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10x Genomics Launches 5,000-Plex Gene Panel for Xenium

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7 months ago

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 New Xenium Prime 5K Pan-Tissue and Pathways panel increases plex by an order of magnitude and delivers industry-leading speed and throughput

PLEASANTON, Calif., May 29, 2024 /PRNewswire/ — 10x Genomics, Inc. (Nasdaq: TXG), a leader in single cell and spatial biology, announced today the launch of its Xenium Prime 5K Pan-Tissue and Pathways panel. The new assay features an enhanced chemistry to increase plex by an order of magnitude while delivering excellent per-gene sensitivity, improved specificity and spatial fidelity, integrated multimodal cell segmentation, and industry-leading speed and throughput.

“Seeing the Xenium Prime 5K data reminded me of the excitement I experienced when I saw single cell RNA-seq data for the first time,” said Dr. Kevin Wei, M.D., Ph.D., Assistant Professor of Medicine at Harvard Medical School. “Now, we can identify relevant molecular pathways in human diseases and explore new biological hypotheses, all from one glass slide.”

The high-plex Xenium Prime 5K assay enables a new level of exploration for pathways, biomarkers, ligand-receptor pairings and cell-cell interactions. Key features include:

Highest plex Xenium panel for comprehensive profiling of cell types and states and cell signaling pathways across multiple tissue and disease types.Excellent data quality to unlock mechanisms of disease, therapeutics and cell behavior. The Xenium Prime 5K assay is optimized for performance and paired with 10x Genomics’ advanced multimodal cell segmentation, enabling high sensitivity, specificity and spatial fidelity.Rapid turnaround time with easy, tissue-agnostic workflows. 10x Genomics’ industry-leading throughput enables researchers to analyze up to 472 mm² of tissue in six days or less.Easily customizable with up to 100 additional genes to capture customers’ specific research needs.Rigorously designed and developed using single cell RNA-seq data from dozens of different organs and tissues, gene expression profiles from hundreds of cell types and a screen of more than 750,000 peer-reviewed publications to pinpoint highly cited biomarkers.

“We successfully launched Xenium with a broad menu of curated and highly customizable gene panels so customers could target specific biology important for their research,” said Michael Schnall-Levin, Founding Scientist and Chief Technology Officer at 10x Genomics. “With the launch of our 5K gene panel, researchers can now also use Xenium for spatial exploration, enabling more biology and more breakthroughs. This assay is yet another example of how we put our innovation engine to work for our customers and build best-in-class products that deliver best-in-class results.”

The Xenium Prime 5K assay, optimized for human and mouse species, is now available for preorder and is expected to ship next month.

About 10x Genomics
10x Genomics is a life science technology company building products to accelerate the mastery of biology and advance human health. Our integrated solutions include instruments, consumables and software for single cell and spatial biology, which help academic and translational researchers and biopharmaceutical companies understand biological systems at a resolution and scale that matches the complexity of biology. Our products are behind breakthroughs in oncology, immunology, neuroscience and more, fueling powerful discoveries that are transforming the world’s understanding of health and disease. To learn more, visit 10xgenomics.com or connect with us on LinkedIn or X (Twitter).

Forward Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 as contained in Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which fall under the “safe harbor” provisions of those sections. All statements, other than statements of historical facts, may be forward-looking statements. Forward-looking statements generally can be identified by the use of forward-looking terminology such as “may,” “might,” “will,” “should,” “expect,” “plan,” “anticipate,” “could,” “intend,” “target,” “project,” “contemplate,” “believe,” “estimate,” “predict,” “potential” or “continue” or variations of them or similar terminology, but the absence of these words does not mean that a statement is not forward-looking. These forward-looking statements include statements regarding 10x Genomics, Inc.’s (“10x Genomics”) product launches, performance, configuration, capabilities, adoption and pipeline. These statements are based on management’s current expectations, forecasts, beliefs, assumptions and information currently available to management, and actual outcomes and results could differ materially from these statements due to a number of factors. Other risks and uncertainties that could affect 10x Genomics’ financial and operating results and cause actual results to differ materially from those indicated by the forward-looking statements made in this press release include those discussed under the captions “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operations” and elsewhere in the documents 10x Genomics files with the Securities and Exchange Commission (the “SEC”) from time to time. Although 10x Genomics believes that the expectations reflected in the forward-looking statements are reasonable, it cannot provide any assurance that these expectations will prove to be correct nor can it guarantee that the future results, levels of activity, performance and events and circumstances reflected in the forward-looking statements will be achieved or occur. The forward-looking statements in this press release are based on information available to 10x Genomics as of the date hereof, and 10x Genomics disclaims any obligation to update any forward-looking statements provided to reflect any change in its expectations or any change in events, conditions or circumstances on which any such statement is based, except as required by law. These forward-looking statements should not be relied upon as representing 10x Genomics’ views as of any date subsequent to the date of this press release.

