Connect with us

Technology

Oncology meets marine biology: When mussels spill the secrets of their environment

Published

4 months ago

on

INRS oncology experts use liquid biopsy to investigate the quality of marine ecosystems.

LAVAL, QC, July 23, 2024 /CNW/ – How can a team of oncology specialists provide insight into the effects of climate change on marine ecosystems? This is the challenge that a team from the Institut national de la recherche scientifique (INRS) brilliantly tackled under the supervision of Professor Yves St-Pierre and doctoral student Sophia Ferchiou, applying the principles of liquid biopsy—a technique used in early cancer detection—to the mussels of Quebec.

Medicine on call for biodiversity
By their very nature, mussels act as filters within their environment. As such, they are excellent bioindicators for assessing marine ecosystems. The research team therefore applied principles of liquid biopsy to the mollusks in order to investigate their ecosystem.

In humans, liquid biopsy involves analyzing DNA circulating in the bloodstream for evidence of cancer. It provides valuable indications of the type of cancer the patient has, the stage to which it has progressed, and the mutations generated by the disease. Since mussels retain traces of everything that enters their environment, liquid biopsy can provide significant insight into the ecological situation.

“The innovation lies in the use of new technology, i.e., multi-omic analysis, with which we can detect mutations, genetic and epigenetic changes, as well as DNA derived from organisms such as viruses, parasites, bacteria, and even certain species of fish in a given ecosystem,” explained Professor Yves St-Pierre, INRS oncology specialist. The researcher, who is based at the Armand-Frappier Santé Biotechnologie Research Centre in Laval, observed: “We are at the junction between biomedical science and marine biology.”

The liquid biopsy consisted of analyzing the hemolymph—a fluid analogous to blood in vertebrates—of several thousand mussels, providing a veritable treasure trove of environmental data and information.

“We are following the same course as we would with a cancer patient,” Professor St-Pierre stated. “We diagnose the disease, prescribe treatment, and then follow up on developments. The sooner we can detect signs of cancer or, in this case, environmental problems, the sooner we can intervene. With liquid biopsy, we are applying the same methodology and even the same philosophy to biodiversity.” 

A collaborative approach rooted in fieldwork
This project is currently at the heart of the work led by doctoral student Sophia Ferchiou at INRS. “My research consists of using mussels as a sentinel species, i.e., a species highly sensitive to changes in its environment, to assess the health status of marine and coastal ecosystems,” stated the marine biology student, who studies under the joint direction of Professor Yves St-Pierre and Stéphane Betoulle of the University of Reims.

The team conducts its research in close collaboration with Parks Canada biologists at four Quebec sites: Moulin-à-Baude, Cap-de-Bon-Désir and Pointe-à-John on the coast of Saguenay-St. Lawrence Marine Park, and Parc national du Bic, managed by Sépaq. Each site has its own distinctive features, such as proximity to domestic and agricultural wastewater disposal or a discovery and observation centre. Key differences have already been observed between these locations.

“By applying medical techniques to marine ecosystems, not only can we make a diagnosis, but we can also observe warning signs for future issues that are likely to affect an ecosystem. Are there traces of chemicals or signs of a viral outbreak? We can therefore apply early corrective measures, which we will monitor regularly using liquid biopsy,” Sophia Ferchiou highlighted.

Initially led by the doctoral student once a month since 2019, these sample collections now take place on a weekly basis thanks to the participation of Parks Canada biologists across the different sites, providing a unique opportunity to regularly monitor the ecosystems. “This partnership has enabled us to collect an extraordinary number of samples,” Sophia Ferchiou exclaimed. “Our study demonstrates the effectiveness of multi-omic analysis of liquid biopsies sampled from mussels to observe their biological response to environmental stress.”

“One of our conservation team’s mandates is to determine and monitor the health of the ecosystems in the Saguenay–St. Lawrence Marine Park. The approach proposed by INRS is part of a series of scientific monitoring projects carried out by our team and various partners to gain a better understanding of the changes and threats to the marine park’s ecosystems. Not only is the method innovative and promising, but it is also non-invasive and relatively simple to apply in the field. We are very pleased to be able to work with the team and rely on their expertise.”

About the study
The article entitled “Assessing marine ecosystem health using multi-omic analysis of blue mussel liquid biopsies: A case study within a national marine park” published in the journal Chemosphere, was coauthored by Sophia Ferchiou, France Caza, Kumardip Sinha, Janelle Sauvageau, and Yves St-Pierre. DOI:10.1016/j.chemosphere.2024.142714.

This research was funded by the Natural Sciences and Engineering Research Council of Canada (NSERC) and the Fonds de recherche du Québec – Nature and Technologies (FRQNT).

