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SOPHiA GENETICS Presents Ground-Breaking Multimodal Research on AI-Driven Patient Stratification at ESMO 2024

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Research highlights the use of multimodal machine learning to identify non-small cell lung cancer patients predicted to derive the most benefit from combination immunotherapy

BOSTON and ROLLE, Switzerland, Sept. 14, 2024 /PRNewswire/ — SOPHiA GENETICS (Nasdaq: SOPH), a cloud-native healthcare technology company and a leader in data-driven medicine, will unveil new research at the European Society for Medical Oncology (ESMO) 2024. The study, conducted in collaboration with AstraZeneca, leverages advanced AI-driven techniques to identify subgroups of stage IV non-small cell lung cancer (NSCLC) patients who could most benefit from the addition of tremelimumab to durvalumab and chemotherapy.

The research is a retrospective, multimodal analysis of the POSEIDON Phase 3 clinical trial (NCT03164616). This trial originally demonstrated that the combination of tremelimumab, durvalumab, and chemotherapy significantly increases progression-free survival (PFS) and overall survival (OS) versus chemotherapy in patients with metastatic NSCLC, which lead to approval of this regiment globally in 1L mNSCLC. The SOPHiA GENETICS study used cutting-edge multimodal machine learning models to analyze clinical, biological, genomic, and imaging data, pinpointing patient subgroups who are most likely to benefit from the combination treatment.

The research highlighted signatures identifying patients with non-squamous metastatic NSCLC who may derive higher OS benefit from the addition of tremelimumab to durvalumab plus chemotherapy in the first-line treatment setting. In particular, EGFR wild-type, FGFR3 wild-type, CDKN2A wild-type, KRAS mutation, and STK11 mutation comprised elements of a signature was identified as being associated with a higher OS benefit. These findings could have significant implications for the treatment of NSCLC, as it provides an exploration avenue towards a more tailored approach to patient care.

“Our collaboration with AstraZeneca represents a major step forward in personalized oncology. Non-small cell lung cancer remains one of the most challenging cancers to treat due to its complex biology and the late stage at which it is often diagnosed,” said Jurgi Camblong, Ph.D., Co-founder and CEO of SOPHiA GENETICS. “This study harnesses the power of multimodal data and advanced AI to identify which patients are most likely to benefit from specific therapies. By tailoring treatment strategies based on a patient’s unique multimodal profile, we aim to improve outcomes and offer new hope to those battling this difficult disease.”

The study will be presented as a poster by Ferdinandos Skoulidis, Department of Thoracic Medical Oncology, University of Texas MD Anderson Cancer Center at ESMO 2024 hosted in Barcelona, Spain from September 13-17, 2024. His presentation showcases the operational feasibility and clinical impact of large-scale multimodal analyses in identifying heterogeneous treatment effects in oncology.

For more information on SOPHiA GENETICS, visit SOPHiAGENETICS.COM, or connect on LinkedIn.

About SOPHiA GENETICS 
SOPHiA GENETICS (Nasdaq: SOPH) is a cloud-native healthcare technology company on a mission to expand access to data-driven medicine by using AI to deliver world-class care to patients with cancer and rare disorders across the globe. It is the creator of the SOPHiA DDM™ Platform, which analyzes complex genomic and multimodal data and generates real-time, actionable insights for a broad global network of hospital, laboratory, and biopharma institutions. For more information, visit SOPHiAGENETICS.COM and connect with us on LinkedIn.

SOPHiA GENETICS products are for Research Use Only and not for use in diagnostic procedures unless specified otherwise. The information in this press release is about products that may or may not be available in different countries and, if applicable, may or may not have received approval or market clearance by a governmental regulatory body for different indications for use. Please contact support@sophiagenetics.com to obtain the appropriate product information for your country of residence. 

SOPHiA GENETICS Forward-Looking Statements: 
This press release contains statements that constitute forward-looking statements. All statements other than statements of historical facts contained in this press release, including statements regarding our future results of operations and financial position, business strategy, products, and technology, as well as plans and objectives of management for future operations, are forward-looking statements. Forward-looking statements are based on our management’s beliefs and assumptions and on information currently available to our management. Such statements are subject to risks and uncertainties, and actual results may differ materially from those expressed or implied in the forward-looking statements due to various factors, including those described in our filings with the U.S. Securities and Exchange Commission. No assurance can be given that such future results will be achieved. Such forward-looking statements contained in this press release speak only as of the date hereof. We expressly disclaim any obligation or undertaking to update these forward-looking statements contained in this press release to reflect any change in our expectations or any change in events, conditions, or circumstances on which such statements are based, unless required to do so by applicable law. No representations or warranties (expressed or implied) are made about the accuracy of any such forward-looking statements.