Disclosure Information
10x Genomics uses filings with the Securities and Exchange Commission, our website (www.10xgenomics.com), press releases, public conference calls, public webcasts and our social media accounts as means of disclosing material non-public information and for complying with our disclosure obligations under Regulation FD.

Contacts
Investors: investors@10xgenomics.com
Media: media@10xgenomics.com

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SOURCE 10x Genomics, Inc

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European Wellness Biomedical Group Announces New Klotho Research Initiative Led by Prof. Mike Chan

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38 minutes ago

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December 25, 2024

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HEIDELBERG, Germany, Dec. 25, 2024 /PRNewswire/ — European Wellness Biomedical Group (EWBG) has launched a new research initiative focused on Klotho, a protein with transformative potential in longevity medicine. Led by Professor Dr. Mike Chan, this project will explore Klotho’s role in combating age-related diseases and its ability to regenerate critical organs, including the brain, kidneys, and heart.

Klotho, identified in 1997, is emerging as a key protein in longevity and regenerative medicine. It plays a pivotal role in regulating oxidative stress, mineral metabolism, and inflammation. The research will investigate how boosting Klotho levels could help address chronic conditions like neurodegenerative diseases, kidney failure, and heart disease, ultimately improving healthspan and extending lifespan.

“Klotho represents the next frontier in longevity medicine,” said Professor Mike Chan, Chief Scientist at EWBG. “Our research aims to understand how Klotho affects aging and how we can use it to treat chronic diseases that have long been associated with aging.”

Research Focus Areas

The new initiative will focus on three primary research areas:

Neurological health: Investigating Klotho’s neuroprotective effects and its potential to slow cognitive decline in diseases like Alzheimer’s and Parkinson’s.Kidney function: Examining Klotho’s role in regulating mineral metabolism and its regenerative potential in treating chronic kidney disease (CKD).Cardiovascular health: Studying Klotho’s influence on vascular function and its ability to prevent vascular calcification, a key contributor to heart disease.

This research builds on existing collaborations at EWBG, where leading scientists focus on advancing Klotho-based therapies for regenerative health.

Klotho: A Potential Breakthrough in Longevity Medicine

Klotho is gaining attention for its ability to regenerate tissues and reverse damage caused by age-related diseases. Unlike NAD+, which primarily enhances cellular metabolism and energy production, Klotho offers a broader range of therapeutic applications, including tissue regeneration, cognitive function improvement, and cardiovascular health.

As we age, Klotho levels naturally decline, leading to conditions such as cognitive decline, heart disease, and kidney failure. Research suggests that restoring Klotho levels can reverse the effects of oxidative stress, inflammation, and cellular senescence, offering new treatment possibilities for a range of age-related diseases.

Professor Mike Chan: Leading the Charge in Klotho Research

Professor Mike Chan, a leading expert in stem cell therapy and longevity medicine, is spearheading this groundbreaking initiative at EWBG. His extensive experience in bio-regenerative medicine positions him as a key figure in exploring Klotho’s potential to revolutionize the treatment of age-related diseases. Through FCTI, a subsidiary of EWBG, Professor Chan and his team are developing therapies that combine stem cell technology and Klotho proteins to stimulate tissue regeneration in the brain, kidneys, and heart.

“By harnessing Klotho’s regenerative properties, we hope to address chronic conditions that were previously untreatable,” said Professor Chan. “Our ultimate goal is to improve quality of life and provide lasting solutions for those affected by aging-related diseases.”

The Future of Klotho in Longevity Medicine

The future of Klotho-based therapies looks promising, with Professor Mike Chan and EWBG at the forefront of this innovative field. As more research is conducted, Klotho is expected to play a pivotal role in advancing longevity medicine, offering a new approach to treating aging and chronic diseases. The potential applications of Klotho are vast, from neurodegenerative disease treatment to kidney regeneration and cardiovascular health.

With strong research partnerships, significant funding, and ongoing clinical trials, Klotho is poised to become a cornerstone of longevity medicine, transforming how we approach aging and disease. Professor Mike Chan’s leadership ensures that this promising protein will soon offer new hope to those seeking longer, healthier lives.

