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Vitamin K supplement slows prostate cancer in mice

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COLD SPRING HARBOR, N.Y., Oct. 24, 2024 /PRNewswire/ — Prostate cancer is a quiet killer. In most men, it’s treatable. However, in some cases, it resists all known therapies and turns extremely deadly. A new discovery at Cold Spring Harbor Laboratory (CSHL) points to a potentially groundbreaking solution. CSHL Professor Lloyd Trotman‘s lab has found that the pro-oxidant supplement menadione slows prostate cancer progression in mice. The supplement is a precursor to vitamin K, commonly found in leafy greens. The story begins more than two decades ago.

In 2001, the National Cancer Institute’s SELECT trial sought to determine if an antioxidant vitamin E supplement could successfully treat or prevent prostate cancer. The trial involving 35,000 men was planned to last up to 12 years. However, after just three years, participants were told to stop taking their supplements. Not only had vitamin E failed to slow or prevent prostate cancer—more men taking the supplement started to get the disease. Seeing these results, Trotman thought, ‘If an antioxidant failed, maybe a pro-oxidant would work.’ His new findings in mice show just that.

When mice with prostate cancer are given menadione, it messes with the cancer’s survival processes. Trotman’s team has discovered that menadione kills prostate cancer cells by depleting a lipid called PI(3)P, which works like an ID tag. Without it, the cells stop recycling incoming materials and eventually explode. Trotman explains:

“It’s like a transport hub, like JFK. If everything that goes in is immediately de-identified, nobody knows where the airplanes should go next. New stuff keeps coming in, and the hub starts to swell. This ultimately leads to the cell bursting.”

This causes the cancer’s progression to slow significantly in mice. Trotman now hopes to see the experiment translated to pilot studies in human prostate cancer patients:

“Our target group would be men who get biopsies and have an early form of the disease diagnosed. We wonder if they start to take the supplement, whether we would be able to slow that disease down.”

Amazingly, Trotman’s research suggests menadione may also prove effective against myotubular myopathy, a rare condition that prevents muscle growth in infant boys. Those diagnosed rarely live beyond early childhood. Trotman’s lab has found that depleting PI(3)P with menadione can double the lifespan of mice with this condition.

If the results hold up in humans, it would mean that men with prostate cancer can enjoy a better quality of life and more time with their families. It could also mean more precious time for children born with an incurable disease.

About Cold Spring Harbor Laboratory
Founded in 1890, Cold Spring Harbor Laboratory has shaped contemporary biomedical research and education with programs in cancer, neuroscience, plant biology and quantitative biology. Home to eight Nobel Prize winners, the private, not-for-profit Laboratory employs 1,000 people including 600 scientists, students and technicians. For more information, visit www.cshl.edu

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SOURCE Cold Spring Harbor Laboratory

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Noted National Engineering Author Jayshree Seth Shares Life Lessons from a Career in STEM at Society of Women Engineers Annual Meeting in Chicago

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Nationally known author, TEDx speaker and 3M Chief Science Advocate Jayshree Seth, Ph.D. was in Chicago today sharing life lessons from her new book with fellow engineers at the Society of Women Engineers Annual Meeting.

CHICAGO, Oct. 24, 2024 /PRNewswire-PRWeb/ — Noted National Engineering Author Jayshree Seth Shares Life Lessons from a Career in STEM at Society of Women Engineers Annual Meeting in Chicago
(ChicagoOctober 24, 2024) – Nationally known author, TEDx speaker and 3M Chief Science Advocate Jayshree Seth, Ph.D. was in Chicago today sharing life lessons from her new book with fellow engineers at the Society of Women Engineers Annual Meeting.

The book, “The Heart of the Science: Engineering Blueprint,” covers a wide range of STEM-related topics in four main sections and is the last in the SWE published trilogy with Seth, which includes “The Heart of Science: Engineering Fine Print,” and “The Heart of Science: Engineering Footprints and Imprints.” The book provides guidance to those in STEM or those considering a career in STEM.

