Connect with us

Technology

DP Technology Announces Nomination of Development Candidate, a CNS Penetrable Lp-PLA2 Inhibitor for Alzheimer’s Disease

Published

on

BEIJING, July 8, 2024 /PRNewswire/ — DP Technology, an “AI for Science” paradigm-driven company, today announced the nomination of DPT0416, a novel CNS penetrable small molecule targeting Lp-PLA2, as a preclinical candidate for the treatment of Alzheimer’s disease (AD).

AD is the most frequent cause of dementia (60%~70%), affecting approximately 57 million people worldwide. Neurovascular dysfunction is an early and predominant event in AD development, independent of classic amyloid pathology. Lp-PLA2 is a phospholipase secreted primarily by inflammatory cells, including peripheral macrophages and CNS microglia. It hydrolyzes oxidized phospholipids typically on low-density lipoprotein (LDL), producing lysophosphatidylcholine (lysoPC) and other potent proinflammatory factors. LysoPC is a key inflammatory mediator on vascular endothelial cells, causing vascular pathology including vessel leakage and BBB damage. The inhibition of Lp-PLA2 by Rilapladib significantly slowed down AD progression and repaired BBB damage in a Phase IIa trial.

DPT0416 is a novel CNS-penetrable Lp-PLA2 inhibitor, exhibiting higher potency, better ADME and physicochemical properties than Rilapladib. In animal models, DPT0416 showed improvement in BBB integrity and a reduction in brain inflammation. The IND-enabling studies are ongoing.

“Alzheimer’s disease imposes increasing burdens on the world. Approvals of three anti-amyloid β (Aβ) antibodies mark a pivotal moment in the fight against AD, but the modest clinical efficacy and side effects highlight the complexity of AD and call for more novel interventions with better efficacy. The future treatment of AD should address multiple aspects of the disease, including anti-oxidants, anti-inflammation, and enhancing brain resilience, among others,” said Xiaomin Zhang, Head of Drug Discovery at DP Technology. “Targeting Lp-PLA2 is a novel therapy that addresses multiple factors beyond amyloid. Given rilapladib’s positive clinical results, the better molecule DPT0416 is expected to bring more benefits to AD and dementia patients.”

“DP Technology is revolutionizing the AI for Science landscape by integrating ‘AI + Simulation + Experiments’ into our processes to address significant medical needs,” said Weijie Sun, Founder and CEO of DP Technology. “The successful identification of DPT0416 highlights the power of our RiDYMO® platform, particularly the contributions of the Uni-FEP and Uni-QSAR modules in enhancing molecular interactions, drug-like characteristics, and BBB penetration. These real-world applications of our cutting-edge algorithms signify an important progression towards our envisioned future. We look forward to forging partnerships with trusted collaborators to advance this initiative to the next pivotal stage.”

The RiDYMO® drug design platform integrates various AI and physical algorithms, dedicated to the development of drugs for “undruggable” targets and “best-in-class” molecules. As one of its core algorithms, Reinforced Dynamics (RiD) has a significant advantage in the sampling efficiency of molecular dynamics simulation. By fully leveraging the high-dimensional representation capabilities of neural networks, RiD can efficiently capture dynamic conformational changes in complicated biomolecular systems.

The RiDYMO® platform is dedicated to studying the dynamics of biological systems and revealing cryptic binding sites, encompassing a range of challenging systems including protein-protein interactions (PPIs), intrinsically disordered proteins (IDPs), membrane proteins, RNA, and others. Its effectiveness has been confirmed through validation on challenging targets, including the c-Myc protein, c-Myc RNA, GPX4 protein, Kv1.3 protein, and others.

About DP Technology

DP Technology, an “AI for Science” new paradigm-driven company, dedicated to applying Artificial Intelligence and Molecular Simulation algorithms to solve important scientific problems by combining advanced computational methods.

Relying on DP Technology’s Dynamics-based drug design platform, RiDYMO®, we have set up a world-leading hit discovery platform. The team has established external collaborations and built up strong internal pipeline, focusing on three areas of CNS, oncology and autoimmune diseases.

For collaboration and further information,please contact Dr. Xiaomin Zhang (zhangxm@dp.tech). 

References:
[1] Alzheimers. Dement. 17(Suppl 10), e051496 (2021).
[2] Nat. Med. 25, 270-276 (2019).
[3] Med. Res. Rev. 40, 79-134 (2020).
[4] Alzheimers. Dement. 1, 131-140 (2015).
[5] Diab. Vasc. Dis. Res. 14, 200-213 (2017).

