago

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BEIJING, Nov. 12, 2024 /PRNewswire/ — Tsingke has delivered high-quality biotechnology services and products to nearly 300,000 users globally. The number of high-level academic papers published using Tsingke’s products and services has grown steadily year after year, continuously driving the advancement of life science research.

We have selected two high-impact papers, published in prestigious journals, spanning a range of fields from gene function research to immunotherapy.

Compilation of High-Impact Literature

1.
Title: Enhancing rice panicle branching and grain yield through tissue-specific brassinosteroid inhibition
DOI: 10.1126/science.adk8838
Journal: Science
Impact Factor: 56.9
Summary:
This study shows that crop yield potential is limited by inherent trade-offs between grain size and number. While brassinosteroids (BRs) promote grain enlargement, their role in regulating grain number has been unclear. By analyzing a cluster-type rice germplasm, the researchers found that activating the BR metabolic gene BRASSINOSTEROID-DEFICIENT DWARF3 (BRD3) significantly increases grain number. A molecular pathway was established where the BR signal inhibitor GSK3/SHAGGY-LIKE KINASE2 phosphorylates and stabilizes the OsMADS1 transcription factor, which targets the TERMINAL FLOWER1-like gene RICE CENTRORADIALIS2. Tissue-specific activation of BRD3 in secondary branch meristems enhances panicle branching, reduces the negative impact on grain size, and improves grain yield. The study demonstrates the powerful role of tissue-specific hormone manipulation in overcoming trait trade-offs and unlocking rice yield potential.

2.
Title: Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer
DOI: 10.1038/s41392-024-01772-w
Journal: Signal Transduction and Targeted Therapy
Impact Factor: 39.3
Summary:
Despite the success of immune checkpoint therapies, resistance and relapse remain common in lung cancer. Cancer stem cells (CSCs) are an important factor in immune therapy resistance. Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, has shown synergistic effects with immunotherapy. This study shows that the key rate-limiting enzyme CPT1A in fatty acid oxidation, together with L-carnitine from tumor-associated macrophages, drives ferroptosis resistance and CD8+ T cell dysfunction in lung cancer. Mechanistically, CPT1A inhibits the ubiquitination and degradation of c-Myc, which transcriptionally activates CPT1A expression. The CPT1A/c-Myc positive feedback loop enhances the NRF2/GPX4 system and reduces the quantity of phospholipid polyunsaturated fatty acids, boosting cellular antioxidant capacity and suppressing ferroptosis in CSCs. Importantly, targeting CPT1A enhances anti-tumor immunity and ferroptosis in immune checkpoint blockade therapy in tumor-bearing mice. These results present a metabolic vulnerability-targeting approach to improve lung cancer immunotherapy efficacy.

Tsynth™ Gene Synthesis

Tsingke is built on a foundation of advanced gene synthesis technology, supported by a gene-smart molecular splitting and assembly platform that enhances accuracy and success rates. Leveraging years of expertise in life sciences, bioinformatics, and computer science, Tsingke has pioneered cutting-edge codon optimization techniques. At the same time, the company utilizes the propeller system (TSINGKE HELIXTECH), an integrated full-cycle management system that combines customer service, production management, and lean management. By employing AI algorithms, it effectively links raw materials, equipment, and processes, powering intelligent production lines and precise gene detection quality control techniques. This enables Tsingke to provide low-cost, high-efficiency, and high-quality gene synthesis services, meeting the needs of researchers in fields such as life science research, biopharmaceuticals, biological breeding, biomanufacturing, and gene storage.

For more high-impact papers utilizing Tsingke’s products and services, visit our website to explore how our solutions are helping advance research worldwide.

View original content:https://www.prnewswire.co.uk/news-releases/2024-tsingke-high-impact-literature-compilation—gene-synthesis-302302369.html

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Technology

“Bleach: Brave Souls” Anime Broadcast Celebration Special: Christmas Zenith Summons: White Night to Begin Soon with Retsu, Nemu, and Others as New 5 Star Characters

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6 minutes ago

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November 27, 2024

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TOKYO, Nov. 27, 2024 /PRNewswire/ — KLab Inc., a leader in online mobile games, announced that its hit 3D action game Bleach: Brave Souls will be holding the Anime Broadcast Celebration Special: Christmas Zenith Summons: White Night from November 30. See the original press release (https://www.klab.com/en/press/) for more information.

Anime Broadcast Celebration Special: Christmas Zenith Summons: White Night

Event Period: Saturday, November 30 16:00 to Sunday, December 15 15:59 (JST/UTC+9)

A Summons will be held featuring Christmas 2024 versions of Retsu Unohana, Nemu Kurotsuchi, and Isane Kotetsu.

