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Kanazawa University research: Sensing a biomarker

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KANAZAWA, Japan, June 7, 2024 /PRNewswire/ — Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Biosensors and Bioelectronics: X a novel approach for detecting a particular biomolecule associated with several diseases. The results show good sensitivity and selectivity, and may lead to the development of a low-cost, rapid detection device useful in cancer prognosis.

Human diseases are often the result of DNA transcriptions gone wrong. Transcription refers to the copying of parts of a DNA molecule — the ‘genetic code’ — into an RNA molecule, which in turn is required for converting the encoded information into proteins. The latter play crucial roles in various biochemical processes taking place in the human body. One transcriptional modification mechanism is adenosine-to-inosine editing, in which adenosine (one of four RNA building blocks) is chemically modified, resulting in an altered RNA molecule. This type of modification is facilitated by catalyst proteins called ADARs (adenosine deaminases acting on RNA). Three such ADARs have been identified in humans. One of them, ADAR1, has been found to be more abundant in the presence of several kinds of chronic diseases, including neurological disorders and cancer. ADAR1 is therefore considered a biomarker — a ‘signature molecule’ — for assessing a patient’s condition and chances of survival. Madhu Biyani from Kanazawa University and colleagues have now developed a new, electrochemical biosensor for detecting ADAR1, offering a low-cost, rapid tool for measuring ADAR1 concentrations in cells. The detector is expected to be useful for monitoring cancer progression.

The procedure presented by Biyani and colleagues is new in two ways. The first is that it uses newly identified aptamers as molecules that can recognize and capture ADAR1. Aptamers are molecules consisting of sequences of (synthetic) DNA, RNA or other biomolecules that bind to a particular target molecule, in this case ADAR1. The second novelty lies in the use of a field-deployable electrochemical sensor DEPSOR (BioSeeds Corp.), which has the advantages of, apart from being fast and non-expensive, requiring only small samples.

In order to find the optimal aptamer — that is, the one that chemically binds easiest to ADAR1 — the researchers screened a large set of DNA sequences and narrowed it down to 15 candidate aptamers. Each of these candidates was then tested in an electrochemical sensing platform: the amount of ADAR1 is ‘sensed’ through chemical reactions that result in an electrical current. The latter can be easily detected. The more ADAR1 in a sample, the higher the measured current.

The candidate aptamer resulting in the highest electrochemical current, called Apt38483, was then checked further. Its electrochemical response to ‘false’ proteins was very low, confirming it to be the optimal aptamer in terms of both sensitivity and selectivity. The scientists then tested an Apt38483-based prototype device on diluted cell samples. They found that even in a 625-fold diluted sample, ADAR1 could still be detected, highlighting the high sensitivity of the device.

The electrochemical biosensor developed by Biyani and colleagues for the detection of ADAR1 in cell samples is a promising platform for monitoring cancer progression in clinical samples. Quoting the scientists: “In the future, it will be promising to evaluate the system for the identification of low to high levels of ADAR1 expression in a cancer cell line sample for clinical prognosis.”

Figure

https://nanolsi.kanazawa-u.ac.jp/wp/wp-content/uploads/Figure1-6.png

Caption

A novel electrochemical biosensor for the detection of ADAR1 in cells is expected to be useful in cancer prognosis. © 2024 Biyani, et al. Published by Elsevier B.V.

Background

Electrochemical biosensors

Electrochemical biosensors are devices that convert biological information, such as the presence of a particular molecule (called the analyte), into a measurable signal. Essentially, biosensors consist of a bioreceptor, an interface and a transducer element. The bioreceptor binds to the analyte at the interface, which results in a signal that is picked up and converted by the transducer into an electric signal. The electric signal is processed through a computer; for example, the signal can be converted into an analyte concentration reading. Electrochemical biosensors are normally robust, low-cost and easy to miniaturize.

Madhu Biyani from Kanazawa University and colleagues have now developed an electrochemical biosensor for the detection of ADAR1, an RNA-editing enzyme associated with cancer progression. They identified a particular biomolecule as the optimal bioreceptor, showing good sensitivity and selectivity for ADAR1. The developed device is expected to be useful for monitoring cancer progression.