About INRS
INRS is an academic institution dedicated exclusively to graduate research and training in strategic sectors in Quebec. Since its creation in 1969, it has actively contributed to Quebec’s economic, social, and cultural development. INRS is first in Canada in research intensity. It is made up of four interdisciplinary research and training centres located in Quebec City, Montreal, Laval, and Varennes, which focus their efforts on strategic sectors: water, earth, and environment (Eau Terre Environnement Research Centre); energy, materials, and telecommunications (Énergie Matériaux Télécommunications Research Centre); urbanization, culture, and society (Urbanisation Culture Société Research Centre); and health and biotechnology (Armand-Frappier Santé Biotechnologie Research Centre). The INRS community includes over 1,500 students, postdoctoral fellows, and faculty and staff members. 

SOURCE Institut National de la recherche scientifique (INRS)

Related Topics:
Continue Reading
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Technology

Minister Champagne wraps up visit to Silicon Valley

Published

1 hour ago

on

November 16, 2024

By

PALO ALTO, CA, Nov. 16, 2024 /CNW/ – Today, the Honourable François-Philippe Champagne, Minister of Innovation, Science and Industry, concluded a visit to Palo Alto, California, where he met with business and tech leaders.

The Minister met with the CEO and Founder of Plug and Play, one of the world’s most active startup accelerators. He also met with the CEO and Founder of Groq, a company specializing in artificial intelligence (AI) chip technology.

Minister Champagne also met with key members of the C100, a not-for-profit association of over 400 Canadian expatriates advancing tech entrepreneurship in the Silicon Valley area.

While in Silicon Valley, Minister Champagne took the opportunity to visit the U.S. Department of Defense’s Defense Innovation Unit, which is designed to accelerate the adoption of cutting-edge commercial technologies by the U.S. military.

The Minister was also a guest speaker at the Trilateral Commission’s North American Group meeting where he was interviewed on a panel by Michael Duffy, Opinions editor at large of The Washington Post.

Quote

“Coming on the heels of the launch of the Canadian AI Safety Institute, this visit to Silicon Valley was a great opportunity to engage with tech leaders and entrepreneurs. As AI and other emerging technologies reshape national security, the economy and society at large, Canada will continue to play a central role in strengthening North America’s long-term competitiveness.”
– The Honourable François-Philippe Champagne, Minister of Innovation, Science and Industry

Associated links

Canada launches Canadian Artificial Intelligence Safety InstituteThe Trilateral Commission

Stay connected

Find more services and information on the Innovation, Science and Economic Development Canada website.

Follow Innovation, Science and Economic Development Canada on social media.
X (Twitter): @ISED_CA | Facebook: Canadian Innovation | Instagram: @cdninnovation | LinkedIn: Innovation, Science and Economic Development Canada

SOURCE Innovation, Science and Economic Development Canada

Continue Reading

Technology

The Mortgage Calculator Delivers Real-Time VA Loan Rates with Advanced Application Tools

Published

2 hours ago

on

November 16, 2024

By

The Mortgage Calculator introduces innovative VA loan calculators and tools featuring live mortgage rates updated by the minute. These tools empower veterans and active-duty military personnel with accurate, real-time insights into VA loan programs.

MIAMI, Nov. 16, 2024 /PRNewswire-PRWeb/ — The Mortgage Calculator, a licensed lender, has launched an advanced VA mortgage calculator platform with real-time mortgage rate integration for all VA loan programs from over 100 banks and lenders. Veterans and active-duty military personnel can now access live VA mortgage rates, updated by the minute, to make precise financial decisions. This technology ensures unmatched accuracy and transparency in VA loan planning.

Offering live mortgage rates is a pivotal enhancement for borrowers. This unique feature allows veterans and active-duty personnel to make well-informed decisions, whether purchasing a home or refinancing with an IRRRL.

The platform also offers tools to calculate VA mortgage loan payments and explore refinancing options like IRRRL loans (Interest Rate Reduction Refinance Loans). These tools simplify the loan application process and provide a complete understanding of financing options available to eligible borrowers.

Key Features of the Real-Time VA Loan Platform:

Live VA Loan Rates: Borrowers can view rates updated every minute, offering precise, real-time market data for all VA loan programs from multiple banks and lenders.Interactive VA Loan Calculator: Helps users estimate monthly payments based on current live rates, including refinancing options like IRRRL.Customizable Financial Tools: Provides tailored insights into VA loan affordability, terms, and eligibility requirements.Seamless Integration Across VA Loan Programs: Supports home purchases and refinancing with clarity and transparency.

“Offering live mortgage rates is a pivotal enhancement for borrowers,” said Jose Gonzalez, CSO of The Mortgage Calculator. “This unique feature allows veterans and active-duty personnel to make well-informed decisions, whether purchasing a home or refinancing with an IRRRL.”