 

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SOURCE SOPHiA GENETICS

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Meet With Culture: Exquisite Craftsmanship of Traditional Chinese Architecture

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BEIJING, Dec. 22, 2024 /PRNewswire/ — The Temple of Agriculture in Beijing played a significant role during the Ming (1368-1644) and Qing (1644-1911) dynasties. Over nearly 600 years, 25 emperors personally visited or sent ministers to perform spring farming ceremonies and offer sacrifices to Shennong, the god of agriculture.

 

Built in 1420 during the Yongle reign, the temple’s predecessor was the Temple of Mountains and Rivers in Nanjing. When Emperor Zhu Di moved the Ming capital to Beijing, he constructed a larger temple inspired by the Nanjing temple, which gradually evolved into the Temple of Agriculture.

The Taisui Hall, the largest building complex in the temple, now serves as a major exhibition hall of the Beijing Ancient Architecture Museum, showcasing models of classical Chinese buildings and demonstrating the solemnity of royal architecture.

Ancient Chinese architecture is predominantly wooden-structured, chosen for its availability, versatility, and earthquake resistance. Artisans developed sophisticated techniques in material selection and construction. The wooden framework consists of columns, beams, girders, and purlins, with innovative structural forms like lifting-beam and piercing-bracket structures.

A unique architectural element is the dougong (bracket sets), which supports weight and connects beam frames with column walls. Mortise-tenon joints were invented to create elastic frameworks by connecting different components.

While discussing the Temple of Agriculture, it’s worth noting another remarkable example of architectural hierarchy which could be found in the Temple of Heaven. The hierarchy of architectural designs reflected social stratification, with eave structures like the triple-layered eaves of the Hall of Prayer for Good Harvest representing the highest-level architectural design.

Over centuries, the Temple of Agriculture has transformed from an imperial garden to a public park and a museum for historical architecture, now standing as a significant cultural landmark that symbolizes China’s agricultural civilization and architectural heritage along Beijing’s Central Axis.

Quickly join Alexandre to study and explore the traditional Chinese architecture.
https://youtu.be/YpA03WiZ9Wc

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SOURCE China International Communications Group

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Second Opinion Expert Announces Filing of U.S. Patent for Method of Generating Medical Opinions Using Artificial Intelligence

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Patent leverages AI technology to improve patient outcomes and reduce cost of care

DANA POINT, Calif., Dec. 22, 2024 /PRNewswire-PRWeb/ — SecondOpinionExpert, Inc. (SOE), a leading healthcare technology company, announced today that it has filed patent application 133902-0002UT01 with the United States Patent and Trademark Office entitled “Method and Apparatus for Generating Automated Medical Opinions Using Artificial Intelligence.” The patent covers the company’s proprietary system that communicates a medical opinion to a user based on a trained model that uses artificial intelligence (AI) or machine learning (ML).

“In the near future, we’ll launch our free app, enabling users to access high-quality medical opinions. This innovative app empowers individuals with insightful medical guidance that improves health and saves lives,” said Steve Krause, President of SecondOpinionExpert, Inc.”

Medical second opinions have traditionally been obtained by seeking out another healthcare professional who reviews the patient’s medical records, diagnoses, and tests. However, the rapidly increasing complexity of medical information, the demand for faster turnaround times, and the limitations of human expert availability have created a need for automated systems that utilize AI to generate both first and second medical opinions.

Artificial intelligence has made significant strides in medical diagnostics, including image recognition, predictive modeling, and natural language processing (NLP). These advancements present an opportunity to augment traditional second opinion systems by automatically processing patient medical records, diagnostic tests, and clinical data to generate high-quality first and second medical opinions.

