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SandboxAQ Collaborates with The Michael J. Fox Foundation to Speed Identification of New Therapies

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Collaboration with KU Leuven, [led by global leader Peter Vangheluwe, PhD, a longstanding partner of The Michael J. Fox Foundation] will leverage Large Quantitative Models (LQMs) and other advanced AI technologies to design and rapidly screen potential new drug compounds

PALO ALTO, Calif., Oct. 29, 2024 /PRNewswire/ — SandboxAQ announced today that The Michael J. Fox Foundation for Parkinson’s Research (MJFF) has selected the company’s AI platform to accelerate the identification of compounds that activate a gene linked to Parkinson’s disease (PD). SandboxAQ’s team of computational chemists and machine learning experts will collaborate with the Vangheluwe lab and CD3 at Belgium-based KU Leuven to identify activators for ATP10B. Peter Vangheluwe is a global leader in lysosomal transporters that are implicated in Parkinson’s disease, such as ATP13A2 and ATP10B. As a long-standing MJFF partner, the Vangheluwe lab has helped to better understand the underlying mechanisms of ATP13A2 and ATP10B dysfunction in Parkinson’s disease and pioneered drug discovery efforts on ATP13A2.

ATP10B is a novel candidate risk gene for PD encoding a sphingolipid-transporting ATPase involved in neuronal lipid homeostasis. As a member of the P4-ATPase family, it flips glucosylceramide across the lysosomal membrane, maintaining essential cellular functions. Despite its potential as a therapeutic target, drug discovery efforts face challenges due to ATP10B’s multiunit structural complexity, poor expression and difficult handling and limited understanding of its large-scale reorganization during a complex functional cycle. Targeting ATP10B requires novel approaches to identify small molecule modulators capable of restoring its function.

“Leveraging innovative technology in Parkinson’s research and fostering a collaboration with leading experts] is one of the many ways MJFF works to enable a diverse pipeline of treatments for people with Parkinson’s disease,” said Michelle Durborow, head of research operations, MJFF. “We look forward to this collaboration with SandboxAQ and KU Leuven to unlock novel treatments for PD.”

SandboxAQ’s Large Quantitative Models (LQMs) integrate active learning with physics-based scoring functions to create detailed protein profiles and complex interaction matrices. This approach enables rapid in silico high-throughput screening of millions of available compounds to identify potential modulators of ATP10B’s function. Leveraging their expertise in challenging protein targets, SandboxAQ will also support assay development and optimization, generate actionable hypotheses for ATP10B activation and advance early-stage drug discovery efforts on a remarkably complex target with major implications in neurodegenerative diseases.

“SandboxAQ’s Large Quantitative Models and AI simulation techniques have proven their ability to rapidly identify ligands and design novel molecules for other challenging neurodegenerative diseases such as Alzheimer’s,” said Nadia Harhen, GM of AI Simulation at SandboxAQ. “KU Leuven hosts one of the world’s foremost research labs for Parkinson’s disease, and we’re eager to apply our Large Quantitative Models to their existing efforts, accelerating new breakthrough treatments for PD.” 

KU Leuven researchers, in collaboration with the Centre for Drug Design and Discovery (CD3) of KU Leuven, have taken the first steps to unlock the ATP10B protein for small molecule drug discovery since first describing the gene in 2020. Despite significant advances in understanding the biology of ATP10B, the protein has proven difficult to study. Also, there is little real-world data available related to this specific class of lipid flippases that researchers can use to identify the most effective compounds. SandboxAQ’s Quantitative AI simulations can generate accurate data that enable a more efficient search of the vast chemical space to find and develop compounds with the correct profile.

“The ability to simulate a drug compound’s effects on ATB10B and analyze its mode of action will greatly accelerate our groundbreaking research, helping us achieve with AI technology what lab experimentation alone could not,” said Peter Vangheluwe, professor and head of the Laboratory of Cellular Transport Systems at KU Leuven. “SandboxAQ’s technology has opened the door to a new way of designing novel molecules from the vast chemistry space and testing our hypotheses with unprecedented speed and accuracy, delivering previously unknowable insights that will guide our research.”