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View original content:https://www.prnewswire.co.uk/news-releases/european-wellness-biomedical-group-announces-new-klotho-research-initiative-led-by-prof-mike-chan-302338980.html

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Apas Port Launches $20M Vehicle Loan Initiative with HARVEST FLOW on Plume Network to Empower Financial Inclusion in Emerging Countries, Starting in Cambodia

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2 hours ago

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December 25, 2024

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NEW YORK, Dec. 24, 2024 /PRNewswire/ — Apas Port Co., Ltd., a Tokyo-based Web3 company dedicated to deploying “kando”—a Japanese term for deep emotional engagement—into the digital realm, has announced the launch of HARVEST FLOW, a social impact-driven cryptocurrency lending platform. Committed to “social action”ーdelivering stable returns alongside meaningful social impact, HARVEST FLOW’s inaugural project is a $20 million initiative offering loans to TukTuk and four-wheel vehicle drivers in Cambodia who don’t have access to the financial system. This venture is set to operate on Plume Network, the leading Layer 1 blockchain specialized in Real-World Asset Finance (RWAfi), offering the necessary infrastructure to transform HARVEST FLOW’s vision of financial inclusion into scalable action.

Bridging Real-World Challenges Through Blockchain Innovation

HARVEST FLOW’s mission is to empower underserved communities and small businesses by granting access to affordable financing solutions. By leveraging blockchain technology, the platform addresses critical societal issues such as poverty alleviation and economic development, creating pathways for stable financial growth while delivering measurable social impact.

The initial focus of this initiative is to provide affordable financing options for TukTuk and four-wheel vehicle drivers in Cambodia—vital tools for local livelihoods. The project not only supports job creation but also enhances financial inclusion in emerging economies.

Why Plume Network?

As the first fully integrated L1 modular blockchain tailored for RWAfi, Plume Network provides the foundation for scalable, secure, and transparent financial ecosystems. With over 180 projects onboarded in its private devnet, Plume enables seamless tokenization and distribution of RWAs through its composable, EVM-compatible infrastructure.

How Plume Powers HARVEST FLOW:

End-to-End Tokenization: Streamlines the conversion of vehicle loans into blockchain-based assets.Investor Transparency: Advanced tools to track and visualize the social and financial impact of investments.Global Scalability: Infrastructure designed to handle the growing demands of HARVEST FLOW’s multi-region projects.DeFi Integration: Unlocks liquidity through decentralized finance primitives within the Plume ecosystem.

IoT-Backed Innovation for Loan Security

HARVEST FLOW’s projects are uniquely supported by embedded IoT technology within TukTuk engines, ensuring an exceptionally low loan default rate while building investor confidence.

Justin Chen, Head of Asset Strategy at Plume Network, noted: “This project highlights the power of combining blockchain and IoT devices to create innovative financial products that drive real-world impact. We’re excited to see HARVEST FLOW’s success on Plume and the positive change it will bring to the urban motility market in Southeast Asia.”

Looking Ahead

Starting with the vehicle mobility sector through 2025, HARVEST FLOW plans to expand into other sectors addressing social challenges and needs beyond 2026. This approach aims to ensure sustainable growth while delivering meaningful societal benefits, powered by Plume’s blockchain technology.

Masaki Minamide, director of HARVEST FLOW, stated: “Plume’s infrastructure empowers us to amplify our impact and support communities in need while offering our investors transparent and reliable returns. With this launch, we continue our mission to combine blockchain technology with meaningful social action.”

For more information, visit Plume Network or contact press@plumenetwork.xyz.

About Plume Network
Plume is the first fully integrated L1 modular blockchain focused on RWAfi, offering a composable, EVM-compatible environment for onboarding and managing diverse RWAs. With 180+ projects on its private devnet, Plume provides an end-to-end tokenization engine and a network of financial infrastructure partners, simplifying asset onboarding and enabling seamless DeFi integration for RWAs.

About HARVEST FLOW
Founded in April 2023, Apas Port Co., Ltd. is a Web3 production company with a mission to deploy “kando” (deep emotional impact) globally. The company leverages blockchain technology to connect carefully curated content with a co-creative community, acting as a “passport” to a new world of Web3 experiences.

X: https://x.com/HarvestFlow_io
Website: https://www.harvestflow.io/

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SOURCE Plume Network

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South Clackamas Business Resource Center Launches Digital Community Platform

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3 hours ago

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December 24, 2024

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The Business Resource Center (BRC) of South Clackamas County unveils a new digital platform featuring an innovative business mapping system developed by COBID-certified IronGlove Studio. The website integrates advanced mapping technology with resource management tools to serve local businesses across nine communities, offering free consultations and scholarship opportunities for eligible residents.