To experience these tools and view live VA mortgage rates, visit the dedicated VA loan calculator page. Borrowers can also calculate savings on VA refinance options with the IRRRL calculator or explore broader resources like the VA mortgage loans guide. For additional information on other mortgage products, such as construction loans, visit the homepage.

About The Mortgage Calculator

The Mortgage Calculator is a licensed Mortgage Lender (NMLS #2377459) that specializes in using technology to enable borrowers to access both Conventional and Non-QM mortgage loan programs with over 100 banks and partners. Using The Mortgage Calculator proprietary technology, borrowers can instantly price and quote thousands of mortgage loan programs in just a few clicks. Our team of over 500 licensed Mortgage Loan Originators can assist our customers with Conventional, FHA, VA and USDA mortgages as well as access thousands of mortgage programs using Alternative Income Documentation such as Bank Statement Mortgages, P&L Mortgages, Asset Based Mortgage Programs, No Ratio CDFI Loan Programs, DSCR Investor Mortgages, Commercial Mortgages, Fix and Flip Mortgages and thousands more! To apply for a mortgage please visit https://themortgagecalculator.com

Mortgage Calculator Company LLC

NMLS#: 2377459

2125 BISCAYNE BLVD SUITE 220

Miami, FL 33137

Media Contact

Kyle Hiersche, The Mortgage Calcualtor, 1 7867331993, pr@themortgagecalculator.com, https://themortgagecalculator.com

Twitter

View original content to download multimedia:https://www.prweb.com/releases/the-mortgage-calculator-delivers-real-time-va-loan-rates-with-advanced-application-tools-302306757.html

SOURCE The Mortgage Calcualtor

Continue Reading

Technology

Norck Expands Custom Manufacturing Services with Enhanced Precision CNC Machining, Engineering Support, and Curated Network of Select Manufacturing Partners

Published

3 hours ago

on

November 16, 2024

By

Norck, a global leader in on demand manufacturing, has expanded its services to include precision CNC machining, custom component manufacturing, and on-demand solutions. The company’s curated network of trusted manufacturing partners and personalized one-on-one engineering support set it apart from automated platforms. Serving industries such as aerospace, defense, robotics, and medical, Norck delivers high-quality, precision-engineered components tailored to specific needs. With capabilities in CNC machining, 3D printing, and hybrid manufacturing, Norck empowers businesses to innovate and scale efficiently. Visit www.norck.com for more information.

IRVINE, Calif. and MANNHEIM, Germany, Nov. 16, 2024 /PRNewswire-PRWeb/ — Norck, a global leader in advanced manufacturing and custom component production, is proud to announce a major expansion of its services, focusing on precision CNC machining, custom component manufacturing, and on-demand CNC machining. A key highlight of this growth is the enhancement of Norck’s curated network of select manufacturing partners, ensuring clients benefit from the highest quality standards and consistent reliability.

By partnering with only the best manufacturers, we ensure that every project meets our clients’ exacting standards. Combined with our one-to-one engineering support, this approach guarantees a superior manufacturing experience.

Complementing its growing capabilities, Norck reaffirms its commitment to personalized, one-to-one engineering and design support, setting it apart from competitors with automated platforms. With a strategic combination of expert guidance and a carefully vetted partner network, Norck is revolutionizing the way businesses approach custom parts manufacturing.

Norck’s Motto: “Prototype. Manufacture. Scale Up. On Demand.”

This guiding principle reflects Norck’s dedication to delivering seamless, end-to-end solutions that meet the dynamic needs of modern industries. From initial prototyping to full-scale production, Norck empowers businesses to innovate and grow with speed and precision.

Expanding a Curated Network of Trusted Manufacturing Partners

Norck’s curated network of select manufacturing partners brings together top-tier facilities specializing in CNC machining, injection molding, and metal 3D printing. Each partner is carefully vetted for quality, reliability, and expertise, ensuring seamless collaboration and superior results.

Key Benefits of Norck’s Manufacturing Partner Network:

Consistent Quality Standards: Partners are selected based on strict adherence to global certifications such as ISO 9001 and AS9100.Diverse Capabilities: Access to advanced manufacturing technologies, including custom CNC machining, custom component manufacturing, and on-demand sheet metal fabrication.Streamlined Project Management: Norck acts as a single point of contact, managing every aspect of production and ensuring seamless coordination across its network.

“Our curated network is an integral part of delivering exceptional results to our clients,” said Faruk Guney, CEO of Norck. “By partnering with only the best manufacturers, we ensure that every project meets our clients’ exacting standards. Combined with our one-to-one engineering support, this approach guarantees a superior manufacturing experience.”

