Technology

Ig Nobel Prize Awarded to Takanori Takebe for “Butt-Breathing” Study

Published

1 week ago

September 13, 2024

Go ahead, crack a joke. Butt seriously, this research from an expert at Cincinnati Children’s and the Tokyo Medical and Dental University might save lives someday by helping people when they cannot get enough oxygen via their lungs

CINCINNATI, Sept. 12, 2024 /PRNewswire/ — On one hand, Takanori Takebe, MD, PhD, would prefer to be remembered for his multiple breakthrough contributions to organoid medicine. However, he may never be forgotten for his work to demonstrate that people can “breathe” through their butts.

Takebe’s unusual insight about an alternative way to deliver oxygen to the bloodstream inspired headlines when a successful animal-model study was featured in June 2021 on the cover of the journal Med. His team’s findings have since attracted attention from media outlets including the New York Times, New York Post, Science NOW, and the Canada-based science television show “The Nature of Things.”

Now, Takebe has received the ultimate snarky scientific honor: an Ig Nobel Prize.

This satiric prize has been awarded to 10 researchers each year since 1991 by the scientific humor magazine Annals of Improbable Research to “honor achievements that first make people laugh, and then make them think.” This year’s prizes were presented Sept. 12, 2024, at the Massachusetts Institute of Technology by actual Nobel Prize laureates.

Takebe is a native of Japan who holds academic posts in Tokyo and the United States. At Cincinnati Children’s, Takebe is Director for Commercial Innovation at the Center for Stem Cell and Organoid Research and Medicine (CuSTOM). In Japan, he is a professor with the Tokyo Medical and Dental University’s Institute of Research.

On the side, he began thinking several years ago about an odd, eel-like fish called a loach. Sometimes this freshwater bottom-dweller can wind up in water that’s running low on oxygen. When this occurs, the fish augments water-breathing via its gills by gulping surface air directly to its intestines.

What if people could do something similar? Well, it appears quite possible.

“There are multiple health conditions including respiratory distress in newborn patients that can threaten lives by disrupting our lungs’ ability to transfer oxygen to the bloodstream. These include injuries or inflammation affecting the airway, pneumonia filling the lungs with fluid, and so on. During the COVID pandemic, many patients suffered in part because there was a global shortage of ventilators and limited accessibility to ECMO,” says Takebe. “Enteric ventilation could serve as an important alternative oxygen delivery route. Further confirmation is needed by our initial studies indicate that our ventilation system is capable of supporting patients experiencing severe respiratory failure.”

The butt-breathing concept involves delivering a liquid (called a perfluorocarbon) that can be loaded with much more oxygen than water normally carries. When delivered through a rectal tube, the lower intestine can absorb oxygen from the liquid and send it directly into the bloodstream—much like receiving an enema.

Takebe and colleagues have shown that this method has helped rodents and porcine models survive low-oxygen conditions that would otherwise be fatal.

Since the initial studies, Takebe and colleagues have co-founded a start-up company called EVA Therapeutics, Inc., to further pursue human clinical trials in Japan. In June 2024, the company announced providing its first dose to a healthy human participant.

More research is needed to evaluate and fine-tune the delivery system, particularly for sick people in multiple settings. Goals include learning how much oxygen can be reliably delivered, for how long, and whether receiving the liquid poses any unforeseen risks.

The good news: Takebe’s Ig Nobel honor comes with a monetary prize to carry on the work–a single banknote worth 100 trillion Zimbabwean dollars. Ig Nobel officials say that adds up to about 40 cents in U.S. currency.

Learn more about Takebe’s work

Learn How Enteral Ventilation Concept Got Started

Watch an Employee Video About Dr. Takebe

Media Contact:
Tim Bonfield
Cincinnati Children’s
Timothy.bonfield@cchmc.org

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SOURCE Cincinnati Children’s Hospital Medical Center

Technology

PEAC Institute Launches “24 Hour Pause for Peace: A Global Concert”

Published

45 mins ago

September 21, 2024

24 Hour Pause for Peace Will Be the Largest Peace Initiative Ever Worldwide, Unifying 96 Countries on Six Continents Through Music

MONTCLAIR, N.J., Sept. 21, 2024 /PRNewswire-PRWeb/ — On this International Day of Peace, PEAC Institute, part of the 2017 Nobel Peace Prize winning team, has launched “24 Hour Pause for Peace: A Global Concert,” the largest peace initiative ever organized worldwide through music.

