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Vazyme Leads Life Science Innovation, Boosting Research Breakthroughs in mIDH1 Cancer Treatment

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NANJING, China, Sept. 16, 2024 /PRNewswire/ — Vazyme (688105.SH), a leading life science technology company, significantly contributed to groundbreaking research published in Science Magazine through its innovative products. The study, which focuses on how mutant IDH1 inhibition activates tumor immunity by inducing double-stranded DNA (dsDNA) sensing, utilized Vazyme’s advanced tools to achieve compelling research results. These findings are driving progress in life science, fostering transformative changes and innovations, and advancing both academic research and the broader medical sector.

The research, led by the cancer research team at Harvard Medical School and Massachusetts General Hospital and the Broad Institute of MIT and Harvard, was authored by Dr. Meng-Ju Wu and his team. Reporting in Science, their paper, “Mutant IDH1 Inhibition Induces dsDNA Sensing to Activate Tumor Immunity”, reveals how mutant IDH1 inhibition activates tumor immunity by inducing dsDNA sensing. Research has found that mIDH1 inhibitors cause DNA demethylation, which reactivates dormant viral genes embedded in the genome from ancient infections, subsequently activating cGAS, a protein responsible for detecting these viral elements. This reactivation triggers a viral mimicry response, effectively mobilizing the immune system to attack and destroy tumor cells. In preclinical models, mIDH1 inhibition led to the rapid recruitment of CD8+ T cells and a strong anti-tumor immune response. These findings suggest that strategies enhancing viral mimicry and immune activation could significantly boost the efficacy of mIDH1 inhibitors, paving the way for innovative combination therapies to combat mIDH1-driven cancers.

Three products from Vazyme were instrumental in this significant research: Equalbit 1 × dsDNA HS Assay Kit (#EQ121), Mycolor One-Step Mycoplasma Detector (#D201), and BCA Protein Quantification Kit (#E112). Among them, Vazyme #EQ121 is a ready-to-use double-stranded DNA (dsDNA) quantification kit that is easy to use, highly sensitive, and accurately quantifies 0.2 – 100 ng dsDNA. By utilizing the dye that specifically binds to DNA and reducing interference from impurities, along with strict standard controls, it provides a good linear relationship in the 0.2 – 100 ng range, achieving accurate quantification. It is an ideal choice for large-scale DNA sample quantification in NGS (e.g., input DNA quantification, DNA library quantification).

Additionally, Vazyme has launched an upgraded mycoplasma detection reagent–the Mycolor One-Step Mycoplasma Detector (#D201). The product introduces a novel red-yellow color change system, which makes operation easy and visually intuitive. Reliable cell culture is vital for cell research; however, mycoplasma contamination remains a frequent and challenging issue. Unlike yeast and bacteria, mycoplasma cannot be directly observed under a microscope, which makes detection more complex. By using isothermal amplification technology to detect whether cells are contaminated with mycoplasma through color change, it provides great convenience for researchers.

The BCA Protein Quantification Kit (#E112) is one of the most sensitive methods for measuring protein concentration. Boasting unparalleled versatility across diverse experimental settings, it enables the exploration of standard curve linearity while maintaining the ease of operation.

These exceptional products, from Cell and Protein Research product line to NGS Library Preparation product line, directly result from Vazyme’s strong research and development capabilities, which form the foundation of its innovations. The dedicated R&D team has developed over 600 types of genetically engineered recombinant enzymes, more than 2,500 high-performance antigens, monoclonal antibodies, and other essential materials. Driven by the robust enzyme library and following a logical progression in disease management—from discovery and prevention to diagnosis and treatment, Vazyme has established nine major product lines along with over 2,000 end products: Nucleic Acid Extraction Reagents, Molecular Biology Reagents, Cell & Protein Research Reagents, NGS Library Preparation Reagents, Reagents for Bio-Medicine, Instruments, Lab Consumables, Animal Disease Detection Kits, and IVD Solutions.

