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Trustworthy and Responsible AI Network expands to help European healthcare organizations enhance the quality, safety and trustworthiness of AI in health

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AMSTERDAM, June 17, 2024 /PRNewswire/ — Monday, at HLTH Europe, the Trustworthy & Responsible AI Network (TRAIN), a consortium of healthcare leaders, announced its expansion to Europe with the objective to help organizations in the region operationalize responsible AI through technology-based guardrails. Organizations that have come together to form the European TRAIN include Erasmus MC (the Netherlands), HUS Helsinki University Hospital (Finland), Sahlgrenska University Hospital (Sweden), Skåne University Hospital (Sweden), Universita Vita-Salute San Raffaele (Italy), and University Medical Center Utrecht (the Netherlands), with Microsoft as the technology enabling partner. Foundation 29, a nonprofit organization that aims to empower patients and transform healthcare through data-driven initiatives and innovative technologies, has also joined European TRAIN. The network is open to other healthcare organizations in Europe interested in joining.

Emerging AI technologies hold significant promise for revolutionizing the healthcare sector in Europe and across the globe. By enhancing patient care outcomes, streamlining processes and reducing costs, AI has the potential to transform the industry. As the technology continues to evolve, robust development and evaluation standards are crucial to ensure responsible and effective AI applications. TRAIN aims to improve the quality, safety and trustworthiness of AI tools implemented in healthcare to help ensure clinicians and patients benefit from this innovative technology.

TRAIN’s initial formation, announced in March 2024, introduced leading healthcare organizations in the U.S. as part of the network. The consortium’s operational objectives include:

Providing technology and tools that enable trustworthy and responsible AI principles to be operationalized at scale.Working in collaboration with other TRAIN members and key stakeholders to enable all organizations, including low-resource settings, to benefit from technology-based responsible AI guardrails.Sharing best practices related to the use of AI in healthcare settings, including the safety, reliability and monitoring of AI algorithms, and the skillsets required to manage AI responsibly. Data and AI algorithms will not be shared between member organizations or with third parties.Working toward enabling registration of AI used for clinical care or clinical operations through a secure online portal.Providing tools to enable measurement of outcomes associated with the implementation of AI, including best practices for studying the efficacy and value of AI methods in healthcare settings and leveraging of privacy-preserving environments, with considerations in both pre- and post-deployment settings. Tools that allow analyses to be performed in subpopulations to assess bias may also be provided.Working toward the development of a federated AI outcomes registry for organizations to share among themselves. The registry will capture real-world outcomes related to efficacy, safety and optimization of AI algorithms.

For more information on European TRAIN, join us at HLTH Europe on Tuesday, June 18, from 12:30 to 12:40 p.m. CEST at The Forum stage (H90), where we’ll share more details about the network and its objectives.

TRAIN member quotes:
“Transforming healthcare using AI must be seen as a global challenge that requires worldwide cross-border collaborations. This approach is an important step that enables us to tackle challenges not only at the national level, but also across the EU and globally. To truly warrant bedside adoption, we must work together to ensure AI benefits all. Safeguards built into the technology will improve such equity.” — Dr. Michel van Genderen, attending intensivist at Erasmus Medical Center and co-founder of the Erasmus MC Datahub

“As an NGO dedicated to researching the use of AI in healthcare, Foundation 29 is deeply concerned with ensuring that the use of AI respects patient privacy and security. While high-quality data, often sourced from patients, is essential for advancing AI technologies, it is equally crucial to guarantee responsible use of this data. For us, safeguarding patient data and fostering a trustworthy environment for AI development and deployment in healthcare is of paramount importance.” — Sarah Harmon, president, Foundation 29

“AI has the potential to transform healthcare, but we must remain vigilant about its ethical implications. In TRAIN, we are joining forces across Europe to share knowledge and tools for successful and sustainable implementation of trustworthy and responsible AI into healthcare practices.” — Magnus Kjellberg, head of AI Competence Center, Sahlgrenska University Hospital

