Technology
Membrane Chromatography Market to Reach USD 637 Million with 14.7% CAGR | MarketsandMarkets™
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CHICAGO, June 17, 2024 /PRNewswire/ — The membrane chromatography market is poised to grow significantly, with a projected value of USD 637 million by 2029, reflecting a robust CAGR of 14.7% from an estimated USD 321 million in 2024. This growth is primarily fueled by the escalating production of biopharmaceuticals like vaccines and monoclonal antibodies, coupled with increased R&D activities in the biopharmaceutical sector. Key players in this market include Danaher Corporation (US), Sartorius AG (Germany), Merck KGaA (Germany), and Thermo Fisher Scientific Inc. (US), who employ strategies such as new product launches, acquisitions, agreements, collaborations, and geographical expansions to bolster their market presence. Danaher Corporation is known for its extensive range of life science and diagnostic products, investing heavily in R&D, while Sartorius AG stands out for its global reach and strategic collaborations like the one with Waters Corporation for downstream biomanufacturing. Merck KGaA, on the other hand, is recognized for its comprehensive solutions and ongoing investments in R&D, as demonstrated by its substantial investment in membrane and filtration manufacturing capabilities in Cork, Ireland.
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DRIVER: Catalyzing Growth Through Increased Biopharmaceutical R&D
As C-level executives, you’re aware of the pivotal role R&D plays in the biopharmaceutical sector, especially amidst the escalating demand for treatments targeting chronic illnesses. The robust increase in R&D investments, exemplified by a significant uptick in spending among Spanish biotech firms in 2022, underscores the driving force behind the membrane chromatography market’s expansion.
RESTRAINT: Slow Adoption in Large-Scale Manufacturing
Despite its promising advantages, membrane chromatography encounters obstacles when it comes to scaling up for large-scale operations. Challenges such as membrane degradation and fouling, coupled with the entrenched dominance of traditional column chromatography, impede widespread adoption. These complexities, alongside the risks of process disruption and quality compromises, restrain the market’s growth within large-scale manufacturing.
OPPORTUNITY: Embracing Single-Use Technologies for Enhanced Efficiency
The shift towards single-use membrane chromatography systems presents a compelling opportunity for executives seeking efficiency gains. These systems offer tangible benefits, including reduced contamination risks and lower capital investments. Collaborative efforts, like the partnership between W. L. Gore & Associates, Inc. and AGC Biologics, signal a strategic move towards streamlining downstream purification processes and maximizing productivity.
CHALLENGE: Competing with Alternative Techniques
In the landscape of membrane chromatography, executives must navigate the challenge posed by alternative techniques such as protein crystallization and capillary electrophoresis. These methods, renowned for their simplicity and cost-effectiveness, present formidable competition, potentially diverting market focus from membrane chromatography solutions and posing a significant hurdle to its sustained growth.
Global Membrane Chromatography Industry Ecosystem Analysis
Executives operating within the membrane chromatography industry are part of a multifaceted ecosystem encompassing raw material suppliers, manufacturers, and end users ranging from pharmaceutical giants to academic institutions. Product portfolios span from essential syringe filters to advanced membrane sheets, catering to diverse needs across the sector’s spectrum.
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Flow-Through Membrane Chromatography Leads Industry Growth in 2023
The dominance of flow-through membrane chromatography in 2023 underscores a strategic focus on biologics development, particularly monoclonal antibodies. The segment’s ascendancy is further fueled by the industry’s quest for efficient chromatography operations, positioning it as a key driver in the membrane chromatography market.
Pharmaceutical & Biopharmaceutical Companies Drive Market Growth
In 2023, pharmaceutical and biopharmaceutical companies emerged as the dominant force within the membrane chromatography landscape, buoyed by the escalating demand for biotherapeutics. The segment’s robust growth trajectory is propelled by increased R&D investments aimed at advancing biopharmaceutical products, solidifying its pivotal role in the membrane chromatography market.
North America Commands Membrane Chromatography Market in 2023
North America’s commanding presence in the membrane chromatography market during 2023 underscores its status as a key hub for biopharmaceutical development and manufacturing. With significant investments in R&D and a well-established healthcare sector, North America leads the global market, followed closely by Europe and the Asia Pacific, reflecting the region’s pivotal role in driving industry innovation and growth.
