Connect with us

Technology

The Lancet Publishes Results from World’s Largest Coronary CT Registry Showing New AI Technology Can Predict Cardiac Events Due to Coronary Inflammation At Least 10 Years in Advance

Published

on

OXFORD, England, May 30, 2024 /PRNewswire/ — Caristo Diagnostics Limited, a global leader in cardiovascular disease diagnostics and risk prediction, announced the results of a landmark clinical study published in The Lancet that support the ability of Caristo’s CaRi-Heart® AI technology to quantify coronary artery inflammation and accurately predict cardiac events.

This landmark study, titled “Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: the ORFAN multicentre, longitudinal cohort study,” analysed results from the first 40,000 patients enrolled in the “ORFAN” registry, the world’s largest study that evaluates coronary computed tomography angiography (CCTA) imaging biomarkers in predicting long-term cardiovascular outcomes.

Key study findings include:

Among patients undergoing CCTA, more than 80% did not have obstructive coronary artery disease (CAD) at the time of imaging, but twice as many fatal and non-fatal cardiac events occurred in that groupCoronary inflammation, as measured by Caristo’s CaRi-Heart FAI-ScoreTM, predicted fatal and non-fatal cardiac events (including heart attack and new heart failure), independently from traditional risk factors, routine clinical CCTA interpretation, calcium scoring and plaque quantification, at least 10 years in advanceEven among the 50% of patients who had no or minimal coronary plaque at the time of the initial CCTA, those with the most abnormal FAI-Score results experienced a 9.5-fold higher risk for cardiac mortality and 5.5-fold higher risk for major adverse cardiac events (MACE)Caristo’s AI-Risk model, CaRi-Heart Risk Score, outperformed other scores in routine clinical use for prediction of cardiac mortality, and when presented to clinicians, resulted in changes of management decision in 45% of the patients. Most changes were due to clinicians’ decision to target the previously undetected coronary inflammation.

“The ORFAN study is an expanding global registry which will include long-term clinical and outcome data for 250,000 patients from around the world, and we are very pleased to publish these initial results,” said Keith Channon, MD, Professor of Cardiovascular Medicine at the University of Oxford, Caristo’s Chief Medical Officer, and co-author of The Lancet publication. “Coronary inflammation is a crucial piece of the puzzle in predicting heart attack risk. We are excited to discover that CaRi-Heart results performed exceptionally well in predicting patient cardiac events. This tool is well positioned to help clinicians identify high-risk patients with seemingly ‘normal’ CCTA scans.”

Ron Blankstein, MD, Professor of Medicine and Radiology at Harvard Medical School, Director of Cardiac Computed Tomography at Brigham and Women’s Hospital, and co-author of the publication, commented: “This study, which represents one of the largest studies in the field of CCTA, has important implications for the field of preventive cardiology. I am excited about the potential of the FAI-Score biomarker, which has promising prognostic value beyond existing CT-based methods such as plaque, calcium scoring, and CAD-RADS based interpretation.”  

The study underlines the need for a robust risk prediction tool that can identify vulnerable patients with inflamed coronary arteries, particularly in those without obstructive CAD. This approach would transform CCTA from a test used to triage a minority of patients for further intervention into a prevention tool that guides management for all patients undergoing CCTA.

SCCT Webinar to Feature Study Co-Authors on June 27:

On June 27 at 11am EDT, the Society of Cardiovascular Computed Tomography (SCCT) will host a webinar on The Lancet publication findings to be presented by the lead author, Prof. Charalambos Antoniades, and joined by several co-authors (Prof. Channon, Prof. Stefan Neubauer, Prof. Ed Nicol, Prof. Blankstein and Prof. Milind Desai). The webinar will present the key results from The Lancet publication along with a panel discussion on the implications of this landmark study. Check www.caristo.com in early June for the webinar registration link.

