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Diadem Unveils Novel Findings on Early Alzheimer’s Disease Detection Using p53-Specific Antibody at CTAD 2024

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MILAN, Nov. 1, 2024 /PRNewswire/ — Diadem SpA, in partnership with researchers from the University of Texas Medical Branch, led by Prof. Rakez Kayed from the Mitchell Center for Neurodegenerative Disorders, presented groundbreaking findings at the 2024 Clinical Trials on Alzheimer’s Disease (CTAD) conference. The study focused on U-p53AZ, a conformational variant of the p53 protein linked to Alzheimer’s disease (AD). Using a U-p53AZ-specific antibody developed by Diadem, the team identified the presence of this misfolded protein in human brain tissue, providing critical insights into AD pathology.

Managing cognitive decline and dementia is particularly challenging in the early stages, partly due to the lack of reliable and affordable biomarkers. Misfolding of the p53 protein, detected by U-p53AZ, has been developed as a prognostic tool for AD. Previous studies showed that measuring U-p53AZ levels in plasma using a proprietary antibody could predict the risk of significant cognitive deterioration in Alzheimer’s disease (AD). This current study extends those findings by applying the U-p53AZ antibody to brain tissue, further validating its role in AD diagnosis.

Researchers applied U-p53AZ to brain samples from various Braak stages, which track AD progression. The antibody selectively bound to misfolded p53 in AD tissues, with minimal binding in healthy controls. Co-staining with phosphorylated tau (pTau), a key AD marker, reinforced the association between p53 misfolding and tau pathology, suggesting a strong link to AD progression.

Prof. Rakez Kayed stated, “The co-localization of misfolded p53 with phosphorylated tau suggests a mechanistic interaction that warrants further investigation, particularly as a target for early diagnostic intervention.” His comments underscore the significance of the findings in identifying new diagnostic and therapeutic strategies.

Dr. Sam Agus, Chief Medical Officer at Diadem, added, “Our results demonstrate that U-p53AZ not only identifies a conformation-specific form of p53 linked to Alzheimer’s disease but also correlates with disease severity through Braak staging.

The study expands on prior work (Piccirella et al, JPAD, 2022), positioning U-p53AZ as a robust tool for both early and advanced AD detection. Its potential for clinical application in diagnostic settings is significant, particularly in light of its ability to distinguish AD-related p53 misfolding from normal p53 conformations. 

About Diadem SpA
Diadem SpA is a leader in diagnostic solutions for Alzheimer’s and neurodegenerative diseases. Based in Milano, Italy, Diadem focuses on early detection to improve patient outcomes.

For more information, contact:
Diadem:
Michael Rasche
CEO
execadmin@diademdx.com  

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The New DePin: OKZOO’s Environmental AIoT Machine Network Leads New Tech Trend

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HO CHI MINH CITY, Vietnam, April 26, 2025 /PRNewswire/ — The “new DePin” (Decentralized Physical Infrastructure Network) trend is arising, as OKZOO’s AIoT devices see explosive growth and traction.

AIoT is short for AI combined with Internet of Things (AIoT), a new category that bridges physical hardware with decentralized network. OKZOO uses AIoT devices to gather environmental data such as noise pollution, air pollution, CO2 levels, and humidity.

OKZOO has already seen massive adoption with 12 million ecosystem users, primarily through its virtual AI pet apps OKZOO V1 and V2.

How AI Pets and Portal Devices Collect Environmental Data

OKZOO’s development began with an intriguing hypothesis: could engaging pet applications serve as the foundation for sophisticated real-world AIoT networks? The team systematically validated this concept through strategic platform iterations.

Their V1 release, a straightforward pet simulator, attracted 7 million users, demonstrating that emotional connections remain powerful in today’s digital landscape. Following this achievement, V2 introduced AI-powered pets capable of learning and evolution, gaining 700,000 users within its initial month.

This validated market traction led to the creation of the P-mini—a compact AIoT device that integrates digital pets with environmental monitoring technology. The P-mini o1 incorporates both sensor technology and an interactive AI companion that reacts to environmental conditions, enabling digital pets to exist in contexts beyond traditional screens.

Traditional environmental monitoring faces significant challenges: data sparsity, lack of real-time granularity, and verification difficulties. Government sensors provide only generalized data that misses hyperlocal variations in air quality, noise pollution, and other environmental factors that directly impact daily life.

This creates blind spots in urban environments where pollution levels can vary dramatically between neighborhoods or even streets.

The P-mini addresses these gaps by creating a grassroots network of sensors collecting street-level data. What sets OKZOO apart from conventional DePin networks is its innovative approach to user engagement. Rather than relying solely on financial incentives, the P-mini integrates virtual pets that respond to environmental surroundings, transforming data collection into an interactive, emotional experience.