Recent Innovations Shape Membrane Chromatography Landscape
Thermo Fisher Scientific Inc. Enhances Presence in Asia Pacific with New Facility
In February 2024, Thermo Fisher Scientific Inc. fortified its position in the Asia Pacific market with the inauguration of a sterile drug facility in Singapore. This strategic investment aligns with the company’s commitment to delivering new medicines and vaccines, complementing enhanced research capabilities at its Customer Experience Center and Bioprocess Design Center. The Customer Experience Center, equipped with a wide array of products spanning molecular biology, genetic analysis sequencing, chromatography mass spectrometry, and cell therapy, underscores Thermo Fisher Scientific’s dedication to innovation and customer-centric solutions.Agilent Technologies Invests in Nucleic Acid Therapeutics Manufacturing
January 2023 witnessed Agilent Technologies’ significant investment of USD 725 million to expand its manufacturing capacity for nucleic acid-based therapeutics. This expansion underscores Agilent’s commitment to meeting the growing demand for advanced therapeutics, positioning the company as a key player in the evolving landscape of nucleic acid-based treatments.Sartorius AG Expands Portfolio Through Novasep Acquisition
In February 2022, Sartorius AG bolstered its chromatography capabilities with the acquisition of Novasep’s chromatography division. This strategic move enables Sartorius to access a portfolio tailored for smaller biomolecules like oligonucleotides, peptides, and insulin, as well as innovative systems for continuous biologics manufacturing. By integrating Novasep’s offerings, Sartorius aims to diversify its revenue streams and strengthen its position as a leading provider of chromatography solutions.3M Introduces Breakthrough Solution for Protein Therapeutic Manufacturing
June 2021 marked the launch of 3M Harvest RC clarifier, a revolutionary single-stage purification solution designed for recombinant protein therapeutic manufacturing. This innovation underscores 3M’s commitment to advancing bioprocessing technologies, offering a streamlined and efficient solution for protein purification, thereby enhancing manufacturing efficiency and product quality.
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Technology
INRS Creates a New Chair in Nanobiophotonics
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January 14, 2025By
QUEBEC CITY, Jan. 14, 2025 /CNW/ – The Institut national de la recherche scientifique (INRS) is pleased to announce the creation of the Chair in Nanobiophotonics funded entirely by the INRS Foundation, which will contribute $100,000 per year for five years.
INRS professors Marc A. Gauthier and Jonathan Perreault are co-directing this new chair, furthering their long-standing collaboration. “Though my lab is already established at the Énergie Matériaux Télécommunications Research Centre (EMT), I recently moved to join Professor Perreault at the INRS Laval campus, where the Armand-Frappier Santé Biotechnologie Research Centre (AFSB) is located, to optimize cooperation for the Chair. You know, people assume that it’s easy for, say, a physicist and a clinician to communicate, but it’s not! It’s important to be in the lab together, interact, explore possibilities together… The Chair’s research projects encourage this kind of interdisciplinarity, which is really rich in opportunities and discoveries.”
In the interest of further expanding the possibilities, the co-chairholders brought fellow INRS professors Jinyang Liang and Maya Saleh on to collaborate as associate researchers.
This kind of interdisciplinarity is very much in line with the core value of collaboration that guides INRS’s activities. The Executive Director of the INRS Foundation, Élise Comtois, adds: “The Foundation is using an endowment fund to set up the Chair in Nanobiophotonics to encourage the INRS centres’ integration and joint efforts, among other things. Combining expertise fuels enthusiasm and maximizes the benefits for the public.”
The INRS Chair in Nanobiophotonics’ potential impact is unprecedented, particularly when it comes to cancer detection and treatment. Involving pharmaceutical chemistry, molecular biology, immuno-oncology, ultrafast imaging, and biophotonics, the Chair’s work focuses on aptamers (short fragments of DNA) as responsive recognition agents, exploring the possibility of designing more efficient tools for analyzing human tissue samples. Professor Perreault foresees significant benefits for the public: “In concrete terms, this could lead to significant advances in precision medicine and more effective diagnostic and therapeutic approaches in immuno-oncology, among other medical applications.”
