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Kyverna’s KYV-101 Receives U.S. FDA RMAT Designation for KYV-101 in the Treatment of Patients With Refractory Stiff-Person Syndrome

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The application was evaluated based on the positive clinical outcomes of KYV-101 in patients treated in Germany under a named-patient treatment option

The Regenerative Medicine Advanced Therapies designation will allow Kyverna to receive expert guidance on efficient drug development and use of surrogate endpoints from senior FDA officials

EMERYVILLE, Calif., July 15, 2024 /PRNewswire/ — Kyverna Therapeutics, Inc. (Kyverna), a patient-centered, clinical-stage biopharmaceutical company focused on developing cell therapies for patients suffering from autoimmune diseases, announced today the designation as Regenerative Medicine Advanced Therapy (RMAT) by the U.S. Food and Drug Administration (FDA) for its autologous, fully human CD19 chimeric antigen receptor (CAR) T-cell product candidate, KYV-101, to be used for the treatment of patients suffering from refractory stiff-person syndrome. 

“Stiff-person syndrome has devastating and life-altering effects on patients suffering from this rare autoimmune disease,” said Amanda Piquet, M.D., director of the Autoimmune Neurology Program at CU Anschutz Medical Campus, Aurora, CO. “I look forward to the data that will emerge from the KYSA-8 trial as this trial could drastically change the treatment landscape for SPS.”

“We are eager to begin generating data from our sponsored trial to advance the knowledge on a potential immunological reset of the patient’s immune system,” said Peter Maag, Ph.D., chief executive officer at Kyverna. “We are humbled by the resilience of the SPS patients and their hope for a potential paradigm-shifting treatment option that could provide durable, immunosuppressant-free remission.”

About Stiff Person Syndrome (SPS) 
SPS is a rare, progressive neurological autoimmune disorder causing debilitating muscle stiffness in the torso, arms, and legs, impacting the ability to walk or move. Patients typically present with muscle spasms and stiffness, resulting in difficulty turning and bending. When stiffness is severe, the patients’ posture resembles a statue. Muscle spasms and stiffness can be precipitated by unexpected stimuli, including sounds, like a phone ring or a siren, sudden touches or conditions triggering anxiety and emotional upset which, when severe, are misdiagnosed as a primary anxiety disorder1. 

About KYV-101
KYV-101 is an autologous, fully human CD19 CAR T-cell product candidate for use in B cell-driven autoimmune diseases. The CAR in KYV-101 was designed by the National Institutes of Health (NIH) to improve tolerability and tested in a 20-patient Phase 1 trial in oncology. Results were published by the NIH in Nature Medicine2.

KYV-101 is currently being evaluated in sponsored, open-label, Phase 1/2 and Phase 2 trials of KYV-101 in the United States and Germany across two broad areas of autoimmune disease: rheumatology and neurology.

With 50 patients treated so far with the CAR in KYV-101 in both oncological and autoimmune conditions at more than 15 locations in Europe and the U.S., we believe that the differentiated properties of KYV-101 are critical for the potential success of CAR T cells as autoimmune disease therapies.

KYV-101 is also being evaluated in investigator-initiated trials for multiple indications in multiple geographies.

About Kyverna Therapeutics
Kyverna Therapeutics, Inc. (Nasdaq: KYTX) is a patient-centered, clinical-stage biopharmaceutical company focused on developing cell therapies for patients suffering from autoimmune diseases. 

Our lead CAR T-cell therapy candidate, KYV-101 is advancing through clinical development with sponsored clinical trials across two broad areas of autoimmune disease: rheumatology and neurology, including Phase 2 trials for stiff person syndrome, multiple sclerosis and myasthenia gravis, a Phase 1/2 trial for systemic sclerosis, and two ongoing multi-center, open-label Phase 1/2 trials in the United States and Germany for patients with lupus nephritis. 

Kyverna’s pipeline includes next-generation CAR T-cell therapies in both autologous and allogeneic formats with properties intended to be well suited for use in B cell-driven autoimmune diseases.