View original content to download multimedia:https://www.prnewswire.com/news-releases/dp-technology-announces-nomination-of-development-candidate-a-cns-penetrable-lp-pla2-inhibitor-for-alzheimers-disease-302190631.html

SOURCE DP Technology

Continue Reading
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Technology

Morrison Foerster Opens Amsterdam Office, Extending the Reach of Its Premier Privacy + Data Security Practice

Published

on

By

The firm’s 18th office worldwide and 4th in Europe, will create deeper connections with global clients.

AMSTERDAM, Netherlands, Jan. 8, 2025 /PRNewswire-PRWeb/ — Morrison Foerster (MoFo), a leading global law firm, is pleased to announce that it has opened an office in Amsterdam to further extend the reach of its premier Privacy + Data Security practice, and forge deeper connections with global clients operating in Europe.
The office is the firm’s 18th globally and 4th in Europe, and will be led by partner Alex van der Wolk, co-chair of MoFo’s preeminent Global Privacy & Data Security practice. Initially, the office will include van der Wolk, partner Marijn Storm, and senior of counsel Lokke Moerel, all admitted to practice in the Netherlands, with further additions to the office expected following the office’s formal opening.

MoFo’s new Amsterdam office enables the firm to further entrench its roots with disputes and transactions clients globally and in the European market, offering closer and more strategic ties with clients that the firm is already advising in the Netherlands, alongside the opportunity to forge new relationships.

“Establishing a presence in the Netherlands creates an exciting proposition for clients as we grow Morrison Foerster’s global platform,” said Eric McCrath, Chair of Morrison Foerster. “Amsterdam represents a thriving, multi-industry hub, with many of the globe’s biggest corporations present in the city alongside innovative new startups and scale-ups. The founder members of our Amsterdam office have been practicing in the Netherlands for many years and already have an established network in the region, affording us a running start as we open our newest office in the MoFo network. We are excited at what Amsterdam can bring to our platform and look forward to the success of our newest office.”

The firm’s Amsterdam office will look to build on its strong Privacy + Data Security practice, advising a cross-section of companies in the technology, life sciences, and artificial intelligence industries.

“Having advised numerous Netherlands-based clients for many years, I am excited to lead our new office in Amsterdam, welcoming existing and new clients to Morrison Foerster’s premier global platform for data privacy and security matters,” said van der Wolk. “Our team in Amsterdam, with market-leading attorneys in data privacy, will not only lead on complex work in their own right, but are also play a crucial role on an array of the firm’s global mandates, from cross-border disputes to billion-dollar deals. I am excited to build the firm’s 18th office in its global network.”

Media Contact

Alexander Smith, Morrison Foerster, +44 (20) 79204064, alexandersmith@mofo.com, mofo.com

View original content:https://www.prweb.com/releases/morrison-foerster-opens-amsterdam-office-extending-the-reach-of-its-premier-privacy–data-security-practice-302345915.html

SOURCE Morrison Foerster

Continue Reading

Technology

AmpUp and Hubject Join Forces to Accelerate EV Charging Across North America

Published

on

By

New collaboration to introduce Plug&Charge technology, followed by expanded access through the eRoaming network

SANTA CLARA, Calif., Jan. 8, 2025 /PRNewswire/ — AmpUp, a leading provider of electric vehicle (EV) charging solutions, and Hubject, the global leader in eRoaming and Plug & Charge services, today announced a partnership aimed at accelerating the EV charging experience across North America.

Under this collaboration, AmpUp will first implement Hubject’s Plug&Charge technology across its new charging stations. This innovative feature simplifies charging by allowing EV drivers to initiate payment without relying on app-based methods or RFID cards. Following this rollout, AmpUp’s charging stations will be integrated into Hubject’s extensive eRoaming network, providing seamless access to over 1 million charging points globally.

“Charger availability and ease of use are vital for making the EV transition accessible to all,” said Tom Sun, CEO and co-founder of AmpUp. “By partnering with Hubject, we are committed to enhancing the charging experience for our customers while expanding charging opportunities in their communities.”

Key benefits of the partnership include:

Plug&Charge Implementation: A simplified payment process for EV drivers.Access to a Vast Network: Integration into Hubject’s global network of over 1 million charging points.Enhanced Interoperability: Ensures driver choice and access to charging infrastructure across borders.

