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DP Technology Announces Nomination of Development Candidate, a CNS Penetrable Lp-PLA2 Inhibitor for Alzheimer’s Disease

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BEIJING, July 8, 2024 /PRNewswire/ — DP Technology, an “AI for Science” paradigm-driven company, today announced the nomination of DPT0416, a novel CNS penetrable small molecule targeting Lp-PLA2, as a preclinical candidate for the treatment of Alzheimer’s disease (AD).

AD is the most frequent cause of dementia (60%~70%), affecting approximately 57 million people worldwide. Neurovascular dysfunction is an early and predominant event in AD development, independent of classic amyloid pathology. Lp-PLA2 is a phospholipase secreted primarily by inflammatory cells, including peripheral macrophages and CNS microglia. It hydrolyzes oxidized phospholipids typically on low-density lipoprotein (LDL), producing lysophosphatidylcholine (lysoPC) and other potent proinflammatory factors. LysoPC is a key inflammatory mediator on vascular endothelial cells, causing vascular pathology including vessel leakage and BBB damage. The inhibition of Lp-PLA2 by Rilapladib significantly slowed down AD progression and repaired BBB damage in a Phase IIa trial.

DPT0416 is a novel CNS-penetrable Lp-PLA2 inhibitor, exhibiting higher potency, better ADME and physicochemical properties than Rilapladib. In animal models, DPT0416 showed improvement in BBB integrity and a reduction in brain inflammation. The IND-enabling studies are ongoing.

“Alzheimer’s disease imposes increasing burdens on the world. Approvals of three anti-amyloid β (Aβ) antibodies mark a pivotal moment in the fight against AD, but the modest clinical efficacy and side effects highlight the complexity of AD and call for more novel interventions with better efficacy. The future treatment of AD should address multiple aspects of the disease, including anti-oxidants, anti-inflammation, and enhancing brain resilience, among others,” said Xiaomin Zhang, Head of Drug Discovery at DP Technology. “Targeting Lp-PLA2 is a novel therapy that addresses multiple factors beyond amyloid. Given rilapladib’s positive clinical results, the better molecule DPT0416 is expected to bring more benefits to AD and dementia patients.”

“DP Technology is revolutionizing the AI for Science landscape by integrating ‘AI + Simulation + Experiments’ into our processes to address significant medical needs,” said Weijie Sun, Founder and CEO of DP Technology. “The successful identification of DPT0416 highlights the power of our RiDYMO® platform, particularly the contributions of the Uni-FEP and Uni-QSAR modules in enhancing molecular interactions, drug-like characteristics, and BBB penetration. These real-world applications of our cutting-edge algorithms signify an important progression towards our envisioned future. We look forward to forging partnerships with trusted collaborators to advance this initiative to the next pivotal stage.”

The RiDYMO® drug design platform integrates various AI and physical algorithms, dedicated to the development of drugs for “undruggable” targets and “best-in-class” molecules. As one of its core algorithms, Reinforced Dynamics (RiD) has a significant advantage in the sampling efficiency of molecular dynamics simulation. By fully leveraging the high-dimensional representation capabilities of neural networks, RiD can efficiently capture dynamic conformational changes in complicated biomolecular systems.

The RiDYMO® platform is dedicated to studying the dynamics of biological systems and revealing cryptic binding sites, encompassing a range of challenging systems including protein-protein interactions (PPIs), intrinsically disordered proteins (IDPs), membrane proteins, RNA, and others. Its effectiveness has been confirmed through validation on challenging targets, including the c-Myc protein, c-Myc RNA, GPX4 protein, Kv1.3 protein, and others.

About DP Technology

DP Technology, an “AI for Science” new paradigm-driven company, dedicated to applying Artificial Intelligence and Molecular Simulation algorithms to solve important scientific problems by combining advanced computational methods.

Relying on DP Technology’s Dynamics-based drug design platform, RiDYMO®, we have set up a world-leading hit discovery platform. The team has established external collaborations and built up strong internal pipeline, focusing on three areas of CNS, oncology and autoimmune diseases.

For collaboration and further information,please contact Dr. Xiaomin Zhang (zhangxm@dp.tech). 

References:
[1] Alzheimers. Dement. 17(Suppl 10), e051496 (2021).
[2] Nat. Med. 25, 270-276 (2019).
[3] Med. Res. Rev. 40, 79-134 (2020).
[4] Alzheimers. Dement. 1, 131-140 (2015).
[5] Diab. Vasc. Dis. Res. 14, 200-213 (2017).

