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Pioneering Insights: ERG, Lotus, and GMG Unveil Study on the potential impact of GLP-1 Agonists and Cognitive Health in Diabetes and Obesity

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NEW PROVIDENCE, N.J., Oct. 29, 2024 /PRNewswire/ — Evolution Research Group (ERG) and Lotus, portfolio companies of Emerge HoldCo, LLC, in collaboration with their strategic partner Gonzaba Medical Group (GMG), have launched a groundbreaking retrospective study to examine the potential cognitive effects of Glucagon-like peptide-1 (GLP-1) agonists in patients with type 2 diabetes and obesity.

Study Overview: This retrospective observational cohort study aims to assess the cognitive impact of GLP-1 agonist therapies. GLP-1 agonists, which have proven highly effective in managing type 2 diabetes and promoting weight loss, are now being studied for their potential neuroprotective effects. The study will leverage GMG’s unique patient base, which reflects San Antonio’s diverse population, including a high proportion of Hispanic individuals. This demographic focus adds to the importance of the study, as addressing health disparities in cognitive outcomes for populations with higher risk factors, such as Type 2 diabetes and obesity, is a pressing area of clinical research. De-identified data from GMG’s extensive electronic medical records (EMRs) will be utilized to evaluate whether the initiation of GLP-1 therapies is associated with changes in cognitive function, as measured by standard cognitive assessment tools such as the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA), compared to a control group with similar baseline characteristics but without GLP-1 exposure. Secondary objectives will explore the role of confounding variables, including comorbidities, age, and concomitant medications known to influence cognitive outcomes.

Advanced Data Analysis: The study is being performed under the oversight of the company’s Publication and Dissemination Group, formed to ensure the quality and rigor of scientific outputs of the company’s subsidiaries. To ensure robust analysis, the study will employ both linear and logistic regression models to assess relationships between GLP-1 use and cognitive outcomes. Confounding factors such as age, gender, baseline cognitive function, and lifestyle characteristics will be adjusted using propensity score matching and multivariate regression models. Exploratory analyses will further investigate the potential effects of GLP-1 therapy duration on cognitive outcomes.

Significance of the Study: This study represents a significant step towards better understanding the broader health benefits of GLP-1 agonists beyond their metabolic effects. Cognitive decline, a common concern for patients with diabetes and obesity, could potentially be mitigated through the neuroprotective properties of GLP-1 agonists. The study’s findings could help pave the way for new therapeutic applications and contribute to the development of clinical guidelines aimed at preserving cognitive function in high-risk populations.

ERG and Lotus, through their collaboration with Gonzaba Medical Group, are dedicated to advancing scientific knowledge and improving patient outcomes. The results of this study are expected to be submitted for consideration at the 2025 American Diabetes Association Scientific Sessions.

For further information or media inquiries, please contact:

Clayton A. Dehn
Chief Scientific Officer &
Therapeutic Area Lead – Metabolism & Endocrinology
Evolution Research Group
Email: CDehn@ERGClinical.com
Phone: 210-859-1918

About Evolution Research Group (ERG) and Lotus CRO:
ERG and Lotus are subsidiaries of Emerge HoldCo, LLC, specializing in clinical research and development across multiple therapeutic areas, including metabolic, endocrine, and neurocognitive disorders. Both companies are committed to advancing scientific innovation through high-quality clinical research.

Contact: Luke Kramer, lkramer@ergclinical.com

View original content to download multimedia:https://www.prnewswire.com/news-releases/pioneering-insights-erg-lotus-and-gmg-unveil-study-on-the-potential-impact-of-glp-1-agonists-and-cognitive-health-in-diabetes-and-obesity-302289057.html

SOURCE Evolution Research Group, LLC

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Stora Enso Oyj: Notification of Change in Holdings according to Chapter 9, Section 10 of the Finnish Securities Markets Act (25 December 2024)

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1 hour ago

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December 27, 2024

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STORA ENSO OYJ STOCK EXCHANGE RELEASE 27 December 2024 at 09:00 EET

HELSINKI, Dec. 27, 2024 /PRNewswire/ — Stora Enso Oyj received a notification pursuant to chapter 9, section 5 of the Securities Market Act from BlackRock, Inc on 27 December 2024.