Caristo’s patented CaRi-Heart technology marks a scientific breakthrough that is radically transforming the traditional approach to heart disease prediction, prevention and management. The technology applies advanced AI algorithms to routine coronary computed tomography angiography (CCTA) scans to visualize and quantify coronary inflammation, the otherwise invisible disease mechanism responsible for many fatal heart attacks and strokes. Prior to this publication by The Lancet, earlier validation results showing CaRi-Heart technology’s ability to aid the prediction of heart attacks were published in leading medical journals including the Lancet, JACC, European Heart Journal, and Cardiovascular Research.

The CaRi-Heart® technology is in clinical use in the UK, European Union, and Australia.

About Caristo Diagnostics Limited

Caristo Diagnostics is a global leader in cardiac and vascular disease diagnostics and risk prediction. Founded in 2018 as a spin-out company from the University of Oxford, the world’s #1 research university, Caristo has developed a portfolio of imaging-based and AI-assisted platforms that can be applied to aid the prediction and diagnosis of heart attack, stroke, and diabetes. Caristo has been recognized by Newsweek as one of the best digital health companies, and highlighted by Nature as one of the most exciting science-based companies to have emerged from academic labs. Find Caristo online on its website, LinkedIn and X.

Logo: https://mma.prnewswire.com/media/2054669/4734272/Caristo_Logo.jpg

Contact
Frank Cheng, Caristo Diagnostics CEO
info@caristo.com

View original content:https://www.prnewswire.co.uk/news-releases/the-lancet-publishes-results-from-worlds-largest-coronary-ct-registry-showing-new-ai-technology-can-predict-cardiac-events-due-to-coronary-inflammation-at-least-10-years-in-advance-302159435.html

Continue Reading
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Technology

Explore Beyond Expo 2025 Osaka with Agoda’s Day Trip Recommendations

Published

on

By

SINGAPORE, April 11, 2025 /PRNewswire/ — Digital travel platform Agoda is spotlighting five enriching day trips for visitors attending Expo 2025 Osaka in Japan. Taking place on Yumeshima Island near Osaka from April 13 to October 13, 2025, the Expo will showcase innovations across health, design, and connectivity. Agoda’s day-trip recommendations aim to enhance the travel experience by encouraging exploration of nearby destinations beyond perennial favorites Osaka and Kyoto.

Expo 2025 Osaka is set to attract international visitors, eager to explore forward-looking exhibits and cultural showcases. Agoda’s insights revealed that the highest number of accommodation searches for the Kansai region came from South Korea, followed by Taiwan, Hong Kong, Thailand and mainland China.

Beyond the Expo, the Kansai region and surrounding areas offer a variety of experiences, from historical landmarks to culinary delights. Agoda has identified five destinations that are ideal for day trips:

Nara: Known for its historical significance, Nara features attractions such as Todai-ji Temple and Nara Park, where deer roam freely. The city’s serene environment provides a contrast to the dynamic atmosphere of the Expo. Nara is accessible in about an hour via the JR Osaka Loop Line.Kobe: This port city combines modernity with tradition, offering highlights such as the Kitano Ijinkan-gai District and panoramic views from Mount Rokko. Kobe beef and the hot springs of Arima Onsen are also popular draws. The JR Kobe Line Rapid Service connects Osaka to Kobe in approximately 30 minutes.Nagoya: A blend of innovation and tradition, Nagoya features landmarks like Nagoya Castle and the Toyota Commemorative Museum of Industry and Technology. Local cuisine, including miso katsu, adds to the city’s appeal. The Shinkansen from Shin-Osaka Station ensures a quick and convenient journey.Himeji: Himeji Castle, a UNESCO World Heritage Site, is a must-see for its architectural beauty and historical significance. The castle’s white facade and surrounding gardens are particularly striking. The JR Sanyo Shinkansen provides access to Himeji in under an hour.Wakayama: Wakayama offers a mix of spiritual and cultural experiences, including Mount Koya, a center of Shingon Buddhism, and Wakayama Castle. Fresh seafood markets add a culinary dimension to the visit. The JR Wakayama Line connects Osaka to this peaceful destination.

