Connect with us

Technology

MetaDeq Diagnostics Announces Two Abstracts to be Presented at the EASL International Liver Congress™

Published

on

HeparDx™ is an investigational MASH (NASH) activity and liver fibrosis blood test designed to diagnose and stage patients, detect at-risk MASH and monitor treatment response to therapy

The data presentations add further evidence supporting HeparDx™ as an accurate blood test to detect liver-specific metabolic dysfunction-associated steatohepatitis (MASH)New findings independently correlate PLIN2 with inflammation and lobular ballooning in a 198-patient analysis from the previous prospective study published in Guti

LONDON and WINTER SPRINGS, Fla., June 4, 2024 /PRNewswire/ — PR Newswire – MetaDeq Ltd. and MetaDeq Diagnostics, Inc., a private medical diagnostic company developing tests for MASH (fatty liver) and liver fibrosis, announced that two posters will be presented at the European Association for the Study of the Liver (EASL) Congress 2024, being held June 5-8 in Milan, Italy. The presented data shed new light on the PLIN2 component of the HeparDx™ diagnostic blood test and provide a further understanding of PLIN2’s mechanism of action for detecting MASH. The abstracts can be found on the EASL website at www.easlcongress.eu and will be available for viewing on Wednesday June 5, 2024 at 8 :30am CEST.

HeparDx™ is a non-invasive blood test aimed to detect MASH activity, their individual components and liver fibrosis.

HeparDx™ is able to identify and quantify inflammation and ballooning in blood monocytes with high accuracy and correlation to liver cells as assessed by liver biopsy. This detection appears to be liver-specific and not associated with inflammation seen in subjects with cardiovascular disease (CVD). There is a clear unmet medical need to improve accuracy for non-invasive tests (NITs) for MASH. HeparDx™ is a blood test comprised of two biomarkers, one for inflammation and ballooning associated with MASH activity (PLIN2), and one for liver fibrosis (RAB14). MetaDeq believes its diagnostic blood test ultimately may enable physicians to: 1. Diagnose MASH patients before significant disease progression occurs, 2. Use it as a pre-treatment medical decision-making tool, and 3. Monitor patient response to treatment.

Prof. Sven Franque, abstract author and collaborating clinician, comments: “After encouraging data published in 2023, at this year’s Liver Congress in Milan, Poster WED-296 undertakes an important analysis to determine if PLIN2 over-expression occurs in other tissues. Cardiac tissue from subjects with cardiovascular disease generally has inflammation as a hallmark characteristic. In this dataset, PLIN2 levels are elevated in liver tissue in subjects with MASH, but not in subjects with cardiac disease; this helps provide evidence that HeparDx™ appears to be liver-specific. I look forward to seeing continued data generation in additional patient cohorts throughout this year.”

POSTER PRESENTATIONS

Title: HeparDx™ (by MetaDeq, Inc.) is a reliable biomarker of MASH capable of detecting the presence of inflammation and ballooning
Authors: Giulia Angelini, Sara Russo, Erminia Lembo, Ornella Verrastro, Antonio Liguori, Stephen Harrison, Aldo Trylesinski, Luca Miele, Geltrude Mingrone
Poster Number: WED-215
Date/Time: Wednesday, June 5th, 8:30 am CEST
Summary: PLIN2 expression is significantly increased in subjects with at-risk MASH (NAS ≥4 and clinically significant fibrosis) compared with subjects without MASH. In 198 subjects with histologically proven at-risk MASH, HeparDx™ analysis for the detection of presence/absence of MASH produced an AUROC of 96.8% vs. liver biopsy, with a sensitivity and specificity of 93.5% and 90.2%, respectively. HeparDx™ was able to detect inflammation and ballooning as individual components, each with high sensitivity and specificity.

Title: PLIN2 is a specific marker for liver related disease
Authors: Giulia Angelini, Sara Russo, Federico Biscetti, Andrea Flex, Jérôme Boursier, Sven Francque, Aldo Trylesinski, Stephen Harrison, Geltrude Mingrone
Poster Number: WED-296
Date/Time: Wednesday, June 5th, 8:30 am CEST
Summary: Plasma PLIN2 is significantly higher in subjects with MASH as compared to subjects without MASH. In 100 subjects analyzed, HeparDx™ clearly showed the ability to detect MASH activity in the liver, but in subjects with CVD and early atherosclerosis, no significantly elevated levels of PLIN2 were detected. Hence, PLIN2 appears to be specific for liver activity related to MASH and is not confounded with inflammation in other tissues, such as cardiac.