The Chair is also a unique learning opportunity for graduate students. “The issues facing Quebec’s society are complex and call for multifaceted solutions. The Chair is another driver of interdisciplinarity, which is vital for training a new generation of scientists capable of meeting the challenges of the future,” finishes Ms. Comtois.
About INRS
INRS is an academic institution dedicated exclusively to graduate research and training in strategic sectors in Quebec. For the past 55 years, it has actively contributed to Quebec’s economic, social, and cultural development. INRS is first in Canada in research intensity. It is made up of four interdisciplinary research and training centres located in Quebec City, Montreal, Laval, and Varennes, which focus their efforts on strategic sectors: water, earth, and environment (Eau Terre Environnement Research Centre); energy, materials, and telecommunications (Énergie Matériaux Télécommunications Research Centre); urbanization, culture, and society (Urbanisation Culture Société Research Centre); and health and biotechnology (Armand-Frappier Santé Biotechnologie Research Centre). The INRS community includes over 1,500 students, postdoctoral fellows, and faculty and staff members.
About the INRS Foundation
Launched in 2020, the INRS Foundation boosts the growth of the Institut national de la recherche scientifique (INRS). It plays an active role in promoting the impacts of the entire INRS, engages the business and philanthropic communities in its mission and projects, and supports the work of its scientific, student and alumni community. Managing an endowment of over ten million dollars, having raised over one million dollars to date, and leading a network of over 4,000 alumni, the Foundation is a welcoming, agile and audacious gateway for all donors and partners who aspire to change the world through research.
SOURCE Institut National de la recherche scientifique (INRS)
Technology
Zenvia announces Conference Call on New Strategic Cycle
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12 minutes agoon
January 14, 2025By
SÃO PAULO, Jan. 14, 2025 /PRNewswire/ — Zenvia (NASDAQ:ZENV) (the “Company”), one of the leading SaaS providers for customer experience (CX) in Latin America announced yesterday the beginning of its new strategic cycle (click here) and is inviting investors to join its management team on a webcast, where they will provide further details about this announcement.
The conference call will be held today, at 10:00 a.m. ET. To access the webcast, click here. To access the presentation, click here. To access the prepared remarks, click here.
Further information about Zenvia can be found at https://investors.zenvia.com.
About Zenvia
Zenvia (NASDAQ: ZENV) is a technology company dedicated to creating a new world of experiences. It focuses on enabling companies to create personalized, engaging and fluid experiences across the entire customer journey, all through its unified, multi-channel customer cloud platform. Boasting two decades of industry expertise, more than 13,000 customers and operations throughout Latin America, Zenvia enables businesses of all segments to amplify brand presence, escalate sales, and elevate customer support, generating operational efficiency, productivity and results, all in one place. To find out more, visit our website and follow our social media profiles on LinkedIn, Instagram, TikTok and YouTube.
Contacts
Investor Relations
Caio Figueiredo
Fernando Schneider
ir@zenvia.com
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SOURCE Zenvia
Technology
WELL Health Provides a Capital Allocation Update Reflecting the Addition of $100M in Annualized Revenue from Acquisitions Completed Since December 2024
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12 minutes agoon
January 14, 2025By
WELL completed seven acquisitions since December 2024 across its Canadian Clinics, WELLSTAR and WELL USA business units, collectively representing total annualized revenue run-rate of approximately $100 million at EBITDA1 margins in line with the Company’s 2024 EBITDA margin guidance.All acquisitions were paid for by cash with no shares being issued as part of any of these transactions. It is estimated that WELL’s leverage ratio post all deals is less than the leverage ratio announced at its last earnings event for fiscal Q3 2024.The seven acquisitions included one of the largest physician recruitment firms in Canada, two Canadian Primary Care Canadian Clinics, one Provider Staffing acquisition in the United States under the CRH banner, two previously announced acquisitions under the WELLSTAR banner and the previously announced acquisition of Jack Nathan Health. Altogether, 75 new clinical assets were added to WELL’s Canadian business.WELL’s current M&A pipeline includes twelve LOIs reflecting approximately $65M in revenues. All but two of the current LOIs are based on targets in Canada.