“TRAIN is a role model for joint efforts between the technology industry and healthcare. AI represents a strategy that gives hope for future healthcare effectiveness. The upcoming European TRAIN effort will be an opportunity to take a fundamental step forward to operationalize  responsible AI solutions by facilitating the generation and validation of algorithms with patient integrity left intact.” — Professor Stefan Jovings, M.D., Ph.D., president of research and education, Skane University Hospital, Sweden

“TRAIN’s focus on responsible AI principles and privacy-preserving collaboration enforces our strategies to safely and ethically leverage AI technologies. This initiative builds trust, protects patient data, and aligns the participating institutions’ practices to the European healthcare standards.” — Carlo Tacchetti, professor and coordinator, AI strategic program of UniSR and director of Experimental Imaging Center, San Raffaele Scientific Institute

“AI in healthcare needs collaborations on a national and an international level to help us use AI’s power for improving patient care and outcomes. We are excited to be part of this collaboration to contribute to the new era of medicine that awaits us.” — Ben Collignon, chief information officer, UMC Utrecht

“The primary goal for TRAIN is to enable individuals and organizations to operationalize responsible AI principles through technology-based guardrails. TRAIN will also enable organizations to collaborate through federated, privacy-preserving approaches. The formation of TRAIN in Europe will help foster trust and confidence in the application of AI in health and ensure that data privacy is maintained.” — David Rhew, M.D., chief medical officer and vice president of healthcare, Microsoft

About the Trustworthy & Responsible AI Network (TRAIN)

The Trustworthy & Responsible AI Network (TRAIN) is one of the first health AI networks aimed at operationalizing responsible AI principles. Through collaboration, TRAIN members will help improve the quality, safety, and trustworthiness of AI in health by sharing best practices, enabling registration of AI used for clinical care or clinical operations, providing tools to enable measurement of outcomes associated with the implementation of AI, and facilitating the development of a federated AI outcomes registry for organizations to share amongst themselves.

 

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SOURCE Microsoft Corp.

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Greater Precision of HER2-Expressing Breast Cancer Treatment with 3D Pathology: New JelloX Research Collaboration

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In the preliminary findings of a study conducted with the National Taiwan University Hospital, over 50% of sample cases were reclassified as HER2-expressing when 3D pathology was applied.

HSINCHU, April 17, 2025 /PRNewswire/ — JelloX Biotech Inc., a Taiwan-based startup at the forefront of cancer pathology, announced the preliminary results of a research collaboration with the National Taiwan University Hospital (NTUH) on breast cancer patients. The study found that JelloX’s 3D pathology technology identified a significantly increased proportion of tumors with HER2-low and HER2-ultralow expression compared to conventional methods, demonstrating this technology’s increased sensitivity and potential as a superior diagnostic tool for HER2 detection in breast cancers.

Contact JelloX at sales@jellox.com to explore partnerships and learn more about the company’s cutting-edge 3D pathology technology.

According to the US National Cancer Institute, breast cancer is the most prevalent form of cancer. However, the difficulty of precisely determining treatment has made the identification of HER2 expression essential. In HER2-low and HER2-ultralow metastatic breast cancer, the novel antibody-drug conjugate (ADC) Trastuzumab deruxtecan (T-DXd) has demonstrated robust efficacy over conventional chemotherapy. Yet considering HER2 spatial heterogeneity, traditional diagnostic methods have shown to be less precise than 3D pathology in detecting the presence of the HER2 protein.

“For the specific challenges posed by metastatic breast cancer and the need to identify predictive biomarkers accurately, the high sampling capacity of 3D pathology holds particular potential,” commented Dr. Yen-Yin Lin, CEO of JelloX. “JelloX Biotech’s Comprehensive HER2 Diagnostic Solution is poised to revolutionize HER2 diagnostics. With a more comprehensive data set on tumor samples, healthcare providers can be empowered to make more precise diagnoses, ensuring that the right patients receive the right treatment at the right time.”