Aldo Trylesinski, M.D., Consulting Chief Medical Officer, comments: “The two posters presented at EASL further validate the scientific basis behind HeparDx™ as a non-invasive blood test aimed to detect MASH activity, their individual components and liver fibrosis. Further validation in other patient cohorts is currently ongoing, but up to now, the evidence described in these posters, coupled with the data published in Gut earlier last year, point to a very encouraging signal.”

In Memory and Acknowledgement: Earlier this year, the liver community lost a brilliant physician, leader, clinical trial investigator and true champion of patients, Dr. and Colonel (Ret.) Stephen A. Harrison. With Stephen’s passing, we at MetaDeq, and many, many others, lost a friend and advisor. Stephen’s work and insight into liver diseases will continue to inspire us. Stephen had been serving as Chair of the MetaDeq Scientific Advisory Board and was an early believer in our technology. 

About MASH (NASH)

Metabolic dysfunction-associated steatohepatitis (MASH) is a leading cause of cirrhosis, liver failure, liver transplant, and hepatocellular carcinoma. Liver biopsy is the diagnostic reference standard, but it is expensive, time consuming, and carries multiple risks to the patient. With the first FDA-approved therapeutic on the market, the need for a highly accurate and reliable non-invasive test (NIT) is imperative to diagnose and monitor patients on therapy. In the U.S., over 25% of adults have metabolic dysfunction-associated steatotic liver disease (MASLD), of which 20%, or 12 million adults, will progress to MASHii. In June 2023, the American Diabetes Association recommended all 28 million people with Type 2 diabetes be tested for MASLD/MASHiii.

About HeparDx

HeparDx™ is an investigational novel blood test to accurately diagnose, stage, and monitor MASH being developed by MetaDeq Diagnostics. HeparDx™ includes two biomarkers correlated with MASH activity and fibrosis in the liver to accurately diagnose MASH patients and potentially replace liver biopsies. Clinical data from a prospective study in 250 patients undergoing liver biopsies has been peer-reviewed and published in Gut1, a leading medical journal, and multiple additional abstracts have been presented at medical congresses. HeparDx™ appears to have the potential to measure, independently, each inflammation and ballooning component in MASH vs. only steatohepatitis.

About MetaDeq Diagnostics

MetaDeq is committed to delivering diagnostics that help physicians identify, diagnose, stage and monitor MASLD and MASH patients with a simple and accurate blood test. MetaDeq’s lead product is HeparDx™, a blood test based on two biomarkers to detect MASH activity and liver fibrosis. For more information, please visit: www.metadeq.com.

Contacts

MetaDeq

Daniel Whittaker

Chief Commercial Officer

d.whittaker@metadeq.com

Oratorium Group

Juliane Snowden

Founder

jsnowden@oratoriumgroup.com

i Gut Feb 2023, 72 (2) 392-403; DOI: 10.1136/gutjnl-2022-327498

ii Int J Mol Sci, 2019; www.liverfoundation.org; Clin Diabetes and Endocrinology, 2020; Gosalia, et al, Diagnostics 2022

iii https://diabetes.org/newsroom/american-diabetes-association-releases-guideline-update-NAFLD-diabetes

View original content to download multimedia:https://www.prnewswire.com/news-releases/metadeq-diagnostics-announces-two-abstracts-to-be-presented-at-the-easl-international-liver-congress-302163710.html

SOURCE Metadeq

Continue Reading
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Technology

2024 Financial Oscars: Waton Securities International Honored as “Outstanding Digital Empowerment Institution” of the Year

Published

on

By

SHENZHEN, China, Dec. 25, 2024 /PRNewswire/ — In early December, at the 18th Huaxia Institutional Investor Annual Conference of 2024, the 18th Golden Cicada Awards were announced. Waton Securities International was awarded the “Outstanding Digital Empowerment Financial Institution of 2024” for its significant achievements in securities brokerage and fin-tech sector.

The selection for the “Outstanding Digital Empowerment Financial Institution” focused on evaluating companies based on financial performance, market competitiveness, customer recognition, digital strategy planning and implementation, digital transformation outcomes, and risk control capabilities. Particularly, it highlighted cases that have made significant strides in digital empowerment.

The evaluation also emphasized the outstanding performance of financial institutions in their own digital transformation and the sound risk control abilities demonstrated during this process, ensuring that while pursuing innovation, companies can effectively manage and control risks. Waton Securities International distinguished itself among the contenders with its sophisticated technology platform, well-defined digital strategy, substantial transformation achievements, and commendable risk control mechanisms.

