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Waters New Bioseparations Tools Accelerate and Improve Development of RNA-based Vaccines and Therapies Using LC-MS Analysis

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Waters new LC-MS grade reagents, enzymes, and software simplify large molecule RNA analysis to accelerate and improve development of mRNA vaccines, personalized cancer therapies, and innovative drugs for genetic disorders.Novel digestion enzymes deliver complete RNA sequence coveragei for more confident characterization, while new LC-MS-grade reagents increase sensitivity and improve detection accuracy of RNA components.iiNew waters_connect™ MAP Sequence software accelerates RNA oligonucleotide mapping using semi-automated workflows that reduce data processing time over manual techniques, enabling routine monitoring of key product attributes.

MILFORD, Mass., Oct. 14, 2024 /PRNewswire/ — Waters Corporation (NYSE: WAT) today introduced a comprehensive set of sample preparation enzymes, reagents, and waters_connect software that simplify sequence and modification confirmation of large molecule RNA therapeutics using liquid chromatography-mass spectrometry (LC-MS) analysis. When used together in a workflow, these bioseparations tools help accelerate and improve the development of innovative large molecule RNA-based pharmaceuticals, such as CRISPR sgRNA and mRNA therapeutics.

Large molecule RNA (ribonucleic acid) therapeutics represent some of the most exciting and potentially life-saving developments in pharmaceuticals today. They include new and more effective vaccines for diseases like COVID-19, personalized cancer treatments, as well as emerging CRISPR RNA therapies that address challenging genetic conditions, such as sickle cell anemia.

“As RNA-based therapies are prepared for widespread use, more direct composition measurements are needed to ensure stability, safety, and effectiveness for patients,” said Erin Chambers, Vice President, Consumables and Lab Automation at Waters Corporation. “The combination of Waters enzymes, reagents, and software are specially designed to simplify the confirmation of sequence and modifications of complex molecules. These analytical tools can accelerate RNA therapeutic development and lower barriers for use by LC-MS non-experts.”

“As innovators looking to help our customers advance nucleic acid-based therapies and reduce the burden of serious diseases, we are always seeking new technologies to improve characterization and accelerate development,” said Arnaud Delobel, PhD, R&D and Innovation Director at Quality Assistance S.A. and beta tester of the Waters RNA analytical tools. “Waters new enzymes efficiently digest mRNA and sgRNA with short incubation times and data processing in MAP Sequence allows the user to obtain reproducible results quickly with confidence.”

The Waters RNA analytical tools include:

Enzymes: Two novel enzymes, RapiZyme™ MC1 and RapiZyme Cusativin, are used in a simplified three-step protocol that provides complete LC-MS sequence coverage over traditional digestion methods enabling more confident characterization of RNA molecules.iiiReagents: IonHance™ HFIP, an LC-MS-grade reagent, is formulated to improve ionization and delivers increased spectral clarity and detection accuracy of RNA components.Software: New MAP Sequence application on the waters_connect software platform simplifies RNA LC-MS oligo mapping workflows to accelerate analysis and data processing time over manual techniques using spreadsheets.

Used together within a workflow, the tools generate an LC-MS fingerprint to confirm product identity, purity, and efficacy. The tools improve sequence coverage, LC-MS spectral data quality, and data interpretation. Supported by the compliance-ready waters_connect software platform, these tools help transition LC and LC-MS-based digestion analysis from discovery and development to release and at-line process analytical testing.

Waters RapiZyme RNAses and IonHance HFIP are now available. The new MAP Sequence App on waters_connect software will be available on October 18, 2024.

Additional Resources

Learn more about the Waters RNA Analytical ToolsListen to our webinar “Cracking the Code: Analyzing mRNA and sgRNA with Advanced Enzymes, Mass Spectrometry, and Informatics on Oct. 16 at 11:00am ETJoin Waters at the PharmSci 360 conference for an expert session on “Oligo Mapping of Large RNA Therapeutics by Novel Enzyme Specificities” with Dr. Bala Addepalli, Waters Director, R&D New Modalities Portfolio on Oct. 21, at 11:00am ETFollow and connect with Waters via LinkedIn, Twitter, and Facebook

About Waters Corporation (www.waters.com)

Waters Corporation (NYSE: WAT), a global leader in analytical instruments and software, has pioneered chromatography, mass spectrometry, and thermal analysis innovations serving the life, materials, food, and environmental sciences for more than 65 years. With approximately 7,500 employees worldwide, Waters operates directly in 35 countries, including 14 manufacturing facilities, and with products available in more than 100 countries.