The interactive format of the book provides an immersive experience for the reader with each chapter addressing practical topics, real-life application of the topic from Seth’s career, infographics providing a visual representation of the chapter, and a workbook for the reader to apply the lessons learned in their life. The book serves as the reader’s personal mentoring session with Seth.

In her introduction to her latest book, Seth sets forth her intention for readers.

“I didn’t start my career knowing how to think in ways that empowered me. I had to come into it through transition, reflection, and empowered action,” she writes. “A lot of these exercises ask you to stretch to places and roles you have only encountered in your imagination. It will plant the seeds in your head that will help you cultivate your specific way of thinking.”

Some of the topics addressed include:

    Influencing others to impact change    Managing opposition to diversity initiatives    Driving a sustainability leadership mindset    Viewing everyone as a mentor

Unique to this book is the workbook at the end of every chapter, which Seth aptly calls “Draft Blueprints” as they provide readers with their personal draft that they can implement using key points gleaned from Seth’s insights and real-life experiences, crafting a dynamic publication that the reader will find engaging and practical.

“SWE is honored to support Jayshree’s book and her commitment to helping young women entering the engineering field,” said Karen Hortin, executive direct and CEO of SWE. “The latest book serves as the perfect capstone course to her trilogy of invaluable teachings.”

Seth, a corporate innovator, and first-ever chief science advocate, is a prolific inventor, author, speaker and thought leader. She holds 80 patents and provides unique and practical perspectives on innovation, leadership, culture, and careers. Seth was featured in the 3M docuseries, “Not the Science Type,” which premiered during Tribeca Film Festival in 2021. She also received The Society of Women Engineers Achievement Award in 2020.

All proceeds go toward the Jayshree Seth Scholarship for Women of Color in STEM, administered by the Society of Women Engineers. The Scholarship is aimed at helping underrepresented minorities advance in STEM education and professionals related to engineering and technology. The scholarship has awarded $29,000 to five individuals since its inception in 2021.

To order “The Heart of Science: Engineering Blueprint,” visit https://a.co/d/bR3NgIN.

About SWE

The Society of Women Engineers (SWE), founded in 1950, is the world’s largest advocate and catalyst for change for women in engineering and technology. The not-for-profit educational and service organization is the driving force that establishes engineering as a highly desirable career aspiration for women. To ensure SWE members reach their full potential as engineers and leaders, the Society offers unique opportunities to network, provides professional development, shapes public policy and provides recognition for the life-changing contributions and achievements of women engineers. As a champion of diversity, SWE empowers women to succeed and advance in their personal and professional lives. For more information about the Society, please visit http://www.swe.org or call 312.596.5223. 

Media Contact

Christopher David Martin, The Society of Women Engineers, 6306702745, cmartin@davidjamesgroup.com, www.swe.org

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SOURCE The Society of Women Engineers

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CFG: UK MEDICAL JOURNAL EXPOSES HEALTH HARM FROM ONLINE GAMBLING

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LONDON, Oct. 24, 2024 /PRNewswire/ — A new report published in The Lancet Public Health reveals the urgent need for regulatory reform as the global expansion of commercial gambling is causing widespread and underestimated harm to public health. 

A new report in The Lancet Public Health reveals the need for gambling reform as expansion is harming public health.

“As a philanthropic gambling reform advocate, I started CFG as a US-facing site, knowing how disastrous the UK experience of online gambling has been,” said Derek Webb, founder and funder of the Campaign for Fairer Gambling (CFG). “This damning Lancet report confirms my worst fears: the financially-motivated trade bodies and their associated proponents have been responsible for generational harm to individuals.”

