Technology

Atomic Antibiotics Developed by Czech Scientists Counter Bacterial Resistance

Published

3 months ago

October 3, 2024

OSTRAVA, Czech Republic, Oct. 3, 2024 /PRNewswire/ — Scientists from Palacký University Olomouc (UP) and the Technical University of Ostrava (VSB-TUO), in collaboration with colleagues from China, have discovered a groundbreaking method for developing a new generation of antibiotics. These antibiotics not only combat a wide range of bacteria but also effectively prevent the development of bacterial resistance. By employing atomic engineering, the researchers transformed manganese—a trace element vital for human health—into a potent antibiotic by embedding it in the structure of chemically modified graphene. Tests conducted on animal models have demonstrated the material’s significant potential, particularly in localized therapies such as wound healing. The discovery has been published in the prestigious journal Advanced Materials, and the team has filed a European patent to safeguard their innovation.

“The material we developed successfully kills and inhibits the growth of all bacteria we studied, including highly resistant pathogens. It operates at low concentrations, which are completely harmless to human cells. Furthermore, bacteria cannot develop resistance to it, thus addressing one of modern medicine’s most pressing challenges. These promising results position atomic antibiotics for practical use in the near future,” said Radek Zbořil, a physical chemist and author of the research concept, who works at the Czech Advanced Technology and Research Institute (CATRIN UP) and the Centre for Energy and Environmental Technologies (CEET) at VSB-TUO.

A Frontal Attack with Manganese

In developing this antibiotic, the scientists drew on their expertise in graphene chemistry and atomic engineering, fields they have extensively studied in recent years. This time, they utilized a graphene derivative enriched with oxygen and nitrogen atoms, chemically incorporating manganese—a transition metal that is involved in metabolism, bone formation, blood sugar regulation and cellular protection against oxidative stress.

“We chose to target one of the strongest defences of bacteria—the carbohydrates in their cell walls and membranes, which are crucial for their survival. These carbohydrates play a protective role, facilitate substance transfer, enable communication with the environment, and serve as energy reserves. By chemically binding manganese to specific carbohydrate groups, we suppressed these critical functions, ultimately causing cell death. The graphene carrier plays an essential role by ensuring the delivery of manganese ions to the bacterial surface, which enables a direct chemical attack on the carbohydrate molecules,” Zbořil explained.

Effective Against Even the Most Resistant Bacteria

The new material also shows remarkable efficacy against bacteria that existing antibiotics struggle to combat. “We observed an excellent bactericidal effect against all bacteria from the ESCAPE group, which includes highly resistant bacterial pathogens. These bacteria are particularly dangerous because they are resistant to conventional antibiotics, which complicates treatment and increases the risk of severe infections, especially in hospital settings. The atomic antibiotic was the only agent that proved effective against all resistant bacteria, compared to commercial antibiotics,” said David Panáček, the first author of the paper, from CATRIN UP and CEET VSB-TUO.

The researchers tested the atomic antibiotic’s effect not only in laboratory settings but also in mouse models in collaboration with their Chinese colleagues. “In in-vivo tests, skin infections caused by resistant strains of Staphylococcus aureus (golden staph) healed quickly and effectively, with all markers of inflammation significantly reduced. We are now considering its use for wound dressings or antibacterial treatments on surfaces of artificial materials. There is tremendous potential to prevent bacterial biofilms from forming on devices such as artificial joint replacements, stents, or cannulas. Given its mode of action, this new material could also help prevent secondary infections, which would have a major impact on healthcare,” said Milan Kolář, a microbiologist and Dean of the Faculty of Medicine and Dentistry at Palacký University Olomouc, who played a key role in the research.

Atomic Antibiotics Open New Possibilities

The research team plans to continue exploring the material’s potential for systemic antibiotic treatments. “Some serious infections are now untreatable with existing antibiotics, and bacterial sepsis is becoming an increasingly common cause of death. We aim to test atomic antibiotics’ effectiveness in treating the most severe bacterial diseases,” Kolář added.

According to the United Nations, if bacterial resistance continues to rise at its current pace, by 2050 untreatable infections caused by multidrug-resistant bacteria could become the leading cause of death worldwide. These so-called ‘superbugs’ pose a global threat, necessitating the development of new antibacterial agents that can bypass the defence mechanisms bacteria use to protect themselves. This research, which also involved colleagues from the Faculty of Science at Palacký University Olomouc and two Chinese institutions, highlights the untapped potential of atomic engineering in addressing one of humanity’s most urgent scientific and social challenges.