Personalized Engineering and Design Support

Unlike platforms that rely heavily on automation, Norck emphasizes a one-on-one collaboration model with clients. This personalized approach ensures that designs are optimized for manufacturability, cost-efficiency, and performance before production begins.

Key Features of Norck’s Engineering and Design Support:

Dedicated Design Consultants: Clients work with experienced engineers who understand their unique requirements and industry challenges.

Seamless Iteration: From concept refinement to rapid prototyping, Norck supports clients at every step to perfect their designs.

Material Selection Guidance: Expert advice to choose the best materials for durability, performance, and cost-effectiveness.

Feasibility Analysis: Comprehensive evaluations to ensure manufacturability and optimal production outcomes.

Precision CNC Machining and Custom Component Manufacturing

Norck’s precision CNC machining services are at the forefront of its manufacturing offerings. With a focus on high-quality production and design optimization, Norck delivers custom CNC parts and components that meet even the most complex specifications.

Key Highlights:

On-Demand CNC Machining: Rapid, efficient production tailored to client needs, from prototypes to large-scale production.

Wire EDM Services: Precision machining for intricate designs requiring tight tolerances.

Custom CNC Machining Near Me: Localized support through Norck’s extensive partner network for faster turnaround times and convenience.

Advanced Metal 3D Printing Services

Norck has also enhanced its metal 3D printing services, providing innovative solutions for lightweight and complex custom metal parts. These services are integrated with Norck’s engineering support to ensure clients achieve the perfect balance of creativity and manufacturability.

Key Features:

Custom Metal 3D Printing: Production of intricate and durable components for aerospace, automotive, and medical applications.Hybrid Manufacturing Solutions: Combining CNC machining and 3D printing for advanced design possibilities.Injection Molding and On-Demand Sheet Metal FabricationNorck’s comprehensive offerings include injection molding and on-demand sheet metal fabrication, enabling clients to produce high-quality custom parts at scale. By leveraging its curated network, Norck delivers consistent results across all manufacturing disciplines.

Industries Served

Norck proudly serves a diverse range of industries, providing tailored solutions to meet specific sector requirements:

Norck offers specialized manufacturing solutions across various industries, delivering precision-engineered components and services tailored to each sector’s unique requirements.

Aerospace: Norck provides high-precision components that meet stringent aerospace standards, ensuring safety and reliability in critical applications.

Defense: Supplying robust and reliable parts, Norck supports mission-critical defense systems and equipment, adhering to rigorous quality and performance criteria.

Robotics: Norck creates intricate components essential for the efficient operation of robotic systems and automation technologies, enhancing performance and precision.

Automotive: Manufacturing custom parts, Norck enhances vehicle performance, durability, and safety across various automotive applications.

Medical: Producing biocompatible and precision-engineered components, Norck supports medical devices, surgical tools, and healthcare technologies, ensuring safety and efficacy.

Consumer Products: Producing high-quality, durable components, Norck serves a wide range of consumer goods, from electronics to appliances, ensuring product longevity and reliability.

Industrial: Providing durable and reliable parts, Norck supports machinery, tools, and industrial systems, ensuring operational efficiency and longevity.

Hardware: Crafting precision hardware components, Norck caters to construction, infrastructure, and various manufacturing applications, meeting specific project needs.

Electronics: Delivering custom components, Norck supports electronic devices, ensuring compatibility and performance in advanced systems.

Energy: Supplying high-performance parts, Norck serves renewable energy, oil and gas, and power generation applications, contributing to efficient energy solutions.

Norck’s tailored solutions ensure each industry’s unique requirements are met with precision and reliability, reinforcing its commitment to quality and innovation.

About Norck

Norck is a global leader in advanced manufacturing, specializing in precision CNC machining, custom component manufacturing, metal 3D printing, and injection molding. With a strong commitment to innovation, quality, and customer satisfaction, Norck delivers tailored manufacturing solutions to businesses worldwide. By combining personalized engineering support, cutting-edge technologies, and a curated network of trusted manufacturing partners, Norck empowers industries to achieve their most ambitious goals.

For more information about Norck’s services and solutions, visit www.norck.com

Media Contact

Dennis Weiss, NORCK INC – NORCK GMBH, 1 949-232-0251, ed@norck.com, www.norck.com

Ed Braun, NORCK INC – NORCK GMBH, www.norck.com

View original content to download multimedia:https://www.prweb.com/releases/norck-expands-custom-manufacturing-services-with-enhanced-precision-cnc-machining-engineering-support-and-curated-network-of-select-manufacturing-partners-302307307.html

SOURCE NORCK INC – NORCK GMBH; NORCK INC – NORCK GMBH

Continue Reading

Trending