Waters, Rapizyme, IonHance, and waters_connect are trademarks of Waters Technologies Corporation.

Contact:
Janice Foley
Senior Public Relations Manager, Corporate Communications
Waters Corporation
janice_foley@waters.com
+1.617.823.5555

i 100% RNA sequence coverage achieved for HPRT sgRNA digested with RapiZyme MC1 and RapiZyme Cusativin compared to traditional digestion methods such as RNase T1. Waters Application Note 720008539EN: “Tunable Digestions of RNA Using RapiZyme RNases to Confirm Sequence and Map Modifications” .

ii IonHance HFIP reagents are certified to contain less than 100 ppb sodium and less than 100 ppb potassium content, resulting in reduced adduct formation and improved sensitivity of RNA detection compared to commercially available HFIP. Waters Application Note 720008540EN: “Evaluating IonHance Hexafluoroisopropanol (HFIP) for Enhanced LC-MS Oligonucleotide Analysis”

iii Waters RapiZyme RNase protocol simplifies sample preparation with three steps including reagent preparation, RNA digestion, and heat inactivation without the need to add chemical denaturants and enzyme inhibitors.

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WEKA Recognized as a Visionary in 2024 Gartner® Magic Quadrant™ for File & Object Storage Platforms

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CAMPBELL, Calif., Oct. 14, 2024 /PRNewswire/ — WekaIO (WEKA), the AI-native data platform company, announced today that it has been named a Visionary in the 2024 Gartner® Magic Quadrant™ for File & Object Storage Platforms. The company was evaluated for its WEKA® Data Platform software solution and recognized for its Completeness of Vision and Ability to Execute. WEKA was previously named a Visionary in the Gartner® Magic Quadrant™ for Distributed File Systems and Object Storage from 2021 through 2023.

According to the report, “Gartner defines file and object storage platforms as software and/or hardware platforms that offer object and distributed file system technologies for storing and managing unstructured data over NFS, SMB and Amazon S3 access protocols.”

Gartner predicts, “By 2029, over 80% of unstructured data will be deployed on a consolidated storage platform instead of separate file and object products, up from 40% in early 2024.” 1

WEKA delivers a unified platform-based solution that provides integrated file and object storage capabilities for unstructured data management and performance-intensive workloads across edge, core, cloud, and hybrid environments. It was purpose-built to deliver exceptional performance at scale and provides an optimal environment for modern data-intensive applications like generative AI, high-performance computing, and GPU acceleration.

“The AI revolution is rapidly reshaping enterprise data strategies, dissolving the walls of the traditional data center in favor of data pipeline-oriented architectures. A decade ago, we saw this wave of modern, data-intensive workloads coming for enterprise customers and set out to create a single, unified platform approach to unstructured data management that would eliminate the performance bottlenecks and inefficiencies of traditional data infrastructure,” said Liran Zvibel, co-founder and chief executive officer at WEKA. “We believe the updated view from Gartner of the file and object storage market aligns with that vision. WEKA is honored to be recognized as a Visionary in the 2024 Gartner Magic Quadrant for File & Object Storage Platforms.”

A complimentary copy of the 2024 Gartner Magic Quadrant for File & Object Storage Platforms can be obtained from WEKA – no registration required. Visit https://www.weka.io/lp/gartner-magic-quadrant-2024-visionary/ to view and download the report.

[1] Gartner Magic Quadrant for File and Object Storage Platforms, Chandra Mukhyala, Julia Palmer, Jeff Vogel, Published 8 October 2024 – ID G00805183

Disclaimer: Gartner does not endorse any vendor, product or service depicted in its research publications and does not advise technology users to select only those vendors with the highest ratings or other designation. Gartner research publications consist of the opinions of Gartner’s research organization and should not be construed as statements of fact. Gartner disclaims all warranties, expressed or implied, with respect to this research, including any warranties of merchantability or fitness for a particular purpose.

GARTNER is a registered trademark and service mark and MAGIC QUADRANT is a registered trademark of Gartner, Inc. and/or its affiliates in the U.S. and internationally and are used herein with permission. All rights reserved.

