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Wheeler Bio Seals Agreement with Charles River to Offer Portable CMC® to Discovery Clients to Accelerate Their Journey to First-in-Human Use

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WILMINGTON, Mass. and OKLAHOMA CITY, Feb. 29, 2024 /PRNewswire/ — Wheeler Bio, Inc., an agile contract development and manufacturing organization (CDMO), announced today a new strategic agreement with Charles River Laboratories International, Inc. (NYSE: CRL), a global leader in pharma services, to offer Wheeler Bio’s Portable CMC® (Chemistry, Manufacturing and Controls) platform to Charles River Laboratory clients. The collaboration is designed to enable a swift transition from pre-clinical stages directly to human clinical trials.

Combining Charles River’s industry-leading experience in antibody discovery services, safety, and analytics with Wheeler’s Portable CMC® platform will accelerate therapeutic discovery to Investigational New Drug (IND) submission timelines. This umbrella offering efficiently connects the preclinical, clinical manufacturing, and release testing journeys, significantly reducing the complexity of managing multiple vendor relationships. Integrating CMC development early in discovery enables therapeutic developers to collaborate with experts across the organizations to utilize phase-appropriate manufacturing and analytics. The services and expertise come together to provide a single concept-to-commercial offering.

Wheeler Bio’s mission is to solve translational challenges inherent in advancing from discovery to CMC development and early-clinical trial material supply. Their Portable CMC® is a validation-ready production process which reduces technical and regulatory risk. The organization operates the Portable CMC® platform in Wheeler’s state-of-the-art process development labs in Oklahoma City, OK, which also houses a CGMP facility-of-the-future including a RightSource™ quality control testing lab. There is an additional satellite lab in Waltham, MA featuring protein sciences and bench scale process capabilities. Wheeler Bio provides startup biotechs with access to a high quality, agile, affordable path to clinical supply with thoughtfully designed, modular work packages featuring the industry leading Leap-In Transposase® mediated gene delivery system from ATUM for robust high titer CHO pool-based workflow parallelization, standard analytics, and discrete CMC milestones that align with innovators’ fundraising milestones.

Jesse McCool, CEO and Co-Founder of Wheeler Bio, stated, “Wheeler is excited to expand our relationship with Charles River and to link with their discovery organization.  By integrating discovery CRO and CDMO workflows, we can speed our clients’ path to first-in-human trials through better insights, thereby achieving clinical decisions faster. Our combined sales teams look forward to co-promoting these services for the benefit of our biotech partners and their pipelines towards clinical impact.”

Julie Frearson, Corporate Senior Vice President, Chief Scientific Officer at Charles River, highlighted the potential of this partnership: “We are thrilled to provide our clients with access to Wheeler’s innovative Portable CMC® platform, which will optimize their workflows and ultimately bring new treatments to patients faster.”

About Wheeler Bio
Wheeler Bio is a biomanufacturing pioneer, founded by a team of industry experts and strategic investors who believe a different CDMO model is needed to help innovators reach their clinical milestones faster. Wheeler’s novel hub-and-spoke operational model, centered in the biomanufacturing metro of Oklahoma City, and integrated with biotechs and discovery CROs, will revolutionize the speed of drug development. Wheeler Bio’s technology platform, Portable CMC® simplifies the path between drug discovery and clinical manufacturing by providing a new bridge for translating discoveries to first-in-human trials. Innovators benefit from increased momentum during technology transfer, shorter timelines, reduced risk, and lower costs. Additional information can be obtained by visiting www.wheelerbio.com or by following Wheeler Bio on LinkedIn

About Charles River
Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. To learn more about our unique portfolio and breadth of services, visit www.criver.com.

