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Vazyme Leads Life Science Innovation, Boosting Research Breakthroughs in mIDH1 Cancer Treatment

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NANJING, China, Sept. 16, 2024 /PRNewswire/ — Vazyme (688105.SH), a leading life science technology company, significantly contributed to groundbreaking research published in Science Magazine through its innovative products. The study, which focuses on how mutant IDH1 inhibition activates tumor immunity by inducing double-stranded DNA (dsDNA) sensing, utilized Vazyme’s advanced tools to achieve compelling research results. These findings are driving progress in life science, fostering transformative changes and innovations, and advancing both academic research and the broader medical sector.

The research, led by the cancer research team at Harvard Medical School and Massachusetts General Hospital and the Broad Institute of MIT and Harvard, was authored by Dr. Meng-Ju Wu and his team. Reporting in Science, their paper, “Mutant IDH1 Inhibition Induces dsDNA Sensing to Activate Tumor Immunity”, reveals how mutant IDH1 inhibition activates tumor immunity by inducing dsDNA sensing. Research has found that mIDH1 inhibitors cause DNA demethylation, which reactivates dormant viral genes embedded in the genome from ancient infections, subsequently activating cGAS, a protein responsible for detecting these viral elements. This reactivation triggers a viral mimicry response, effectively mobilizing the immune system to attack and destroy tumor cells. In preclinical models, mIDH1 inhibition led to the rapid recruitment of CD8+ T cells and a strong anti-tumor immune response. These findings suggest that strategies enhancing viral mimicry and immune activation could significantly boost the efficacy of mIDH1 inhibitors, paving the way for innovative combination therapies to combat mIDH1-driven cancers.

Three products from Vazyme were instrumental in this significant research: Equalbit 1 × dsDNA HS Assay Kit (#EQ121), Mycolor One-Step Mycoplasma Detector (#D201), and BCA Protein Quantification Kit (#E112). Among them, Vazyme #EQ121 is a ready-to-use double-stranded DNA (dsDNA) quantification kit that is easy to use, highly sensitive, and accurately quantifies 0.2 – 100 ng dsDNA. By utilizing the dye that specifically binds to DNA and reducing interference from impurities, along with strict standard controls, it provides a good linear relationship in the 0.2 – 100 ng range, achieving accurate quantification. It is an ideal choice for large-scale DNA sample quantification in NGS (e.g., input DNA quantification, DNA library quantification).

Additionally, Vazyme has launched an upgraded mycoplasma detection reagent–the Mycolor One-Step Mycoplasma Detector (#D201). The product introduces a novel red-yellow color change system, which makes operation easy and visually intuitive. Reliable cell culture is vital for cell research; however, mycoplasma contamination remains a frequent and challenging issue. Unlike yeast and bacteria, mycoplasma cannot be directly observed under a microscope, which makes detection more complex. By using isothermal amplification technology to detect whether cells are contaminated with mycoplasma through color change, it provides great convenience for researchers.

The BCA Protein Quantification Kit (#E112) is one of the most sensitive methods for measuring protein concentration. Boasting unparalleled versatility across diverse experimental settings, it enables the exploration of standard curve linearity while maintaining the ease of operation.

These exceptional products, from Cell and Protein Research product line to NGS Library Preparation product line, directly result from Vazyme’s strong research and development capabilities, which form the foundation of its innovations. The dedicated R&D team has developed over 600 types of genetically engineered recombinant enzymes, more than 2,500 high-performance antigens, monoclonal antibodies, and other essential materials. Driven by the robust enzyme library and following a logical progression in disease management—from discovery and prevention to diagnosis and treatment, Vazyme has established nine major product lines along with over 2,000 end products: Nucleic Acid Extraction Reagents, Molecular Biology Reagents, Cell & Protein Research Reagents, NGS Library Preparation Reagents, Reagents for Bio-Medicine, Instruments, Lab Consumables, Animal Disease Detection Kits, and IVD Solutions.

Vazyme prioritizes global customer connections, ensuring their satisfaction. Through local customer support teams in key markets, the company engages directly with users in over 60 countries with local warehouses for efficient delivery and service.

By leveraging technical expertise in various disciplines, including enzymology, immunology, cell biology, material science, and organic chemistry, Vazyme solidifies its role as a vital partner in scientific exploration. The driving force behind Vazyme’s work is empowering customers in their pursuit of advancing the innovation of science. And together, exploring the unknown and fostering collaborations towards a healthier life for all.