About WEKA 
WEKA is architecting a new approach to the enterprise data stack built for the AI era. The WEKA® Data Platform sets the standard for AI infrastructure with a cloud and AI-native architecture that can be deployed anywhere, providing seamless data portability across on-premises, cloud, and edge environments. It transforms legacy data silos into dynamic data pipelines that accelerate GPUs, AI model training and inference, and other performance-intensive workloads, enabling them to work more efficiently, consume less energy, and reduce associated carbon emissions. WEKA helps the world’s most innovative enterprises and research organizations overcome complex data challenges to reach discoveries, insights, and outcomes faster and more sustainably – including 12 of the Fortune 50. Visit www.weka.io to learn more, or connect with WEKA on LinkedIn, X, and Facebook.

WEKA and the WEKA logo are registered trademarks of WekaIO, Inc. Other trade names used herein may be trademarks of their respective owners. 

 

View original content:https://www.prnewswire.com/apac/news-releases/weka-recognized-as-a-visionary-in-2024-gartner-magic-quadrant-for-file–object-storage-platforms-302274159.html

SOURCE WekaIO

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LG Electronics Partners with BillEase to Offer 0% Installment Plans on LG Products

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MANILA, Philippines, Oct. 14, 2024 /PRNewswire/ — LG Electronics Philippines, a global leader in consumer electronics, has teamed up with BillEase, a top digital finance app, to offer 0% interest installment plans on their official online store. Through this partnership, LG customers can now enjoy flexible payment options, including 3- or 6-month installment plans with no interest, as well as extended terms of up to 12 months for all LG products.

The LG-BillEase partnership offers several key features designed to benefit consumers. Customers can take advantage of real 0% interest plans on 3- or 6-month installment options, providing a truly cost-effective way to purchase LG products. For those needing more time, the partnership offers flexible payment terms, allowing shoppers to extend their 3- or 6-month payment plans to as long as 12 months. This flexibility ensures that customers can choose a payment schedule that best fits their financial situation.

New customers will appreciate the quick approval process, with a fast and easy sign-up that provides approval in just a few minutes. This streamlined approach minimizes wait times and allows customers to complete their purchases swiftly. Additionally, eligible buyers can purchase their preferred LG electronics without any upfront payment, as no down payment is required. This feature makes it even easier for consumers to access LG’s high-quality products without immediate financial strain.

Kurt Molina, Head of Merchant Products at BillEase, shared, “We’re thrilled to collaborate with LG Electronics to bring these convenient installment plans to Filipino consumers. This partnership underscores our mission to empower both businesses and customers with financial solutions that enhance accessibility and affordability.”

LG Philippines’ Managing Director, Nakhyun Seong added, “At LG, we are committed to bringing high-quality electronics to every Filipino home. By partnering with BillEase, we’re able to offer more flexible and hassle-free payment options, allowing more consumers to enjoy our cutting-edge technology without the financial burden.”

The partnership between LG Electronics and BillEase comes at a crucial time for the Philippine e-commerce market. With the digital economy experiencing unprecedented growth, online shopping has become an integral part of consumers’ lives. According to recent industry reports, the Philippines’ e-commerce sector is projected to grow by 15% annually through 2025, driven by increasing internet penetration and smartphone usage. This collaboration not only aligns with the shifting consumer preferences toward online purchases but also addresses the growing demand for flexible payment solutions. By offering installment plans, LG and BillEase are making high-quality electronics more accessible to a broader segment of Filipino consumers, thus playing a significant role in driving digital inclusion and economic growth in the country.

LG products are now available for purchase with BillEase installment options on LG’s official website. Visit https://www.lg.com/ph to explore this exclusive offer.

About BillEase

BillEase is a leading consumer finance app in the Philippines. The company leverages machine learning and AI to build financial products while mixing traditional global best practices in credit underwriting to meet the needs of its customers. BillEase offers personal loans, e-wallet top-ups, prepaid load, gaming credits, bill payment, and a unique buy now, pay later (BNPL) that offers competitive interest rates and deals from over 10,000 merchants and over 600,000 QRPh-accepting merchants. For more information, visit https://billease.ph/.

About LG
LG Electronics Philippines delivers top-of-the-line consumer electronics and home appliances that prepare Filipinos for their greatest moments. LG promises to bring “Innovation for a Better Life” nationwide, and their products are available via https://www.lg.com/ph/.

