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PacBio and International Research Consortium CoLoRS Announce Release of First-Ever HiFi Long-Read Variant Database

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Consortium Delivers Publicly Available Datasets that Enrich Detection of Rare and Novel Genetic Variants for Advances in Human Disease Research

MENLO PARK, Calif., June 10, 2024 /PRNewswire/ — PacBio (NASDAQ: PACB), a leading developer of high-quality, highly accurate sequencing solutions, in collaboration with the international Consortium for Long-Read Sequencing (CoLoRS), today announced the launch of the first publicly available and free HiFi long-read variant frequency database with global representation. This innovative resource fills a critical void for rare disease researchers, providing access to genetic variants that are not detectable through short-read sequencing methods. By enabling the filtering of common structural variants from long-read sequencing data, this database allows for the identification of rare and novel variants in rare disease cases. The launch of this database better enables researchers to utilize long-read genomic data to advance human health research.

“Joining forces with PacBio has enabled us to leverage their HiFi sequencing capabilities, enhancing the depth and accuracy of the genomic data we can offer to the research community,” said Michael Schatz, Bloomberg Distinguished Professor at Johns Hopkins University. “This effort complements existing databases such as gnomAD, as long reads enable much greater sensitivity and precision for complex variants (SVs) and tandem repeats. The CoLoRS database is a tremendous step forward in our collective effort to understand complex genetic variations and their implications in disease.”

Studies have shown that long-read sequencing finds 15,000 more structural variants (SVs) and 300,000 more small variants than short reads. SVs are crucial as they account for much of the genetic diversity between humans and are associated with disease pathogenesis. The CoLoRS database integrates data from nearly 1,000 long-read genomes, providing detailed insights into human variation and improving the detection of complex variants and tandem repeats. This resource is developed by a global coalition from top clinical and academic institutions, pooling diverse long-read genome data from various research projects.

“We are thrilled to see the launch of the CoLoRS database, a pivotal development in genomics research,” said Christian Henry, President, and Chief Executive Officer of PacBio. “This collaboration with the CoLoRS members exemplifies our commitment to supporting the scientific community with tools that enhance the accuracy and utility of genetic research. It also demonstrates the unique capabilities of our HiFi sequencing technology. By making this information accessible to the public, we are empowering researchers around the world to make significant advances in areas such as oncology, rare diseases, and genetic disorders.”

Researchers are invited to access the CoLoRS database and explore its capabilities at www.colorsdb.org. Supported by PacBio’s HiFi sequencing technology, this platform provides researchers with new insights into human genomic variation, accelerating advancements in critical areas of medical research.

About PacBio
PacBio (NASDAQ: PACB) is a premier life science technology company that designs, develops, and manufactures advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems. Our products and technologies stem from two highly differentiated core technologies focused on accuracy, quality and completeness which include our HiFi long-read sequencing and our SBB® short-read sequencing technologies. Our products address solutions across a broad set of research applications including human germline sequencing, plant and animal sciences, infectious disease and microbiology, oncology, and other emerging applications. For more information, please visit www.pacb.com and follow @PacBio.

PacBio products are provided for Research Use Only. Not for use in diagnostic procedures.

Forward-Looking Statements
This press release may contain “forward-looking statements” within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and the U.S. Private Securities Litigation Reform Act of 1995. All statements other than statements of historical fact are forward-looking statements, including statements relating to the uses, coverage, advantages, quality or performance of, or benefits or expected benefits of using, PacBio products or technologies; enabling researchers to utilize long-read genomic data to advance human health research; empowering researchers to make significant advances in areas such as oncology, rare diseases, and genetic disorders; and other future events. You should not place undue reliance on forward-looking statements because they are subject to assumptions, risks, and uncertainties and could cause actual outcomes and results to differ materially from currently anticipated results, including, challenges inherent in sequencing a large number of whole human genomes, and the difficulty of generating discoveries across various areas of research; unanticipated increases in costs or expenses; interruptions or delays in the supply of components or materials for, or manufacturing of, PacBio products and products under development; potential product performance and quality issues; third-party claims alleging infringement of patents and proprietary rights or seeking to invalidate PacBio’s patents or proprietary rights; and other risks associated with international operations. Additional factors that could materially affect actual results can be found in PacBio’s most recent filings with the Securities and Exchange Commission, including PacBio’s most recent reports on Forms 8-K, 10-K, and 10-Q, and include those listed under the caption “Risk Factors.” These forward-looking statements are based on current expectations and speak only as of the date hereof; except as required by law, PacBio disclaims any obligation to revise or update these forward-looking statements to reflect events or circumstances in the future, even if new information becomes available.

Contacts
Investors: 
Todd Friedman
ir@pacificbiosciences.com

Media:
pr@pacificbiosciences.com

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SOURCE Pacific Biosciences of California, Inc.

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Huawei Participates in the First In-Person Internet of Things (IoT) Architecture Working Group Meeting on IEEE P2413.2, Standard for Reference Architecture for Power Distribution IoT (PDIoT)

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November 14, 2024

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MILAN, Nov. 14, 2024 /PRNewswire/ — On October 23, 2024, the first in-person Internet of Things (IoT) Architecture Working Group Meeting on IEEE P2413.2, Standard for Reference Architecture for Power Distribution IoT (PDIoT) was held in Milan, Italy. During the meeting, representatives of State Grid of China and several European power companies discussed the IEEE P2413.2 standard outline, IDS reference architecture, and cloud-edge-device-pipe functional requirements, shared the latest research results, and submitted key proposals.