For more information, please visit the following website:
www.vazyme.com 

E-mail: support@vazyme.com
Tel: +86 400-168-5000

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SOURCE Vazyme

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KNEX Technology CTO Gustavo Gonzalez Elected 2025 President-Elect of OATUG

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48 minutes ago

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January 11, 2025

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Gustavo Gonzalez, KNEX Technology’s CTO, has been elected 2025 President-Elect of OATUG, emphasizing his dedication to Oracle innovation, collaboration, and leadership, including Ascend 2025’s strategic initiatives.

IRVINE, Calif., Jan. 10, 2025 /PRNewswire-PRWeb/ — KNEX Technology, a leading Oracle Cloud solutions provider, is proud to announce that its Chief Technology Officer, Gustavo Gonzalez, has been elected as the 2025 President-Elect of the Oracle Applications & Technology Users Group (OATUG). This esteemed appointment highlights Gonzalez’s longstanding commitment to advancing innovation and collaboration within the Oracle community.

OATUG has played a pivotal role in my professional growth, and it is a privilege to contribute to this community which has enriched my career. As President-Elect, I look forward to collaborating with my peers to strengthen the Oracle user community and further its impact on businesses worldwide.

In his new role, Gonzalez will work closely with the OATUG leadership team throughout 2025, preparing to serve as OATUG President in 2026. He will focus on empowering Oracle professionals worldwide by fostering knowledge-sharing, community engagement, and professional development. OATUG, a globally recognized organization, supports its members in overcoming challenges, enhancing the value of Oracle solutions, and driving organizational success.

“OATUG has played a pivotal role in my professional growth, and it is a privilege to contribute to this community which has enriched my career,” said Gustavo Gonzalez. “As President-Elect, I look forward to collaborating with my peers to strengthen the Oracle user community and further its impact on businesses worldwide.”

Gonzalez’s election underscores his dedication to giving back to the Oracle ecosystem. A key focus of his role will include shaping OATUG’s strategic initiatives, such as the annual Ascend Conference, which unites Oracle users, thought leaders, and technology innovators for unparalleled learning and networking opportunities.

The upcoming Ascend 2025 Conference, scheduled for June 8–11 in Orlando, Florida, promises to build on the success of the 2024 event, which attracted more than 1,800 attendees. With early bird registration now open, Gonzalez aims to ensure the conference continues to deliver transformative insights and experiences for the Oracle community.

About OATUG

The Oracle Applications & Technology Users Group (OATUG) is the premier global organization for Oracle users, providing year-round education, networking, and advocacy. OATUG empowers its members to unlock the full potential of Oracle solutions, fostering innovation and collaboration across industries.

About KNEX Technology

KNEX Technology is a trusted leader in Oracle Cloud solutions, delivering cutting-edge products and services to help businesses achieve their objectives. Through its innovative approach and customer-focused strategies, KNEX enables organizations to navigate the complexities of today’s technology landscape. For more information, visit www.knextech.com.

Media Contact

Husna Gyasi, KNEX Technology, 1 (949) 232-0786, husna.ghayaisi@knextech.com, https://knextech.com/

Twitter, LinkedIn

View original content:https://www.prweb.com/releases/knex-technology-cto-gustavo-gonzalez-elected-2025-president-elect-of-oatug-302347693.html

SOURCE KNEX Technology

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Dr. Gerard van Belle Appointed Director of Science at Lowell Observatory, Charting a Bold Future for Research

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2 hours ago

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January 11, 2025

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Dr. van Belle to guide scientific exploration and foster innovation in the next era of astronomical research

FLAGSTAFF, Ariz., Jan. 10, 2025 /PRNewswire/ — Lowell Observatory is pleased to announce the appointment of Dr. Gerard van Belle as the new Director of Science. Van Belle, who has been an astronomer at the observatory since 2011, has been serving as the interim Director of Science.

In his new role, van Belle will lead a diverse team of astronomers and planetary scientists. He will spearhead the observatory’s new Science Vision, which focuses on advancing research capabilities and implementing cutting-edge technological improvements supporting Lowell’s leadership in astronomical research.

Under his leadership, the science department will continue to advance Lowell Observatory’s mission to pursue the study of astronomy, including the study of our solar system and its evolution, and to conduct pure research in astrophysical phenomena.

Van Belle’s own research focuses on fundamental stellar parameters, including the sizes, shapes, masses, distances, and temperatures of various types of stars. He is also renowned for his expertise in optical and near-infrared astronomical interferometry.

He earned his bachelor’s degree in physics from Whitman College in 1990, followed by a master’s degree from The Johns Hopkins University in 1993, and a Ph.D. in physics from the University of Wyoming in 1996.

