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Diadem Unveils Novel Findings on Early Alzheimer’s Disease Detection Using p53-Specific Antibody at CTAD 2024

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MILAN, Nov. 1, 2024 /PRNewswire/ — Diadem SpA, in partnership with researchers from the University of Texas Medical Branch, led by Prof. Rakez Kayed from the Mitchell Center for Neurodegenerative Disorders, presented groundbreaking findings at the 2024 Clinical Trials on Alzheimer’s Disease (CTAD) conference. The study focused on U-p53AZ, a conformational variant of the p53 protein linked to Alzheimer’s disease (AD). Using a U-p53AZ-specific antibody developed by Diadem, the team identified the presence of this misfolded protein in human brain tissue, providing critical insights into AD pathology.

Managing cognitive decline and dementia is particularly challenging in the early stages, partly due to the lack of reliable and affordable biomarkers. Misfolding of the p53 protein, detected by U-p53AZ, has been developed as a prognostic tool for AD. Previous studies showed that measuring U-p53AZ levels in plasma using a proprietary antibody could predict the risk of significant cognitive deterioration in Alzheimer’s disease (AD). This current study extends those findings by applying the U-p53AZ antibody to brain tissue, further validating its role in AD diagnosis.

Researchers applied U-p53AZ to brain samples from various Braak stages, which track AD progression. The antibody selectively bound to misfolded p53 in AD tissues, with minimal binding in healthy controls. Co-staining with phosphorylated tau (pTau), a key AD marker, reinforced the association between p53 misfolding and tau pathology, suggesting a strong link to AD progression.

Prof. Rakez Kayed stated, “The co-localization of misfolded p53 with phosphorylated tau suggests a mechanistic interaction that warrants further investigation, particularly as a target for early diagnostic intervention.” His comments underscore the significance of the findings in identifying new diagnostic and therapeutic strategies.

Dr. Sam Agus, Chief Medical Officer at Diadem, added, “Our results demonstrate that U-p53AZ not only identifies a conformation-specific form of p53 linked to Alzheimer’s disease but also correlates with disease severity through Braak staging.

The study expands on prior work (Piccirella et al, JPAD, 2022), positioning U-p53AZ as a robust tool for both early and advanced AD detection. Its potential for clinical application in diagnostic settings is significant, particularly in light of its ability to distinguish AD-related p53 misfolding from normal p53 conformations. 

About Diadem SpA
Diadem SpA is a leader in diagnostic solutions for Alzheimer’s and neurodegenerative diseases. Based in Milano, Italy, Diadem focuses on early detection to improve patient outcomes.

For more information, contact:
Diadem:
Michael Rasche
CEO
execadmin@diademdx.com  

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View original content:https://www.prnewswire.co.uk/news-releases/diadem-unveils-novel-findings-on-early-alzheimers-disease-detection-using-p53-specific-antibody-at-ctad-2024-302291701.html

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Revolutionizing E-motorcycles: Ampace to Showcase Kun-Era’s All-Scenario Innovations at EICMA 2024

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MILAN, Nov. 1, 2024 /PRNewswire/ — Driven by the global shift towards electric mobility, Ampace, a leading innovator in new energy technology, will make its debut at the 2024 EICMA Milan International Motorcycle Show. Ampace will launch its Kun-Era series, a line of versatile power solutions for all-scenario E-motorcycle applications. Leveraging its six core features, Ampace has developed a highly adaptable lithium battery solution that empowers a new era of E-motorcycles.

Ampace: a joint venture driving the future of green mobility

Ampace, a joint venture between CATL and ATL, is a technology pioneer committed to pushing the boundaries of new energy technology. The company is dedicated to achieving ultimate safety, innovation, and intelligent manufacturing. Since its inception, Ampace has been at the forefront of the Micro-Electric Vehicles, Energy Storage Systems and High-Power Products industry. With its strong technological innovation capabilities and global reach, the company supports a wide range of electric vehicles, including motorcycles, bicycles, urban battery swaps, tricycles, and scooters.

In 2023, Ampace launched its self-developed BP system, tackling critical challenges in lithium battery safety, endurance, and weight. This innovation highlights Ampace’s commitment to “ultimate safety” throughout the entire product lifecycle. Ampace has successfully reduced the safety failure rate of battery cells to the PPB level (one in a billion), setting a new safety benchmark in the industry. Ampace is committed to translating its groundbreaking technology into high-quality power solutions that users can trust and driving the industry forward.