Established in Hong Kong in 1989, Waton Securities International has steadily grown with a deep understanding of professional financial services and regulatory compliance. It has obtained licenses 1/4/5/9 from the Hong Kong Securities and Futures Commission, becoming a fully licensed brokerage with comprehensive financial service qualifications. Through continuous technological innovation and digital transformation, it has successfully built a one-stop brokerage cloud service platform, promoting advanced digital financial technology globally. Its pioneering SaaS product, “Broker Cloud”, allows corporate clients to independently deploy and operate high-performance digital customer information management and trading systems without their own IT teams. The solution is relatively low-cost and adaptive to industry, which is the core competitiveness of Waton Securities International.

Data reveals that of the 1,100 securities firms in Hong Kong, approximately 600 are actively trading, yet fewer than 50 have developed their own mobile applications. On a global scale, among the 30,000 securities companies, only a handful—less than 300—feature brokerage trading Apps in App stores. This underscores a significant market demand for the digital enhancement of the securities sector.

With the swift growth of technologies like generative AI LLMs, blockchain, big data, and cloud computing, the securities industry can use these tools to streamline trading strategies, assess risks more accurately, and forecast market trends. These technologies also help the industry to move towards more integrated, platform-focused, and digital operations. The main goal of technology in finance is to increase the efficiency of financial institutions. A good starting point for applying technology is to focus on financial services and build a solid technical foundation for these institutions.

View original content to download multimedia:https://www.prnewswire.com/news-releases/2024-financial-oscars-waton-securities-international-honored-as-outstanding-digital-empowerment-institution-of-the-year-302339091.html

SOURCE Waton Securities

Continue Reading

Technology

Mega Matrix Announced that the English Version of “Getting Even: The Secret Prodigy’s Playbook” Now Streaming on FlexTV

Published

on

By

SINGAPORE, Dec. 25, 2024 /PRNewswire/ — The highly anticipated English adaptation of the revenge rebirth series, Getting Even: The Secret Prodigy’s Playbook, officially premiered on December 19th on FlexTV, the world-leading short drama streaming platform operated by Mega Matrix Inc. (NYSE American: MPU). The series delves into the intricacies of power struggles within the White family, chronicling the protagonist’s journey of rebirth and empowerment to rewrite her destiny.

Audrey White, the legitimate daughter of the White family, was sent abroad at a young age due to family circumstances, gradually estranging her from her kin. When she finally returns home, eager to reunite with her family, she unexpectedly becomes the target of jealousy from Ruby White, the family’s adopted daughter. Harboring deep resentment, Ruby orchestrates a kidnapping plot, culminating in a devastating fire designed to test the loyalty and affection of the White family.

Left to perish in the flames, Audrey is abandoned by her family but heroically rescued by her uncle. Miraculously, she is granted a second chance at life, returning three years prior with the power to alter her fate. Determined to expose Ruby’s schemes, rebuild her family bonds, and claim her rightful respect and happiness, Audrey embarks on a journey of resilience and redemption.

FlexTV, operated by MPU, is a global leader in short drama streaming, delivering content in over 100 countries in multiple languages, including English, Japanese, Korean, Portuguese, Spanish, French, and Arabic. Known for its premium-quality dramas and unparalleled user experience, FlexTV has captured the hearts of audiences worldwide. The English version of Getting Even: The Secret Prodigy’s Playbook, now streaming on FlexTV, offers a compelling exploration of familial power dynamics, the complexities of human nature, and the protagonist’s growth and self-redemption in adversity. For more exciting content, please visit https://www.flextv.cc/.

