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New Space-Based Study Shows Promising Results for Treating, Preventing Post-Traumatic Osteoarthritis

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11 months ago

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MIT Conducts Accelerated Bone Loss Research Through ISS National Lab

KENNEDY SPACE CENTER, Fla., May 28, 2024 /PRNewswire/ — More than 650 million people worldwide are affected by osteoarthritis, and few treatment options exist. However, new promising results from an International Space Station (ISS) National Laboratory-sponsored experiment detail a tissue chip model that accurately reproduces the conditions under which post-traumatic osteoarthritis (PTOA) is initiated. Published in Frontiers in Space in March, these findings mark an important step forward in understanding and testing treatments for the underlying causes of osteoarthritis and related conditions.

In the latest issue of Upward, the official magazine of the ISS National Lab, study author Alan Grodzinsky, a biological engineering professor at the Massachusetts Institute of Technology (MIT), discusses experiments on the space station using his team’s innovative tissue chip model. The model effectively replicated a joint environment with viable human cartilage, bone, and synovium cocultures, establishing a baseline for understanding and testing treatments for PTOA, which can occur after a traumatic injury to a joint and affects around 20 percent of the millions of people with osteoarthritis. Despite its prevalence, no U.S. Food and Drug Administration-approved drugs exist to treat or prevent osteoarthritis and related conditions.

Grodzinsky commented on the significance of these findings in Upward, stating, “This opens up new possibilities for testing drugs and interventions for osteoarthritis and other joint disorders. It could also aid in developing preventative treatments.”

The space environment was essential to the experiment’s success, as it appeared to simulate osteoarthritis characteristics quicker than similar experiments on Earth, with past research demonstrating accelerated bone loss in microgravity. Key findings from the study show the tissue chip’s capability to emulate the initiation and progression of PTOA and the effects of various treatment modalities. Notably, the device accurately simulated the impact of drugs commonly used to alleviate inflammation and pain in patients. Additionally, it showed potential for evaluating a drug designed to stimulate cartilage growth and repair, offering promising avenues for therapeutic intervention.

By providing a platform for precise and controlled experimentation, the tissue chip model offers researchers a powerful tool to explore the mechanisms underlying joint diseases and develop targeted therapeutic strategies, says Grodzinsky.

To download a high-resolution photo for this release, click here.

About the International Space Station (ISS) National Laboratory:
The International Space Station (ISS) is a one-of-a-kind laboratory that enables research and technology development not possible on Earth. As a public service enterprise, the ISS National Laboratory® allows researchers to leverage this multiuser facility to improve quality of life on Earth, mature space-based business models, advance science literacy in the future workforce, and expand a sustainable and scalable market in low Earth orbit. Through this orbiting national laboratory, research resources on the ISS are available to support non-NASA science, technology, and education initiatives from U.S. government agencies, academic institutions, and the private sector. The Center for the Advancement of Science in Space™ (CASIS™) manages the ISS National Lab, under Cooperative Agreement with NASA, facilitating access to its permanent microgravity research environment, a powerful vantage point in low Earth orbit, and the extreme and varied conditions of space. To learn more about the ISS National Lab, visit our website.

As a 501(c)(3) nonprofit organization, CASIS accepts corporate and individual donations to help advance science in space for the benefit of humanity. For more information, visit our donations page.

Media Contact  

Patrick O’Neill     

904-806-0035

PONeill@ISSNationalLab.org

 

International Space Station (ISS) National Laboratory

Managed by the Center for the Advancement of Science in Space, Inc. (CASIS)

6905 N. Wickham Rd., Suite 500, Melbourne, FL 32940 • 321.253.5101 • www.ISSNationalLab.org

 

View original content to download multimedia:https://www.prnewswire.com/news-releases/new-space-based-study-shows-promising-results-for-treating-preventing-post-traumatic-osteoarthritis-302156944.html

SOURCE International Space Station National Lab

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Aldo Cazzullo of Corriere della Sera to discuss his book “The Neverending Empire: The Infinite Impact of Ancient Rome” at a National Press Club on May 9

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49 minutes ago

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April 25, 2025

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WASHINGTON, April 25, 2025 /PRNewswire/ — Aldo Cazzullo plans to discuss his book “The Neverending Empire: The Infinite Impact of Ancient Rome” at a Headliners Book Event on May 9, 2025 at 5:30 p.m.

You can purchase tickets for the event here: https://www.press.org/events/npc-headliners-neverending-empire-aldo-cazzullo

Cazzullo has been reporting on major Italian and international events for 35 years. He is special correspondent and editorialist of Corriere della Sera in Milan.  He has written over 30 books on Italian history and identity.  His recent book “Mussolini il capobanda” has sold over 150,000 copies.  He hosts Una giornata particolare (a particular day) on the La7 tv channel: the first season had an average of one million viewers per episode; the second season is currently on air and has already achieved even greater success than the previous season with an average of 1.3 million viewers.

“The Neverending Empire” claims the true heirs of the Roman Empire are western civilization and the United States. Rome 2000 years ago and the United States today have more in common that many may think. Both had a multicultural, multiethnic and multireligious society with pressure from within and without.