OREGON CITY, Ore. and SOUTH CLACKAMAS COUNTY, Ore., Dec. 24, 2024 /PRNewswire-PRWeb/ —  The Business Resource Center of South Clackamas County (BRC) is proud to announce the launch of its new website, https://brcscc.org, developed by Oregon City-based IronGlove Studio, LLC. The launch marks a significant expansion of its online presence and services, representing a major step forward in the BRC’s mission to support and empower local businesses and community members in the South Clackamas area.

This initiative offers an unbiased and equitable opportunity for every small business in the South Clackamas region to connect, discover, and grow through access to training, resources, and support.

Who is the Business Resource Center of South Clackamas County

The Business Resource Center (BRC) of South Clackamas County is a vital hub for small business support, resources, and training opportunities, dedicated to fostering economic growth and development in the region. Funded through the American Rescue Plan Act (ARPA) and operating until December 31, 2024, or until funding is exhausted, the BRC provides free consultations, training programs, and scholarships to empower small business owners in Gladstone, Oregon City, Beavercreek, Canby, Molalla, Mulino, Colton, Eagle Creek, and Estacada. Through initiatives like its comprehensive website and Local Business Map, the BRC connects entrepreneurs with the community, creating opportunities for growth and promoting sustainable, community-based economic development.

Key Offerings

Free Business Resource Consultations: Local entrepreneurs can access expert advice and guidance at no cost, ensuring they are not alone in their small business journey.

Exclusive Scholarship Opportunities: The BRC offers scholarships for Clackamas Community College’s Career & Technical Education programs, covering up to $3,500 per semester for eligible students in select zip codes.

Local Business Map: As part of its marketing initiative, the BRC features an innovative Local Business Map developed by IronGlove Studio. This custom solution integrates advanced mapping technology with COBID certification filters, enabling small businesses to connect with one another while providing valuable demographic insights for community stakeholders.

Website Performance

Since its soft launch in August 2024, the BRC website has quickly become a vital resource for the South Clackamas business community. The platform has attracted nearly 3,000 visitors, with users spending an average of 4 minutes engaging with the site’s resources and information. The site’s success is particularly evident in its scholarship program, which has already received 82 applications, including 6 from Spanish-speaking community members, demonstrating the BRC’s commitment to serving our diverse business community.

Strategic partnerships with Here is Oregon and Oregon’s Mt. Hood Territory allowed us to create targeted social media campaigns that have helped drive over 2,000 visitors to the site, resulting in more than 7,000 total pageviews. Visitors are actively engaging with the platform’s resources, averaging 2.7 actions per visit, including accessing business resources, downloading materials, and utilizing the local business map.

The platform, developed by IronGlove Studio, LLC of Oregon City, a COBID-certified firm, showcases innovative integration of WordPress with proprietary Angular mapping technology. “The BRC website demonstrates how enterprise-level solutions can be scaled down to serve community needs,” says Derek Neuts, Owner of IronGlove Studio. “By incorporating advanced features like COBID certification filters and demographic reporting capabilities, we’ve created a platform that not only connects consumers to businesses but also provides valuable insights for community development.”

Community Support

The BRC extends its gratitude to its advocates, partners and supporters, including the previous Oregon State Senator Bill Kennemer, previous Oregon State Representative (now Senator) — Mark Meek, the Chambers of Commerce for Canby, Estacada, Molalla and Oregon City, the Cities of Colton and Gladstone and the Hamlets of Beavercreek and Mulino.

“The launch of our comprehensive website marks a significant milestone in our commitment to supporting the South Clackamas County business community,” said Shatrine Krake, Director of Communications at the Business Resource Center of South Clackamas County. “This initiative offers an unbiased and equitable opportunity for every small business in the South Clackamas region to connect, discover, and grow through access to training, resources, and support.”

For more information or to schedule a free business consultation, visit https://brcscc.org.

Media Contact

Shatrine Krake, Director of Communications, Business Resource Center of South Clackamas County, 1 503-656-1619, shatrine@brcscc.org, https://brcscc.org/

Technical Development Contact: Derek Neuts, IronGlove Studio LLC, 1 503-501-4645, contact@ironglove.studio, https://www.ironglove.studio

View original content to download multimedia:https://www.prweb.com/releases/south-clackamas-business-resource-center-launches-digital-community-platform-302338692.html

SOURCE Business Resource Center of South Clackamas County

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