The draw rate for 5 Star characters in this Summons is 6%.
One 5 Star character is guaranteed every five Steps of the x10 Summons except for Step 25 and Step 50.
On Steps 25 and 50, players will be given Tickets to receive a 5 Star character of their choosing.

https://youtu.be/MN7CTyWHPho

Free Thousand-Year Blood War Summons

Event Period: Saturday, November 30 16:00 to Tuesday, December 31 15:59 (JST/UTC+9)

Don’t miss out on a special one-time Summons that guarantees a 5 Star Thousand-Year Blood War character.

Free Seasonal Brave Souls Summons

Event Period: Saturday, November 30 16:00 to Thursday, December 19 15:59 (JST/UTC+9)

One free x10 Summons every day for up to ten days.

Santa’s Helpers Campaign

Campaign Period: Saturday, November 30 16:00 to Sunday, December 15 23:59 (JST/UTC+9)

All participants in this campaign will receive digital Christmas cards.

Plus, an additional 50 winners will also be selected to receive a Brave Souls original greeting card set.

How to Enter
1. Follow the Bleach: Brave Souls official X account (@Bleachbrs_en).
2. Post with a character you have selected to help from the campaign post.

Please check the Brave Souls official X account or the news on the Brave Souls official website for more details.

BLEACH Soul Puzzle Update Campaign

To celebrate the addition of Support Characters to BLEACH Soul Puzzle, players will be given presents alongside Support Items in a special login bonus.

Please check the BLEACH Soul Puzzle in-game news or the official X account (@BLEACHPuzzle_en) for more details.

*Please note that campaign contents and the campaign period are subject to change without notice.
*Please check the in-game news for further details.

Overview of Bleach: Brave Souls

Platform:                                  iOS /Android™/PC/PS4™/Nintendo Switch/Xbox One
Genre:                                      3D Action
Price:                                        Free-to-play (In-game purchases available)
Official Website:                      https://www.bleach-bravesouls.com/en/
Official X Account:                  @bleachbrs_en
Official Facebook Page:         https://www.facebook.com/BleachBS.en
Official YouTube Channel:      https://www.youtube.com/channel/UC1QJ4uNQeijEx0jlo4nqauA
Official Instagram:                   @bleachbravesouls_official
Official Discord:                       https://discord.com/invite/bleachbravesouls
Official TikTok:                         https://www.tiktok.com/@bleachbrs_en_official
Copyright:                                 © Tite Kubo/Shueisha, TV TOKYO, dentsu, Pierrot     
                                                   © KLabGames

Download Here:

App Store: https://itunes.apple.com/app/id1003168863
Google Play: https://play.google.com/store/apps/details?id=com.klab.bleach
Steam: https://store.steampowered.com/app/1201240/BLEACH_Brave_Souls
PlayStation Store: https://store.playstation.com/concept/10002097
Nintendo eShop: https://nintendo.com/us/store/products/bleach-brave-souls-switch
Xbox Store: https://www.xbox.com/games/store/bleach-brave-souls/9nnrnx65nknb

View original content to download multimedia:https://www.prnewswire.com/news-releases/bleach-brave-souls-anime-broadcast-celebration-special-christmas-zenith-summons-white-night-to-begin-soon-with-retsu-nemu-and-others-as-new-5-star-characters-302317174.html

SOURCE KLab Inc.

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Maran Timber Sdn. Bhd. Pioneers EUDR-Compliant Shipments from Malaysia to Europe

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6 minutes ago

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November 27, 2024

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Image link:
https://drive.google.com/file/d/1oVhRggdwfKYbMWyEHqtQNvdYnoCeLhaZ/view?usp=drive_link 

KUALA LUMPUR, Malaysia, Nov. 27, 2024 /PRNewswire/ — Maran Timber Sdn. Bhd., a leading Malaysian timber exporter, has become the first company in the country to achieve European Union Deforestation Regulation (EUDR) compliance using the cutting-edge Proteus platform from #dltledgers, a Singapore-based digital supply chain solutions provider. This milestone marks a significant advancement for the Malaysian timber industry, enabling seamless, transparent, and compliant shipments to the European Union (EU).

The EUDR, which came into force in June 2023, aims to curb global deforestation by regulating commodities that contribute to environmental degradation. As part of its commitment to sustainability and responsible forestry, Maran Timber is leveraging the multi-party Proteus framework to ensure the traceability of its timber exports, demonstrating compliance with the strict EU regulations. The platform offers real-time auditability and immutable record-keeping, ensuring transparency and accountability from upstream forestry activities to downstream manufacturing and shipment processes.

With over 60 years of experience, Maran Timber is no stranger to innovation, but this latest partnership with #dltledgers marks a pivotal shift towards digitalization and enhanced collaboration across its supply chain. The Proteus platform integrates advanced technologies such as blockchain and AI to streamline multi-party transactions, from raw material sourcing to regulatory submissions. This ensures not only compliance but also increased efficiency and sustainability in every shipment.