About SandboxAQ
SandboxAQ is a B2B company delivering AI solutions that address some of the world’s greatest challenges. The company’s Large Quantitative Models (LQMs) deliver critical advances in life sciences, financial services, navigation, cyber and other sectors. The company emerged from Alphabet Inc. as an independent, growth capital-backed company in 2022, funded by leading investors including T. Rowe Price, Eric Schmidt, Breyer Capital, Guggenheim Partners, Marc Benioff, Thomas Tull, Section32, and others. For more information, visit http://www.sandboxaq.com.

About KU Leuven
KU Leuven boasts a rich tradition of education and research spanning six centuries. Recognized with the European HR Excellence in Research Award, the university’s commitment to fundamental research remains unwavering. Simultaneously, KU Leuven stays attuned to contemporary cultural, economic, and industrial developments, as well as the needs and expectations of the community.

As Belgium’s largest university in terms of research funding and expenditure, KU Leuven is a proud charter member of LERU. The university excels in both fundamental and applied research across all academic disciplines, maintaining a strong international orientation. In the Times Higher Education 2023 ranking, KU Leuven was ranked as the 14th best European university. Additionally, for four consecutive years, it has been recognized as the most innovative university in Europe by Reuters’ Top 100 of the World’s Most Innovative Institutions.

The Lab of Cellular Transport Systems (LCTS), led by Prof. Dr. Peter Vangheluwe, is dedicated to advancing our understanding of cellular transport mechanisms. The lab focuses on the unique molecular properties of P-type ATPases and their crucial roles in health and disease. Through cutting-edge research, LCTS aims to uncover the physiological functions of these transport systems, contributing to the development of novel therapeutic strategies for various diseases.

The Centre for Drug Design and Discovery (CD3) is a pioneering drug discovery centre and investment fund. KU Leuven Research & Development and the European Investment Fund created CD3 in 2006 to drive the translation of innovative basic research to the clinic. With a focus on the discovery and development of new medicines, CD3 supports academic research groups and small companies by providing expert drug discovery capabilities and financial resources. The center has successfully launched multiple investment funds, including a €70 million fund (CD3 IV) in 2023 to expand its scope and impact.

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SOURCE SandboxAQ

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Leoguar Electric Bike Makes Christmas Unforgettable with Exclusive Holiday Offers

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HOUSTON, Dec. 25, 2024 /PRNewswire/ — As the holiday season draws near, Leoguar is excited to offer exclusive deals on their range of electric bikes, bringing families together for memorable moments. With a collection designed to combine fun and fitness, this Christmas is the perfect time to gift an unforgettable experience.

“This Christmas, we’re inviting families to rediscover the joy of outdoor exploration. Our bikes help you bond, stay active, and make the most of every moment,” said the Leoguar COO.

Leoguar’s holiday lineup offers premium e-bikes for every rider, now with unbeatable deals: 

Flippo Folding eBike: A lightweight, foldable ride perfect for urban commutes. Upgrade to the Flippo Pro for enhanced performance with a torque sensor for smoother rides.

Fastron Fat Tire eBikes: Built for rugged terrains, the Fastron features a durable, rugged build, and speeds up to 28 MPH, making it the perfect choice for adventurous riders.

Zephyr Beach Cruiser eBikes: Crafted for effortless coastal cruising, the design combines style and comfort, featuring a comfort saddle that ensures a smooth, seamless ride.

Sprint Utility eBike: A versatile, practical choice featuring a sturdy frame and passenger seat, perfect for errands or leisure.

Trailblazer EMTB: Designed for tough off-road trails, the model features a 500W mid-drive motor, offering powerful performance, extended range, and excellent climbing ability.

To make this holiday gift even sweeter, all Leoguar bikes come with free shipping and a two-year warranty for worry-free riding. Additionally, customers can join the holiday giveaway to win prizes like $59 bottle holders, or even a free e-bike!

Leoguar bikes cater to all experience levels, offering comfort and a seamless riding experience. They promote health benefits like improved fitness and stress relief while creating lasting memories on scenic rides.