In-House Manufacturing Capabilities

A key competitive advantage for OKZOO lies in its in-house manufacturing capabilities. Unlike many projects that rely on third-party manufacturers, OKZOO controls its hardware production process, ensuring scalability, quality control, and faster iteration based on user feedback. This vertical integration allows for rapid adaptation to market demands and technological advances.

The ecosystem operates on an incentive model that rewards users for running P-mini devices and contributing environmental data. These contributions establish a comprehensive database powering sophisticated AI applications ranging from customized health guidance to urban planning solutions.

As environmental awareness becomes increasingly important, OKZOO positions itself at the intersection of utility and engagement. By making data collection enjoyable through pet companions, the project creates sustainable user participation while addressing real environmental monitoring needs.

For a market seeking practical applications, OKZOO’s unique positioning across AI, environmental monitoring, and hardware manufacturing presents a compelling vision for addressing real-world challenges while creating engaging user experiences.

Website: https://okzoo.app/en
X: https://x.com/okzoo_app

 

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SOURCE OKZOO

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CCTV4: 20th China Film Huabiao Awards

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BEIJING, April 26, 2025 /PRNewswire/ — The latest data from the National Film Administration have revealed that the box office revenue of the mainland Chinese film market has already passed the 25 billion yuan (US$3.4 billion) mark in 2025. This compares to 42.5 billion yuan (US$5.8 billion) for the whole of last year, and shows that Chinese cinema is continuing to dominate the global film market. In 2025, the world is celebrating 130 years of cinema and China is marking the 120th anniversary of its own film industry. On April 27th Qingdao in Shandong Province is hosting the 20th China Film Huabiao Awards ceremony. Hundreds of industry luminaries will gather for the event, the theme of which is “Building Dreams through Film, Embracing the Spirit of the Era”. Together they will honor the collaborative and pioneering spirit of China’s filmmakers and celebrate the outstanding progress made by its film sector. The gala will be broadcast live on the CCTV-6 Movie Channel and the CCTV-4 Chinese International Channel, with simultaneous online coverage on China Media Group’s multi-platform networks, the Movie Channel’s own digital ecosystem, and other online platforms.

 

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SOURCE CCTV4

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Petal Ads Hosts “Think Tank 2025” Seminar in Japan to Empower Japanese Companies’ Global Expansion

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TOKYO, April 26, 2025 /PRNewswire/ — Petal Ads, Huawei’s leading global mobile advertising platform, today successfully hosted the “Think Tank 2025” seminar in Japan. The event convened prominent brands and domestic agencies from the travel, beauty, luxury goods and lifestyle services sectors to showcase Huawei’s all-scenario intelligent advertising solutions built on the HarmonyOS ecosystem, offering Japanese enterprises fresh digital-marketing strategies for entering the Chinese and wider global markets.

As a technology company deeply rooted in Japan for nearly two decades, Huawei leverages its global ecosystem and the innovation of HarmonyOS to continuously empower partners’ digital transformation. “Through in-depth local insights, we have built an intelligent advertising platform that connects global users,” said Zhou Rong, Director of Asia-Pacific Ecosystem Development and Operations at Huawei Consumer Business Group. “Petal Ads’ unique all-scenario solutions not only precisely reach segmented audiences but also help Japanese brands unlock commercial value in cross-cultural communication.”

At the seminar, Yang Yang, Global Marketing Director of Huawei Ads, presented an integrated marketing strategy within the HarmonyOS ecosystem. Syaliza Abd Aziz, Japan representative of the Malaysia Tourism Promotion Board, discussed her organization’s strategic partnership with Petal Ads on Visit Malaysia 2026. Colin Duan, Chief Product Officer of third-party data firm QuestMobile, used detailed analytics to decode Chinese internet users’ consumption patterns in travel, beauty and other industries, providing decision-making insights for Japanese companies’ local-market campaigns. Fukuzumi Ryo, co-founder of leading Japanese ad agency Unbot, shared multiple success stories on site, demonstrating Petal Ads’ technical strengths in precise customer acquisition and performance conversion in Japan.

The upgraded “Think Tank 2025” marks a significant milestone in Petal Ads’ globalization strategy. With three core advantages—intelligent ad technology, a premium global user base and customizable all-scenario solutions—the platform now delivers monetization services to 53,000 apps across more than 200 industries worldwide. Looking ahead, Petal Ads will deepen strategic collaborations with its Japanese partners and continue to foster more high-quality brands’ international growth through an innovative digital-marketing ecosystem.

For more information, please visit: https://ads.huawei.com/

About Petal Ads

Petal Ads is Huawei Terminal Cloud Services’ global commercial-service platform, dedicated to providing advertisers and developers with intelligent marketing and traffic-monetization solutions. As of March 2023, the platform spans over 200 industry verticals and operates in more than 170 countries and regions, continually empowering partners’ commercial growth and brand enhancement via HarmonyOS’s all-scenario intelligent distribution capabilities.

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SOURCE Huawei Mobile Services

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