Read the paper at: Single Atom Engineered Antibiotics Overcome Bacterial Resistance – Panáček – Advanced Materials – Wiley Online Library

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Technology

OceanBase Receives Honorable Mention for the Second Consecutive Year in the 2024 Gartner® Magic Quadrant™ Report

Published

31 minutes ago

December 26, 2024

SINGAPORE, Dec. 26, 2024 /PRNewswire/ — OceanBase has once again been named as Honorable Mention in the 2024 Gartner® Magic Quadrant™ for Cloud Database Management Systems (Cloud DBMS), marking the second consecutive year it has received this recognition.

OceanBase offers scalable distributed database for data-intensive transactional and real-time operational analytics workloads, with ultra-fast performance and high compatibility across major global cloud infrastructures, including Amazon Web Services, Google Cloud, Alibaba Cloud and Tencent Cloud. Operating across more than 30 regions in Asia, Europe, and America, OceanBase has already served over 2,000 customers, such as SAIC Volkswagen, DiDi Global, vivo, Pop Mart, Haidilao, Kwai, Trip.com, GCash, DANA, and PalmPay.

Over the past year, OceanBase has made significant strides in the Southeast Asian market. In December 2024, Starpay, a leading financial technology company in the Philippines, announced a partnership with OceanBase to leverage its cutting-edge distributed database solutions.

OceanBase hosted the inaugural OceanBase INFINITY tech conference in Jakarta, Indonesia in June 2024. During the event, the company announced strategic partnerships with leading local resellers to better serve customers in the Indonesian market.

According to Gartner’s latest DBMS market data in the Magic Quadrant, “the overall database management system market grew by 13.4% in 2023, reaching $103.2 billion“, up from $91 billion in 2022. The DBMS segment remains one of the fastest-growing areas within the software market, alongside analytic platforms, networking software, and supply chain management software.

In May 2024, OceanBase was also recognized as an Asia/Pacific Customers’ Choice and also named a Strong Performer in the 2024 Gartner® Peer Insights™ Voice of the Customer for Cloud DBMS report.

Gartner, Magic Quadrant for Cloud Database Management Systems, 18 December 2024

Gartner, Voice of the Customer for Cloud Database Management Systems, 24 May 2024

Gartner Peer Insights content consists of the opinions of individual end users based on their own experiences, and should not be construed as statements of fact, nor do they represent the views of Gartner or its affiliates. Gartner does not endorse any vendor, product or service depicted in this content nor makes any warranties, expressed or implied, with respect to this content, about its accuracy or completeness, including any warranties of merchantability or fitness for a particular purpose.

About OceanBase

OceanBase is a distributed database launched in 2010. It provides strong data consistency, high availability, high performance, cost efficiency, elastic scalability, and compatibility with mainstream relational databases. It handles transactional, analytical, and AI workloads through a unified data engine, enabling mission-critical applications and real-time analytics.

To learn more, please visit: https://www.oceanbase.com/

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Technology

Matwings Technology Raised Series A Funding of Tens of Millions USD to Redefine Protein Design

Published

31 minutes ago

December 26, 2024

‘Beyond Structure, Predicting Function’

SHANGHAI, Dec. 25, 2024 /PRNewswire/ — Recently, Shanghai Matwings Technology Co., Ltd. (‘Matwings’), a global leader in AI-driven protein design, announced the successful completion of Series A funding rounds, raising tens of millions of USD, led by Qiming Venture Partners.

Matwings is pioneering a new frontier in protein engineering with its proprietary AI-based general protein design platform, AccelProtein™, which directly predicts protein functionality beyond the structural data. By predicting functionality, AccelProtein™ offers a new approach for acquiring high-functioning proteins.

AccelProtein™ is built on the Pro-PRIME model, a breakthrough developed by a collaborative team led by Professor Liang Hong at Shanghai Jiao Tong University. After years of research focused on data collection, curation, and optimization, the team developed the Pro-series – an AI framework for protein design. Their work, titled “A General Temperature-Guided Language Model to Design Proteins of Enhanced Stability and Activity” was recently published in Science Advances.