Forward-Looking Statements
Statements in this press release about future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute “forward-looking statements.” The words, without limitation, “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “will,” “would” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these or similar identifying words. Forward-looking statements in this press release include, without limitation, those related to: the potential impact of named-patient case studies; Kyverna’s goals to develop certain paradigm-shifting treatment options; Kyverna’s beliefs about the differentiated properties of KYV-101; and Kyverna’s clinical trials. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: uncertainties related to market conditions, and other factors discussed in the “Risk Factors” section of Kyverna’s most recent Annual Report on Form 10-K and Quarterly Reports on Form 10-Q that Kyverna has filed or may subsequently file with the U.S. Securities and Exchange Commission. Any forward-looking statements contained in this press release are based on the current expectations of Kyverna’s management team and speak only as of the date hereof, and Kyverna specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise. 

For more information, please visit https://kyvernatx.com

Investor Contact:
George Thampy
Kyverna Therapeutics
InvestorRelations@kyvernatx.com 

Kyverna Media Contact:
Consort Partners for Kyverna
kyvernatx@consortpartners.com 

1 Dalakas, M.C., Neurotherapeutics 2022; 19, 832–847.
2 Brudno et al., Nature Medicine 2020; 26:270-280. 

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SOURCE Kyverna Therapeutics

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MILESOPEDIA 2025 RANKINGS: The Best Programs, Credit Cards, and Bank Accounts in Canada to Amplify Your Purchasing Power

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MONTREAL, Jan. 9, 2025 /CNW/ – In an economic context where the rising cost of living heavily impacts households, personal finance is at the heart of Canadians’ concerns. To help them navigate this new year, Milesopedia, Canada’s leading platform for comparing credit cards and loyalty programs, publishes its grand 2025 Rankings of the Best Programs, Credit Cards, and Bank Accounts in Canada for the fourth consecutive year.

“2025 begins in an economy marked by the persistence of inflation and uncertainty contributing to the rising cost of living, making it essential to make the most out of every dollar spent. A good credit card can not only simplify payments but also enrich your daily life. Whether you want to reduce your everyday expenses, earn cash back on your essential purchases, gain access to airport lounges, or enjoy hotel upgrades, your credit cards can bring you much more than you might imagine. In the sea of banking offers, here is a ranking of cards and financial institutions that will allow you to maximize benefits according to your spending habits and needs. Too many Canadian consumers leave money on the table due to a lack of time or information. Our 2025 Rankings aim to democratize access to the best financial solutions and the rewards you deserve,” explains Jean-Maximilien Voisine, President and Founder of Milesopedia.

NOTABLE NEW ADDITIONS IN THE 2025 RANKINGS

The 2025 Rankings have been expanded to better represent the diversity of the Canadian market and are based on an in-depth analysis of 255 financial products (171 credit cards and 84 bank accounts), evaluated using over 190 criteria.

From this thorough review, Milesopedia has awarded:

22 awards for credit cards5 awards for banking services

New this year, 6 Milesopedia Community’s Choice Award were granted following a public vote conducted between December 1 and December 14, 2024:

2 credit cards, and4 loyalty programs.

The 2025 Rankings highlight notable changes, with new players emerging in the Milesopedia Community’s Favourite Categories.

Voted Best Travel Credit Card, the American Express Cobalt Card dominated the competition. It stands out for its generous rewards on dining and travel, offering an unparalleled travel experience for Canadians.

As for cash back Credit Cards, the Scotiabank Gold American Express Card has been recognized as the Best Cash Back Credit Card by the community. Offering 5% cashback on grocery and dining purchases, this card enables everyday savings while maximizing rewards.

New products also make their way into the rankings, highlighting the diversification of offers and the evolving expectations of consumers regarding flexibility and accessibility.

In the realm of preferred loyalty programs, the Aeroplan Program was recognized for its exclusive benefits and flexibility in earning and redeeming points, while the American Express Membership Rewards program stood out for its versatility and the wide range of reward options available.

