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Global Times: Species thriving thanks to policy, consensus in China

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BEIJING, Oct. 31, 2024 /PRNewswire/ — Under the global framework for biodiversity, more wildlife species are increasing in number and enjoying a better space for living and breeding in China with the help of advanced technology and more popular caring, according to the Chinese delegation from diverse institutes and organizations at the 16th meeting of the Conference of the Parties (COP16) to the Convention on Biological Diversity that is being held in Cali, Colombia.

A prolonged whistle resonated through the sky, prompting visitors to lift their cameras in anticipation of capturing the migratory birds that were arriving. In recent years, tens of thousands of migratory birds such as cormorants fly each autumn to Shenzhen, a subtropical metropolis in South China, making the city one of the most important stops for these birds in the Eastern Hemisphere.

Their numbers are still increasing as the local environment improves. Environmental conservation organizations, including the Mangrove Conservation Foundation (MCF), see the growing population of migratory birds as a signal that urban biodiversity in China is heading in the right direction. 

Only around a few meters away from visitors, a black-faced spoonbill heads down in search of food over the wetlands at the Futian Mangrove National Nature Reserve alongside dozens of its brethren. Meanwhile, in the Futian Mangrove Ecological Park, an Eurasian otter, a species that disappeared from the Shenzhen Bay for nearly 20 years, has re-emerged.  

Chen Yudong, a staff member with the Mangrove Conservation Foundation who focuses on the protection and biodiversity of wetlands, told the Global Times that the Futian Mangrove Ecological Park is currently home to five species listed as National Key Protected Wildlife, including the Eastern imperial eagle, the black-faced spoonbill, and the small Indian civet. 

Additionally, the park has 39 nationally protected wildlife species at the second level (including birds, mammals, and reptiles). From 2015 to 2023, the number of insect species had risen from 109 to 1,224, while bird species had increased from 83 to 220.  

To maintain and improve biodiversity in metropolises like Shenzhen, Chinese environmentalists are exploring the effective application of emerging technologies and analytical methods in biodiversity monitoring, such as bioacoustics, weather radar data, and artificial intelligence, according to Insights for Cities on Biodiversity, an initiative focusing on how to sustain urban biodiversity, published in Shenzhen in September. 

For instance, during the migratory season, weather radar is being promoted to analyze and predict the flight paths of bird flocks, informing the implementation of lighting management strategies. This technology can help reduce accidents involving birds colliding with tall buildings or windows, particularly at night.

The delegation of the conservation foundation brought the initiative to COP16 and shared China’s experience with people who are concerned about how global biodiversity is being impacted by the continuously expanding urban areas around the world. 

Chen said that these projects and technologies are all aimed at speeding up achieving the global target set for 2030 and beyond to safeguard and sustainably use biodiversity, which was clarified in the framework, also known as the Kunming-Montreal Global Biodiversity Framework adopted at the COP15 during the Chinese presidency.

Shenzhen is not the only city that protects wetlands and preserves an international channel for migratory birds. Black-faced spoonbills have also been observed in the wetlands in East China’s Zhejiang and Fujian provinces and South China’s Guangxi.

Li Cheng, founder of the Xizijiang Ecological Conservation Center, has also been encouraged and guided by the biodiversity framework. 

“Since the COP15 was held in Kunming, I have felt the growing emphasis on ecological and biological protection from the public and authorities. More people are aware of the importance of sustaining the populations of each species on the Earth through public outreach programs,” Li told the Global Times, noting growing social consensus on biodiversity conservation seen in his daily work.

The infrared cameras set up by Li’s patrol team around the Wuqinzhang Mountain in Guangdong have recently captured additional pangolin movements, further bolstering Li’s confidence that the population of these endangered creatures is increasing.

Li still remembers the excitement he felt when one infrared camera first captured a pangolin at the end of 2018 and the night when he and colleagues repeatedly checked the pangolin’s photo multiple times. 

Chinese pangolins were assessed as “critically endangered” by the IUCN Red List of Endangered Species in 2019 and was even thought to be functionally extinct at the time of its assessment.

Now more and more people, including local villagers who have joined the patrol team, have begun to devote their lives to protecting pangolins. To improve the efficiency of their conservation efforts, Li noted that in addition to infrared cameras, a mobile application especially developed for patrol personnel has been put into use. The app is constantly updated with real-time information on the pangolins, thereby informing those on patrol of urgent situations.

“We have begun to shift our priorities and are more focused on restoring the pangolins’ habitat and making more creative use of conservation technologies,” Li noted.

