Technology

Zapping the right brain cells: The path to improved stimulation

Published

7 months ago

June 4, 2024

New findings could help scientists develop better ways to treat brain disorders with electrical stimulation.

SEATTLE, June 4, 2024 /PRNewswire/ — New research by scientists at the Allen Institute’s Brain and Consciousness group and Cedars-Sinai offers an unprecedented look at how neurons respond to ES. Far from being uniform, different types of neurons showed distinct patterns of ‘syncing up’ with electrical fields. These patterns varied depending on the rate at which the ES was delivered.

The findings, published today in Neuron, could help doctors fine tune where, when, and how to apply ES to the brain, said Soo Yeun Lee, Ph.D., the paper’s first author and a Senior Scientist at the Allen Institute.

“With this study, we now have a much better idea of what types of stimulation work for specific cell classes,” she said. “We can use that knowledge to develop more efficient ways of using electrical stimulation to treat disorders.”

Using tissue samples from mice and humans, the research team delivered oscillating waves of ES within tens of micrometers of individual neurons. This extraordinary precision enabled an unprecedented look at electrical stimulation’s impact at a single-cell level. They observed strong, cell-class-specific responses. Excitatory neurons synchronized firing with both slow and fast stimulation frequencies, while inhibitory neurons primarily responded to fast frequencies. These class-specific responses are significant, Lee said, because they reveal that adjusting the stimulation frequency allows for the selective targeting of different neurons. That discovery could lead to more precise therapies to modulate neural activity.

For example, inhibitory neurons that express a protein called parvalbumin are implicated in epilepsy and in cognitive dysfunctions, she noted. This study shows that these cell classes are most responsive to certain frequencies. Future treatments could tailor ES to the most effective frequency, potentially improving outcomes and limiting side effects.

Beyond its clinical implications, the study also revealed a universal truth about how neurons function, Lee added. Regardless of cell class, cortical areas, or species, neurons exhibit a remarkable ability to synchronize with an external electric field.

This general property is superimposed on the brain’s dazzling cellular diversity, Lee said—and the newfound understanding of these underlying mechanisms could transform our approach to treating complex brain disorders.

Research described in this article was supported by award numbers R01NS120300 and R01NS130126 from the National Institute of Neurological Disorders and Stroke of the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH and its subsidiary institutes.

About the Allen Institute
The Allen Institute is an independent, 501(c)(3) nonprofit research organization founded by philanthropist and visionary, the late Paul G. Allen. The Allen Institute is dedicated to answering some of the biggest questions in bioscience and accelerating research worldwide. The Institute is a recognized leader in large-scale research with a commitment to an open science model. Its research institutes and programs include the Allen Institute for Brain Science, launched in 2003; the Allen Institute for Cell Science, launched in 2014; the Allen Institute for Immunology, launched in 2018; and the Allen Institute for Neural Dynamics, launched in 2021. In 2016, the Allen Institute expanded its reach with the launch of The Paul G. Allen Frontiers Group, which identifies pioneers with new ideas to expand the boundaries of knowledge and make the world better. For more information, visit alleninstitute.org.

Media Contact
Peter Kim, Sr. Manager, Media Relations
206-605-9884 | peter.kim@alleninstitute.org

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SOURCE Allen Institute

Technology

Casect Launches AI-Enhanced Case Log Platform for Surgeons

Published

3 hours ago

December 25, 2024

SHERIDAN, Wyo., Dec 25, 2024 /PRNewswire/ — Casect, LLC, a medical education technology company, announces the launch of an innovative platform to revolutionize how surgeons and medical professionals document cases. Casect empowers users to track surgical Cases, refine Techniques, organize References, and collaborate with Colleagues — all within a user-friendly, HIPAA-compliant system.

Say goodbye to inefficient notebooks, spreadsheets, and outdated case logs. Casect offers a modern, comprehensive solution tailored to the surgical community, enabling professionals to focus on growth, learning, and excellence in patient care.

A New Era of AI-Powered Case Tracking

Time is critical for surgeons, yet valuable insights are often lost due to outdated documentation methods like handwritten notes or spreadsheets. Casect’s HIPAA-compliant platform, with a no data retention policy for protected health information, uses optional AI to pre-fill case details, analyze uploads, and organize data seamlessly. This transforms hours of documentation into minutes, giving surgeons more time to refine skills and improve patient care.

Casect addresses an unmet need in medical education, residency, fellowship, credentialing, and research. It enables detailed documentation of Cases, Techniques, and References, accessible from any computer or mobile device with a subscription.

Key Features

AI-Assisted Case Entry (Optional): Streamline input with AI or manually add details; supports spreadsheet uploads.Customizable Fields: Track cases your way.Refine Techniques: Create, document, and improve surgical techniques.Multimedia Support: Upload, organize, and access photos, videos, and documents.Organize References: Annotate, markup, and securely store documents and literature.Collaborate Seamlessly: Share cases and techniques effortlessly with colleagues.Analyze and Export: Generate insights through charts or export data as CSV.HIPAA-Compliant: Designed to meet strict HIPAA standards, ensuring the security and confidentiality of protected health information.

Additional Resources

Stay Informed: Unlock a 30-day free trial by signing up for the latest updates on Casect’s launch.Learn More: Discover why Casect is the preferred choice for surgeons at Why Casect?Explore Features: View the Full Feature List.Stay Connected: Follow us on X, Facebook, Instagram, and LinkedIn for updates, tips, and stories. Join the conversation with #MedEd, #CaseLog, and #Casect.

