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Kanazawa University research: Sensing a biomarker

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KANAZAWA, Japan, June 7, 2024 /PRNewswire/ — Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Biosensors and Bioelectronics: X a novel approach for detecting a particular biomolecule associated with several diseases. The results show good sensitivity and selectivity, and may lead to the development of a low-cost, rapid detection device useful in cancer prognosis.

Human diseases are often the result of DNA transcriptions gone wrong. Transcription refers to the copying of parts of a DNA molecule — the ‘genetic code’ — into an RNA molecule, which in turn is required for converting the encoded information into proteins. The latter play crucial roles in various biochemical processes taking place in the human body. One transcriptional modification mechanism is adenosine-to-inosine editing, in which adenosine (one of four RNA building blocks) is chemically modified, resulting in an altered RNA molecule. This type of modification is facilitated by catalyst proteins called ADARs (adenosine deaminases acting on RNA). Three such ADARs have been identified in humans. One of them, ADAR1, has been found to be more abundant in the presence of several kinds of chronic diseases, including neurological disorders and cancer. ADAR1 is therefore considered a biomarker — a ‘signature molecule’ — for assessing a patient’s condition and chances of survival. Madhu Biyani from Kanazawa University and colleagues have now developed a new, electrochemical biosensor for detecting ADAR1, offering a low-cost, rapid tool for measuring ADAR1 concentrations in cells. The detector is expected to be useful for monitoring cancer progression.

The procedure presented by Biyani and colleagues is new in two ways. The first is that it uses newly identified aptamers as molecules that can recognize and capture ADAR1. Aptamers are molecules consisting of sequences of (synthetic) DNA, RNA or other biomolecules that bind to a particular target molecule, in this case ADAR1. The second novelty lies in the use of a field-deployable electrochemical sensor DEPSOR (BioSeeds Corp.), which has the advantages of, apart from being fast and non-expensive, requiring only small samples.

In order to find the optimal aptamer — that is, the one that chemically binds easiest to ADAR1 — the researchers screened a large set of DNA sequences and narrowed it down to 15 candidate aptamers. Each of these candidates was then tested in an electrochemical sensing platform: the amount of ADAR1 is ‘sensed’ through chemical reactions that result in an electrical current. The latter can be easily detected. The more ADAR1 in a sample, the higher the measured current.

The candidate aptamer resulting in the highest electrochemical current, called Apt38483, was then checked further. Its electrochemical response to ‘false’ proteins was very low, confirming it to be the optimal aptamer in terms of both sensitivity and selectivity. The scientists then tested an Apt38483-based prototype device on diluted cell samples. They found that even in a 625-fold diluted sample, ADAR1 could still be detected, highlighting the high sensitivity of the device.

The electrochemical biosensor developed by Biyani and colleagues for the detection of ADAR1 in cell samples is a promising platform for monitoring cancer progression in clinical samples. Quoting the scientists: “In the future, it will be promising to evaluate the system for the identification of low to high levels of ADAR1 expression in a cancer cell line sample for clinical prognosis.”

Figure

https://nanolsi.kanazawa-u.ac.jp/wp/wp-content/uploads/Figure1-6.png

Caption

A novel electrochemical biosensor for the detection of ADAR1 in cells is expected to be useful in cancer prognosis. © 2024 Biyani, et al. Published by Elsevier B.V.

Background

Electrochemical biosensors

Electrochemical biosensors are devices that convert biological information, such as the presence of a particular molecule (called the analyte), into a measurable signal. Essentially, biosensors consist of a bioreceptor, an interface and a transducer element. The bioreceptor binds to the analyte at the interface, which results in a signal that is picked up and converted by the transducer into an electric signal. The electric signal is processed through a computer; for example, the signal can be converted into an analyte concentration reading. Electrochemical biosensors are normally robust, low-cost and easy to miniaturize.

Madhu Biyani from Kanazawa University and colleagues have now developed an electrochemical biosensor for the detection of ADAR1, an RNA-editing enzyme associated with cancer progression. They identified a particular biomolecule as the optimal bioreceptor, showing good sensitivity and selectivity for ADAR1. The developed device is expected to be useful for monitoring cancer progression.