VANCOUVER, BC, Jan. 14, 2025 /CNW/ – WELL Health Technologies Corp. (TSX: WELL) (OTCQX: WHTCF) (“WELL” or the “Company”), — a practitioner focused digital health company that is positively impacting health outcomes by tech-enabling healthcare providers and their patients globally, is pleased to provide a corporate update on its capital allocation activity reflecting the addition of $100M in annualized revenue from acquisitions completed since December 2024 as well as an outlook on its continued M&A pipeline and momentum. These transactions are expected to strengthen WELL’s operational platform for long-term growth:
Description of Acquisition
WELL Business Unit
Ownership
Provider Staffing company
WELL USA
Majority
Physician Recruitment company
Canadian Clinics
Majority
Two Primary Care Clinics in North Vancouver, BC
Canadian Clinics
100 %
Primary Care Clinic in London, ON (Absorption)
Canadian Clinics
100 %
Regional EMR (Electronic Medical Record)
WELLSTAR
100 %
Healthcare technology services
WELLSTAR
Majority
Primary Care Clinic Network (Jack Nathan Health)
Canadian Clinics
100 %
Hamed Shahbazi, Founder and CEO of WELL, commented, “WELL ended 2024 and the beginning of 2025 with a flurry of capital allocation activity. Between Dec 1, 2024, and Jan 2, 2025, we added approximately $100M in revenues at EBITDA1 margins in line with our 2024 EBITDA margin guidance without issuing a single share of WELL stock. These transactions demonstrate the powerful compounding capabilities of our company’s M&A program and the free cashflow that underpins its momentum. Our track record shows that we consistently identify and integrate valuable assets that enhance our operational capabilities and deliver meaningful returns. As we look ahead to 2025, we are committed to continuing an active yet disciplined M&A program, capitalizing on a robust pipeline, and delivering continued compounding momentum to our shareholders for years to come.”
Q4 2024 Acquisitions: Expanding WELL’s Canadian Footprint
WELL has significantly expanded its clinic network through key acquisitions in December 2024, solidifying its position as a leading healthcare provider in Canada. These acquisitions have allowed WELL to capture a meaningful share of the fragmented Canadian healthcare market while greatly expanding its geographic footprint and deepening its range of healthcare services across the country.
On December 1, 2024, WELL completed the previously announced acquisition of Jack Nathan Health, which operates 72 clinics2 across Canada, and represents one of WELL’s largest expansions to date, significantly increasing its reach and patient care capabilities. In addition, WELL acquired three new clinics—Lonsdale Clinic in North Vancouver, BC and HealthPark in London, ON —which combined, add 35 physicians into the WELL network and expand WELL’s presence in British Columbia and Ontario.
The newly acquired clinics represent a material step forward in WELL’s mission to provide comprehensive, accessible healthcare to communities nationwide. In addition to increasing its physical presence, WELL plans to implement its suite of digital patient engagement tools and other advanced technologies across these locations. These enhancements are designed to improve the overall experience for both providers and patients, streamlining operations and ensuring more seamless access to care.
All newly acquired clinics3 are actively undergoing WELL’s clinic transformation program, a proven initiative designed to optimize operations, integrate digital workflows as well as back office shared services and enhance EBITDA1 margins.
The Company further strengthened its support for healthcare providers by acquiring Physicians For You, one of the largest physician recruitment platforms in Canada that addresses one of nations most pressing healthcare challenges: the shortage of physicians. The recruitment and retention of doctors remain critical issues in Canada’s healthcare system, with demand significantly outstripping supply. Physicians For You specializes in recruiting internationally trained doctors who meet the qualifications to practice medicine in Canada, providing an essential solution to this growing problem.
This acquisition represents a major enhancement to WELL’s recruitment capabilities, ensuring its clinics remain fully staffed and able to meet patient demand. Physicians For You is expected to play a key role in supporting WELL’s growth, and the Company plans to scale its recruitment efforts significantly to surpass current levels. By incorporating this platform into its ecosystem, WELL is better positioned to address staffing shortages while enabling primary care clinics to operate more efficiently. This scale ensures clinics remain sustainable and focused on delivering exceptional care to their communities.
Additionally, as previously announced on December 12, 2024, WELL made two new acquisitions under its newly branded WELLSTAR division, which will bolster the Company’s ability to provide advanced digital solutions to healthcare providers. These additions will complement WELL’s existing suite of tools, enabling clinics to streamline operations and improve patient engagement, further reinforcing WELL’s leadership in healthcare innovation.