Throughout his career, van Belle has been instrumental in the development and commissioning of major optical interferometers worldwide, including the Palomar Testbed Interferometer, the Keck Interferometer, and the Very Large Telescope Interferometer. His pioneering work in stellar surface imaging earned him the inaugural Edward Stone Award for Outstanding Research Publication at NASA’s Jet Propulsion Laboratory in 2002.

In 2011, van Belle joined Lowell Observatory’s science staff, where he applied high-resolution astronomical techniques to detect nearby exoplanets and map stellar surfaces. He served as the Director of the Navy Precision Optical Interferometer (NPOI) in Flagstaff, Arizona, from 2017 to 2018, and subsequently as its Chief Scientist until 2022.

Notably, van Belle was among the astronomers who voted against the definition of ‘planet’ advanced during the 2006 International Astronomical Union (IAU) conference in Prague, which relegated Pluto to being a ‘dwarf planet’ (which according to the IAU resolution is not a planet).

His extensive experience and dedication to advancing astronomical research make him a valuable leader for Lowell Observatory’s scientific endeavors.

“I am honored to take on this role at such a pivotal time for Lowell Observatory,” said van Belle. “Our Science Vision will guide us in exploring new frontiers in astronomy while strengthening our commitment to public engagement and education.”

Executive Director Dr. Amanda Bosh expressed her confidence in van Belle’s leadership: “Gerard’s extensive experience and dedication to our mission make him the ideal person to lead our scientific endeavors. I look forward to working closely with him as we embark on this exciting new chapter for Lowell Observatory.”

For more information about Lowell Observatory’s research and public programs, visit lowell.edu.

About Lowell Observatory
Founded in 1894, Lowell Observatory in Flagstaff, Arizona, is a renowned nonprofit research institution. It is the site of historic and groundbreaking discoveries, including the first evidence of the expanding universe and the discovery of Pluto. Today, Lowell’s astronomers utilize global ground-based and space telescopes, along with NASA spacecraft, for diverse astronomical and planetary science research. The observatory hosts more than 100,000 visitors annually for educational tours, presentations, and telescope viewing through a suite of world-class public telescopes.

View original content to download multimedia:https://www.prnewswire.com/news-releases/dr-gerard-van-belle-appointed-director-of-science-at-lowell-observatory-charting-a-bold-future-for-research-302348440.html

SOURCE Lowell Observatory

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ALTICE USA IS ABANDONING LOCAL SPORTS FANS AND IS KEEPING MSG NETWORKS AND ITS KNICKS, RANGERS, ISLANDERS AND DEVILS COVERAGE OFF THE AIR

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3 hours ago

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January 10, 2025

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NEW YORK, Jan. 10, 2025 /PRNewswire/ — MSG Networks released the following statement about their dispute with Altice USA:

“Altice USA has pulled their last proposal and walked away from negotiations to bring MSG Networks back to its Optimum subscribers. They also just dropped WPIX Channel 11 in New York and other local stations around the country. If you have been waiting, like we have, for them to do right by their customers – don’t wait any longer. Now is the time to switch to Verizon Fios who has a special offer for Optimum subscribers. Meanwhile, Optimum has been charging their over 1 million customers for local sports programming they have not been receiving and EVERY subscriber should be credited at least $10 a month.

Verizon Fios is ready to take your business. If you are not in Verizon Fios area, you can get games through these other providers DirecTV, DirecTV Stream, Fubo and The Gotham Sports App. For more options on how to switch providers, visit www.keepMSG.com.”

About MSG Networks

MSG Networks, a pioneer in sports media, owns and operates two award-winning regional sports and entertainment networks (MSG and MSG Sportsnet) and MSG+, a direct-to-consumer and authenticated streaming offering (included in the Gotham Sports App), that serve the nation’s number one media market, the New York DMA, as well as other portions of New York, New Jersey, Connecticut and Pennsylvania. The networks feature a wide range of compelling sports content, including exclusive live local games and other programming of the New York Knicks, New York Rangers, New York Islanders, New Jersey Devils and Buffalo Sabres, as well as significant coverage of the New York Giants and Buffalo Bills. This content, in addition to a diverse array of other sporting events and critically acclaimed original programming, has established MSG Networks as the gold standard in regional sports. MSG Networks is part of the Sphere Entertainment Co. (NYSE: SPHR).

Contact:

Dan Schoenberg (dan.schoenberg@msg.com)

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SOURCE Sphere Entertainment Co.

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