New findings with NTUH on HER2 breast cancer

In JelloX’s research collaboration with NTUH, preliminary findings indicate that more than half of the analyzed cases exhibited diagnostic discrepancies when re-evaluated using the company’s advanced 3D pathology methods. Notably, among patients initially classified as HER2-null by traditional methods, more than 66.7% were reclassified as HER2-expressing (HER2-low or HER2-ultralow) using 3D technology, thereby becoming potentially eligible for T-DXd treatment.

These findings echo the company’s recent results using samples from colorectal and esophageal cancers, demonstrating that 3D pathology may have broader potential across various cancer types.

The full findings will be shared at the Global Breast Cancer Conference in South Korea on April 17. https://gbcc.kr/Main.asp

Implications for breast cancer treatment and drug guidelines

T-DXd has demonstrated significant efficacy in tumors with HER2 expression. However, tumors classified as HER2-null under conventional pathological testing are ineligible for T-DXd treatment. By detecting HER2 more precisely using 3D pathology methods, we can identify more patients eligible for T-DXd therapy.

In addition to cancer patients, JelloX’s 3D pathology technology has the potential to expand possibilities across healthcare stakeholders:

For physicians: This advanced diagnostic tool offers a more comprehensive patient data set and, when integrated with AI, helps reduce physician workloads.For pharmaceutical companies and research institutions: The technology enhances companion diagnostics (CDx) for drug usage and is a valuable tool for new drug development.For healthcare systems: 3D pathology optimizes medical resource allocation and minimizes unnecessary financial and healthcare burdens.

About JelloX Biotech Inc.

Based in Hsinchu, Taiwan, JelloX Biotech Inc. is a startup that focuses on advancing cancer pathology through 3D digital imaging and AI technology. 

For more information, please visit: https://jellox.com/en/home/

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SOURCE JelloX Biotech Inc.

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HTX Completes Fireblocks Off-Exchange Integration, Advancing Institutional Trading Security and Efficiency

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SINGAPORE, April 16, 2025 /PRNewswire/ — HTX, a leading global cryptocurrency exchange, has successfully integrated and launched Fireblocks Off-Exchange, a next-generation solution for institutional trading.

“This integration represents a strategic expansion of HTX’s institutional offerings,” said Justin Sun, Advisor to HTX. “Fireblocks’ state-of-the-art technology enhances our platform’s security infrastructure while streamlining institutional operations within a compliant framework. Looking ahead, we remain committed to delivering cutting-edge solutions that make HTX the preferred gateway for institutions entering the digital asset market.”

This milestone reinforces HTX’s commitment to delivering a secure, compliant, and seamless trading environment for its global institutional clientele.

Fireblocks Off-Exchange: Revolutionizing Institutional Asset Security

Fireblocks Off-Exchange enables institutions to securely trade digital assets by maintaining funds in self-custodied, off-exchange collateral accounts, while simultaneously receiving 1:1 credit on the exchange. This dramatically reduces counterparty risk while maintaining the speed and capital efficiency of centralized trading.

The solution facilitates rapid, low-cost settlement across platforms, ensuring assets remain under institutional-grade security throughout the trade lifecycle. A robust disaster recovery mechanism guarantees recoverability of funds even under extreme conditions, enabling institutional clients to retain control over private keys while accessing deep exchange liquidity.

HTX: Reinforcing Institutional Confidence in the Crypto Market

By deploying Fireblocks Off-Exchange, HTX strengthens its platform’s regulatory posture and operational resilience—critical factors in today’s evolving digital asset landscape. The integration aligns with HTX’s broader mission to advance institutional participation through enhanced asset protection and compliance infrastructure.

Since the launch, HTX has onboarded numerous institutional clients and recorded a 200% increase in trading volume, validating market demand for secure off-exchange settlement models.