Trishan Peruma, Hubject North America CEO, said, “We welcome AmpUp as a valued partner in the Hubject eMobility ecosystem as we look to provide a seamless and secure charging experience for even more drivers across North America.”

The partnership between AmpUp and Hubject marks a pivotal advancement in expanding reliable and user-friendly EV charging infrastructure across the continent. Together, the companies are driving toward a future where sustainable transportation is accessible to everyone.

About AmpUp
AmpUp is breaking down barriers to widespread EV adoption with the most reliable, flexible, and user-friendly EV charging platform. Since its founding in 2018, AmpUp has powered over 1,500 charging networks across 75 North American markets, enabling businesses and property owners to seamlessly deploy and manage EV charging solutions. Trusted by industry leaders such as JLL, CBRE, Domino’s Pizza, Goodyear, Under Armour, and Hilton, AmpUp is at the forefront of advancing sustainable transportation. For more information, visit www.ampup.io. For marketing inquiries, please contact randa@ampup.io

About Hubject
Hubject simplifies the charging of electric vehicles. Through its eRoaming platform intercharge, the eMobility specialist connects Charge Point Operators (CPOs) and eMobility Service Providers (EMPs) to provide standardized access to charging infrastructure regardless of any network. Hubject has established the world’s largest cross-provider charging network for electric vehicles by connecting CPO networks encompassing over 1 million connected charging points and more than 2,250 B2B partners across 63 countries and four continents. In addition, Hubject is a trusted consulting partner in the Mobility market, advising automotive manufacturers, charging providers, and other EV-related businesses looking to launch eMobility services or implement Plug&Charge using ISO15118-2 and ISO15118-20. In essence, Hubject promotes eMobility and its advancement worldwide. For more information, please visit www.hubject.com follow us on LinkedIn.

 

View original content to download multimedia:https://www.prnewswire.com/news-releases/ampup-and-hubject-join-forces-to-accelerate-ev-charging-across-north-america-302345957.html

SOURCE AmpUp

Continue Reading

Technology

Therap Services Strengthens Documentation with Advanced HIPAA-Compliant Secure Video Documentation Tool

Published

on

By

TORRINGTON, Conn., Jan. 8, 2025 /PRNewswire/ — Therap Services, the national leader in HIPAA-compliant electronic documentation solutions for organizations in the Long-Term Services and Supports (LTSS), Home and Community-Based Services (HCBS), and other human services industries, strengthens its documentation capabilities with the Secure Video Documentation tool and giving service providers a highly secure and HIPAA-compliant solution for managing videos containing Protected Health Information (PHI). This tool is designed to meet the needs of organizations that require efficient, secure, and integrated video documentation within their workflows.

The Secure Video Documentation tool allows users to upload and store videos in a centralized Video Library. These videos can be attached directly to existing modules within the Therap system, including General Event Reports (GER), GER Resolution, Individual Home Page, ISP Program, and T-Logs. This integration strengthens the documentation process by enabling providers to enhance traditional records with video evidence, improving both the clarity and comprehensiveness of reports.

Therap’s solution ensures that PHI-related video content is managed in a secure environment, with access strictly controlled through user privilege assignments. Based on their roles, users can view or download videos as needed, supporting collaborative workflows while safeguarding sensitive data. This functionality aligns with Therap’s commitment to privacy and security, ensuring that service providers can meet regulatory requirements while improving care and operational efficiency.

Designed specifically for service providers, the Secure Video Documentation tool is an invaluable resource for documenting incidents. By integrating video content into their systems, organizations can achieve better communication, more detailed documentation, and greater accountability in their service delivery.

The availability of this tool highlights Therap’s dedication to providing innovative and practical solutions for the human services sector. Service providers using the Therap system now have a reliable and secure way to incorporate video documentation into their processes, further enhancing their ability to deliver high-quality care while maintaining compliance with privacy regulations.

For more information on Therap’s HIPAA Compliant Secure Video Streaming, please visit:
https://www.therapservices.net/products/hipaa-compliant-video-storage/

About Therap

Therap’s comprehensive and HIPAA-compliant software is used in human services settings for documentation, communication, reporting, EVV and billing.

Learn more at  www.therapservices.net.

Related Links

http://www.therapservices.net

View original content:https://www.prnewswire.com/news-releases/therap-services-strengthens-documentation-with-advanced-hipaa-compliant-secure-video-documentation-tool-302345921.html

SOURCE Therap Services

Continue Reading

Trending