About Casect

Born from decades of tracking cases with stickers, notes, and spreadsheets, Casect empowers surgeons with efficient, comprehensive tools to document cases, collaborate, and drive professional growth. By simplifying the case log, Casect helps surgeons identify trends, enhance skills, and improve patient outcomes. For more information, visit www.casect.com or follow us on X, Facebook, Instagram, and LinkedIn @CasectLLC.

CONTACT: support@casect.com

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SOURCE Casect, LLC

Technology

Interact Marketing Expands AI Marketing Offerings for 2025

Published

3 hours ago

December 25, 2024

Campaign Optimization, Video, and Content lead the pack.

NEWBURGH, N.Y., Dec. 25, 2024 /PRNewswire-PRWeb/ — Interact Marketing, a leading national digital marketing agency in Newburgh, is thrilled to announce the expansion of its AI-powered marketing solutions for 2025. With a focus on cutting-edge campaign optimization, AI-enhanced video production, and content generation, Interact Marketing continues to push the boundaries of what’s possible in digital marketing innovation.

“As AI technology evolves, so do our strategies,” said Joe Beccalori, CEO of Interact Marketing. “Our expanded AI offerings represent a commitment to helping businesses thrive in an increasingly competitive digital landscape, especially search.”

Revolutionizing Campaign Optimization
Leveraging advanced machine learning algorithms, Interact Marketing’s AI tools now provide unprecedented insights into campaign performance. These enhancements enable businesses to predict customer behaviors, optimize ad placements in real-time, and achieve higher ROI through precise targeting and budget allocation.

AI-Driven Video Production
Video remains a cornerstone of digital engagement, and Interact Marketing is leading the charge with AI-assisted video production. The latest offerings include automated editing, personalized video content for targeted audiences, and AI-powered analytics to measure video effectiveness. These tools empower businesses to create dynamic video content that captivates and converts audiences.

Elevating Content Creation
In 2025, content reigns supreme, and Interact Marketing is ensuring clients stay ahead with AI-driven content solutions. From blog posts and social media updates to comprehensive SEO-optimized web content, AI technology enables faster production of high-quality, engaging material. The result is content that drives traffic, enhances brand visibility, and resonates with target audiences. Rigid human editing and content-humanization is also included to reduce over dependence on AI and protect against future algorithm decisions which may penalize pure AI content.

A Commitment to Innovation
“As AI technology evolves, so do our strategies,” said Joe Beccalori, CEO of Interact Marketing. “Our expanded AI offerings represent a commitment to helping businesses thrive in an increasingly competitive digital landscape, especially search. By harnessing the power of AI, we aim to deliver smarter, faster, and more impactful marketing solutions for our clients.”

Media Contact

Joe Beccalori, Interact Marketing, 845-567-7703, press@interactmarketing.com, www.InteractMarketing.com

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SOURCE Interact Marketing

Technology

Leoguar Electric Bike Makes Christmas Unforgettable with Exclusive Holiday Offers

Published

12 hours ago

December 25, 2024

HOUSTON, Dec. 25, 2024 /PRNewswire/ — As the holiday season draws near, Leoguar is excited to offer exclusive deals on their range of electric bikes, bringing families together for memorable moments. With a collection designed to combine fun and fitness, this Christmas is the perfect time to gift an unforgettable experience.

“This Christmas, we’re inviting families to rediscover the joy of outdoor exploration. Our bikes help you bond, stay active, and make the most of every moment,” said the Leoguar COO.

Leoguar’s holiday lineup offers premium e-bikes for every rider, now with unbeatable deals:

Flippo Folding eBike: A lightweight, foldable ride perfect for urban commutes. Upgrade to the Flippo Pro for enhanced performance with a torque sensor for smoother rides.

Fastron Fat Tire eBikes: Built for rugged terrains, the Fastron features a durable, rugged build, and speeds up to 28 MPH, making it the perfect choice for adventurous riders.

Zephyr Beach Cruiser eBikes: Crafted for effortless coastal cruising, the design combines style and comfort, featuring a comfort saddle that ensures a smooth, seamless ride.

Sprint Utility eBike: A versatile, practical choice featuring a sturdy frame and passenger seat, perfect for errands or leisure.

Trailblazer EMTB: Designed for tough off-road trails, the model features a 500W mid-drive motor, offering powerful performance, extended range, and excellent climbing ability.

To make this holiday gift even sweeter, all Leoguar bikes come with free shipping and a two-year warranty for worry-free riding. Additionally, customers can join the holiday giveaway to win prizes like $59 bottle holders, or even a free e-bike!

Leoguar bikes cater to all experience levels, offering comfort and a seamless riding experience. They promote health benefits like improved fitness and stress relief while creating lasting memories on scenic rides.

“Whether it’s cruising the city streets, riding mountain trails, or relaxing by the beach, a Leoguar electric bike is the ideal Christmas gift,” the COO added. “This holiday season, choose a cycling gift that will last for years to come — there’s no better way to kick off the new year.”

To check out the full collection and take advantage of these limited-time offers, visit www.leoguarbikes.com

About Leoguar:

Leoguar is an eco-conscious e-bike brand founded by Johnny, an engineer with decades of industry expertise. Combining innovation, agility, and power, Leoguar delivers high-quality electric bikes designed for adventure, sustainability, and individuality.

Media contact: lily@leoguarbikes.com

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SOURCE Leoguar Electric Bikes