Reference

Madhu Biyani, Kirti Sharma, Maeda Shoei, Hinako Akashi, Masataka Nakano, Miki Nakajima, and Manish Biyani. A novel aptamer-antibody sandwich electrochemical sensor for detecting ADAR1 in complex biological samples, Biosensors and Bioelectronics: 19, 100491 (2024).

DOI: 10.1016/j.biosx.2024.100491

https://doi.org/10.1016/j.biosx.2024.100491

Contact
Hiroe Yoneda
Senior Specialist in Project Planning and Outreach
NanoLSI Administration Office, Nano Life Science Institute (WPI-NanoLSI)
Kanazawa University
Kakuma-machi, Kanazawa 920-1192, Japan
Email: nanolsi-office@adm.kanazawa-u.ac.jp
Tel: +81 (76) 234-4555

About Nano Life Science Institute (WPI-NanoLSI), Kanazawa University

Understanding nanoscale mechanisms of life phenomena by exploring “uncharted nano-realms”.

Cells are the basic units of almost all life forms. We are developing nanoprobe technologies that allow direct imaging, analysis, and manipulation of the behavior and dynamics of important macromolecules in living organisms, such as proteins and nucleic acids, at the surface and interior of cells. We aim at acquiring a fundamental understanding of the various life phenomena at the nanoscale.

https://nanolsi.kanazawa-u.ac.jp/en/

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Alliant Credit Union Foundation Announces Record Breaking Year in Efforts to Bridge the Digital Divide

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January 9, 2025

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Foundation awarded over $1.6 million to community organizations focused on digital equity in Illinois and Nationwide in 2024

CHICAGO, Jan. 9, 2025 /PRNewswire/ — With the goal of providing reliable broadband, digital literacy resources and technology equipment for underserved communities across the United States, the Alliant Credit Union Foundation, today announced its 2024 efforts. In 2024, the Alliant Credit Union Foundation launched it’s Million Dollar Challenge, aiming to invest at least one million dollars in organizations working to close the digital gap. By 2024 year-end, the foundation has donated over $1.6 million to fifteen organizations nationwide.

The Alliant Credit Union Foundation funds were strategically allocated to charitable partners empowering local initiatives in Illinois and throughout the nation to enhance access to digital tools, and provide essential resources in rural, digitally challenged, and under-resourced populations.

“2024 has been a year of mission-driven and meaningful progress for the Alliant Foundation,” said Meredith Richie, President of the Alliant Credit Union Foundation. “From funding initiatives nationwide to facilitating technology access and driving important conversations, we’ve taken significant strides in addressing the digital gap. These achievements reflect the collective efforts of our partners, donors, and community members who share our vision of a more connected and equitable future.”

Some key grants from the Alliant Foundation in 2024 include:

$500,000 to PCs for People to expand their St. Louis processing center and purchase shipping trailers to run regular routes transporting devices and equipment from four of market locations (including Chicago).$250,000 to Digitunity for their Software Modernization Project a platform that will help states and corporations generate the supply they need to meet their Digital Equity Plan device goals.$250,000 to Compudopt for the Connectivity Chicago Project. The grant will allow the organization to expand their services and provide devices, education, and free internet to households.$100,040 to EveryoneOn for the Digital Connections Project to provide training and devices to individuals looking to enhance skills in the everchanging digital landscape.

Recognizing the importance of access to functional technology, the foundation hosted multiple events throughout the year to provide access to those who need it most. In February, the foundation partnered with EveryoneOn, Visa and with Nevada Partners, to open The Community Access Lab in Las Vegas’ Westside as a part of Visa’s Super Bowl Giveback Program. The Lab works to enhance community residents’ digital and financial literacy and foster Westside entrepreneurship. In the Spring and Fall the foundation partnered with PCs for People to host electronic drives at Alliant Credit Union headquarters in Chicago, a record-breaking 15,686 pounds of tech equipment was collected to be refurbished and distributed to populations in need.

The Digital Divide by the Numbers:

11.5 million American households without internet access, per the 2020 U.S. Census.1 in 5 parents say children’s homework cannot be completed without computer or internet access.$1 million+ Alliant Credit Union Foundation grants to foster digital inclusion within at-risk communities in 2024.