Harmony: Strengthening U.S. Anesthesia Staffing Leadership
On Jan 2, 2025, WELL’s subsidiary, CRH, acquired a 65% interest in Harmony Anesthesia Staffing (“Harmony”), a full-service anesthesia staffing company based in Atlanta, Georgia. Harmony provides locum tenens and permanent placement anesthesia staffing solutions, specializing in Certified Anesthesiologist Assistants (“CAAs”) and other anesthesia professionals for its network of customers, which includes anesthesia groups, hospitals, and ambulatory surgical centers (ASCs) across eight U.S. states. The placement of CAAs is a rapidly growing trend in addressing industry-wide staffing challenges, and Harmony has quickly established itself as a leader in this space. As one of the pioneers in CAA placements, Harmony has played a crucial role in meeting the anesthesia staffing challenges experienced throughout the industry.
Jay Kreger, CEO of CRH Medical commented, “We are very pleased to welcome the Harmony team to the CRH family. This acquisition is a synergistic and complimentary addition to our current platform Radar which will immediately enhance our staffing offering to our network of customers. The Harmony platform provides us further diversification beyond clinical anesthesia services and brings us significant growth potential and upside as it pertains to anesthesia staffing. We are looking forward to partnering with the Harmony leadership team and helping them accelerate their growth potential and expand into new states.”
Rad Zamani, Founder of Harmony commented, “We are thrilled to partner with the WELL Health USA and CRH family. We believe this partnership will enable us to capitalize on our full growth potential and ensure that healthcare facilities are able to have access to quality anesthesia providers. We are excited about the prospect of newfound opportunities and resources that this partnership can bring to Harmony.”
Harmony currently serves over 20 customers and is well-positioned to further increase its footprint of providers and clients as CAA placements gain broader acceptance across the healthcare industry. The two co-founders of Harmony, who retain a 35% interest in the business, will continue to play a key role in its growth, leveraging CRH and WELL’s operational support. The acquisition reinforces WELL’s strategy of diversifying its business lines while maintaining a focus on high-margin, capital-efficient growth opportunities.
WELL’s M&A Outlook: Building on Strong Momentum
Looking ahead, WELL’s current M&A pipeline includes 12 LOIs reflecting approximately $65M in total revenues with EBITDA1 margins in line with the Company’s 2024 EBITDA margin guidance. All but two of the current LOIs are based on targets in Canada. WELL continues to see a robust pipeline of opportunities in the highly fragmented Canadian healthcare market. As the largest owner-operator of clinics in Canada—significantly outpacing the scale of any other operators —WELL is uniquely positioned to support physicians that no longer want the responsibility to operate clinics and capitalize on the long runway for growth this fragmented industry presents. The Company’s proven ability to efficiently operate clinics while delivering meaningful benefits to providers, patients, and public health systems has solidified its reputation as a leader in Canadian healthcare.
WELL’s clinic absorption program has been instrumental in driving organic growth while maintaining capital efficiency. This program allows clinics to join WELL’s network with minimal upfront costs, benefiting from WELL’s operational expertise and technology platform. Additionally, the recently introduced WELL Affiliate Clinic model provides an innovative approach to growth. These clinics, while not owned and operated by WELL, will increasingly leverage WELL’s technology and infrastructure, generating high-margin income for the Company and extending its reach and influence across the industry.
WELL’s three-pronged approach to growth in the Canadian clinics market—through acquisitions, clinic absorptions, and the affiliate model—combined with its track record of being an excellent operator, underscores the immense opportunity ahead. With over 200 clinics now owned and operated across Canada and a growing presence in the U.S., WELL has established a strong foundation for its vision of creating a nationwide, integrated healthcare network.