“We are proud to be the first timber company in Malaysia to implement EUDR-compliant shipments using #dltledgers’ Proteus framework. This partnership is a game-changer for us, allowing us to meet the stringent demands of the EU market while supporting our sustainability goals,” said Mr. Kay Yip Ng, CEO of Maran Timber Sdn. Bhd. “This collaboration aligns with our vision to build a digitalized ecosystem and further strengthens our commitment to sustainability across the entire supply chain.”

“Proetus is a game changing multi-party collaboration platform for global Compliance and sustainability, with industry specific models for faster customer journey towards a circular economy. We work with multiple industries across the globe; EUDR compliance and submission are deployed at rapid speed, authenticated at real time for compliant exports” said Mr. Samir Neji, CEO of #dltledgers. “We are ecstatic to support the Malaysian Timber Industry. Maran Timber paves the way for further leadership and collaboration across the industry, driving compliance, sustainability, and innovation.”

About Maran Timber Sdn. Bhd.

Maran Timber, formerly known as Maran Road Sawmill, is a premier fully integrated Maran Timber, a prominent timber company in Malaysia, focuses on producing high-quality timber products while maintaining strong commitments to sustainability and responsible practices. The company operates an FSC-certified forest concession under Asrama Raya, a sawmill in Terengganu, and an integrated timber manufacturing facility in Pahang.

Maran Timber offers a range of engineered timber products, including kiln-dried lumber, laminated scantlings, fascia boards, and Noawood, a thermally modified wood product derived from Malaysian tropical timber, designed for enhanced durability and stability. The company remains dedicated to sustainable forest management and adhering to ESG principles, ensuring a balance between business growth and environmental responsibility.

About #dltledgers

#dltledgers is a global multi-party collaboration platform offering state of the art solution in Multi-tier supply chain, Sustainability, Compliance and Digital finance.

Global businesses face significant multi-party collaboration challenges and there is a pressing need for enabling inter-enterprise data-sharing processes. Organizations across diverse geographies often struggle with incompatible technologies. #dltledgers offers clarity through the seamless virtualization of invisible data points across the value chain.

Our flagship product, Proteus, enhances collaboration and authenticity, leveraging advanced virtualization technologies in Gen AI, Blockchain and Web3 frameworks to streamline data sharing, improve visibility and ensure global compliance.

View original content:https://www.prnewswire.com/apac/news-releases/maran-timber-sdn-bhd-pioneers-eudr-compliant-shipments-from-malaysia-to-europe-302317295.html

SOURCE dltledgers

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Technology

Daikin Selects IPfolio from Clarivate

Published

6 minutes ago

on

November 27, 2024

By

Enhancing operational efficiency for leading air conditioner manufacturer

LONDON, Nov. 27, 2024 /PRNewswire/ — Clarivate Plc (NYSE: CLVT), a leading global provider of transformative intelligence, announced today that Daikin Industries, Ltd. (Daikin) has selected IPfolio™ from Clarivate. The leading air conditioner manufacturer will utilize this solution to optimize its intellectual property (IP) assets, enabling more confident strategic decision-making and sustainable growth.

IPfolio will support Daikin’s IP teams in maximizing operational efficiency, keeping pace with increasing IP filing and data volumes, and eliminating manual processes. As an easily configurable solution, IPfolio will help Daikin meet its unique needs for managing its IP assets. In the future, Daikin will also use IPfolio for its global offices to facilitate collaboration through connected services and integrations.

Glen Nath, Senior Vice President, Intellectual Property, Clarivate, said: “We are very proud to provide our IP management solution to Daikin to help them transform their IP management. Our IPfolio supports Daikin to efficiently manage its IP assets with maximum control and minimal effort, giving its business a competitive edge.”

Gordon Samson, President, Intellectual Property, Clarivate, said: “This is another great example of how we connect our clients to leading solutions to ensure an IP-empowered future. We are confident that our powerful and flexible cloud-based solution will empower clients to make strategic IP decisions with greater confidence and efficiency.”

Mr. Takeo Abe, General Manager of Intellectual Property Department at Daikin, said, “As the Intellectual Property Division is transforming into a creative division, we have decided on Clarivate as a partner to build a new system to optimize and innovate our IP operations. We believe IPfolio is the best system to achieve our goals with its high flexibility and diverse features.”

About Clarivate 
Clarivate™ is a leading global provider of transformative intelligence. We offer enriched data, insights & analytics, workflow solutions and expert services in the areas of Academia & Government, Intellectual Property and Life Sciences & Healthcare. For more information, please visit www.clarivate.com. 

Media Contact:
Jack Wan, Director, External Communications
newsroom@clarivate.com 

SOURCE Clarivate Plc

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