Regarding bank accounts, the National Bank Checking Account for Newcomers was awarded Best Bank for Newcomers in Quebec, while the EQ Bank Personal Account was recognized as the Best Online Banking Account for its ease of access and lack of fees.

Discover our 2025 Rankings now and explore a selection of the best financial products on the market, including credit cards, bank accounts, and loyalty programs. A variety of options to meet the needs of every profile: families, travellers, students, entrepreneurs, and newcomers, with tangible benefits on everyday spending, travel, and financial management.

Press Room
https://milesopedia.com/en/about/press-releases/ 

Photos for release
Photo credit : Milesopedia (2025)
https://bit.ly/40oPRlW 

ABOUT MILESOPEDIA

Since its founding in 2015, the Montreal-based Fintech Milesopedia has established itself as the leading bilingual Canadian reference on loyalty programs, credit cards, and bank accounts (chequing and savings) offered to Canadians. Constantly sought after for its unique expertise, the company has experienced prosperous growth, particularly due to its advanced credit card and bank account comparison solutions, the most widely used in the country, reaching over 2 million unique consumers monthly through the Milesopedia Network, which includes nearly 15 partners: Protégez-Vous, François Charron, Educfinance, Dollars et cents | L’actualité, BB Jetlag, Retraite 101, Club Boomerang, Le Jeune retraité, NoovoMoi (Bell Media), InfoBref, The Canadian Jetsetter and RedFlagDeals (VerticalScope Inc.). Originally launched as a blog by Jean-Maximilien Voisine, an aviation and travel enthusiast, the team now includes 16 employees. The company makes financial products more accessible to consumers by simplifying financial literacy and promoting the responsible and profitable use of financial tools available in Canada.

SOURCE Milesopedia

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Senske Family of Companies Expands Southeast Presence with Acquisition of TurfPride

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DALLAS, Jan. 9, 2025 /PRNewswire/ — Senske Family of Companies (SFC) is proud to announce the acquisition of TurfPride, a leading provider of residential lawn care services in the Atlanta market. This strategic acquisition builds on SFC’s growing presence in the Southeastern United States, which began with the acquisition of Arbor-Nomics in 2024. TurfPride will now become part of the Arbor-Nomics portfolio, further solidifying SFC’s commitment to delivering industry-leading lawn care solutions in the region.

TurfPride has earned a reputation as a trusted name in lawn care, offering services tailored to the specific needs of Georgia’s unique landscapes and climate. Their offerings include lawn fertilization, weed control, aeration, overseeding, disease prevention, and tree and shrub care. With a customer-first approach and a dedication to excellence, TurfPride has been a key player in the Atlanta market, delivering customized treatment programs developed in collaboration with leading turf specialists from institutions like NC State, Clemson, and the University of Georgia.

“Expanding our Southeast operations through strategic acquisitions like TurfPride allows us to strengthen our footprint and bring best-in-class lawn care services to even more customers,” said Casey Taylor, CEO of Senske Family of Companies. “TurfPride’s expertise and dedication to their customers make them a perfect fit for the Arbor-Nomics portfolio. We’re excited to build on the strong foundation they’ve established and continue growing our presence in the Atlanta market and beyond.”

TurfPride will add an additional depot in Kennesaw to Arbor-Nomics’ existing locations in Norcross, Marietta, Cumming, Winder, and Douglasville, GA. This acquisition highlights SFC’s broader strategy to expand in key markets while maintaining the exceptional service and trusted reputation customers expect.

About Senske Family of Companies: Since securing investments from the private equity firm GTCR, the Senske Family of Companies has completed eighteen acquisitions. Senske serves customers in sixteen U.S. states as well as Canada and remains committed to its international expansion strategy by actively seeking partnerships with distinguished home services companies. 

More on Senske’s M&A process can be found at www.senske.com/why-senske/mergers-and-acquisitions/.

