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PacBio and International Research Consortium CoLoRS Announce Release of First-Ever HiFi Long-Read Variant Database

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3 months ago

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Consortium Delivers Publicly Available Datasets that Enrich Detection of Rare and Novel Genetic Variants for Advances in Human Disease Research

MENLO PARK, Calif., June 10, 2024 /PRNewswire/ — PacBio (NASDAQ: PACB), a leading developer of high-quality, highly accurate sequencing solutions, in collaboration with the international Consortium for Long-Read Sequencing (CoLoRS), today announced the launch of the first publicly available and free HiFi long-read variant frequency database with global representation. This innovative resource fills a critical void for rare disease researchers, providing access to genetic variants that are not detectable through short-read sequencing methods. By enabling the filtering of common structural variants from long-read sequencing data, this database allows for the identification of rare and novel variants in rare disease cases. The launch of this database better enables researchers to utilize long-read genomic data to advance human health research.

“Joining forces with PacBio has enabled us to leverage their HiFi sequencing capabilities, enhancing the depth and accuracy of the genomic data we can offer to the research community,” said Michael Schatz, Bloomberg Distinguished Professor at Johns Hopkins University. “This effort complements existing databases such as gnomAD, as long reads enable much greater sensitivity and precision for complex variants (SVs) and tandem repeats. The CoLoRS database is a tremendous step forward in our collective effort to understand complex genetic variations and their implications in disease.”

Studies have shown that long-read sequencing finds 15,000 more structural variants (SVs) and 300,000 more small variants than short reads. SVs are crucial as they account for much of the genetic diversity between humans and are associated with disease pathogenesis. The CoLoRS database integrates data from nearly 1,000 long-read genomes, providing detailed insights into human variation and improving the detection of complex variants and tandem repeats. This resource is developed by a global coalition from top clinical and academic institutions, pooling diverse long-read genome data from various research projects.

“We are thrilled to see the launch of the CoLoRS database, a pivotal development in genomics research,” said Christian Henry, President, and Chief Executive Officer of PacBio. “This collaboration with the CoLoRS members exemplifies our commitment to supporting the scientific community with tools that enhance the accuracy and utility of genetic research. It also demonstrates the unique capabilities of our HiFi sequencing technology. By making this information accessible to the public, we are empowering researchers around the world to make significant advances in areas such as oncology, rare diseases, and genetic disorders.”

Researchers are invited to access the CoLoRS database and explore its capabilities at www.colorsdb.org. Supported by PacBio’s HiFi sequencing technology, this platform provides researchers with new insights into human genomic variation, accelerating advancements in critical areas of medical research.

About PacBio
PacBio (NASDAQ: PACB) is a premier life science technology company that designs, develops, and manufactures advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems. Our products and technologies stem from two highly differentiated core technologies focused on accuracy, quality and completeness which include our HiFi long-read sequencing and our SBB® short-read sequencing technologies. Our products address solutions across a broad set of research applications including human germline sequencing, plant and animal sciences, infectious disease and microbiology, oncology, and other emerging applications. For more information, please visit www.pacb.com and follow @PacBio.

PacBio products are provided for Research Use Only. Not for use in diagnostic procedures.

Forward-Looking Statements
This press release may contain “forward-looking statements” within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and the U.S. Private Securities Litigation Reform Act of 1995. All statements other than statements of historical fact are forward-looking statements, including statements relating to the uses, coverage, advantages, quality or performance of, or benefits or expected benefits of using, PacBio products or technologies; enabling researchers to utilize long-read genomic data to advance human health research; empowering researchers to make significant advances in areas such as oncology, rare diseases, and genetic disorders; and other future events. You should not place undue reliance on forward-looking statements because they are subject to assumptions, risks, and uncertainties and could cause actual outcomes and results to differ materially from currently anticipated results, including, challenges inherent in sequencing a large number of whole human genomes, and the difficulty of generating discoveries across various areas of research; unanticipated increases in costs or expenses; interruptions or delays in the supply of components or materials for, or manufacturing of, PacBio products and products under development; potential product performance and quality issues; third-party claims alleging infringement of patents and proprietary rights or seeking to invalidate PacBio’s patents or proprietary rights; and other risks associated with international operations. Additional factors that could materially affect actual results can be found in PacBio’s most recent filings with the Securities and Exchange Commission, including PacBio’s most recent reports on Forms 8-K, 10-K, and 10-Q, and include those listed under the caption “Risk Factors.” These forward-looking statements are based on current expectations and speak only as of the date hereof; except as required by law, PacBio disclaims any obligation to revise or update these forward-looking statements to reflect events or circumstances in the future, even if new information becomes available.