Vazyme prioritizes global customer connections, ensuring their satisfaction. Through local customer support teams in key markets, the company engages directly with users in over 60 countries with local warehouses for efficient delivery and service.

By leveraging technical expertise in various disciplines, including enzymology, immunology, cell biology, material science, and organic chemistry, Vazyme solidifies its role as a vital partner in scientific exploration. The driving force behind Vazyme’s work is empowering customers in their pursuit of advancing the innovation of science. And together, exploring the unknown and fostering collaborations towards a healthier life for all.

For more information, please visit the following website:
www.vazyme.com 

E-mail: support@vazyme.com
Tel: +86 400-168-5000

View original content to download multimedia:https://www.prnewswire.com/news-releases/vazyme-leads-life-science-innovation-boosting-research-breakthroughs-in-midh1-cancer-treatment-302248301.html

SOURCE Vazyme

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Dana-Farber Cancer Institute Partners with Clinical.ly to Enhance Regulatory Operations with eReg Solutions

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September 19, 2024

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NEW YORK, Sept. 19, 2024 /PRNewswire/ — The Dana-Farber Cancer Institute, a world leader in cancer treatment and research, chose Clinical.ly’s (www.clinical.ly) Research Suite™ to streamline regulatory operations, marking a significant step toward more efficient and compliant clinical trial management. Dana-Farber joins a growing number of research organizations that leverage Clinical.ly’s innovative solutions to streamline clinical trial processes. Clinical.ly’s eReg platform offers a comprehensive, paperless solution that centralizes regulatory workflows, ensuring compliance and transparency across clinical trials.

“We are thrilled to support Dana-Farber’s clinical research operations,” said Henry Kravchenko, Clinical.ly’s CEO.

This partnership continues Clinical.ly’s success in providing best-in-class enterprise tools for conducting clinical research. “We are thrilled to support Dana-Farber’s clinical research operations,” said Henry Kravchenko, Clinical.ly’s CEO. “Our eReg platform and wider set of features in Clinical.ly Research Suite™ will empower that renowned organization, and we all look forward to supporting their teams.”

About Clinical.ly Research Suite™ 

Clinical.ly Research Suite™ is a comprehensive solution that eliminates traditional, paper-based processes. By automating and centralizing essential workflows in the Clinical.ly Research Suite™, organizations achieve huge efficiency improvements, greater trial oversight, document management, and regulatory compliance. The Clinical.ly Research Suite™ includes:

eReg: A best-in-class electronic regulatory bindereSource: An intuitive & feature-rich, paperless data capture solution that streamlines data collection from trial participantseConsent: A fully digital solution for capturing informed consent, improving participant engagement and site complianceClinicallySign: 21 CFR Part 11 compliant eSignature functionalityClinicallyPay: A secure and instantaneous participant stipend payment and reimbursement solution

About Dana-Farber Cancer Institute

Founded in 1947, Dana-Farber Cancer Institute is committed to providing adults and children with the best treatment available today while developing tomorrow’s cures through cutting-edge research. Based in Boston, Dana-Farber is a teaching affiliate of Harvard Medical School and ranks consistently as one of the top cancer hospitals in the world.

About Clinical.ly

Clinical.ly provides differentiated, cloud-native technology solutions to the clinical research industry, enabling research organizations to conduct studies with greater efficiency and ease. Clinical.ly is dedicated to developing technology that eliminates tedious manual labor, allowing clinical research professionals to focus on patient care.