At the meeting, the proposal for key features of the PDIoT architecture and the first standard version proposal was submitted. This marks a key progress made by the working group in promoting the PDIoT architecture towards international standards and the official start of the formulation of the PDIoT international standard.

Standards are the cornerstone upon which any industry is built and are a great tool to promote industry digitalization. They help drive collaboration and cooperation across each phase of digitalization as they unify expectations for interfaces and guide technical paths. They also lead the direction of technological innovation and encourage enterprises to explore new technologies and models to adapt to market needs and industry transformation.

IEEE is the world’s largest technical professional organization, comprising of 460,000 members from more than 190 countries. The IEEE Standards Association is a global standardization body where diverse expert communities focus on formulating standards regarding emerging technology areas such as AI, AI Ethics, quantum, metaverse as well as standards around electrical devices, experiment methods, original components, symbols, definitions, and test methods. The organization is a key source of global, market-relevant standards across many emerging and critical technology fields.

The new power system faces challenges relating to green energy structure, flexible power grid control, interactive power consumption, coordinated and interactive energy storage on the power generation-grid-load sides, and the complex electricity-carbon transaction system. Digitalization and intelligence are key to coping with these challenges.

The PDIoT is a key component of smart grids. It uses highly interconnected devices and systems to implement efficient energy distribution and optimized management. The standards working group meeting was focused on PDIoT. Huawei and other working group members proposed the draft outline, IDS architecture, and cloud-pipe-edge-device functions. State Grid Shaanxi took the lead in providing 14 application scenarios for the PDIoT architecture.

Jason Li, President of Global Marketing & Solutions, Electric Power Digitalization Business Unit, Huawei, said that to meet the challenges of the new power system in the future, an open and cooperative environment and a unified international standard architecture are crucial. “Based on the IEEE P2413 IoT standards platform, Huawei works with global power companies, ecosystem partners, and IEEE Standards Association to establish a framework that is globally applicable, open, and sustainable. This will not only promote the intelligent development of power distribution networks and the coordinated development of the power industry, but also provide a technical innovation foundation for future power systems,” He explained. The standard architecture will also contribute to global energy transition and sustainable development.

The formulation of the IEEE P2413.2 PDIoT international standards at this meeting is intended to meet specific power distribution requirements amid the digital transformation of the global power industry and help high-speed power line communications (HPLC) play a more important role in the power sector.

Photo – https://mma.prnewswire.com/media/2557533/Participants_celebrating_a_successful_meeting.jpg 

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Gentoo Media – Mandatory notification of trade

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November 14, 2024

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ST JULIANS, Malta, Nov. 14, 2024 /PRNewswire/ — MJ Foundation Fundacja Rodzinna, a company related to Mateusz Juroszek, Board Member and primary insider of Gentoo Media Inc. (Gentoo) has today acquired 115,604 shares in Gentoo at a price of SEK 24,996 per share. After this transaction, close associates of Mateusz Juroszek hold 24,027,766 shares in Gentoo.

This information is subject to the disclosure requirements pursuant to Section 5-12 of the Norwegian Securities Trading Act.

For further information, contact:
Tore Formo, Group CFO, tore.formo@g2m.com, +47 91668678

About Gentoo Media

Gentoo Media is a market-leading affiliate connecting operators and players in the online gambling and sports betting industry. Gentoo Media offers an array of iGaming affiliate solutions, such as paid marketing expertise and quality traffic through our prominent industry sites including AskGamblers, Time2Play, CasinoTopsOnline, WSN and Casinomeister. In 2024, Gentoo Media (formerly GiG Media) became Gentoo Media Inc. following a legal split separating the Media and Platform and Sportsbook business in Gaming Innovation Group (GiG) into two independently listed companies. Gentoo Media Inc. is dual listed on the Oslo Stock Exchange (ticker “G2MNO”) and Nasdaq Stockholm (ticker “G2M”). www.gentoomedia.com

This information was brought to you by Cision http://news.cision.com

https://news.cision.com/gentoo-media-inc/r/gentoo-media—mandatory-notification-of-trade,c4066199

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Xinhua Silk Road: World IoT expo 2024 opens in E. China’s Wuxi to showcase future of smart connectivity

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60 minutes ago

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November 14, 2024

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BEIJING, Nov. 14, 2024 /PRNewswire/ — The World Internet of Things (IoT) Exposition 2024 kicked off on Monday in Wuxi City of east China’s Jiangsu Province, attracting industry leaders, representatives of enterprises and experts from across the globe to discuss industry trends and demonstrate innovative applications.

At the expo’s opening ceremony, Wuxi unveiled a national pilot project in intelligent connected vehicles, which aims to create a cohesive mode for car owners, vehicles and cities connection, contributing Wuxi’s expertise to smart vehicle initiatives.

Additionally, a new smart sensing chip engineering center was launched, representing an investment of over 1 billion yuan and focusing on high-density large-scale substrates and other advanced chip technologies to strengthen the city’s integrated circuit development.

The event also saw the release of several major IoT research achievements, including the 2024 IoT innovation development Taihu index and the 2024 white paper on advanced sensing technology and applications.

The three-day event features exhibitions, panel discussions, and thematic sessions that showcase the latest development in IoT innovations and applications. This year’s expo is poised to drive Wuxi’s high-quality growth in IoT while promoting global tech collaboration and knowledge sharing in the IoT field.

Wuxi has become a navigator of the IoT industry in China. The latest statistics show that in 2023, the scale of the IoT industrial cluster in Wuxi surpassed 450 billion yuan, taking the lead in Jiangsu Province.

Original link: https://en.imsilkroad.com/p/343117.html

SOURCE Xinhua Silk Road

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