A Step Toward the Future of Compliant Institutional Trading

As the crypto industry continues to mature, HTX remains committed to innovation in asset protection, regulatory alignment, and institutional services. The Fireblocks Off-Exchange integration marks another key milestone in HTX’s journey to provide a best-in-class, compliant trading experience tailored to institutional needs—positioning the exchange as a global leader in secure digital asset trading.

About HTX

Founded in 2013, HTX has evolved from a virtual asset exchange into a comprehensive ecosystem of blockchain businesses that span digital asset trading, financial derivatives, research, investments, incubation, and other businesses.

As a world-leading gateway to Web3, HTX harbors global capabilities that enable it to provide users with safe and reliable services. Adhering to the growth strategy of “Global Expansion, Thriving Ecosystem, Wealth Effect, Security & Compliance,” HTX is dedicated to providing quality services and values to virtual asset enthusiasts worldwide.

To learn more about HTX, please visit HTX Square or https://www.htx.com/, and follow HTX on X, Telegram, and Discord.

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Rio Tinto and AMG Metals & Materials to assess low-carbon aluminium project in India

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LONDON, April 17, 2025 /PRNewswire/ — Rio Tinto and AMG Metals & Materials (AMG M&M), an energy transition solutions provider, have signed a Memorandum of Understanding (MOU) to jointly assess the feasibility of developing an integrated low-carbon aluminium project powered by renewable energy in India. AMG M&M is promoted by the two founders of Greenko and AM Green.

Together, the parties will consider the potential development of up to a 1 million tonnes per annum (Mtpa) primary aluminium smelter and 2 Mtpa of alumina production, both powered by renewable wind and solar energy firmed by pumped hydro storage. The development will comprise a study to evaluate a potential first phase 500,000 tonnes per annum primary aluminium smelter in a favourable location in India.

Rio Tinto Aluminium Chief Executive Jérôme Pécresse said: “This study is an important step in our ambition to grow our global, low-carbon aluminium footprint while exploring new project delivery approaches and opportunities in emerging markets. Partnering with AMG Metals & Materials enables us to assess how we can develop low-cost responsible aluminium production powered by renewable energy. With its rapid economic growth and strategic position, India is a compelling location for this potential project and aligns with our long-term vision for a globally more diverse and resilient aluminium business.”

As part of the study, AMG M&M will examine a firmed renewable energy solution with Greenko, while Rio Tinto will explore a commercial alumina solution. The study will also assess smelting technology options to determine the most cost-effective solution for the project.

Group President of AMG Metals & Materials and Greenko Mahesh Kolli said: “Over the last few years, we have been able to deliver a multitude of decarbonization solutions comprising electricity, molecules, chemicals and fuels. We are excited to expand that further to the materials space. This MOU could deliver much needed low-carbon metal at scale to propel decarbonization initiatives in global supply chains across auto, construction, consumer packaging and many more segments.”

About AMG Metals & Materials

AMG Metals & Materials is incorporated by Anil Chalamalasetty and Mahesh Kolli, the founders of Greenko Group, one of India’s leading energy transition solutions providers, and AM Green, a global decarbonization solution provider. Greenko has a near-term operational renewable energy capacity of 10 GW across solar, wind and hydro and is building 100 GWh of single cycle storage capacity across India. AM Green is developing low-carbon ammonia projects across multiple locations in India with a goal to reach 5 Mtpa of green ammonia capacity by 2030. Its first plant currently under construction in Kakinada with a projected capacity of 1 Mtpa of green ammonia will be one of the world’s largest RFNBO compliant green ammonia facilities, supporting efforts to achieve net zero targets both in India and OECD markets. AM Green is also developing production capabilities for other net zero molecules and chemicals including green caustic soda, e-methanol, olefins & biofuels for decarbonization in hard to abate industries. Further information at www.amgreen.com

Contacts

AMG Metals & Materials

Suheil Imtiaz
Public Affairs & Strategic Communication
suheil.m@amgreen.com

Rio Tinto
media.enquiries@riotinto.com

 

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