“Now, we need companies, government entities, other nonprofits and donors who care about our cause for peace to join us in lifting up the biggest event of this generation.”

On October 4, 2025, this ground-breaking program will activate a massive network of youth ensembles that spans 96 countries and territories across six continents and host two 24-hour commercial festivals featuring some of the biggest acts in music and entertainment. This extraordinary day-long event will be live-streamed globally, allowing millions to participate simultaneously.

“It has been 40 years since Live Aid and We Are the World historically unified and changed the world through music,” said Rebecca Irby, president and CEO of PEAC Institute. “With our planet riddled with post-pandemic fatigue, climate chaos, unsettling wars and more, we believe it is time to create a new trajectory for humanity by inviting everyone around the globe to a 24 hour pause for peace to enjoy the sounds of music and feel the transformative power of human connection,” Irby explained.

Additionally, 24 Hour Pause for Peace plans to amass more than 100 million ambassadors to sign an appeal to the United Nations calling for a 24 hour ceasefire during the children’s concerts and commercial music events. All countries are welcome to participate with no exceptions. One of Pause for Peace’s core beliefs is everyone has the right to be equally respected and heard, particularly in collectively calling for peace.

“Achieving this ambitious global endeavor requires the support and participation from the most impactful brands, organizations, and influential leaders, artists and celebrities,” said Jennifer McKenna, 24 Hour Pause for Peace CEO.

Pause for Peace is a $165 million global initiative. Currently, it is in its first phase of raising seed capital through consumer brand-aligned sponsorships and private donors. Funding for the program is tax-deductible through PEAC’s 501(c)(3) status.

“We have assembled an exceptional executive team of change agents in entertainment, production, consumer marketing, charitable development and global security to make this extraordinary, worldwide peace event happen.” McKenna added. “Now, we need companies, government entities, other nonprofits and donors who care about our cause for peace to join us in lifting up the biggest event of this generation.” To become involved in 24 Hour Pause for Peace: A Global Concert as a sponsor, partner or donor, sign up to be an Ambassador, or for more information, go to www.24hourpauseforpeace.org.

About PEAC Institute

PEAC Institute is a 501(c)(3) nonprofit organization based in the United States. PEAC stands for peace, education, art and communication. It was formed in 2016 through a campaign with partner organization, International Campaign to Abolish Nuclear Weapons (ICAN), which garnered a 2017 Nobel Peace Prize. PEAC now holds special consultative status with the Economic and Social Council of the United Nations and has a global presence working with countries and territories worldwide to reach the most marginalized youth through art and communication activities to help them explore and express. For more information on PEAC Institute, go to www.peacinstitute.org.

Media Contact

Chadwick Boyd, Pause for Peace, 1 4046060611, chadwick@24hourpauseforpeace.org, www.24hourpauseforpeace.org

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SOURCE Pause for Peace

Technology

Global Times: China opens 12 nuclear research facilities to global scientists

Published

2 hours ago

September 21, 2024

The involved facilities span areas such as basic nuclear research, isotope production, nuclear environment simulation, equipment testing, and radioactive waste treatment and disposal.

VIENNA, Sept. 21, 2024 /PRNewswire/ — China will open 12 nuclear research facilities and testing platforms to international scientists and institutions to enhance global cooperation, a senior Chinese official said here on Monday.

These include the China Advanced Research Reactor, the new-generation tokamak device Huanliu-3, and the Beishan Underground Research Laboratory, Liu Jing, vice chairman of the China Atomic Energy Authority (CAEA), said at a meeting on the sidelines of the International Atomic Energy Agency’s (IAEA) annual general conference.

The facilities span areas such as basic nuclear research, isotope production, nuclear environment simulation, equipment testing, and radioactive waste treatment and disposal.

Monday’s meeting, themed “Share for Development,” was organized by the CAEA to promote international cooperation in nuclear technology research and development, as China marks the 40th anniversary of its accession to the IAEA.

Yu Jianfeng, chairman of China National Nuclear Corporation, said at the event that the company aims to deepen cooperation with the IAEA and expand international collaboration. He expressed hope that opening China’s nuclear research facilities will contribute to advancing nuclear technology globally.

IAEA’s Deputy Director General Mikhail Chudakov commended China’s remarkable achievements in nuclear energy development and highlighted the long-standing, fruitful relationship between the IAEA and the CAEA.