View original content to download multimedia:https://www.prnewswire.com/news-releases/dana-farber-cancer-institute-partners-with-clinically-to-enhance-regulatory-operations-with-ereg-solutions-302253690.html

SOURCE Clinical.ly

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Fall Into Creativity with the Monport Laser Fall Sale

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5 mins ago

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September 19, 2024

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NEW YORK, Sept. 19, 2024 /PRNewswire/ — Experience laser innovation this Fall with Monport Laser, an industry frontrunner in laser engraving and cutting technology, with an exclusive Fall Sale offering incredible discounts and free accessories on a wide range of high-performance laser engraving machines. From September 19th to September 30th, customers can take advantage of this limited-time opportunity to elevate their laser engraving businesses with cutting-edge laser innovation at unbeatable prices.

Monport Laser has been dedicated to providing innovative and reliable laser machines that empower businesses and individuals to achieve their goals. With a focus on quality, precision, and customer satisfaction, Monport Laser has established itself as a trusted leader in the industry. Their commitment to excellence is evident in every laser they produce, ensuring exceptional performance, reliability, and value.

Embrace the Power of CO2 Laser Technology with Exclusive Offers

Monport Laser will offer two free accessories with selected CO2 laser machines during the Monport Fall sale. These versatile lasers are ideal for various applications, including engraving, cutting, and marking wood, acrylic, leather, and more. By taking advantage of this Fall sale, laser engraving businesses can enhance their productivity and expand their creative possibilities.

Experience Unmatched Value with Fiber Laser Discounts

Monport Laser offers substantial discounts of up to $4200 and 3 free accessories on selected models for those seeking the precision and speed of fiber laser technology. Fiber lasers are renowned for their ability to process metals with exceptional efficiency and accuracy, making them indispensable for metal fabrication, manufacturing, and jewelry production. Additionally, customers purchasing fiber lasers during the Fall sale will receive three free accessories, further sweetening the deal.

Elevate Your Desktop Laser Experience with a Free Water Chiller

Monport Laser is committed to providing comprehensive solutions for businesses of all sizes. As part of the Fall sale, customers who purchase the 40W Desktop laser will receive a Free Water Chiller Cw3000. This essential accessory ensures optimal cooling and performance, prolonging the lifespan of the laser and guaranteeing consistent results.

Discover Additional Savings on a Wide Range of Accessories

Monport Laser offers an additional 20% discount on selected accessories to complete your laser setup. From lenses and nozzles to rotary tables and smoke extraction systems, customers can find everything they need to maximize the potential of their laser machines.

Unleash Your Creativity and Productivity

Monport Laser’s Fall sale is the perfect opportunity to invest in laser technology that empowers your business or fuels your creative passions. With exceptional discounts and free accessories, you can acquire the ideal laser solution to meet your needs and budget.

Whether you’re an entrepreneur, artist, or manufacturer, Monport Laser’s advanced laser machines offer unparalleled precision, versatility, and reliability. Take advantage of this limited-time Fall sale and unlock your projects’ full potential for laser innovation.

About Monport Laser

Monport Laser is a global leader in designing, manufacturing, and distributing high-quality laser machines and accessories. With a commitment to innovation and customer satisfaction, Monport Laser provides cutting-edge solutions for various industries, including manufacturing, engraving, marking, and more.

For more information, visit monportlaser.com and follow them on social media for the latest updates.

Website: https://www.monportlaser.com/

 

 

 

View original content:https://www.prnewswire.com/news-releases/fall-into-creativity-with-the-monport-laser-fall-sale-302253699.html

SOURCE Monport Laser

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MEDIA ADVISORY – Minister Wilkinson to Make a Critical Minerals Infrastructure Announcement

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5 mins ago

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September 19, 2024

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VANCOUVER, BC, Sept. 19, 2024 /CNW/ – The Honourable Jonathan Wilkinson, Minister of Energy and Natural Resources, and Ranj Pillai, the Premier of Yukon, will make a funding announcement in support of critical minerals infrastructure projects. A media availability will follow.

Date: September 20, 2024

Time: 10:30 a.m. PT

All accredited media are asked to pre-register by emailing media@nrcan-rncan.gc.ca. A dial-in line is available for media and will be provided upon registration.

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SOURCE Natural Resources Canada

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