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Alida Biosciences Announces Series A Funding and Early Access Launch of Innovative Products for Epitranscriptomic Research

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SAN DIEGO, June 12, 2024 /PRNewswire/ — Alida Biosciences (AlidaBio), an innovator in epigenomic research tools, proudly announces the successful completion of a $7.5 million Series A funding round. This funding, led by Genoa Ventures with participation from FusionX Ventures and Vertical Venture Partners, is complemented by two ongoing SBIR grants totaling $4 million from The National Human Genome Research Institute (NHGRI). Additionally, AlidaBio unveils the Early Access launch of two products: the EpiPlex™ RNA Library Prep Kit and the EpiScout™ Analysis Suite. These products provide a comprehensive solution for multiplexed epitranscriptomic analysis of input-limited clinical research RNA samples, offering unprecedented sensitivity and accuracy.

Innovative Solutions for Pioneering Research

EpiPlex RNA Library Prep Kit is designed to revolutionize epitranscriptomic research by enabling unprecedented multiplexed detection of RNA modifications. This kit integrates a streamlined assay workflow with an intuitive bioinformatics platform, facilitating high-sensitivity analysis of RNA modifications. The epitranscriptome, consisting of a diverse array of naturally occurring RNA modifications, plays a crucial role in regulating RNA biology, including RNA-protein interactions, splicing, three-dimensional RNA structure, transcript stability, intracellular trafficking, and translation.

Traditional methods, relying on antibody-based and chemical approaches, are limited to detecting a single type of modification per assay and require high input amounts of RNA. The EpiPlex kit overcomes these limitations by using non-antibody binders (NABs), which exhibit high affinity and minimal off-target binding. This results in superior reproducibility, sensitivity, and accuracy, even with low RNA inputs. The early access launch of these products is aligned with the completion of several beta customer experiences, with customers expressing high satisfaction with the improved workflow and exceptional data quality.

“The AlidaBio EpiPlex Library Prep Kit proved to have several advantages over alternative methods,” said beta customer Dr. Daniel Kupers of Fred Hutchinson Cancer Research Center. “We observed ease-of-use going from input RNA to sequence-ready libraries all in one kit, time savings and usability for situations with limited amounts of RNA, and lower background than other methods. The inclusion of bioinformatics analysis with EpiScout is also a plus, as high-quality calls are challenges with other methods.”

EpiScout Analysis Suite complements the EpiPlex kit by providing an intuitive bioinformatics platform for analyzing and visualizing complex epitranscriptomic data. This suite streamlines data interpretation and offers powerful tools for researchers to explore the multifaceted landscape of RNA modifications and multiomic integration of data sets.

Clinical Relevance and Applications

The EpiPlex kit is particularly suited for profiling multiple RNA modifications in clinical research samples where RNA input is limited. Typically, tissue samples, clinical biopsies, and other native biological materials provide small quantities of total RNA, with mRNA constituting only 1-3% of this total. The EpiPlex kit’s high sensitivity and efficiency make it ideal for these scenarios, ensuring high-quality results from even the smallest RNA samples. This efficiency, driven by the NABs’ high affinity and specificity, ensures high-quality modification site calling without increasing sequencing depth requirements.

Series A Funding: A Milestone Achievement

The successful Series A funding for AlidaBio underscores investor confidence in the innovative approach. This funding will facilitate faster and enhanced product development, as well as a focused effort to bring the EpiPlex kit into customers’ hands, maximizing its impact in the field. “Securing this Series A funding is a testament to the groundbreaking potential of our technology,” said Dr. Gudrun Stengel, CEO of AlidaBio. “We are excited to introduce the EpiPlex RNA Library Prep Kit and the EpiScout Analysis Suite, and to accelerate our technology development in the multiplexed RNA modification detection space. The strong support from our investors reflects our shared enthusiasm in building research tools needed to uncover new insights into RNA biology and advance the field of epitranscriptomics.”

The funding recognizes both the potential and immediate impact of AlidaBio’s solutions. “AlidaBio has created a technical yet elegant solution to uncover hidden regulatory information on RNA, scalable with current NGS technology,” said Landon Merrill, principal at Genoa Ventures. “With this technology and Dr. Stengel’s talented team, AlidaBio is poised to lead the mainstream adoption of epitranscriptomics by the genomics customer base.”

About AlidaBio

AlidaBio, founded in 2020, is revolutionizing the field of epigenomics by commercializing accessible tools that broaden the application of epitranscriptomics in life sciences. Our groundbreaking products empower researchers to concurrently analyze multiple RNA modifications with relative quantification, using RNA inputs suitable for clinically relevant samples and supported by user-friendly bioinformatics.

For more information about the EpiPlex RNA Reagent Kit, the EpiScout Analysis Suite, and other future products, please visit our website at www.alidabio.com or contact:

Media Contact: 

Natasha Moshirian Wagner 
VP, Product Marketing 
AlidaBio 
Email: nwagner@alidabio.com 

AlidaBio — Redefining the frontier of RNA biology. 

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SOURCE Alida Biosciences

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Gentoo Media – Mandatory notification of trade

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33 minutes ago

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November 14, 2024

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ST JULIANS, Malta, Nov. 14, 2024 /PRNewswire/ — MJ Foundation Fundacja Rodzinna, a company related to Mateusz Juroszek, Board Member and primary insider of Gentoo Media Inc. (Gentoo) has today acquired 115,604 shares in Gentoo at a price of SEK 24,996 per share. After this transaction, close associates of Mateusz Juroszek hold 24,027,766 shares in Gentoo.