Hiroto Ooka, Associate Vice President, North Asia at Agoda, shared, “Expo 2025 Osaka is not just about innovation; it’s also an opportunity to explore the rich culture and history of the Kansai region and beyond. Agoda is excited to help travelers uncover these destinations and create unforgettable memories with great value deals on accommodation, flights, and activities.”

With over 5 million holiday properties, 130,000 flight routes, and 300,000 activities, Agoda makes it easy to plan your next celestial escape. Visit Agoda.com or download the Agoda mobile app for the best deals.

View original content to download multimedia:https://www.prnewswire.com/apac/news-releases/explore-beyond-expo-2025-osaka-with-agodas-day-trip-recommendations-302426352.html

SOURCE Agoda

Continue Reading

Technology

Lakshmi Finance Center: Jonathan Dale Benton Unveils the Strategic Leap from TradeGenius AI 3.0 to 4.0

Published

on

By

Lakshmi Finance Center announces the next generation of its flagship AI platform, TradeGenius AI 4.0, showcasing advanced learning capabilities, re-engineered infrastructure, and cross-domain scalability under the direction of founder Jonathan Dale Benton.

SAN DIEGO, April 10, 2025 /PRNewswire-PRWeb/ — Lakshmi Finance Center has officially launched TradeGenius AI 4.0, the most significant architectural and functional overhaul of its intelligent automation platform to date. Building on the foundational framework of version 3.0, the new system introduces a series of transformative upgrades designed to meet the demands of increasingly complex and dynamic real-time environments.

The development, led by Founder and CEO Jonathan Dale Benton, reflects the institution’s ongoing investment in modular artificial intelligence systems that prioritize learning adaptability, high-volume data responsiveness, and operational transparency.

“TradeGenius AI 4.0 is not simply a version update—it’s a complete strategic reinvention of the system’s intelligence core,” said Jonathan Dale Benton. “It now thinks in contexts, adapts in cycles, and learns in real time across environments that no static model could survive.”

While TradeGenius AI 3.0 introduced essential advancements such as adaptive learning databases and preliminary decision feedback loops, version 4.0 redefines those foundations by integrating reinforcement learning, temporal abstraction layers, and dynamic task routing engines. These upgrades allow the system to execute multi-stage, variable-output strategies across non-linear data streams—an essential feature for modern AI operations.

One of the key innovations in 4.0 is its event-driven processing model, which replaces sequential logic chains with flexible response modules. This model enables the system to react to new inputs based on weighted probabilities rather than fixed triggers, dramatically reducing latency and enhancing situational awareness.

In parallel, the platform now supports natural language command interpretation through an upgraded NLP parser, allowing users to construct complex operational logic using simple language prompts. These are dynamically translated into structured tasks, enabling broader accessibility across non-technical roles in systems management and automation testing.

The memory module—a critical improvement over 3.0’s short-term feedback structure—has been expanded into a context-aware temporal buffer. This allows TradeGenius AI 4.0 to maintain variable-length memory trails for long-form decision-making, improving continuity in strategy across extended sessions.

Another core advancement is the scalability architecture, which now supports simultaneous deployment across decentralized nodes with real-time synchronization. This enables federated learning experiments and distributed intelligence deployment in simulated or live multi-agent environments.

The engineering teams behind TradeGenius AI worked through 14 months of sprint-based iterations and regression testing to ensure that legacy logic sets could be retained while accommodating the system’s expanded capabilities. Cross-disciplinary contributions from Lakshmi’s internal data scientists, systems theorists, and interface designers ensured a consistent balance between depth, speed, and usability.

In preparation for broader use, Lakshmi Finance Center is releasing a developer sandbox environment for institutions and research labs, including access to API layers, custom training modules, and anonymized datasets for testing. Internal pilot programs have already demonstrated successful applications in automation orchestration, real-time analytics, and process modeling.

Looking ahead, Lakshmi Finance Center plans to integrate real-world knowledge graph structures and symbolic reasoning systems in future iterations of the TradeGenius framework. Version 4.1, currently in prototype, is expected to introduce explainability modules and internal audit trails for transparency in critical system decisions.