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SOURCE DP Technology

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Ursa Major to Deliver Chemical Propulsion Capability for Tactical Satellite Bus Systems

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DENVER, March 13, 2025 /PRNewswire/ — Ursa Major has been awarded a contract for delivery of fully integrated GEO propulsion systems for a customer focused on critical space missions. The multi-year award totaling $10 to $15 million supports the development, manufacturing, assembly, integration, and testing of a full propulsion system capable of six degree-of-freedom maneuverability.

Building upon successful flights for hypersonic and defense applications in 2024, Ursa Major is leveraging its expertise in scaling manufacturing of propulsion systems to provide unfettered access to space. The recent growth in the satellite industry has demonstrated an increased demand for advanced propulsion systems that provide efficient mobility for maneuverability, collision avoidance, and timely deorbiting. A pillar to responsive space domain is a resilient supply chain that can meet the necessary mission lead times. Ursa Major is responding to this need with an off-the-shelf and scalable manufacturing approach to enable rapid delivery of mission critical capabilities.

“This award demonstrates the engineering rigor in propulsion systems to yield a new generation of highly maneuverable buses at significantly faster lead times than currently fielded systems,” said Ursa Major CEO Dan Jablonsky.

The development and production work of these in-space propulsion systems will take place at Ursa Major’s design, test, and production facility in Berthoud, Colorado and apply advanced digital manufacturing processes alongside vertical integration of key technologies to enable rapid deployment.

About Ursa Major

Ursa Major is an aerospace and defense company, providing products and solutions for hypersonic, tactical missile, and space mobility systems. The company applies state-of-the-art digital and additive manufacturing techniques to rapidly produce the most advanced, cost-effective solutions. Ursa Major has category-leading hypersonic, on-orbit, and solid rocket motor propulsion capabilities. Ursa Major’s customers range from commercial space technology providers to enterprise-level aerospace and defense leaders as well as the U.S. government. The company employs the most sought-after engineers from top aerospace programs and universities, united in the core values of disruptive innovation, flying faster, and providing reliable and cost-effective systems. Headquartered in Berthoud, Colorado, with additive manufacturing facilities in Youngstown, Ohio, Ursa Major was named one of the best places to work by Built in Colorado three years in a row.

For more information, visit www.ursamajor.com

Media Contacts

Ursa Major

media@ursamajor.com

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SOURCE Ursa Major Technologies

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PROPERTY MELD EXPANDS PROPERTY MAINTENANCE OPERATIONS WITH ADDITION OF ZINSPECTOR INTEGRATION

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RAPID CITY, S.D., March 13, 2025 /PRNewswire/ — Property Meld, the leading property maintenance platform for property managers, announces its strategic integration with zInspector, highlighting its commitment to advancing property maintenance operations (PMO). This partnership marks a significant leap in unifying inspections and maintenance, enhancing efficiency while capturing reliable data for smarter maintenance decisions, naturally propelling PMO to the next level.

This partnership fits into Property Meld’s broader plan for ‘Nexus’, its initiative to bring every facet of maintenance operations together. ‘Nexus’ embodies its purpose: a connection point that eliminates inefficiencies, drives data-driven decisions, and redefines property maintenance. From vendor management to property accounting integrations, Property Meld is creating the future of property maintenance through connectivity—and the integration with zInspector’s inspection platform is helping bring that vision to life.

“Everyone knows that the property management industry continues to evolve at top speed, and data is the key to making informed decisions,” says Ray Hespen, CEO and Co-Founder of Property Meld. “With zInspector on board, we’re delivering on our promise to expand the Nexus ecosystem and give property managers the visibility they need to tackle maintenance issues head-on, and ultimately protecting investor returns.”

“At zInspector, we are dedicated to making property inspections as thorough and seamless as possible,” said Andrew Wallace, CEO and Founder of zInspector. “By integrating with Property Meld, we’re enabling property managers to take immediate action on inspection work, ensuring maintenance needs are addressed with speed and precision. This partnership represents a major step forward in how inspections and maintenance work together in the industry.”

This integration goes far beyond simply syncing zInspector’s inspection solution with Property Meld’s maintenance platform. By leveraging the data captured during every inspection, property managers gain deeper insights into their operations, allowing them to optimize workflows, reduce downtime, and ultimately boost profitability.

Additionally, Property Meld and zInspector will co-host a webinar on March 19, providing property managers with insights into how this partnership will optimize overall operational performance and the force behind a strong inspections and maintenance integration. For more details on this integration, visit www.propertymeld.com or www.zinspector.com.

About Property Meld
Property Meld is a property maintenance operations platform designed to enhance efficiency and provide clear oversight through improved data visibility. It significantly reduces repair times while optimizing and documenting communication to create a better experience for all stakeholders. Property Meld offers valuable performance metrics, enabling data-driven decisions to drive growth and profitability. Seamlessly integrating with leading property accounting software, it is an essential tool for modern property management.