The Lancet Public Health Commission calls for regulatory reform to tackle the health impacts of the rapid global expansion of commercial gambling. Key findings include:

Gambling harms are far more substantial than previously understood, exacerbated by rapid global expansion and digital transformation of the gambling industry. Harms from gambling include physical and mental health problems, relationship breakdown, heightened risk of suicide and domestic violence, increased crime, loss of employment and financial losses.An estimated 80 million adults globally experience gambling disorder or problematic gambling.The harms of gambling are not evenly distributed; adolescents, children and those from disadvantaged socioeconomic groups are more at risk. Lower- and middle-income countries are less equipped to regulate the industry and deal with the harms it generates. Effective and well-resourced regulatory controls and international leadership are urgently needed to reduce the impact of commercial gambling on public health and protect progress on UN Sustainable Development Goals.

Stronger global regulatory controls are needed to reduce the impact of commercial gambling on worldwide health and wellbeing, according to the Lancet Public Health Commission.

The Commission brought together a multidisciplinary group of leading experts in gambling studies, public health, global health policy, risk control and regulatory policy, alongside contributors who have first-hand experience of gambling harms. After reviewing the literature, and figures generated from a systematic review and meta-analysis, the Commissioners concluded that “gambling poses a threat to public health, the control of which requires a substantial expansion and tightening of gambling industry regulation.”

“There is an urgent need for a US federal investigation into online gambling, which did not exist when the last gambling investigation occurred in 1999,” Webb concluded. 

CFG is an independent gambling reform group with deep knowledge of the gambling sector’s business and lobbying practices in both the U.K. and the U.S. CFG is dedicated to promoting fairer gambling practices through research, advocacy, and reform. CFG exists to equip policymakers with real, reliable data to foster more informed, balanced debates and ultimately smarter gambling policy. For more information, visit fairergambling.com or follow @fairergambling on X.

View original content to download multimedia:https://www.prnewswire.com/news-releases/cfg-uk-medical-journal-exposes-health-harm-from-online-gambling-302286763.html

SOURCE The Campaign for Fairer Gambling

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Cato Networks Announces Inaugural Americas Partner Awards at 2024 Americas Partner Summit

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Cato recognizes partners with highest business impact in 2024

LAS VEGAS, Oct. 24, 2024 /PRNewswire/ — Cato Networks, the SASE leader, today announced the winners of its inaugural Americas Partner Awards at the 2024 Cato Networks Americas Partner Summit in Las Vegas. The 2024 Cato Networks Americas Partner Awards celebrate partners that demonstrate commitment to the Cato customer experience, innovation with the use of Cato products, and outstanding business results.

“As the SASE leader and a partner-first company, Cato Networks is committed to empowering the channel community to be in the best position to win and retain SASE customers,” said Frank Rauch, global channel chief at Cato Networks. “Our partners drive Cato’s success and it’s important that we recognize them for their accomplishments this year. Congratulations to our partner award winners. Together, we are redefining the IT security market with SASE.”

Winners include:

Reseller Partner of the Year – Alchemy Technology GroupTSD Partner of the Year – AVANT CommunicationsTrusted Advisor Acceleration Partner of the Year – CompuNetAcceleration Partner of the Year – GuidePoint SecurityMarketing Campaign of the Year – Intrepid TEQMSP Partner of the Year – Matrix NetworksTrusted Advisor Partner of the Year – Paradigm Technology GroupService Provider Partner of the Year – Windstream EnterpriseBrand and Social Media Partner of the Year – XenTegra

Resources

Visit Cato’s partner page for more information about the global partner program.Visit the Cato MSASE Partner Platform page for more information about managed SASE.

About Cato Networks

Cato Networks delivers enterprise security and networking in a single cloud platform. The SASE leader creates a seamless and elegant customer experience that effortlessly enables threat prevention, data protection, and timely incident detection and response. With Cato, organizations replace costly and rigid legacy infrastructure with an open and modular SASE architecture based on SD-WAN, a purpose-built global cloud network, and an embedded cloud-native security stack. 

Want to learn why thousands of organizations secure their future with Cato? Visit us at www.catonetworks.com.

Media Contact

Cato Communications
press@catonetworks.com

View original content:https://www.prnewswire.co.uk/news-releases/cato-networks-announces-inaugural-americas-partner-awards-at-2024-americas-partner-summit-302286392.html

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