The Roman Empire lives on today in books, movies, television programs, language, law, and other areas of our lives. Join us on May 9 and travel from the distant past to the present.

To submit a question in advance, put EMPIRE in the subject line and email it to headliners@press.org

The National Press Club is located on the 13th Floor of the National Press Building at 529 14th St., NW, Washington, D.C.

PRESS CONTACT: Cecily Scott Martin for the National Press Club; cscottmartin@press.org; (202) 662-7525

View original content to download multimedia:https://www.prnewswire.com/news-releases/aldo-cazzullo-of-corriere-della-sera-to-discuss-his-book-the-neverending-empire-the-infinite-impact-of-ancient-rome-at-a-national-press-club-on-may-9-302438654.html

SOURCE National Press Club

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HitPaw Launches 2025 Global Cat Tax Campaign with Top Prizes

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49 minutes ago

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April 25, 2025

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LOS ANGELES, April 25, 2025 /PRNewswire/ — HitPaw, the innovative platform for creative video tools, has officially launched its global Cat Tax photo event — perfect for feline lovers everywhere. From April 10 through May 7, cat lovers are invited to share their most adorable cat photos to win exciting prizes, including a DJI Pocket Camera.

The total value of the prizes is over $1,000.

SHARE YOUR CAT, WIN BIG

Do you have the cutest cat on the internet? Prove it! The HitPaw Cat Tax event is a global celebration of our favorite pets: cats. Whether your furry friend is silly, sleepy, or sassy, every cat deserves the spotlight.

EXCITING REWARDS AWAIT YOU!

1st Prize (250+ entries): DJI Pocket Camera ($699)
 2nd Prize (160+ entries): Automatic Pet Feeder ($100)
 3rd Prize (100+ entries): Apple AirTag ($30)

In addition to the grand prizes, each week offers participants new creative challenges with surprise prizes. Don’t miss your chance to earn extra rewards!

HOW TO PARTICIPATE

Join the Fun – Participate in various engaging activities on our event page.
 Earn Entries – Complete tasks on the event page to increase your chances.
 Win Amazing Prizes – The more entries, the better your chance to win amazing prizes!

MEOW, POST, AND WIN! Share your best cat photo in the HitPaw Cat Tax contest for a chance to win amazing prizes.

Grab your camera and join the fun! HitPaw Cat Tax Event: Show Your Cat & Win a DJI

WHY JOIN?

Engaging and effortless – Share your favorite cat photos to participate in a lighthearted, global celebration of feline charm.
 Exciting prizes await – With multiple winners and grand prizes, including the DJI Pocket Camera, participants have more chances than ever to be rewarded.
 Celebrate creativity and community. Join fellow cat lovers in a fun-filled campaign by HitPaw that combines social sharing with the joy of pet ownership.

Join The HitPaw Cat Tax Event Now!

Don’t miss out on this limited-time event!

Visit: HitPaw Cat Tax Event: Show Your Cat & Win a DJI to learn more.

About HitPaw:

HitPaw is a creative software company that empowers users with intuitive video editing, screen recording, and AI-powered media tools. From content creators to pet lovers, HitPaw makes digital storytelling easy, fun, and accessible for everyone.

To know more, you may visit: [OFFICIAL] HitPaw: Powerful AI Video, Audio, and Image Solutions Provider

Follow Us for More Updates:

YouTube: https://www.youtube.com/@hitpaw
 X/Twitter: @HitPawofficial
 Instagram: @hitpawofficial
 Pinterest: HitPaw

Celebrate creativity, share the love, and win big with the HitPaw Cat Tax event!

This release was issued through Send2Press® on behalf of the news source. For more information, visit Send2Press Newswire at https://www.send2press.com/. 

View original content to download multimedia:https://www.prnewswire.com/news-releases/hitpaw-launches-2025-global-cat-tax-campaign-with-top-prizes-302438574.html

SOURCE HitPaw. Co., Ltd

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Trimble Announces Filing of Form 10-K for 2024

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50 minutes ago

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April 25, 2025

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WESTMINSTER, Colo., April 25, 2025 /PRNewswire/ — Trimble Inc. (the “Company”) (Nasdaq: TRMB) announced today that it has filed its Annual Report on Form 10-K for the year ended January 3, 2025 with the Securities and Exchange Commission. There were no changes to the Company’s financial statements as presented during the earnings call held by the Company on February 19, 2025.

About Trimble

Trimble is a global technology company that connects the physical and digital worlds, transforming the ways work gets done. With relentless innovation in precise positioning, modeling and data analytics, Trimble enables essential industries including construction, geospatial and transportation. Whether it’s helping customers build and maintain infrastructure, design and construct buildings, optimize global supply chains or map the world, Trimble is at the forefront, driving productivity and progress. For more information about Trimble (Nasdaq: TRMB), visit: www.trimble.com.

FTRMB

View original content to download multimedia:https://www.prnewswire.com/news-releases/trimble-announces-filing-of-form-10-k-for-2024-302438657.html

SOURCE Trimble

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