Welcoming China’s decision to open up more of its nuclear research and development facilities, Chudakov said the move will further strengthen the agency’s technical capacity to support its member states.

On Monday evening, the CAEA and China’s permanent mission to the United Nations (UN) and other international organizations in Vienna jointly held a reception at the UN headquarters in Vienna to celebrate the 40th anniversary of China’s accession to the IAEA. More than 200 participants, including IAEA representatives and foreign envoys to Vienna, attended the event.

Li Song, China’s permanent representative to the UN and other international organizations in Vienna, said at the reception that China and the IAEA have expanded practical cooperation and jointly promoted the development of nuclear energy over the past 40 years.

China, he said, will continue to strengthen collaboration with the IAEA and its member states to address emerging challenges in international security, safeguard the global non-proliferation regime, and promote the use of nuclear energy and technology for the benefit of the Global South.

At the reception, Liu, Li and IAEA Director General Rafael Grossi jointly unveiled a bronze statue of Qian Sanqiang, a renowned Chinese nuclear physicist and one of the founders of China’s nuclear industry.

The statue, donated by China, will be permanently displayed at the IAEA headquarters, alongside sculptures of Polish-French physicist Marie Curie and other prominent figures who have made significant contributions to the peaceful use of nuclear energy.

Contact: xutianshu@globaltimes.com.cn

View original content:https://www.prnewswire.com/news-releases/global-times-china-opens-12-nuclear-research-facilities-to-global-scientists-302254830.html

SOURCE Global Times

Technology

The Ar-King of Spirits: Ed Arking’s Impact on the Liquor Industry

Published

3 hours ago

September 21, 2024

In the interest of providing luxury liquors in a convenient and stress-free format, Served Neat was born. When asked about his intentions for the company, Ed states, “My goal with Served Neat is to create a one-stop shop where customers can easily discover these rare gems.”

MOORESTOWN, N.J., Sept. 21, 2024 /PRNewswire-PRWeb/ — Served Neat is an emerging online platform with a curated selection of some of the world’s most popular luxury spirits. The website offers daily flash deals that highlight a variety of high-end international brands including Pappy Van Winkle, Buffalo Trace, Clase Azul, and more.

“While there are websites selling spirits, none have the decades of experience that we bring from WTSO. Served Neat will offer not only incredible bottles but also the best customer service in the industry.”

Ed and Joe Arking, the father-son team behind the concept of Served Neat, have decades of experience hand-selecting and supplying sought-after liquors. Ed Arking, CEO of New Jersey’s Roger Wilco, grew up in the world of wine and spirits and formed his own business aspirations.

“Growing up, I watched my father navigate and succeed in the ever-evolving wine and spirits industry,” Ed explains. “While I always aspired to create something similar, I knew I needed to wait for the right moment.” Ed has gone on to manage his own liquor store and lead projects for up-and-coming brands, such as the vodka-infused and non-carbonated Smooth Water.

As he evolved in his career, Ed discovered the perfect time to make his lifelong vision a reality. He recalls, “I noticed a gap in the market—especially for whiskey and tequila. These categories have surged in popularity, making it difficult for the everyday consumer to find those elusive sought-after allocated bottles.”

When it comes to Served Neat, quality and knowledge is key. Ed adds, “While there are websites selling spirits, none have the decades of experience that we bring from WTSO. Served Neat will offer not only incredible bottles but also the best customer service in the industry.”

Served Neat is the sister company to WTSO and The Wine Market, two online platforms dedicated to sourcing and distributing top-notch wines from every corner of the globe.

At The Wine Market, an online marketplace for the world’s most popular wine brands, convenience and quality are key. Each bottle in their curated collection is a testament to exceptional flavor and craftsmanship.

Since 2006, WTSO has enjoyed creating a unique wine experience and sharing it with new beginners and seasoned connoisseurs alike. Using an extensive network of wineries and wine makers, WTSO connects customers to thousands of brands from top wine appellations around the globe. The strong relationships they’ve formed within the wine world allow the business to deliver authentic and high-quality bottles to homes across the United States.

Wine and spirits lovers alike are invited to explore Served Neat, WTSO, and The Wine Market to find their next favorite bottle. Visit their websites to learn more about these one-of-a-kind online marketplaces!

Media Contact

Julie Blount, WTSO, 1 8669572795, marketing@wtso.com

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SOURCE WTSO