About Alliant Credit Union Foundation:
The Alliant Credit Union Foundation is dedicated to enhancing the well-being of communities by supporting initiatives that foster financial literacy, economic empowerment, and access to essential resources. As the philanthropic arm of Alliant Credit Union, the Foundation partners with organizations that align with its mission to create opportunities for underserved populations, promote financial education, and address the digital divide. The Alliant Credit Union Foundation is committed to making a lasting impact and helping individuals and families build a brighter financial future through strategic grants and community partnerships.

Media Contact:
Natalie Symonds 
nsymonds@alliantcreditunion.com
Sr. Media Strategist
Alliant Credit Union

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SOURCE Alliant Credit Union

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Old World Labs Unveils Advanced AI Agents at CES 2025: Revolutionizing Robotics and Virtual Worlds

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January 9, 2025

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LAS VEGAS, Jan. 9, 2025 /PRNewswire/ — On the first day of CES 2025, Old World Labs (OWL) is proud to announce groundbreaking advancements in its “Agents as a Service” technology, showcasing how these cutting-edge AI systems seamlessly integrate into humanoid robots and virtual environments. These innovations mark a significant leap forward in bridging the physical and digital worlds, setting a new standard for adaptability and intelligence in robotics.

 

The Next Generation of AI-Driven Robotics

At the forefront of OWL’s innovations is the “Replicants” system, a first-of-its-kind platform enabling self-replicating humanoid robots equipped with advanced AI agents. These agents combine real-time reasoning, resource-aware adaptability, and dynamic interaction, making them invaluable across industries—from manufacturing to immersive virtual experiences.

Key Features of the Replicants System:

Humanoid Robotics Integration: AI agents embedded within robots capable of natural human-like interactions and precise task execution.Virtual World Interoperability: Unified AI presence across physical robots and digital environments for seamless collaboration.Resource-Aware Design: Sustainable, scalable solutions that adapt to complex challenges in real time.

Why This Matters

The evolution of AI agents into humanoid robotics represents a paradigm shift in how humans engage with technology. OWL’s advancements enable robots to:

Understand and interact with 3D environments.Execute complex tasks autonomously, enhancing productivity and user experience.Transition seamlessly between physical and digital spaces, redefining the role of AI in daily life and industrial applications.

Quote from Nick Liverman, Founder of Old World Labs

“At CES 2025, we’re showcasing how Old World Labs is driving the future of AI and robotics. Our Replicants system empowers humanoid robots and virtual agents to function as intelligent companions and collaborators. These breakthroughs push beyond traditional boundaries, enabling accessible, adaptive, and scalable solutions for everyone,” said Nick Liverman.

Live Demonstrations and Interactive Sessions

Attendees at CES 2025 are invited to Booth #8777 in the LV North Hall to:

Experience Real-Time AI Integration: See how OWL’s agents operate humanoid robots with precision and adaptability.Explore Virtual World Interactions: Witness how AI agents transition seamlessly between robotics and immersive virtual platforms.Participate in Workshops: Learn how OWL’s “Agents as a Service” technology can transform industries and projects.

About Old World Labs

Founded in 2012 by Nick Liverman, Old World Labs has been a pioneer in robotics and AI innovation. Renowned for its high-precision 3D printing solutions, OWL is now at the forefront of integrating intelligent agents into humanoid robots and virtual worlds. With a mission to make advanced technology accessible and impactful, OWL continues to set the industry standard.

Media Contact

Eric Faust
Business Development
Old World Labs
info@oldworldlabs.com

Click here for more details about our booth at: https://ces25.mapyourshow.com/8_0/exhibitor/exhibitor-details.cfm?exhid=0014V00003uGRiBQAW

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SOURCE Old World Labs

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BLUETTI Unveils Apex 300 and EnergyPro 6K at CES 2025, Highlighting Brand Refinement Strategy for 2025

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January 9, 2025

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BLUETTI reinforces its role as a technology pioneer in clean energy with innovative energy solutions at CES 2025.

LAS VEGAS, Jan. 9, 2025 /PRNewswire/ — BLUETTI, a leading provider of clean energy solutions and this year’s CES Innovation Award honoree, debuted its latest energy storage solutions, the Apex 300 portable power station and EnergyPro 6K whole house battery backup, during its brand refinement event at booth 9837 at CES 2025.