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SOURCE Senske Services

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West Academic, A BARBRI Company Partners with The American Law Institute to Elevate Legal Education Resources

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DALLAS, Jan. 9, 2025 /PRNewswire/ — West Academic, a BARBRI company, the leading provider of legal education content and digital learning tools, has added a valuable new addition to its subscription offerings: The American Law Institute Collection. In partnership with The American Law Institute (ALI), this collection offers law schools access to official texts and Tentative Drafts of Restatements, Principles, and the Model Penal Code. The ALI Collection is available as a supplement to the West Academic Study Aids & Reference Collection, providing comprehensive support for legal education.

“We’re excited to partner with ALI to deliver their content with the West Academic Study Aids & Reference Collection. The user-friendly eReader format our platform provides will make it easier for law librarians, faculty, and students at subscribing schools to access this valuable content and incorporate it into their research, teaching, and studies. Our team has loved working with ALI and looks forward to continued collaboration,” said Pamela Siege Chandler, Chief Content and Learning Officer at BARBRI.

The inclusion of ALI’s collection with West Academic’s digital platform means access to critical legal texts with greater ease and convenience. The ALI Collection includes comprehensive resources fundamental to understanding and interpreting the law, such as Restatements of the Law, Principles of the Law, and the Model Penal Code.

“We are thrilled the published books and Tentative Drafts of The American Law Institute’s Restatements, Principles, and the Model Penal Code are now available through West Academic’s Study Aids Collection,” said ALI Director Diane P. Wood. “A core component of our mission is to clarify the law, and now students embarking on their legal education will have easy access to our current library to assist in their studies.”

Wood continued, “While our work in Torts, Contracts, Property, and other areas has long been a cornerstone of legal education, this partnership ensures law schools have convenient electronic access to not only our published books but also our works in progress, including Tentative Drafts on crucial subjects like Children and the Law, Copyright, and Corporate Governance.”

This partnership aligns with BARBRI’s ongoing commitment to providing comprehensive and accessible legal education resources. By including ALI’s texts alongside its digital learning platform, West Academic continues to support the academic and professional growth of law students, equipping them with the essential resources needed for success in the legal field.

For more information about the ALI Collection or to learn more about subscription options, please contact your West Academic Account Manager.

About The American Law Institute
The American Law Institute is the leading independent organization in the United States producing scholarly work to clarify, modernize, and improve the law. The ALI drafts, discusses, revises, and publishes Restatements of the Law, Model Codes, and Principles of Law that are influential in the courts and legislatures, as well as in legal scholarship and education. By participating in the Institute’s work, its distinguished members have the opportunity to influence the development of the law in both existing and emerging areas, to work with other eminent lawyers, judges, and academics, to support the rule of law and the legal system, and to contribute to the public good. For more information about The American Law Institute, visit www.ali.org.

About West Academic, A BARBRI Company
In 2021, BARBRI acquired West Academic. West Academic offers industry-leading legal education materials and digital learning resources for law schools. Rooted in a rich history of legal expertise and innovation, West Academic delivers trusted resources that support faculty instruction and enhance student learning.

BARBRI is the global leader and largest provider of tech-enabled legal learning solutions for law students, law schools, universities, professionals, law firms, and organizations.

BARBRI has been the number one brand in legal education for over 50 years and has forged a trusted relationship with more than 1.5 million legal professionals around the world. BARBRI’s ongoing commitment to innovation in technology, learning science, and expert content and curriculum — developed by renowned experts — empowers global legal learners at every step of their career journey. From helping aspiring lawyers prepare for the LSAT and succeed in law school, to delivering effective U.S. Bar and SQE preparation courses and a lifetime of legal education through professional development courses, BARBRI’s exceptional resources, data insights, and personalized support help legal learners, law schools and organizations achieve their goals and provide excellent learner outcomes.

BARBRI is headquartered in Dallas, Texas, with offices in the United States and United Kingdom.

For more information, please visit www.barbri.com

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SOURCE BARBRI

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