On 25 December 2024, BlackRock’s holding in Stora Enso’s shares decreased below the 5 percent threshold.

% of shares and voting rights (total of 7.A)

% of shares and voting rights through financial instruments (total of 7.B)

Total of both in % (7.A + 7.B)

Resulting situation on the date on which threshold was crossed or reached

4.76% shares

Below 5% voting rights

0.27% shares

Below 5% voting rights

5.04% shares

Below 5% voting rights

Position of previous notification (if applicable)

Below 5% shares

Below 5% voting rights

Below 5% shares

Below 5% voting rights

Below 5% shares

Below 5% voting rights

 

A: Shares and voting rights

Class/type of shares

ISIN code (if possible)

Number of shares and voting rights

% of shares and voting rights

Direct

(SMA 9:5)

Indirect

(SMA 9:6 and 9:7)

Direct

(SMA 9:5)

Indirect

(SMA 9:6 and 9:7)

FI0009005961

37,609,170  shares

Below 5% voting rights

4.76% shares Below 5% voting rights

SUBTOTAL A

37,609,170 shares

Below 5% voting rights

4.76% shares

Below 5% voting rights

B: Financial Instruments according to SMA 9:6a

Type of financial instrument

Expiration date

Exercise/Conversion Period

Physical or cash settlement

Number of shares and voting rights

% of shares and voting rights

American Depositary Receipt (US86210M1062)

N/A

N/A

Physical

596,930 shares

Below 5% voting rights

0.07% shares

Below 5% voting rights

Securites lent

N7A

N/A

Physical

1,036,720 shares

Below 5% voting rights

0.13% shares

Below 5% voting rights

CFD

N/A

N/A

Cash

563,510 shares

Below 5% voting rights

0.07% shares

Below 5% voting rights

SUBTOTAL B

2,197,160 shares

Below 5% voting rights

0.27% shares

Below 5% voting rights

 

Stora Enso has two series of shares. Each A share and every ten R shares carry one vote. Stora Enso has 175,664,079 A shares and 612,955,908 R shares in issue. The Company does not hold its own shares. The total number of Stora Enso shares is 788,619,987 and the total number votes at least 236,959,669.

Investor enquiries:
Anna-Lena Åström
SVP Investor Relations
tel. +46 70 210 7691 

Stora Enso

Part of the global bioeconomy, Stora Enso is a leading provider of renewable products in packaging, biomaterials and wooden construction, and one of the largest private forest owners in the world. We create value with our low-carbon and recyclable fiber-based products, through which we support our customers in meeting the demand for renewable sustainable products. Stora Enso has approximately 20,000 employees and our sales in 2023 were EUR 9.4 billion. Stora Enso shares are listed on Nasdaq Helsinki Oy (STEAV, STERV) and Nasdaq Stockholm AB (STE A, STE R). In addition, the shares are traded in OTC Markets (OTCQX) in the USA as ADRs and ordinary shares (SEOAY, SEOFF, SEOJF). storaenso.com/investors

STORA ENSO OYJ

Investor enquiries:
Anna-Lena Åström
SVP Investor Relations
tel. +46 70 210 7691 

This information was brought to you by Cision http://news.cision.com.

https://news.cision.com/stora-enso-oyj/r/stora-enso-oyj–notification-of-change-in-holdings-according-to-chapter-9–section-10-of-the-finnish,c4086606

The following files are available for download:

https://mb.cision.com/Main/13589/4086606/3189711.pdf

STORA ENSO Class R_2024-12-25_Issuer

 

View original content:https://www.prnewswire.com/news-releases/stora-enso-oyj-notification-of-change-in-holdings-according-to-chapter-9-section-10-of-the-finnish-securities-markets-act-25-december-2024-302339535.html

SOURCE Stora Enso Oyj

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Truecaller continues strong growth, surpasses 400 million Android users

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1 hour ago

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December 27, 2024

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STOCKHOLM, Dec. 27, 2024 /PRNewswire/ — Truecaller, the leading global platform for verifying contacts and blocking unwanted communication, reached another important milestone on 24th of December, when the number of monthly active users (MAU) on the operating system Android surpassed 400 million. Truecaller continues to grow rapidly in many geographic markets and the total user base has grown with more than 57 million users during 2024 and has now surpassed 433 million users in total.