Contacts
Investors: 
Todd Friedman
ir@pacificbiosciences.com

Media:
pr@pacificbiosciences.com

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SOURCE Pacific Biosciences of California, Inc.

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The Battery Show Asia 2025: Uniting Global Innovators in Hong Kong

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12 mins ago

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September 20, 2024

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July 15-17, 2025 | AsiaWorld-Expo, Hong Kong

HONG KONG, Sept. 20, 2024 /PRNewswire/ — The Battery Show, organized by Informa Markets, is a globally recognized platform for cutting-edge battery technology, energy storage solutions and electric/hybrid vehicle (EV/HV) innovations. It is expanding its reach with the inaugural The Battery Show Asia 2025, which will take place from July 15-17, 2025, at AsiaWorld-Expo in Hong Kong. This landmark event builds on the long-lasting success of The Battery Show in North America and Europe, highlighting the strategic importance of the Asian in the fast-evolving advanced battery, energy storage and e-mobility sectors. 

Over three days, The Battery Show Asia 2025 will feature 350+ exhibitors, attract over 15,000 industry professionals, and host 150+ expert speakers. The event will be a pivotal meeting ground for innovators, engineers, manufacturers, and thought leaders from Asia and around the world, offering a unique platform for collaboration, knowledge sharing, and business development in this dynamic industry.

Hong Kong, strategically located within the Greater Bay Area (GBA), is an ideal venue for this prestigious event. With its world-class connectivity and business-friendly environment, Hong Kong offers unparalleled access to the vibrant and diverse markets of China and the broader Asia-Pacific region, making it the perfect location for industry professionals looking to expand their global business footprint, either into Asia or from Asia to the rest of world.

The Battery Show Asia 2025 will feature a comprehensive exhibition showcasing the latest advancements in battery technology, energy storage solutions, and EV/HV innovations. Complementing the exhibition will be a cutting-edge conference program addressing critical topics such as policy and regulation, advanced technology, hydrogen energy, emerging applications, and investment trends. The show will be co-located with Mobility Tech Asia and Data Center Asia, further enhancing its appeal and reach across interconnected sectors.

Attendees will have exclusive opportunities to engage with leading battery and component manufacturers, EV/HV producers, renewable energy experts, and influential decision-makers from across the globe. With a strong international presence, the event promises to foster meaningful connections and strategic partnerships, particularly for those looking to engage with China’s rapidly advancing technology sector.

A series of exclusive networking events, including VIP receptions, an all-day Open Tech Forum, and the premium TBSA/MTA 2025 Conference, will offer additional opportunities for deep engagement and collaboration. Whether you’re showcasing innovations, exploring market insights, or expanding your professional network, The Battery Show Asia 2025 is the essential event to drive your business forward.

Contact:
For more information or partnership and sales inquiries, please contact:
info@thebatteryshow.asia

About Informa Markets:
Informa Markets creates platforms for industries and specialist markets to trade, innovate, and grow. Through our comprehensive portfolio of exhibitions, digital content, and services, we enable customers and partners to connect, discover new opportunities, and drive industry progress.

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SOURCE Informa Markets Asia-The Battery Show Asia & Mobility Tech Asia

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Valmet to supply a new BCTMP line and an evaporator line to JK Paper Limited in India

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12 mins ago

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September 20, 2024

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Valmet Oyj press release, September 20, 2024, at 9:30 a.m. EEST

ESPOO, Finland, Sept. 20, 2024 /PRNewswire/ — Valmet is to supply a new bleached chemi-thermomechanical pulp (BCTMP) line and a related evaporator line to JK Paper Limited’s Fort Songadh mill in India. The new BCTMP line will manufacture high-quality BCTMP pulp for lightweight coated board production. The start-up is scheduled for the end of 2025.

The order was included in Valmet’s orders received of the second quarter 2024. The value of the order will not be disclosed.

“The new BCTMP and evaporator line will play a crucial role in our production process, enabling us to meet increasing market demands while adhering to the highest quality and environmental responsibility standards. Valmet’s unique high-temperature (HT) BCTMP technology will allow us to achieve superior pulp quality and energy efficiency, ensuring that we remain competitive in the global marketplace,” says A.S. Mehta, President, JK Paper Limited.

“The BCTMP order from JK Paper marks a significant continuation of our cooperation. We are privileged that Valmet has been chosen to contribute to their ongoing success. Our advanced HT-BCTMP and evaporator line technologies will enhance their production capabilities and support their efforts to minimize environmental impact through energy-efficient and resource-saving solutions,” says Fredrik Willgottson, Vice President, Pulp & Energy, Asia Pacific, Valmet.