Kun-Era Series ignites global innovation with its debut at EICMA 2024

At the 2024 EICMA, Ampace will unveil its Kun-Era series of all-scenario E-motorcycle power solutions. This launch is set to revolutionize the E-motorcycle industry. The 7428, the inaugural product in the Kun-Era series has rapidly gained traction worldwide, becoming a flagship product in the global E-motorcycle market. Since its debut, the 7428 has garnered the support of more than 50 E-motorcycle companies, powering more than 80 flagship models and reaching consumers in more than 30 countries and regions.

Building on the success of the 7428, Ampace is expanding its design concept to a wider range of applications. The Kun-Era series not only showcases Ampace’s cutting-edge technology but also delivers a customized power solution for global users. With six core strengths: extreme power, ultimate safety, ultra-long cycle, multi-package parallel, lightweight design, and high adaptability, the series is designed to meet the diverse needs of different E-motorcycle models, offering a broader choice for riders worldwide. Ampace’s commitment to “one battery to meet all needs” sets a new standard for innovation in E-mobility.

Ampace will also showcase its urban battery-swapping solutions and flagship models developed in partnership with OEMs, aimed at making electric travel more convenient, safe, and environmentally friendly. In the spirit of collaborative growth, Ampace invites partners and visitors alike to explore these advancements firsthand. Join us at Hall 24, O86a booth to experience the grand launch of the Kun-Era series and be part of the journey toward a new era of lithium battery innovation.

View original content:https://www.prnewswire.co.uk/news-releases/revolutionizing-e-motorcycles-ampace-to-showcase-kun-eras-all-scenario-innovations-at-eicma-2024-302293958.html

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GoodWe Australia Hosts Inaugural Awards Event at All Energy 2024, Shining a Light on Solar Success and Community Contributions

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MELBOURNE, Australia, Nov. 1, 2024 /PRNewswire/ — GoodWe hosted its inaugural GoodWe Awards during the All-Energy Australia exhibition, celebrating the exceptional achievements of its partners, retailers, and distributors in advancing clean energy solutions across Australia. The GoodWe Awards spotlighted individuals and organisations whose dedication has elevated the solar industry, culminating in the annual GoodWill Award, which recognises outstanding contributions to charitable causes, environmental sustainability, and community development.

The evening honoured eight distinguished award winners and additional nominees. Among the recipients were Solahart Industries Pty Ltd, named Top Energy Storage Retailer of the Year, OSW (One Stop Warehouse), celebrated as Distributor of the Year, Solar Panel Options was recognised as the Top C&I Retailer of the Year, and Alspec Solar took the BIPV Dealership of the Year award for GoodWe’s range of PV Building Materials. Ian Gittus from UV Power was commended with the Individual Outstanding Commitment award, Solar Naturally was honoured as the Top Residential Retailer, and Resinc Solar earned the Retailer Outstanding Commitment award.

The evening concluded with the highlight presentation of the Award to Six Star Plus, by Roshan Ramnarain from Energy Matters. Six Star was selected as the winner for their extraordinary community throughout the year, covering community kitchens, forest regeneration, litter collecting, supporting the Victorian Homeless Fund and raising nearly $20,000 for Myeloma Australia, a charity for those suffering with bone marrow cancer. GoodWill Award nominees, including Original Power, Bushgrid, AWM Echuca, Matthias Huchel from AGL, and SolEnergy Group, received gift card vouchers in recognition of their inspiring efforts across Australia.

Guests enjoyed a dynamic evening filled with networking opportunities and interactions with industry leaders, including representatives from the Smart Energy Council, AWISE (Australian Women in Solar Energy), and Energy Matters.

Dean Williamson, Country Manager for GoodWe Australia, commented:

“The reason we wanted to organise this awards event, is to recognise the remarkable efforts we have witnessed this year in advancing clean energy and supporting communities. To highlight those who go above and beyond, not only in solar innovation but also in making a meaningful impact across Australia. It was a privilege to celebrate such dedication and passion with our partners and we look forward to our 2025 awards event next year.”