Footnotes:
Earnings before interest, taxes, depreciation, and amortization (“EBITDA”) and EBITDA Margin are each non-GAAP measures. EBITDA should not be construed as alternatives to net income/loss determined in accordance with International Financial Reporting Standards (“IFRS”). EBITDA does not have any standardized meaning under IFRS and therefore may not be comparable to similar measures presented by other issuers. The Company believes that EBITDA is a meaningful financial metric as it measures cash generated from operations which the Company can use to fund working capital requirements, service future interest and principal debt repayments and fund future growth initiatives. For a reconciliation of EBITDA to Net income, please refer to the Company’s most recent Management Discussion and Analysis on Sedar.com. EBITDA Margin is EBITDA as a percentage of total revenue.13 clinics are owned and operated by WELL. The remaining 59 clinics are licensee clinics operating under WELL’s new ‘Affiliate Clinic’ business model. For more information on this please see WELL’s press release dated December 2, 2024.At this time only WELL’s owned and operated clinics will undergo the full clinic transformation process. The clinics under WELL’s Affiliate Clinic business model will be supported by technology solutions from WELLSTAR, WELL’s SaaS & Services. Please see WELL’s press release dated December 12, 2024.
WELL HEALTH TECHNOLOGIES CORP.
Per: “Hamed Shahbazi”
Hamed Shahbazi
Chief Executive Officer, Chairman and Director
About WELL Health Technologies Corp.
WELL’s mission is to tech-enable healthcare providers. We do this by developing the best technologies, services, and support available, which ensures healthcare providers are empowered to positively impact patient outcomes. WELL’s comprehensive healthcare and digital platform includes extensive front and back-office management software applications that help physicians run and secure their practices. WELL’s solutions enable more than 28,000 healthcare providers between the US and Canada and power the largest owned and operated healthcare ecosystem in Canada with more than 200 clinics supporting primary care, specialized care, and diagnostic services. In the United States WELL’s solutions are focused on specialized markets such as the gastrointestinal market, women’s health, primary care, and mental health. WELL is publicly traded on the Toronto Stock Exchange under the symbol “WELL” and on the OTC Exchange under the symbol “WHTCF”. To learn more about the Company, please visit: www.well.company
About CRH Medical Corporation
CRH is a North American company focused on providing gastroenterologists throughout the United States with innovative services and products for the treatment of gastrointestinal diseases. CRH also provides locum tenens and permanent placement anesthesia staffing solutions through its wholly owned subsidiary Radar Healthcare (“Radar”) to a network of customers which include provider groups, hospitals, and ASCs. In 2014, CRH became a full-service gastroenterology anesthesia company that provides anesthesia services for patients undergoing endoscopic procedures in ambulatory surgical centers. To date, CRH has completed 49 anesthesia acquisitions, and now serves over 140 ambulatory surgery centers in 20 states. In addition, CRH owns the “CRH O’Regan System,” a single-use, disposable, hemorrhoid banding technology that is safe and highly effective in treating all grades of hemorrhoids. CRH distributes the O’Regan System, treatment protocols, operational and marketing expertise as a complete, turnkey package directly to gastroenterology practices, creating meaningful relationships with the gastroenterologists it serves. CRH’s O’Regan System is currently used in all 50 US states Puerto Rico, USVI and Canada.
Notice Regarding Forward Looking Statements
Certain statements in this news release are forward-looking statements and are prospective in nature including the statements regarding: the anticipated benefits of the acquisitions and the future strategy of WELL and CRH. Forward-looking statements are not based on historical facts, but rather on current expectations and projections about future events and are therefore subject to risks and uncertainties which could cause actual results to differ materially from the future results expressed or implied by the forward-looking statements. These statements generally can be identified by the use of forward-looking words such as “may”, “should”, “could”, “would”, “intend”, “estimate”, “plan”, “anticipate”, “expect”, “believe”, “working on” or “continue”, or the negative thereof or similar variations. There are numerous risks and uncertainties that could cause actual results and WELL’s plans and objectives to differ materially from those expressed in the forward-looking information, including: business disruption risks relating to COVID-19; regulatory risks, including those related to healthcare, privacy and data security; integration risks relating to the acquired business on a post-closing basis, including any failure to realize expected benefits of the acquisitions; and the other risks described in WELL’s publicly filed documents available on SEDAR. Actual results and future events could differ materially from those anticipated in such information. These and all subsequent written and oral forward-looking information are based on estimates and opinions of management on the dates they are made and are expressly qualified in their entirety by this notice. Except as required by law, WELL does not intend to update these forward-looking statements.
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SOURCE WELL Health Technologies Corp.
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