A featured case of AccelProtein™’s impact is the design of a specialized Glycosyltransferase enzyme, which is used in the production of EPS-G7, a core material for pancreatitis screening. Within just 4 months, Matwings increased the enzyme’s total glycosylation activity by 7 times, enhanced product specificity from 60% to 98%, and reduced hydrolytic activity by 33%. These improvements cut down the cost of EPS-G7 by 90%.

In another application, Matwings successfully engineered a super alkali-resistant affinity ligand (a nanobody) for affinity chromatography, improving alkali resistance by 3 folds, binding capacity over 100%, and heat stability by 8℃. This innovation saved millions of USD in CMC costs for a Matwings client. Additionally, scale-up production to 5000L has been successfully completed. Such advancement enables low-cost affinity chromatography purification a viable option for a wide range of biologics, bringing more cost-effective solutions for drug production.

Since 2021, Matwings has successfully delivered over 30 protein-engineering and enzyme-mining projects either proprietary (e.g., Enterokinase, Carboxypeptidase B, KEX2 Protease, Maltogenic Amylase, Subtilisin, Protein A, PETase, T7 RNA Polymerase, and phi29 DNA Polymerase) and co-developed with our stakeholders. These projects span across various applications, including drug innovation, in vitro diagnostics, nutrition and healthcare, food and beverage, and green energy.

About Matwings

Matwings, founded in 2021 by an elite team from Shanghai Jiao Tong University, is one of the earliest companies to focus on AI protein models.

Matwings is dedicated to moving beyond directed evolution methods to design and engineer functionally optimized proteins by leveraging a proprietary, pre-trained, AI-based general protein design platform with 780 million curated full-length protein sequence data, including nearly 500 million private data.

This cutting-edge technology platform, AccelProtein™, enables us to engineer proteins and uncover or de novo design novel proteins with significantly improved properties, including stability, activity, affinity, yield, etc.

To date, Matwings has successfully engineered more than 30 proteins either proprietary or co-developed with its stakeholders, and more than 40 ongoing projects across various applications in pharmaceutical industries and synthetic biology industries, e.g. key enzymes and proteins for CMC, innovative Biologics, synthetic biology and more.

Matwings is actively seeking global partnerships to jointly develop and commercialize new products.

Contact Information:
Email: info@matwings.com
Website: https://www.matwings.com/en/
Tel: +86 158 2106 5410
Paper Link: https://www.science.org/doi/10.1126/sciadv.adr2641

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SOURCE Matwings Technology

Technology

Agoda Highlights Tokyo as Top Global New Year’s Eve Destination

Published

2 hours ago

December 26, 2024

SINGAPORE, Dec. 26, 2024 /PRNewswire/ — Digital travel platform Agoda has announced Tokyo as the most popular destination for New Year’s Eve, based on accommodation searches. This marks a shift from last year when Taipei held the top spot. Following Tokyo, the list includes Bangkok, Taipei, Pattaya, and Osaka, showcasing a diverse range of preferences among travelers.

The data highlights a perpetual interest in Tokyo, a city known for its unique blend of tradition and modernity. Travelers are drawn to its vibrant celebrations, cultural experiences, and iconic landmarks. Bangkok and Taipei, too, continue to be favored destinations, offering rich cultural festivities and lively atmospheres. Pattaya and Osaka also make the list, appealing to those seeking beachside celebrations and culinary delights, respectively.

Agoda’s data reveals Tokyo’s prominence not only on a worldwide scale but also within Japan. Domestic accommodation searches have increased by 23%, with Tokyo leading as the preferred destination, followed by Osaka, Kyoto, Yokohama, and Okinawa Main Island. For Japanese traveling abroad, the destinations primarily considered are Taipei, Seoul, Bangkok, Pattaya, and Hong Kong.

Hiroto Ooka, Associate Vice President North Asia at Agoda said: “Tokyo’s rise to the top of Agoda’s New Year’s Eve destination list is a testament to the city’s global appeal. Whether you’re celebrating New Year’s Eve in Tokyo, Osaka, or anywhere else in the world, Agoda is ready to help you find the perfect spot to ring in the New Year.”

As travelers prepare for their New Year’s Eve plans, Agoda offers a comprehensive selection of over 4.5 million holiday properties, more than 130,000 flight routes, and over 300,000 activities, all available for seamless booking. Download the Agoda app for the latest deals or visit agoda.com/deals.

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SOURCE Agoda