Reference

Madhu Biyani, Kirti Sharma, Maeda Shoei, Hinako Akashi, Masataka Nakano, Miki Nakajima, and Manish Biyani. A novel aptamer-antibody sandwich electrochemical sensor for detecting ADAR1 in complex biological samples, Biosensors and Bioelectronics: 19, 100491 (2024).

DOI: 10.1016/j.biosx.2024.100491

https://doi.org/10.1016/j.biosx.2024.100491

Contact
Hiroe Yoneda
Senior Specialist in Project Planning and Outreach
NanoLSI Administration Office, Nano Life Science Institute (WPI-NanoLSI)
Kanazawa University
Kakuma-machi, Kanazawa 920-1192, Japan
Email: nanolsi-office@adm.kanazawa-u.ac.jp
Tel: +81 (76) 234-4555

About Nano Life Science Institute (WPI-NanoLSI), Kanazawa University

Understanding nanoscale mechanisms of life phenomena by exploring “uncharted nano-realms”.

Cells are the basic units of almost all life forms. We are developing nanoprobe technologies that allow direct imaging, analysis, and manipulation of the behavior and dynamics of important macromolecules in living organisms, such as proteins and nucleic acids, at the surface and interior of cells. We aim at acquiring a fundamental understanding of the various life phenomena at the nanoscale.

https://nanolsi.kanazawa-u.ac.jp/en/

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Margex Announces a Charting Partnership With TradingView

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Margex integrates TradingView to simplify market analysis for users

VICTORIA, Seychelles, Nov. 16, 2024 /PRNewswire/ — Margex, a cryptocurrency trading platform boasting ultra-convenient and user-friendly copy trading, is excited to announce a charting partnership with TradingView to elevate user experience.

Margex is excited to integrate TradingView charts into its platform, enabling traders to benefit from the best-in-class visual analysis tools.

This partnership aims to provide Margex users with seamless access to TradingView’s advanced charting tools, enhancing the best trading experience and empowering well-informed decisions in the market.

Margex users can enjoy a TradingView-like trading experience through this product partnership, which includes 100+ technical indicators, 110+ drawing tools, and 17+ chart types without leaving the Margex platform.

This collaboration further solidifies Margex’s commitment to ensuring its users of all kinds have access to a secure, user-friendly trading experience.

Margex Adds DOGE as Withdrawal and Deposit Option
Marge has also included Dogecoin (DOGE) as an instant withdrawal and deposit option in addition to other existing options, such as KAS and TON to enable users to carry out transactions seamlessly.

About Margex

Margex is a boutique cryptocurrency exchange established in 2019, providing users access to a safe, powerful, and convenient copy trading platform. Margex copy trading makes trading simple yet effective for traders of any experience level. Users of all types can earn a return on their equity by replicating the trades of professional traders with no experience required, while skilled traders can earn income by allowing other users to copy successful strategies.

With a minimum deposit of $10, traders can access all of Margex’s copy trading functionality, as it remains the most user-friendly platform in the crypto industry.

Follow Margex on Facebook, Twitter, Telegram, Discord, and YouTube, or join the Margex team.

About TradingView

TradingView is an acclaimed charting and trading platform used by a vibrant community of over 80 million traders worldwide who gather to chat, chart, and trade the international markets.

The platform ambitiously yet consistently empowers its users with best-in-class charting tools, live market data, a comprehensive market analysis suite, and a proprietary programming language.

Beyond premier user experience, TradingView provides solutions for businesses, including advertising, news partnerships, market widgets, charting libraries, and trading integrations with selected partners.

This press release was issued through 24-7PressRelease.com. For further information, visit http://www.24-7pressrelease.com

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Launch of Al Faisal Al Baladi Holding

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A strategic partnership between two of the largest Qatari companies to add value to the local and regional market, enhancing food security and innovation in several key sectors.

DOHA, Qatar, Nov. 16, 2024 /PRNewswire/ — Senyar Trading & Distribution Company and Al Baladi Holding have announced the launch of their strategic partnership under the name of ‘Al Faisal Al Baladi Holding’. The launch ceremony was attended by Sheikh Faisal bin Qassim Al Thani, Chairman of Al Faisal Holding, and Mr. Mohammed Abdullah Al Attiyah, Chairman of Al Baladi Holding. This partnership aims to provide added value to the Qatari and regional markets, and to enhance the role of Qatari companies in supporting and developing the local economy in line with Qatar National Vision 2030.