“Truecaller’s strong commitment to help businesses and individuals communicate better through both calls and messages, continues to grow. Our geographical footprint is growing each day, and the development in our targeted growth markets is strong. We’re thrilled at achieving this milestone and we look forward to serving the next 400 million Android users,” says Rishit Jhunjuhnwala, Chief Product Officer and incoming CEO of Truecaller.

The growth in India continues to be strong with a growth of approximately 37 million users in but the relative growth in other parts of the world is stronger with a growth of 20 million users during 2024.

Truecaller will continue to report the average number of monthly and daily users on a quarterly basis in connection with interim reports.

For more information, please contact:
Andreas Frid, Head of IR & Communication
+46 705 29 08 00
andreas.frid@truecaller.com

About Truecaller:

Truecaller (TRUE B) is the leading global platform for verifying contacts and blocking unwanted communication. We enable safe and relevant conversations between people and make it efficient for businesses to connect with consumers. Fraud and unwanted communication are endemic to digital economies. especially in emerging markets. We are on a mission to build trust in communication. Truecaller is an essential part of everyday communication for more than 433 million active users. Truecaller is listed on Nasdaq Stockholm since 8 October 2021. For more information. please visit corporate.truecaller.com

This information was brought to you by Cision http://news.cision.com

https://news.cision.com/truecaller-ab/r/truecaller-continues-strong-growth–surpasses-400-million-android-users,c4086573

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View original content:https://www.prnewswire.com/news-releases/truecaller-continues-strong-growth-surpasses-400-million-android-users-302339536.html

SOURCE Truecaller AB

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Xinhua Silk Road: Conference on deepening financial openness and co-op in Northeast Asia held in NE. China’s Shenyang

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1 hour ago

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December 27, 2024

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BEIJING, Dec. 27, 2024 /PRNewswire/ — The 2nd Northeast Asia Finance Conference and 2024 “Revitalizing Liaoning with Finance” Excellent Cases Release kicked off on Tuesday in Shenyang, capital of northeast China’s Liaoning Province, aiming to further deepen financial openness and cooperation in the Northeast Asian region and advance construction of a regional financial center.

The main forum held a series of activities, including an opening ceremony, two round-table dialogues on “finance + biomedical industry” and “finance + cultural industry”, a symposium for foreign financial institutions, a seminar on innovative development of financial clusters, a forum on development of technology and finance, a forum on industrial low-carbon transformation and financial innovation, as well as an enterprise project roadshow and industry-finance matchmaking event.

During the conference themed on “accelerating the construction of a regional financial center in Northeast Asia and creating a new highland for opening up”, excellent cases of revitalizing Liaoning through finance in 2024 were unveiled and the index for core areas of regional financial centers in northeast China was released.

The conference also held an unveiling ceremony for the upgrading of the Shenyang finance and trade development zone to a national-level development zone, and a launch ceremony of a platform for Shenyang industrial insights and decision analysis.

The conference was co-hosted by China Economic Information Service, Liaoning Branch of Xinhua News Agency, Shenhe District People’s Government, Shenyang local financial administration under guidance of Shenyang Municipal People’s Government and Liaoning local financial supervision and administration bureau.

Original link: https://en.imsilkroad.com/p/343777.html

View original content to download multimedia:https://www.prnewswire.com/apac/news-releases/xinhua-silk-road-conference-on-deepening-financial-openness-and-co-op-in-northeast-asia-held-in-ne-chinas-shenyang-302339540.html

SOURCE Xinhua Silk Road

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