View original content:https://www.prnewswire.com/news-releases/global-times-species-thriving-thanks-to-policy-consensus-in-china-302293621.html

SOURCE Global Times

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Tech employment ends year with uptick in hiring, CompTIA analysis finds

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January 10, 2025

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Tech unemployment rate falls to 2%

DOWNERS GROVE, Ill., Jan. 10, 2025 /PRNewswire/ — Tech hiring increased during the latest jobs data release, resulting in a corresponding decrease in the tech unemployment rate, CompTIA, the world’s leading provider of vendor-neutral information technology (IT) training and certification products, reported today.

Analysis of U.S. Bureau of Labor Statistics (BLS) #JobsReport data reveals the tech unemployment rate dropped to 2% in December, the lowest level since November 2023. The national unemployment rate was essentially unchanged at 4.1% for the month.

The base of tech employment throughout the economy increased by a net new 7,000 positions. In the aggregate the core tech workforce totals nearly 6.5 million workers.¹

Employment within the technology industry sector, encompassing all types of workers, declined by 6,117 jobs.² Positions in PC, semiconductor and components manufacturing accounted for the bulk of the cuts. The tech sector employs nearly 5.6 million people, which translates to a percentage decline of 1%.

“This marks the 100th release of the CompTIA Tech Jobs report,” noted Tim Herbert, chief research officer, CompTIA. “What an incredible journey in tracking tech workforce trends over the past decade. A true honor to be at the center of such an innovative and dynamic space.”

There were 434,415 active employer job postings for tech positions in December, including 165,189 newly added during the month.³ Both totals were down from November. Positions in software development and engineering, IT project management, cybersecurity, data science and analysis and tech support had the most activity.

Companies with the largest numbers of December job postings included Amazon, Accenture, Deloitte, PricewaterhouseCoopers, GovCIO, Robert Half, Lumen Technologies and Insight Global.

Employers listed open positions at all career levels. Among postings that specified a work experience requirement, 22% sought candidates with 0-3 years of experience; 28% of openings sought workers with 4-7 years of experience; and 16%, 8 years or more.

Across all tech occupations 45% of December job postings did not specify a four-year degree requirement for applicants. Openings for network support specialists (85%), tech support specialists (72%) and computer programmers (54%) had notably higher percentages.

The “CompTIA Tech Jobs Report” is available at https://www.comptia.org/content/tech-jobs-report.

About CompTIA
CompTIA Inc. is the world’s leading provider of vendor-neutral information technology (IT) training and certification products. CompTIA unlocks potential in millions of aspiring technology professionals and careers changers. Working in partnership with thousands of academic institutions and training providers, CompTIA helps students build career-ready skills through best-in-class learning solutions, industry-recognized certifications and career resources.
Learn more at https://www.comptia.org/.

Media Contact
Steven Ostrowski
CompTIA
sostrowski@comptia.org
+1.630.678.8468

¹ Monthly occupation level data from the U.S. Bureau of Labor Statistics tends to experience higher levels of variance and volatility.
² Labor market data from the U.S. Bureau of Labor Statistics and employer job postings from Lightcast may be subject to backward revisions.
³ Active job postings include open postings carried over from previous months and new postings added by employers.

View original content to download multimedia:https://www.prnewswire.com/news-releases/tech-employment-ends-year-with-uptick-in-hiring-comptia-analysis-finds-302348198.html

SOURCE CompTIA

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Iktos and Cube Biotech Announce Launch of Small Molecule AI Drug Discovery Collaboration

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January 10, 2025

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Partnership will leverage Iktos’s AI-enabled drug discovery platform and Cube Biotech’s advanced protein technologies to develop novel agonists of the Amylin Receptor

PARIS and MONHEIM, Germany, Jan. 10, 2025 /PRNewswire/ — Iktos, a leader in Artificial Intelligence (AI) and Robotics for drug design, and Cube Biotech, a pioneer in membrane protein production and purification technologies, today announced a strategic collaboration to discover novel small molecule agonists of the Amylin Receptor.

The partnership combines Iktos’ generative AI-driven drug discovery and robotic synthesis platform with Cube Biotech’s advanced native membrane protein technology NativeMPTM, as well as their purification and biophysical assay expertise, to accelerate the development of breakthrough therapies. This paves the way for a joint collaborative offering directed towards pharmaceutical companies, combining the strengths of both platforms to undertake their most challenging drug discovery programs.