 

 

Within this partnership, a strong economic icon was established under the name ‘Al Faisal Al Baladi Holding Group’, capable of implementing huge projects across the MENA region in a number of different vital sectors, especially livestock and agricultural production projects, which contributes to supporting food security and enhancing livestock in a sustainable manner. In addition, the retail sector constitutes a significant part of the Company’s activities.

Al Faisal Al Baladi Holding Group Holding includes Al Faisal Al Baladi Holding LLC, based in Qatar, Al Faisal Al Baladi Group for Malls Management and Operations, based in Egypt, and Al Faisal Al Baladi Holding, based in the Sultanate of Oman. As well as livestock and agricultural production, these companies will operate in several diverse sectors including distribution and wholesale, manufacturing, hospitality and hotels, restaurants, food and beverages, with the retail sector also constituting a significant area of focus. Through these activities, they will seek to meet the growing demand for innovative products and solutions, while supporting sustainable economic development in Qatar and the region.

Commenting on this announcement, Sheikh Faisal Bin Qassim Al Thani, Chairman of Al Faisal Holding, stated: “I am pleased to witness the formation of this strategic partnership that represents the development of the private sector in Qatar and enhances its ability to compete through cooperations built on solid foundations. This partnership is a realization of Qatar Vision 2030 of empowering the private sector and enhancing its contribution to the local economy. I wish both parties success in this promising partnership.”

Mr Mohammed Abdullah Al Attiyah, Chairman of Al Baladi Holding and Chairman of Al Faisal Al Baladi, said: “We are delighted with this cooperation which opens new horizons for growth and expansion. Al Baladi Holding has achieved remarkable successes in recent years, and this partnership comes to underpin our position in the market and expand the scope of our activities. We hope that Al Faisal Al Baladi Holding will contribute to the development of successful and innovative projects that will be a source of pride for everyone.”

Sheikh Mohammed bin Faisal Al Thani, Vice Chairman of Al Faisal Al Baladi Holding, added: “We share common goals, integrated resources, and expertise with Al Baladi Holding. Through this partnership, we will achieve integration and synergy in diverse businesses to maximize value for all parties, including consumers and investors, which will benefit all stakeholders and contribute to achieving a positive impact across every level.”

Mr. Abdullah Mohammed Al Attiyah, Vice Chairman of Al Baladi Holding, said: “Undoubtedly, the stability of the Qatari economy, the diversity of investment opportunities, and the positive business environment, have all contributed to Al Baladi Holding’s market leading position. We look forward to this partnership with confidence in its promise to help build a bright future”

Mr. Tarek Mahmoud Al Sayed, Board Member of Al Faisal Al Baladi Holding, added: “Food security projects hold special importance, especially in their comprehensive and sustainable concept, which constitute an essential part of our future strategy. We seek to play a pivotal role in the region through livestock and agricultural production projects, as we currently own a number of livestock and agricultural production companies in Qatar and Oman, and we plan to expand and launch new projects in a number of countries in the region and North Africa. This will support Al Faisal Al Baladi in becoming a leading company in achieving food security at the regional level.”

Mr Hany Al Sayyadi, CEO and Board Member of Al Faisal Al Baladi Holding, concluded by saying: “This partnership strengthens our diversified investment portfolio and facilitates the expansions of our presence in regional and global markets. Our vision is to achieve a strong presence in the Middle East region, by focusing on innovation and quality in all our sectors. This partnership is a natural extension of the vision of both companies to enhance economic integration and contribute to driving development in Qatar and the region.”

Al Faisal Al Baladi plans to expand its business activities in regional and global markets, by utilizing the diverse investment opportunities represented by the manufacturing, hospitality and retail sectors. The Group’s current portfolio includes more than 30 leading companies in their fields, including Al Baladi and Al Baladi Express Markets, Al Wajba Dairy and Juice Factory, City Limousine Company, in addition to a number of restaurants and companies in the food sector, and many others.

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CGTN: From Chancay to Shanghai: Transforming Latin America’s trade future

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BEIJING, Nov. 16, 2024 /PRNewswire/ — “From Chancay to Shanghai” has become a popular slogan in Peru as the Chancay Port, a flagship project of the China-proposed Belt and Road Initiative (BRI), held a grand opening ceremony on Thursday.