For more information, visit and follow their social media channels on Facebook, Instagram, TikTok, and YouTube (@lgphilippines).

For more information about this press release, please contact us at marketing@billease.ph.

View original content:https://www.prnewswire.com/apac/news-releases/lg-electronics-partners-with-billease-to-offer-0-installment-plans-on-lg-products-302274529.html

SOURCE BillEase

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Gunbound Returns! Gravity and Softnyx Unite to Bring Iconic Game to LATAM & SEA Players

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A Strategic Partnership for a Beloved PC Online Classic

SINGAPORE, Oct. 14, 2024 /PRNewswire/ — Gravity Game Hub, a subsidiary of Gravity Co., Ltd. (NasdaqGM: GRVY), a global leader in online game development and publishing, and Softnyx, the original creator of Gunbound, today announced a strategic partnership to bring the beloved artillery game back to players worldwide.

This collaboration represents a key milestone for both companies as they combine their respective strengths to revive a PC Online classic. Gravity brings its extensive publishing expertise, honed through successes such as the globally recognized Ragnarok Online franchise, while Softnyx contributes its deep understanding of Gunbound’s gameplay and community, ensuring an authentic and engaging experience for both long-time fans and new players.

Shared Vision for Gunbound’s Revival

“While Ragnarok Online has been a cornerstone of our success, we understand the importance of diversifying our game portfolio. Gunbound’s strong brand and dedicated fan base align with our growth strategy. As a beloved classic that resonates with a different audience segment, we aim to rekindle the passion and excitement it once ignited among gamers, creating a fresh and engaging experience for both existing and new players.”, said Harry Choi, President of Gravity Game Hub.

Gunbound, renowned for its fast-paced, competitive gameplay and vibrant community, captured the hearts of millions of players during its initial release. Recognizing the enduring popularity of the game and the strong demand from fans, Gravity sought to partner with the original creators to ensure an authentic and faithful revival.

Softnyx, with its deep understanding of the Gunbound universe and a proven track record in game development, is the ideal partner to bring this iconic game back to life. “We are thrilled to collaborate with Gravity to introduce Gunbound to a wider audience, especially in the SEA and LATAM regions. Our goal is to create an unforgettable gaming experience that captures the essence of the original while incorporating modern features and enhancements.”, said Lim Choon Geun, CEO of Softnyx. 

Gunbound Takes Center Stage at Brazil Game Show 2024

The recent Brazil Game Show served as the grand stage for the official unveiling of the Gravity and Softnyx partnership. During the event, thousands of fans flocked to the Gunbound booth to experience the game firsthand. A main stage presentation offered an exclusive look into the plans for Gunbound, generating immense excitement and anticipation among attendees.

A panel discussion featuring key members from both Gravity and Softnyx provided valuable insights into the development process and shared the team’s vision for the game’s future. The session was met with enthusiastic questions from the audience, further demonstrating the enduring appeal of Gunbound.

Pre-Register Now for Exclusive Rewards

Celebrating this momentous occasion, pre-registration for Gunbound is now open in the official website gunbound.gnjoy.asia. Players who pre-register will receive exclusive in-game rewards and gain early access to exciting updates and announcements.

As the official launch date approaches, Gravity and Softnyx are committed to delivering a Gunbound experience that surpasses expectations. The game will feature a dedicated server, fostering a strong and active community, while incorporating beloved classic elements.

About Gunbound
Genre: MMO Turn-Based Artillery Game
Platform: Microsoft Windows (PC Online Game)
Website: https://gunbound.gnjoy.asia
Facebook: https://www.facebook.com/gunboundggh
Discord: https://discord.gg/QMGCGQe5rg
Instagram: https://www.instagram.com/gunbound.ggh
Tiktok: https://www.tiktok.com/@gunbound.official

About Gravity Game Hub – Publisher

Established in 2021, Gravity Game Hub (GGH) Pte. Ltd. is a game publisher and developer focusing on online and mobile games. Gravity Game Hub is committed to delivering an interactive gaming experience and creating a dynamic community for all players in South East Asia.

About Softnyx – IP holder

Founded in April 2001, Softnyx has spent the past 20 years releasing a diverse range of online games. The company has established a unique gaming world enjoyed by 50 million users across 60 countries worldwide.

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SOURCE Gravity Game Hub (GGH) Pte. Ltd.

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