As part of its strategy to refine and elevate its global brand, BLUETTI launched its new product era 3.0, showcasing its groundbreaking new product series: Bluetti Elite, Apex, and EnergyPro. The highly anticipated products, Apex 300 and EnergyPro 6K, were officially unveiled during the event, marking a significant leap in the company’s ongoing commitment to pioneering clean energy storage.

BLUETTI Apex 300: The All-in-One Solution for Every Scenario

The Bluetti Apex 300 Portable Power Station is a versatile portable power station with a 2,764.8Wh capacity and 3,840W output, providing reliable power for home backup, RV road trips, and other off-grid scenarios. It can deliver both 120V and 240V power simultaneously, meaning user can handle essential appliances and heavy-duty devices like well pumps and dryers.

With advanced parallel-expansion technology, the Apex 300 can scale up to an impressive 58kWh storage and 11.52kW output, ensuring up to a week of power supply during extended outages. In parallel, it is powerful enough to charge an electric vehicle.

Charging is fast and flexible — powered by Turbo Boost charging technology, users can recharge the Apex 300 to 80% in just 45 minutes from mains power. Alternative charging options include solar panels, vehicles, generators, and EV stations. With industry-leading PV charging capacity of up to 30,720W, the Apex 300 ensures stable power even in remote locations or prolonged blackouts.

The Apex 300 is expected to be officially released in the second quarter of 2025.

BLUETTI EnergyPro 6K: The Ultimate Power Solution for Small to Medium Homes

Designed for residential and small-to-medium business use, the Bluetti EnergyPro 6K Whole House Battery Backup is a reliable, affordable and cost effective home energy storage system that integrates solar, battery, grid, generator, and EV power sources. It supplies dependable backup power during power outages, peak periods, or other off-grid settings.

The EnergyPro offers flexible scalability for a personalized power experience. By connecting up to five EnergyPro 6K units, users can achieve substantial power output and storage capabilities to weather extended blackouts or support small off-grid farms.

Seamlessly integrating with users’ existing rooftop solar systems, the EnergyPro 6K optimizes energy usage by storing excess solar power. This allows homeowners to always be prepared for power interruptions while reducing their electricity bills. The AT1 Smart Distribution Box further enhances energy efficiency by allowing any supported EV to charge the battery during extended power outages, and home standby generators to automatically fuel the battery without manual switching. This comprehensive energy solution ensures uninterrupted power in any situation, without relying on the grid or favorable weather conditions.

The EnergyPro 6K is expected to be officially released in the second quarter of 2025.

Powered by BLUETTI Future Tech System

The Apex 300 and EnergyPro 6K are powered by BLUETTI’s cutting-edge Future Energy Tech System, which consists of four key pillars:

BLUEPEAK Innovation Hub: The core of BLUETTI’s hardware and physical innovations in energy storage.BLUELINK Energy Network: The brain behind BLUETTI’s product and energy solutions, providing intelligent and seamless connectivity.BLUEGRID Power Infrastructure: Tailored tech solutions for households and SME businesses, offering scalable and efficient power management.BLUELIFE Ecosystem Tech: A lifestyle-driven tech ecosystem that integrates energy seamlessly into daily life, empowering consumers to embrace sustainable living.

BLUETTI’s ongoing commitment to innovation, sustainability, and clean energy solutions is poised to reshape how consumers and businesses manage their power needs in 2025 and beyond. For more information on the upcoming products and BLUETTI’s vision, visit us at booth 9837 CES 2025 and explore the future of energy.

About BLUETTI

Founded in 2009, BLUETTI is a pioneer force in clean energy technology, committed to a sustainable future by providing green and independent energy storage solutions for every household. With a strong focus on innovation and customer needs, BLUETTI has gained the trust of 3.5 million customers and established a presence in over 110 countries & regions. Through initiatives like the LAAF (Lighting An African Family) Program, BLUETTI is dedicated to bringing power to millions of African families in off-grid areas.

Contact: Ellen Lee, ellenlee@bluetti.com 

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SOURCE BLUETTI POWER INC

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