The $1.3 billion mega project is set to revolutionize regional trade by accommodating the world’s largest cargo ships and significantly reducing shipping times. The first phase of the project will reduce the sea shipping time from Peru to China to 23 days, cutting logistics costs by at least 20 percent.

The new port has four berths with a maximum depth of 17.8 meters, capable of hosting ultra-large container ships with a capacity of 18,000 twenty-foot equivalent units (TEUs). The port’s designed annual throughput capacity is one million TEUs in the near term and 1.5 million TEUs in the long term, positioning it as a key hub for trade between Latin America and Asia.

Chinese President Xi said in his signed article, published Thursday in the Peruvian media outlet El Peruano, that the Chancay Port project is expected to generate $4.5 billion in yearly revenues for Peru and create over 8,000 direct jobs.

Xi and his Peruvian counterpart Dina Boluarte attended the opening ceremony of Chancay Port via video link on Thursday.

“From Chancay to Shanghai, what we are witnessing is not only the root and blossom of the Belt and Road Initiative in Peru, but also the birth of a new gateway that connects land and sea, Asia and Latin America,” said President Xi when addressing the opening ceremony.

Xi flew in earlier Thursday to pay a state visit to Peru and attend the 31st APEC Economic Leaders’ Meeting. This is his sixth visit to the continent since 2013.

Transforming regional trade dynamics

The Chancay Port is not only a good deep-water port, but also the first smart port and green port in South America, Xi said.

Strategically located as Peru’s gateway to the Pacific, the port is connected to the Pan-American Highway via a tunnel, providing direct access to Peru’s capital Lima. As the first “maritime expressway” into Latin America, it will enable faster and more cost-efficient transport of Peruvian exports, such as cranberries and avocados, to Asian markets.

“Our goal is to become the Singapore of Latin America, so that port cargo passes through here when going to Asia. When someone from Brazil, Venezuela, Bolivia, Paraguay and Argentina wants to go to Asia, they should think of Peru as a point of departure,” Peruvian Transport Minister Raul Perez Reyes told reporters last month.

The construction of Chancay Port aligns perfectly with the growing demands for trade between China and Latin America.

Additionally, Peru has initiated plans to develop a railway and highway network connecting Chancay Port to major cities across the country, with potential future links to transportation networks in other regional countries, and could support the efficient export of Brazilian soybeans, iron ore, frozen meat, Colombian coffee, avocados and other goods to Asia via this new trade route.

“The Chancay Port will help Peru improve shipping efficiency and deepen trade cooperation with Asia,” said David Gamero, a deputy manager at the Chancay megaport project. He added that beyond direct economic benefits, the massive port will also drive the development of Latin America’s logistics value chain and advance technological and industrial growth, creating a “multiplier effect.”

Xi once referred to Peru as “China’s neighbor across the Pacific,” and cited an ancient Chinese poem to characterize China’s relations with countries in Latin America and the Caribbean: “True friends always feel close to each other no matter the distance between them.”

Once the Chancay Port comes into operation, it will be able to integrate the entire Latin American region into the dynamic economic framework of the Asia-Pacific, greatly bolstering connectivity within and beyond the continent.

Intensifying China-Latin America cooperation

The BRI, proposed by China in 2013, incorporated Latin America and the Caribbean region in 2017.

As of 2023, 22 countries in the region have signed BRI cooperation documents with China, according to the report by a steering group for the Belt and Road Initiative. Notable projects include the Belo Monte Hydropower Plant ultra-high-voltage transmission line in Brazil, Argentina’s Belgrano Cargas railway, among others.

Additionally, since 2012, China has been the second-largest trading partner of Latin America. In 2023, the total trade volume between China and Latin American countries exceeded $489 billion.

Experts say China’s investment and technical support are helping Latin American countries accelerate their economic development and have become an important driving force for the development of the Global South. They also voiced expectation for Xi’s attendance at APEC to inject positive momentum into regional integration and economic cooperation.

Rafael del Campo Quintana, vice president of the Peruvian Exporters Association, said that APEC is not only an important platform for promoting regional trade and economic cooperation but also provides developing countries, including Peru, with opportunities to deeply integrate into the global economy.

https://news.cgtn.com/news/2024-11-14/Peru-s-Chancay-megaport-poised-to-reshape-trade-in-the-Pacific-1yveJbUsORy/p.html 

SOURCE CGTN

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