“Whether it’s cruising the city streets, riding mountain trails, or relaxing by the beach, a Leoguar electric bike is the ideal Christmas gift,” the COO added. “This holiday season, choose a cycling gift that will last for years to come — there’s no better way to kick off the new year.”

To check out the full collection and take advantage of these limited-time offers, visit www.leoguarbikes.com

About Leoguar:

Leoguar is an eco-conscious e-bike brand founded by Johnny, an engineer with decades of industry expertise. Combining innovation, agility, and power, Leoguar delivers high-quality electric bikes designed for adventure, sustainability, and individuality.

Media contact: lily@leoguarbikes.com 

 

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SOURCE Leoguar Electric Bikes

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2024 Financial Oscars: Waton Securities International Honored as “Outstanding Digital Empowerment Institution” of the Year

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SHENZHEN, China, Dec. 25, 2024 /PRNewswire/ — In early December, at the 18th Huaxia Institutional Investor Annual Conference of 2024, the 18th Golden Cicada Awards were announced. Waton Securities International was awarded the “Outstanding Digital Empowerment Financial Institution of 2024” for its significant achievements in securities brokerage and fin-tech sector.

The selection for the “Outstanding Digital Empowerment Financial Institution” focused on evaluating companies based on financial performance, market competitiveness, customer recognition, digital strategy planning and implementation, digital transformation outcomes, and risk control capabilities. Particularly, it highlighted cases that have made significant strides in digital empowerment.

The evaluation also emphasized the outstanding performance of financial institutions in their own digital transformation and the sound risk control abilities demonstrated during this process, ensuring that while pursuing innovation, companies can effectively manage and control risks. Waton Securities International distinguished itself among the contenders with its sophisticated technology platform, well-defined digital strategy, substantial transformation achievements, and commendable risk control mechanisms.

Established in Hong Kong in 1989, Waton Securities International has steadily grown with a deep understanding of professional financial services and regulatory compliance. It has obtained licenses 1/4/5/9 from the Hong Kong Securities and Futures Commission, becoming a fully licensed brokerage with comprehensive financial service qualifications. Through continuous technological innovation and digital transformation, it has successfully built a one-stop brokerage cloud service platform, promoting advanced digital financial technology globally. Its pioneering SaaS product, “Broker Cloud”, allows corporate clients to independently deploy and operate high-performance digital customer information management and trading systems without their own IT teams. The solution is relatively low-cost and adaptive to industry, which is the core competitiveness of Waton Securities International.

Data reveals that of the 1,100 securities firms in Hong Kong, approximately 600 are actively trading, yet fewer than 50 have developed their own mobile applications. On a global scale, among the 30,000 securities companies, only a handful—less than 300—feature brokerage trading Apps in App stores. This underscores a significant market demand for the digital enhancement of the securities sector.

With the swift growth of technologies like generative AI LLMs, blockchain, big data, and cloud computing, the securities industry can use these tools to streamline trading strategies, assess risks more accurately, and forecast market trends. These technologies also help the industry to move towards more integrated, platform-focused, and digital operations. The main goal of technology in finance is to increase the efficiency of financial institutions. A good starting point for applying technology is to focus on financial services and build a solid technical foundation for these institutions.

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SOURCE Waton Securities

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Mega Matrix Announced that the English Version of “Getting Even: The Secret Prodigy’s Playbook” Now Streaming on FlexTV

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SINGAPORE, Dec. 25, 2024 /PRNewswire/ — The highly anticipated English adaptation of the revenge rebirth series, Getting Even: The Secret Prodigy’s Playbook, officially premiered on December 19th on FlexTV, the world-leading short drama streaming platform operated by Mega Matrix Inc. (NYSE American: MPU). The series delves into the intricacies of power struggles within the White family, chronicling the protagonist’s journey of rebirth and empowerment to rewrite her destiny.

Audrey White, the legitimate daughter of the White family, was sent abroad at a young age due to family circumstances, gradually estranging her from her kin. When she finally returns home, eager to reunite with her family, she unexpectedly becomes the target of jealousy from Ruby White, the family’s adopted daughter. Harboring deep resentment, Ruby orchestrates a kidnapping plot, culminating in a devastating fire designed to test the loyalty and affection of the White family.