About zInspector
zInspector is an industry-leading property inspection platform designed to streamline documentation, enhance transparency, and simplify inspections for property managers and owners. Through its advanced technology, zInspector ensures accurate, data-driven insights that support better property management decisions.

Contact: Madison Zimmerman, Property Meld
Phone: (605) 431-0265
Email: madison@propertymeld.com 

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SOURCE Property Meld

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Skylark Labs Reveals Scout MK I: Next-Generation Privacy-Preserving Public Safety Platform

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NEW YORK, March 13, 2025 /PRNewswire/ — Skylark Labs, a leading provider of AI-powered security and safety solutions, today announced the launch of Scout MK I AI Tower, an advanced mobile surveillance system designed specifically for public safety applications within the United States. This cutting-edge system leverages Skylark Labs’ proprietary Kepler AI platform to deliver unprecedented threat detection capabilities for law enforcement agencies, public event managers, and construction site operators across America.

Following the successful deployment of the Scout MK II for border security operations, Skylark Labs has adapted its revolutionary technology to strengthen security within American communities. As public spaces face increasingly complex safety challenges—from unauthorized access at construction sites to dangerous situations at community events—conventional surveillance systems typically sacrifice either comprehensive coverage or individual privacy. The Scout MK I AI Tower integrates multiple proprietary privacy-preserving sensors with adaptive AI for rapid deployment in any environment where public safety monitoring is needed.

MOBILE MK I MONITORING PLATFORM

The Scout MK I features a compact 20-50 feet telescoping design that deploys in under an hour and operates for 72+ hours on integrated solar power, eliminating the need for fixed infrastructure or external power sources. The system integrates proprietary privacy-preserving spatial mapping technology, multi-spectrum imaging, advanced radar, and AI-powered audio analysis into a rapidly deployable tower. The system’s onboard Kepler AI can detect weapons, unauthorized access, violence, crowd formations, and destructive activities in real-time. The audio analysis system identifies critical sounds including gunshots, breaking glass, and distress calls. The system can be fully operational within 60 minutes at construction sites, public events, critical infrastructure, or remote locations without existing security infrastructure.

PROPRIETARY PRIVACY-PRESERVING MULTI-SENSOR APPROACH

The Scout MK I’s privacy-preserving design creates a crucial balance for modern policing. By using proprietary spatial sensors rather than continuous video surveillance, the system protects privacy while maintaining security effectiveness. This approach allows police departments to deploy advanced monitoring in privacy-sensitive locations, reducing both community resistance and data storage requirements. When threats are detected, targeted visual verification activates only as needed, ensuring effective response without unnecessary surveillance of law-abiding citizens.

REVOLUTIONARY ADAPTIVE INTELLIGENCE

At the heart of the Scout MK I is Skylark Labs’ groundbreaking Kepler adaptive AI platform—a breakthrough on-device intelligence system that learns instantly from new environments without pre-training, detects threats proactively through multi-sensor analysis, operates entirely on-device with no external data transmission, adapts continuously to evolving security challenges, and maintains complete functionality without internet connectivity.

“What makes our Kepler platform revolutionary is its ability to recognize potential threats before they fully manifest,” explains Dr. Amarjot Singh, CEO of Skylark Labs. “The system begins learning immediately upon deployment, identifying normal patterns and distinguishing them from potential threats without requiring massive datasets or cloud connectivity. As it encounters new scenarios, it continuously refines its detection capabilities, dramatically reducing false positives while ensuring genuine threats aren’t missed.”

PROVEN TECHNOLOGY

The Scout MK I AI Tower is already being used by public safety clients across the United States.

“As security professionals, we’re constantly balancing effectiveness against resource constraints,” notes Greg West, Western Hemisphere Consulting. “The Scout MK I’s combination of mobility, adaptive intelligence, and privacy protection solves our most pressing operational challenges while building community trust. Its ability to continuously improve threat detection while reducing false alarms addresses the fundamental limitations we’ve faced with previous technologies.”

The Scout MK I AI Tower is now available for demonstration and deployment to qualified agencies and security operators across the United States. For more information about Skylark Labs’ public safety solutions, please visit Mobile Tower System: Advanced Multi-Sensor Surveillance Platform | Skylark Labs.

ABOUT SKYLARK LABS

Skylark Labs is a U.S.-based artificial intelligence company that is revolutionizing AI with adaptive technology that learns on any device from a single experience. Our brain-inspired architecture enables AI that adapts continuously like the human brain, eliminating operational disruptions while reducing costs. As a U.S.-based company, we specialize in advanced AI solutions for defense and security, delivering actionable intelligence at the tactical edge for enhanced situational awareness.

For more information, please contact us at info@skylarklabs.ai.

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SOURCE Skylark Labs, Inc.

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