SecondOpinionExpert’s technology increases the quality and efficiency of healthcare delivery, improves healthcare access and empowers doctors and patients to make better informed medical decisions. The HIPAA-compliant patented platform leverages recent advancements in artificial intelligence, machine learning and electronic medical record systems enabling the company to provide fast, reliable and secure online medical opinions. The system provides patients greater peace of mind by leveraging the power of AI and ML.

“Our patent-pending AI enabled technology platform provides a cost-effective choice that improves patient care,” said Steve Krause, President, SecondOpinionExpert, Inc. “In the near future, we look forward to launching our user-friendly app that will be initially free of charge. People using our platform will be able to quickly obtain high quality medical opinions while avoiding unnecessary travel time and expense, knowing that they will be getting insightful medical guidance that improves health and saves lives.”

About SecondOpinionExpert

SOE’s mission is to provide innovative medical technology solutions to improve healthcare while reducing costs.

Our patented HIPAA-compliant platform leverages recent advancements in artificial intelligence, machine learning and electronic medical record systems, enabling the company to provide fast, reliable and secure online medical opinions to inform both diagnosis and treatment planning. We empower patients, providers and payors to work together to make the best possible medical decisions, leading to better health outcomes and greater peace of mind for patients. SOE’s panel of 400+ board-certified medical specialists are available to render expert opinions informed as needed by AI and genomics.

SOE also owns and/or manages a rapidly growing network of facilities for post-acute care and substance treatment. Our proprietary platform for Electronic Medical Records (EMR) empowers best practices in administration and medical services.

Our proprietary TeleMedics Mobile Platform empowers and chronicles on-site visits from qualified medics or nurses. Mobile staff provide the human connection, capturing vitals and doing diagnostics and therapeutics, with the patient’s doctor participating as needed through live video. We work with our affiliate Intra Care, Inc. to provide superior home health and hospice care. We provide Remote Patient Monitoring (RPM) delivered through a strategic relationship with KangarooHealth, in-home respirators delivered and monitored by SOE affiliate Momentum Equipment and Pandemic Response through our MaxVax solution.

Additional information can be found at SOE.CARE

Media Contact

Jay Kilberg, Second Opinion Expert, Inc., 1 917.543.6285, jay.kilberg@soe.care, https://soe.care

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SOURCE Second Opinion Expert, Inc.

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The 6th “My China Story” International Short Video Competition Award Ceremony Held in Harbin

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HARBIN, China, Dec. 22, 2024 /PRNewswire/ — The 6th “My China Story” International Short Video Competition Award Ceremony was held in Harbin, northeast China’s Heilongjiang Province on December 19, 2024.

Du Zhanyuan, member of the Standing Committee of the 14th National Committee of the Chinese People’s Political Consultative Conference and president of China International Communications Group, and He Liangjun, member of the Standing Committee of the Heilongjiang Provincial Committee of the Communist Party of China (CPC) and director of the Publicity Department of the CPC Heilongjiang Provincial Committee, addressed the ceremony respectively. Lan Feng, member of the Standing Committee of the CPC Harbin Municipal Committee and director of the Publicity Department of the CPC Harbin Municipal Committee, attended the event. The ceremony was also attended by 300 other people from home and abroad, including Chinese and international video creators, experts, judges, and representatives from the publicity departments at different levels across the country, as well as representatives from various corporations.

For this year, the competition received a total of 59,559 videos from more than 130 countries and regions around the globe. After three rounds of strict comparison and appraisal by more than 30 professional Chinese and international judges from the fields of media, film and television, Internet, and international communication, 112 pieces of all videos finally won awards in different categories.

Heilongjiang, the northernmost and easternmost province of China, boasts a long history and rich culture. Harbin, the capital city of Heilongjiang Province, is famous for its local culture, music, art and architecture of Chinese and Western integrated styles as well as its openness and inclusiveness, making the city a unique source of inspiration to tell China stories to the world.

Under the theme of “Heaven of Ice and Snow, City of Charm and Vigor”, this year’s competition highlights the feature of the host city Harbin, attracting a lot of participants to make videos surrounding the topic. From the perspective of international creators, these short videos together present a dynamic Harbin and a charming Heilongjiang, as well as show a real China to the world.

View original content to download multimedia:https://www.prnewswire.com/news-releases/the-6th-my-china-story-international-short-video-competition-award-ceremony-held-in-harbin-302337936.html

SOURCE “My China Story” International Short Video Competition Organizing Committee

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