Amylin receptor agonists hold significant promise for addressing unmet medical needs in cardiometabolic disorders, including obesity, diabetes, and metabolic dysfunction-associated steatotic hepatitis (MASH). The Amylin Receptor regulates appetite and satiety, making it a compelling target for obesity, which affects over one-third of the global population. Existing GLP-1 receptor agonist therapies like semaglutide or the peptide Amylin analogue Pramlintide have limited impact due to high costs, accessibility, and undesirable side effects.

Orally administered novel small molecule agonists of the Amylin receptor could overcome these barriers, offering scalable and effective treatments and providing better management for the growing obesity epidemic and its comorbidities. However, the receptor’s structural and biological complexity has long posed challenges for discovering viable low-molecular-weight modulators.

“By tackling one of the most pressing unmet needs in cardiometabolic disorders, our partnership with Cube Biotech aims to discover improved treatments for patients affected by obesity, diabetes, and related conditions,” said Yann Gaston-Mathé, Co-founder and CEO of Iktos. “We are excited to add the Amylin Receptor to our pipeline as this complex, yet promising target demands innovation at every stage. We see this collaboration as a foundation for future initiatives, extending the reach of our combined platform to address the most challenging membrane targets for the benefit of our pharma partners.”

Iktos has developed a cutting-edge 3D generative chemistry technology for structure-guided de novo design that natively accounts for protein flexibility during molecule optimization—a key advantage over models like AlphaFold, which can only be applied post-molecule generation. Cube Biotech has developed a world-leading protein production platform, based on NativeMP™ technology, which preserves the natural configuration of membrane proteins – a key advantage in accessing biologically active drug targets for testing. The company’s native protein stabilization technology enhances the reliability and precision of functional assays, structural insights, and downstream applications.

“Amylin Receptor is a challenging but highly promising target for metabolic disorders”, said Dr. Barbara Maertens, Co-founder and COO of Cube Biotech. “Through our collaboration with Iktos, we aim to leverage our advanced protein stabilization and structural analysis technologies to validate and accelerate the discovery of novel small molecule agonists. Together, we are setting a new standard for efficiency and innovation in drug discovery.”

These integrated technologies endeavor to overcome longstanding inefficiencies in drug discovery, shortening timelines, improving success rates, and unlocking new possibilities for targeting complex and historically elusive membrane proteins, such as G-protein coupled receptors (GPCRs), membrane transporters, ion channels, and others.

About Iktos

Iktos is a leader in artificial intelligence and robotic solutions applied to research in medicinal chemistry and new drug design. Iktos’ proprietary and innovative generative AI solution enables the design of molecules that are optimized in silico to meet all the success criteria of a small molecule discovery project. The use of Iktos technology enables major productivity gains in upstream pharmaceutical R&D. Iktos offers its technology through the SaaS software platforms Makya™ for generative drug design and Spaya™ for retrosynthesis, and through strategic collaborations with pharma companies where Iktos mobilizes its unique platform and leading-edge capabilities to expedite small molecule drug discovery for the benefit of its partners. Iktos has also developed Iktos Robotics, a unique AI-driven synthesis automation platform that dramatically accelerates the Design-Make-Test-Analyze cycle in drug discovery and is developing its own pipeline of drug candidates targeting oncology and auto-immune and inflammatory diseases. In March 2023, Iktos completed a 15.5M€ Series A financing round co-led by M Ventures and Debiopharm Innovation with contribution by Omnes Capital. In July 2024, Iktos announced the acquisition of Synsight, thereby complementing its Chemistry AI platform with a groundbreaking biology platform for the discovery of new drugs targeting Protein-Protein Interactions (PPI) and RNA-Protein Interactions (RPI).

About Cube Biotech Cube Biotech is a leader in membrane protein production, purification, and characterization technologies. With proprietary copolymer-based solutions that maintain biological integrity in native-like protein states, Cube Biotech enables groundbreaking research in challenging drug targets, including membrane receptors, protein co-expressions, and even larger complexes.

The company’s expertise in assay development, biophysical characterization, and structural resolution supports efficient drug discovery workflows across the pharmaceutical and biotechnical industries. Additionally, an extensive purification resin and magnetic bead portfolio for affinity chromatography and efficient protein purification is manufactured in-house at high quality. For more information, visit www.cube-biotech.com.