GoodWe is a world-leading PV inverter and energy storage systems manufacturer listed on the Shanghai Stock Exchange (Stock Code: 688390). The company has nearly 5000 employees located in 15 different countries and a team of over 1000 engineers. GoodWe storage inverters were ranked in the top 3 globally by Wood Mackenzie in 2022. The company has been ranked 2nd for 3 consecutive years by Sunwiz. Having achieved over seven consecutive TÜV Rheinland “All Quality Matters” awards and consistently being ranked at the top in terms of overall product quality, GoodWe’s comprehensive portfolio of products and solutions for residential, commercial, and utility-scale PV systems is guaranteed to deliver high performance and reliable quality across the board. For more information, please visit www.goodwe.com.au

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SOURCE GoodWe

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Unika Atma Jaya and Knowledge Catalyst Launched a Blockchain-Based Student Platform on Indonesia Innovation Day

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JAKARTA, Indonesia, Nov. 1, 2024 /PRNewswire/ — Atma Jaya Catholic University of Indonesia (AJCUI) and Knowledge Catalyst, a technology company based in Singapore, have launched an innovative blockchain-based platform to enhance academic records management and inter-institutional connectivity.

The newly launched platform simplifies and streamlines the process for students to store, access, and securely share verified academic documents – such as transcripts and diplomas – with employers, universities, and industry partners.

“We are proud to introduce this secure and transparent system for managing academic records at Unika Atma Jaya,” said Dr. Yohanes Eko Adi Prasetyanto, Deputy Chancellor for Academic, Student Affairs, and Human Resources. “This strategic step will strengthen our educational ecosystem and increase competitiveness in the global market.”

Dr. Yohanes Eko further explained that the platform can improve document management standards in educational institutions, prevent data falsification, and, most importantly, enhance operational efficiency.

Designed to meet the needs of an increasingly digital education landscape, the platform positions the institution as a leader in academic data management innovation. With real-time access to verified documents, the platform accelerates recruitment processes, strengthens the institution’s reputation, and opens new opportunities for institutional collaboration.

Regina Kanani, Director of Product of Knowledge Catalyst, added, “Our partnership with Unika Atma Jaya is a promising beginning, creating an impact in building a trusted academic ecosystem and producing graduates with internationally recognized credentials.”

About Atma Jaya Catholic University of Indonesia

Founded on June 1st, 1960, Atma Jaya Catholic University of Indonesia (AJCUI) offers 20 undergraduate (S1) programs, 14 postgraduate programs, and 4 professional study programs. The university has earned various accolades, including the highest category award for Social Responsibility and Employability in 2019 and five stars in online learning from QS Stars in 2020. AJCUI has three campus locations: Semanggi Campus, a hub for Business, Government, and Society studies; Pluit Campus, focused on international-quality Medical and Pharmacy education and home to Atma Jaya Hospital; and BSD Campus, dedicated to student development and character building as future leaders of the nation.

For more information, please contact:

Corporate Communications
Atma Jaya Catholic University of Indonesia
Website: https://www.atmajaya.ac.id/id/
Fransisca Vena Apriliana (0812 8800 8721)
Email: corcomm@atmajaya.ac.id 

About Knowledge Catalyst

Knowledge Catalyst (KC) is a pioneering digital trust ecosystem that empowers talent, healthcare, trade finance, and sustainability stakeholders by providing seamless, verifiable, and secure credentialing and data management solutions. With its proprietary technology, KC integrates effortlessly across multiple platforms, enabling institutions, companies, and individuals to interact with trust and transparency while supporting compliance and governance needs. KC is expanding rapidly and driving transformation in education, health, and financial services through the innovative use of blockchain and identity technologies.

For further information, please contact

Knowledge Catalyst Pte. Ltd. / PT. Kredensia Cipta Utama

Website : www.knowledgecatalyst.io

Regina Kanani
Director of Product, Knowledge Catalyst
Email: marketing@knowledgecatalyst.io 

View original content:https://www.prnewswire.com/apac/news-releases/unika-atma-jaya-and-knowledge-catalyst-launched-a-blockchain-based-student-platform-on-indonesia-innovation-day-302293968.html

SOURCE Knowledge Catalyst Pte. Ltd.; Universitas Katolik Indonesia Atma Jaya

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