Technical details about the delivery

The 400 ADMT/d BCTMP line is based on Valmet’s HT-BCTMP technology for optimized impregnation, producing pulp with high bulk and low shive content at minimum energy consumption. The line will include all main process technology for chip washing, pre-steaming, PREX impregnation, HC refining, MC bleaching, HC bleaching, LC refining, screening, reject refining, steam separation, heat recovery, and pulp washing.

The delivery includes a Mechanical Vapor Recompression (MVR) tube evaporator plant for handling the BCTMP plant liquor. It covers MVR evaporator effects, a tube concentrator, and a condensate treatment plant. The evaporator line includes Valmet’s patented Internal Condensate Treatment for producing cleaner condensate for recycling in the mill. The new line will have a design capacity of 180 tons of water per hour.

Information about JK Paper Limited

JK Paper Limited, an integrated pulp and paper plant, was established in 1962. The company is a leading Indian producer of office papers, coated papers, writing and printing papers, and high-end packaging boards. The company has three integrated Pulp and Paper Mills: Unit JKPM at Rayagada (Odisha), Unit CPM at Songadh (Gujarat), and Unit SPM at Kagaznagar, Telangana. The company’s installed capacity is around 800,000 tonnes per annum.

VALMET
Corporate Communications

For further information, please contact:
Pawan Kumar Agarwal, Director, India Region, Asia Pacific, Valmet, tel. +91 96540 69641
Fredrik Willgottson, Vice President, Pulp and Energy, Asia Pacific, Valmet, tel. +66 61384 7911

Valmet has a global customer base across various process industries. We are a leading global developer and supplier of process technologies, automation and services for the pulp, paper and energy industries, and with our automation and flow control solutions we serve an even wider base of process industries. Our more than 19,000 professionals around the world work close to our customers and are committed to moving our customers’ performance forward – every day.

The company has over 220 years of industrial history and a strong track record in continuous improvement and renewal. Valmet’s net sales in 2023 were approximately EUR 5.5 billion.

Valmet’s shares are listed on the Nasdaq Helsinki and the head office is in Espoo, Finland.

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The Second “FROM ZIQUEJIE TERRACES TO THE WORLD” Global Farming Culture Exchange and Mutual Learning Conference Held

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12 mins ago

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September 20, 2024

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LOUDI, China, Sept. 20, 2024 /PRNewswire/ — On September 12, the opening ceremony and keynote speeches of the Second “FROM ZIQUEJIE TERRACES TO THE WORLD” Global Farming Culture Exchange and Mutual Learning Conference were presented in Xinhua County, Loudi City, Hunan Province. Over 200 guests, including representatives from international organizations such as the International Union for Conservation of Nature (IUCN), the Food and Agriculture Organization of the United Nations (FAO), diplomats from terrace-cultivating countries like France and Peru, and domestic and international experts from the agriculture, culture, and tourism sectors, gathered to discuss key issues including the protection of global agricultural cultural heritage and the development of the green agricultural economy. Together, they explored ways to preserve and promote farming culture, showcasing Hunan’s unique approach to agricultural heritage protection and innovation, while contributing China’s solutions for the safeguarding of global agricultural cultural heritage.

During the opening ceremony, the Consensus on the Integrated Development of Terraces in Agriculture, Culture, and Tourism was released. The document promotes the understanding of the value of terraces, the protection of terrace ecosystems, the preservation of farming culture, the active promotion of agriculture, culture, and tourism integration, enhanced international exchange and cooperation, and the innovation of development models. The aim is to promote the effective protection and sustainable development of terraces globally, deepen the integration of agriculture, culture, and tourism, build distinctive terrace-based industrial chains, enhance the overall competitiveness of terrace regions, and achieve ecological, economic, and social benefits for all.

Terraced fields exemplify the harmonious coexistence of human ingenuity and nature. They carry rich agricultural traditions and historical memories, and their value in preserving biodiversity, ensuring food security, and promoting regional economic development is immeasurable. The Ziquejie Terraces, recognized as both a Globally Important Agricultural Heritage System and a World Heritage Irrigation Structure, are the product of the collective labor of the Miao, Yao, Dong, Han, and other ethnic groups throughout history. These terraces are a historical testament to the merging of mountain hunting cultures with rice farming cultures.

Looking ahead, Loudi City will further strengthen the protection of agricultural cultural heritage, promote cultural inheritance, and foster the integration of agriculture, culture, and tourism. Through these efforts, it aims to provide concrete examples of “authentic protection, living use, and industrial integration” for the world.

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