Media Contact:
Eleonora Echegaray
P: 35 823189279
E: 388591@email4pr.com

View original content to download multimedia:https://www.prnewswire.com/news-releases/iktos-and-cube-biotech-announce-launch-of-small-molecule-ai-drug-discovery-collaboration-302348215.html

SOURCE Iktos

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Rule 10b-5 Private Securities-Fraud Litigation Peaked in 4Q’24

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January 10, 2025

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BETHESDA, Md., Jan. 10, 2025 /PRNewswire/ — SAR, a data analytics company specialized in the securities litigation risk of U.S. public companies, today published the Securities Class Action Rule 10b-5 Exposure Report for 4Q 2024. According to the report, securities litigation exposure of public company defendants that trade in the NYSE and NASDAQ peaked during the fourth quarter of 2024, when records were set across the buoyant U.S. equity markets. During the bullish market conditions of 2024, shareholders claimed approx. $665.2 billion in market capitalization losses due to alleged violations of Rule 10b-5 – the most in the last five years.

Rule 10b-5 settlements increased over 20% in 2024 relative to the last 6 years.

According to the report, global quarterly Rule 10b-5 securities litigation exposure in 2024 was 17% greater than the average of 2023. Actual monetary settlements with investor plaintiffs last year were, on average, 23% greater than during the last six years.

SAR data and analysis indicate that the litigation exposure of U.S. public company defendants amounts to approximately $380.3 billion in 2H 2024. Shareholders claimed approximately $4.0 billion in market capitalization losses per securities class action filing, and approximately $2.0 billion per allegedly fraud-related stock drop in 2H 2024. The former metric increased by 32.1%, and the latter by 15.4% during the second half of 2024.

“Our data and analyses indicate that securities litigation exposure against U.S. public companies peaked in the fourth quarter of last year. This peak may be short-lived with an expected increase in volatility and new headwinds for U.S. equities given greater shareholder scrutiny of corporate disclosures. With average Rule 10b-5 settlements over 20% greater in 2024 than during the last six years, litigation activity is expected to increase in 2025,” said Anthony Kabanek, EVP of SAR.

According to the report, in 2023 and 2024 investor plaintiffs claimed $13.6 billion and $20.5 billion, respectively, in private Rule 10b-5 securities-fraud class actions that relied on short-seller research.

Key takeaways:

86 U.S. issuers were sued for alleged violations of Rule 10b-5 during 2H 2024. Based on allegations presented in the first-filed class action complaint against each defendant issuer, U.S. SCA Rule 10b-5 Exposure amounts to $259.4 billion. U.S. SCA Rule 10b-5 Exposure decreased -5.4% relative to 1H 2024.

U.S. SCA Rule 10b-5 Exposure peaked in the 2nd and 3rd quarters, followed by a decline to trend in the 4th quarter of 2024.

9 Non-U.S. issuers were sued for alleged violations of Rule 10b-5 during 2H 2024. Based on allegations presented in the first-filed class action complaint against each defendant issuer, ADR SCA Rule 10b-5 Exposure amounts to $120.9 billion. ADR SCA Rule 10b-5 Exposure increased by 11.3x relative to 1H 2024.

An anomalously high 4th quarter exposure among Non-U.S. issuers contributed to a remarkably volatile year for ADR SCA Rule 10b-5 Exposure.

Rule 10b-5 private securities-fraud filing frequency and potential loss severity need not move in tandem. Global exposure increased by approximately 34% in the 2H 2024 relative to 1H 2024, while filing frequency remained relatively stable.

38 U.S. Large Caps were sued for alleged violations of Rule 10b-5 in 2H 2024, the same observed frequency as 1H 2024. The U.S. Large Cap SCA Rule 10b-5 Exposure amounts to $233.7 billion, a decrease of 10.1% relative to 1H 2024.

22 U.S. Mid Caps were sued for alleged violations of Rule 10b-5 In 2H 2024. The U.S. Mid Cap SCA Rule 10b-5 Exposure amounts to $19.8 billion, more than 3 times the amount in 1H 2024.

26 U.S. Small Caps were sued for alleged violations of Rule 10b-5. The U.S. Small Cap SCA Rule 10b-5 Exposure amounts to $5.9 billion, a decrease of 33% relative to 1H 2024.

9 Non-U.S. issuers that trade via ADRs in the U.S. public markets were sued for alleged violations of Rule 10b-5. The ADR SCA Rule 10b-5 Exposure increased by over 11.3x to ~$121 billion, relative to 1H 2024.

Media contact: info@sarlit.com

View original content to download multimedia:https://www.prnewswire.com/news-releases/rule-10b-5-private-securities-fraud-litigation-peaked-in-4q24-302348187.html

SOURCE SAR

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