Left to perish in the flames, Audrey is abandoned by her family but heroically rescued by her uncle. Miraculously, she is granted a second chance at life, returning three years prior with the power to alter her fate. Determined to expose Ruby’s schemes, rebuild her family bonds, and claim her rightful respect and happiness, Audrey embarks on a journey of resilience and redemption.

FlexTV, operated by MPU, is a global leader in short drama streaming, delivering content in over 100 countries in multiple languages, including English, Japanese, Korean, Portuguese, Spanish, French, and Arabic. Known for its premium-quality dramas and unparalleled user experience, FlexTV has captured the hearts of audiences worldwide. The English version of Getting Even: The Secret Prodigy’s Playbook, now streaming on FlexTV, offers a compelling exploration of familial power dynamics, the complexities of human nature, and the protagonist’s growth and self-redemption in adversity. For more exciting content, please visit https://www.flextv.cc/.

#WealthyFamily #Revenge #Rebirth #ShortDrama #FlexTV #MPU

About Mega Matrix Inc.: Mega Matrix Inc. (NYSE American: MPU) is a holding company and operates FlexTV, a short-video streaming platform and producer of short dramas, through its subsidiary, Yuder Pte, Ltd.. Mega Matrix Inc. is a Cayman Island corporation headquartered in Singapore. For more information, please contact info@megamatrix.io or visit: http://www.megamatrix.io.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the “safe harbor” provisions of the United States Private Securities Litigation Reform Act of 1995. All statements in this press release other than statements that are purely historical are forward looking statements. When used in this press release, the words “estimates,” “projected,” “expects,” “anticipates,” “forecasts,” “plans,” “intends,” “believes,” “seeks,” “may,” “will,” “should,” “future,” “propose,” and variations of these words or similar expressions (or the negative versions of such words or expressions) are intended to identify forward-looking statements. These forward-looking statements are not guarantees for future performance, conditions or results, and involve a number of known and unknown risks, uncertainties, assumptions and other important factors, many of which are outside the Company’s control, that could cause actual results or outcomes to differ materially from those discussed in the forward-looking statements. Important factors, among others, are: the ability to manage growth; ability to identify and integrate future acquisitions; ability to grow and expand our FlexTV business; ability to execute the strategic cooperation with TopReels, ability to obtain additional financing in the future to fund capital expenditures; ability to establish the investment fund with 9 Yards Communications under the memorandum of understanding; fluctuations in general economic and business conditions; costs or other factors adversely affecting the Company’s profitability; litigation involving patents, intellectual property, and other matters; potential changes in the legislative and regulatory environment; a pandemic or epidemic; the possibility that the Company may not succeed in developing its new lines of businesses due to, among other things, changes in the business environment, competition, changes in regulation, or other economic and policy factors; and the possibility that the Company’s new lines of business may be adversely affected by other economic, business, and/or competitive factors. The forward-looking statements in this press release and the Company’s future results of operations are subject to additional risks and uncertainties set forth under the “Risk Factors” in documents filed by the Company’s predecessor, Mega Matrix Corp., with the Securities and Exchange Commission, including the Company’s latest annual report on Form 10-K, as amended, and are based on information available to the Company on the date hereof. In addition, such risks and uncertainties include the Company’s inability to predict or control bankruptcy proceedings and the uncertainties surrounding the ability to generate cash proceeds through the sale or other monetization of the Company’s assets. The Company undertakes no obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by applicable law. Readers are cautioned not to place undue reliance on forward-looking statements, which speak only as of the date of this press release.

Disclosure Channels

We announce material information about the Company and its services and for complying with our disclosure obligation under Regulation FD via the following social media channels:

The Company will also use its landing page on its corporate website (www.megamatrix.io) to host social media disclosures and/or links to/from such disclosures. The information we post through these social media channels may be deemed material. Accordingly, investors should monitor these social media channels in addition to following our website, press releases, SEC filings and public conference calls and webcasts. The social media channels that we intend to use as a means of disclosing the information described above may be updated from time to time as listed on our website.

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SOURCE Mega Matrix Corp.

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