TradeGenius AI 4.0 is now available for enterprise deployment, research collaboration, and curriculum integration within Lakshmi’s technical education programs.

With this release, Lakshmi Finance Center not only extends the capabilities of intelligent systems but reinforces its role as a center for continuous innovation in scalable, modular, and explainable AI.

Media Contact

Charlotte Evans, Lakshmi Finance Center, 1 619-379-7337, contact@lakshmifinance.com, https://www.lakshmifinance.com/

View original content:https://www.prweb.com/releases/lakshmi-finance-center-jonathan-dale-benton-unveils-the-strategic-leap-from-tradegenius-ai-3-0-to-4-0–302424230.html

SOURCE Lakshmi Finance Center

Continue Reading

Technology

ROLLER Celebrated on AFR’s Best Places to Work List and Certified as a Great Place to Work

Published

on

By

ROLLER’s purpose is to help create experiences that bring joy and happiness to the world. They achieve this by connecting attraction venues with powerful, easy-to-use technology.

AUSTIN, Texas, April 10, 2025 /PRNewswire/ — ROLLER, the all-in-one venue management platform for the leisure and attractions industry, is proud to announce it has been named a finalist on the Australian Financial Review’s Best Places to Work List for 2025, in the Technology category. Presented in collaboration with Bendelta, the list evaluates hundreds of companies across Australia and New Zealand based on employee experience, policies, and innovation. For the ROLLER team, being recognized among such respected companies is a meaningful acknowledgment of the culture they’re continuing to build as they scale.

“Our people are the heart of everything we do,” says Bee Hepburn, Chief People Officer at ROLLER. “Being included on the AFR’s Best Places to Work List reflects our team’s passion for not only creating joyful guest experiences through our platform but also cultivating a workplace where people love to show up every day.”

ROLLER was also honored to be officially certified as a Great Place to Work® for the third consecutive year in Australia and the second year running in the United States.

“Great Place To Work Certification is a highly coveted achievement that requires consistent and intentional dedication to the overall employee experience,” says Sarah Lewis-Kulin, Vice President of Global Recognition at Great Place To Work. She emphasizes that Certification is based entirely on real feedback from employees, making it a genuine reflection of how people feel about the company culture. “By successfully earning this recognition, it is evident that ROLLER stands out as one of the top companies to work for, providing a great workplace environment for its employees.”

ROLLER’s employee experience is driven by core values that promote collaboration, trust, innovation, and personal growth. With a global team spanning the Americas, EMEA, and APAC, ROLLER emphasizes flexibility, psychological safety, and opportunities for career progression. Recent initiatives include working with Equidi to close the gender pay gap, a public holiday swap program, and DEI-driven hiring practices.

“We’re intentional about creating an environment where people feel connected to their work, each other, and the impact we’re making,” added Bee Hepburn. “Whether you’re based in Austin, Melbourne, or London, you’ll find the same level of openness, encouragement, and energy that defines ROLLER’s culture.”

As the company continues to grow and evolve, ROLLER remains focused on maintaining a culture-first approach, recognizing that happy, fulfilled teams are the key to delivering world-class products and support to the attractions industry.

About ROLLER

ROLLER is the cloud-based venue management platform for modern attractions, purpose-built to remove friction from the guest experience at every touchpoint. Their all-in-one platform simplifies its customers’ business processes, improving efficiency and maximizing revenue. ROLLER’s comprehensive solution includes: Online Checkout & Ticketing, Point-of-Sale, Integrated Payments, Memberships, Gift Cards, Waivers, Self-Serve Kiosks, Cashless Wallets, Guest Surveys, and more. To learn more, visit roller.software.

View original content to download multimedia:https://www.prnewswire.com/news-releases/roller-celebrated-on-afrs-best-places-to-work-list-and-certified-as-a-great-place-to-work-302426320.html

SOURCE ROLLER

Continue Reading

Trending