This information is subject to the disclosure requirements pursuant to Section 5-12 of the Norwegian Securities Trading Act.

For further information, contact:
Tore Formo, Group CFO, tore.formo@g2m.com, +47 91668678

About Gentoo Media

Gentoo Media is a market-leading affiliate connecting operators and players in the online gambling and sports betting industry. Gentoo Media offers an array of iGaming affiliate solutions, such as paid marketing expertise and quality traffic through our prominent industry sites including AskGamblers, Time2Play, CasinoTopsOnline, WSN and Casinomeister. In 2024, Gentoo Media (formerly GiG Media) became Gentoo Media Inc. following a legal split separating the Media and Platform and Sportsbook business in Gaming Innovation Group (GiG) into two independently listed companies. Gentoo Media Inc. is dual listed on the Oslo Stock Exchange (ticker “G2MNO”) and Nasdaq Stockholm (ticker “G2M”). www.gentoomedia.com

This information was brought to you by Cision http://news.cision.com

https://news.cision.com/gentoo-media-inc/r/gentoo-media—mandatory-notification-of-trade,c4066199

View original content:https://www.prnewswire.co.uk/news-releases/gentoo-media—mandatory-notification-of-trade-302305030.html

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Xinhua Silk Road: World IoT expo 2024 opens in E. China’s Wuxi to showcase future of smart connectivity

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33 minutes ago

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November 14, 2024

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BEIJING, Nov. 14, 2024 /PRNewswire/ — The World Internet of Things (IoT) Exposition 2024 kicked off on Monday in Wuxi City of east China’s Jiangsu Province, attracting industry leaders, representatives of enterprises and experts from across the globe to discuss industry trends and demonstrate innovative applications.

At the expo’s opening ceremony, Wuxi unveiled a national pilot project in intelligent connected vehicles, which aims to create a cohesive mode for car owners, vehicles and cities connection, contributing Wuxi’s expertise to smart vehicle initiatives.

Additionally, a new smart sensing chip engineering center was launched, representing an investment of over 1 billion yuan and focusing on high-density large-scale substrates and other advanced chip technologies to strengthen the city’s integrated circuit development.

The event also saw the release of several major IoT research achievements, including the 2024 IoT innovation development Taihu index and the 2024 white paper on advanced sensing technology and applications.

The three-day event features exhibitions, panel discussions, and thematic sessions that showcase the latest development in IoT innovations and applications. This year’s expo is poised to drive Wuxi’s high-quality growth in IoT while promoting global tech collaboration and knowledge sharing in the IoT field.

Wuxi has become a navigator of the IoT industry in China. The latest statistics show that in 2023, the scale of the IoT industrial cluster in Wuxi surpassed 450 billion yuan, taking the lead in Jiangsu Province.

Original link: https://en.imsilkroad.com/p/343117.html

SOURCE Xinhua Silk Road

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Agoda Highlights Five Urban Hikes for Adventurous Travelers

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33 minutes ago

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November 14, 2024

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SINGAPORE, Nov. 14, 2024 /PRNewswire/ — Digital travel platform Agoda introduces five urban hikes across Asia, offering travelers a chance to experience the perfect blend of city life and nature. These hikes, ranging from family-friendly to more challenging trails, provide an unmatched perspective on some of Asia’s most dynamic cities.

Whether it’s Elephant Hill in Taipei, with its stunning views of the Taipei 101, or Hong Kong’s famous Dragon Back, active travelers are in for a treat when embarking on these city hike adventures.

Andrew Smith, Senior Vice President, Supply at Agoda said: “Asia is special to have so many incredible hike routes right in the heart of these popular cities. The five highlighted hikes are just a sample of the many breathtaking city trails the continent has to offer. Adventurous travelers will want to try them all and thankfully Agoda helps make travel affordable with great value deals on over 4.5 million properties globally.”

These are the five city hikes, ranked from easiest to most challenging:

Kuala Lumpur’s Bukit Nanas Forest Reserve offers a unique experience of trekking through a tropical rainforest right in the city center. The trail is relatively easy, with well-marked paths and informative signboards about the local flora and fauna, making it a great choice for families and nature enthusiasts.

Elephant Hill in Taipei offers a short but rewarding climb. The trail is well-maintained and provides stunning views of Taipei’s skyline, including the famous Taipei 101. It’s an ideal spot for those looking to enjoy a quick escape into nature without straying far from the city.

In Singapore, the Southern Ridges trail offers a moderate hike through a series of interconnected parks and gardens. Spanning 10 kilometers, this trail provides a lush green corridor amidst the urban environment, with highlights including the Henderson Waves bridge and panoramic views of the city.

Namsan in Seoul presents a slightly more challenging hike, leading to the N Seoul Tower. The trail is popular among locals and tourists alike, offering a mix of natural beauty and cultural landmarks, with several routes to choose from depending on the desired difficulty level.

Finally, Hong Kong’s Dragon’s Back is a favorite for its breathtaking views of the coastline and the South China Sea. This moderately challenging hike is known for its undulating ridges and scenic vistas, providing a rewarding experience for those willing to tackle its ups and downs.

In each of these city hike destinations, Agoda offers great value accommodation. In addition to holiday properties, Agoda’s 130,000 flight routes and 300,000 activities ensure the platform is the one-stop travel solution to help booking an entire trip. The latest Agoda deals can be found in the Agoda app or on agoda.com/deals.

— ENDS —

 

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SOURCE Agoda

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