#WealthyFamily #Revenge #Rebirth #ShortDrama #FlexTV #MPU

About Mega Matrix Inc.: Mega Matrix Inc. (NYSE American: MPU) is a holding company and operates FlexTV, a short-video streaming platform and producer of short dramas, through its subsidiary, Yuder Pte, Ltd.. Mega Matrix Inc. is a Cayman Island corporation headquartered in Singapore. For more information, please contact info@megamatrix.io or visit: http://www.megamatrix.io.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the “safe harbor” provisions of the United States Private Securities Litigation Reform Act of 1995. All statements in this press release other than statements that are purely historical are forward looking statements. When used in this press release, the words “estimates,” “projected,” “expects,” “anticipates,” “forecasts,” “plans,” “intends,” “believes,” “seeks,” “may,” “will,” “should,” “future,” “propose,” and variations of these words or similar expressions (or the negative versions of such words or expressions) are intended to identify forward-looking statements. These forward-looking statements are not guarantees for future performance, conditions or results, and involve a number of known and unknown risks, uncertainties, assumptions and other important factors, many of which are outside the Company’s control, that could cause actual results or outcomes to differ materially from those discussed in the forward-looking statements. Important factors, among others, are: the ability to manage growth; ability to identify and integrate future acquisitions; ability to grow and expand our FlexTV business; ability to execute the strategic cooperation with TopReels, ability to obtain additional financing in the future to fund capital expenditures; ability to establish the investment fund with 9 Yards Communications under the memorandum of understanding; fluctuations in general economic and business conditions; costs or other factors adversely affecting the Company’s profitability; litigation involving patents, intellectual property, and other matters; potential changes in the legislative and regulatory environment; a pandemic or epidemic; the possibility that the Company may not succeed in developing its new lines of businesses due to, among other things, changes in the business environment, competition, changes in regulation, or other economic and policy factors; and the possibility that the Company’s new lines of business may be adversely affected by other economic, business, and/or competitive factors. The forward-looking statements in this press release and the Company’s future results of operations are subject to additional risks and uncertainties set forth under the “Risk Factors” in documents filed by the Company’s predecessor, Mega Matrix Corp., with the Securities and Exchange Commission, including the Company’s latest annual report on Form 10-K, as amended, and are based on information available to the Company on the date hereof. In addition, such risks and uncertainties include the Company’s inability to predict or control bankruptcy proceedings and the uncertainties surrounding the ability to generate cash proceeds through the sale or other monetization of the Company’s assets. The Company undertakes no obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by applicable law. Readers are cautioned not to place undue reliance on forward-looking statements, which speak only as of the date of this press release.

Disclosure Channels

We announce material information about the Company and its services and for complying with our disclosure obligation under Regulation FD via the following social media channels:

The Company will also use its landing page on its corporate website (www.megamatrix.io) to host social media disclosures and/or links to/from such disclosures. The information we post through these social media channels may be deemed material. Accordingly, investors should monitor these social media channels in addition to following our website, press releases, SEC filings and public conference calls and webcasts. The social media channels that we intend to use as a means of disclosing the information described above may be updated from time to time as listed on our website.

View original content to download multimedia:https://www.prnewswire.com/news-releases/mega-matrix-announced-that-the-english-version-of-getting-even-the-secret-prodigys-playbook-now-streaming-on-flextv-302339090.html

SOURCE Mega Matrix Corp.

Continue Reading

Technology

Xinjiang Kashgar distribution grid achieves “minute-level self-healing” for the first time

Published

on

By

KASHGAR, China, Dec. 25, 2024 /PRNewswire/ — On December 23, the State Grid Kashgar Power Supply Company successfully implemented the operation of accurate isolation of fault areas and rapid restoration of power supply in non-fault areas on the 10kV Zao Line and Zazhen Line, marking a major breakthrough in the fault handling of the Kashgar power grid and achieving “minute-level self-healing” for the first time.

In the past, when the 10 kV distribution line failed, the emergency repair personnel needed to patrol the site, judge the fault location, and then manually operate to restore the power supply in the non-fault area. The whole process took a long time. The construction and commissioning of the self-healing line has greatly shortened the time of fault search and isolation through network topological analysis, from “hourly level” to “minute level”, effectively reducing the power outage perception of users in non-fault sections. Since the beginning of this year, the State Grid Kashgar Power Supply Company has closely focused on the practical construction of distribution network automation, so as to achieve the goal of “non-stop power, less power failure, and fast power recovery” for users, and continued to promote the automation construction of the distribution network. A total of 3,200 “three remote” terminal access and debugging have been completed, achieving a terminal access rate of 98.28%, and the online rate has been steadily increased to 95.8%. Combined with the maintenance plan, mode adjustment, accident remote control disposal operation 825 times, and the remote control success rate is 90.68%.

In the next step, the State Grid Kashgar Power Supply Company will summarize the experience of the construction of feeder automation, steadily improve the effective coverage of feeder automation, and make every effort to promote the construction of power distribution automation, aiming to comprehensively improve the intelligence level of the Kashgar distribution grid and provide more reliable and efficient power services for local residents.

 

View original content:https://www.prnewswire.com/apac/news-releases/xinjiang-kashgar-distribution-grid-achieves-minute-level-self-healing-for-the-first-time-302339085.html

SOURCE State Grid Kashgar Power Supply Company

Continue Reading

Trending