About ATUM
ATUM is a fully integrated Californian based CRDO (Contract Research & Development Organization) biotechnology industry leader. ATUM, over the last two decades, has served life science researchers by delivering high quality services including but not limited to Gene Design and Gene Synthesis, Protein Engineering, Protein Production, Leap-In Transposase®, Cell Line Development, and Master Cell Banking (MCB).  With a state-of-the-art machine learning platform, proprietary algorithms, and a fully integrated Laboratory Information Management System (LIMS), ATUM provides platforms and services that span from virtual sequence to manufacturing ready MCB. ATUM has a culture of continuous commitment to innovation where solutions are built on bioengineered solutions to bring speed to market, supporting the biotech ecosystem from pre-clinical research through IND and beyond. Contact us today for more information at www.atum.bio.

For Further Information:
Wheeler Bio, Inc.
Contact: Jaden Polston
jpolston@wheelerbio.com

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SOURCE Wheeler Bio

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Carro brings back award-winning ‘No Drama’ ads to celebrate 10 years of revolutionary car buying and selling services for customers

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Carro brings back ‘No Drama’, their award-winning ad series which parodies drama cliches to highlight its trustworthy, reliable, and transparent practicesThe 2-part campaign will reveal a second film in June Their 2023 ‘No Drama’ campaign garnered more than 38 million views and took home six awards at the YouTube Works Awards Southeast Asia

SINGAPORE, May 19, 2025 /PRNewswire/ — Carro, Asia Pacific’s largest and fastest-growing online used car platform, is celebrating thousands of satisfied customers in Asia Pacific since 10 years of inception, in a new campaign that spotlights their drama-free and seamless car buying and selling experience. A second Hong Kong crime genre ad will be released in June.

 

Produced by Carro’s in-house team and fully shot in South Korea, the first ‘No Drama’ ad takes us back to the Joseon Dynasty where even the king cannot escape conniving tricksters who are trying to persuade him to sell off his trusty ride for a fraction of what it’s worth. How will Carro save the kingdom from ruins?

Carro’s ‘No Drama’ series first launched in 2023 in the form of 3 short films that tapped into typical drama cliches to juxtapose the drama-free nature of buying a Carro Certified car that is As Good As New. The campaign went viral with more than 38 million views in total, and earned Carro six awards at the YouTube Works Awards Southeast Asia, including the Overall Winner for “The Big Bang Southeast Asia” category.

Carro Chief Marketing Officer Katherine Teo says, We’ve heard what our customers have said over the last 10 years: that selling their car can be stressful, complicated and long drawn. That’s why we keep our processes transparent and stress-free, and all the drama they see will only be from our ads – no matter whether they’re selling to us or buying a Carro Certified car that is As Good As New. Comedy remains a great medium for us to tell our story and we are so excited to be able to deliver our message in a manner that is entertaining and fresh.”

Carro offers a 100% transparent and convenient process that allows customers to begin their car-selling journey online at carro.co. In markets like Hong Kong and Malaysia, customers don’t even have to leave their home as Carro staff take the inspection and quotation processes right to their homes.

“At Carro, we take pride in setting a new standard of transparency and trust in the used car industry. Our commitment to providing 100% clear quotations and straightforward processes ensures that our customers feel confident and cared for at every step, even if it means appearing at their doorstep,” says Carro Chief Operating Officer Chua Zi Yong. “With the understanding that every market is unique, we are deeply committed to delivering the Carro experience in a way that is not only convenient and worry-free, but also truly resonates with what our customers value and need.”

Since its founding in 2015, Carro has been building its proprietary technologies and tapping into AI solutions to revolutionise the car ownership experience. Carro has grown from a Singaporean used car marketplace to Asia Pacific’s No. 1 used car online marketplace spanning 7 markets, complete with a strong in-house ecosystem that includes financing options, insurance offerings and aftersales services. The company also started selling brand new cars in Singapore, with plans to roll out this product line in other selected markets.

The ad is running in Singapore, Malaysia, Indonesia, Japan and Hong Kong. Look forward to No Drama Part 2 in June 2025, and head over to carro.co for all your car needs.

About Carro

Founded in 2015, Carro is Asia Pacific’s largest online used car marketplace. By offering a trustworthy and transparent experience, Carro transforms the traditional way of buying and selling cars through proprietary pricing algorithms, AI-enabled capabilities, and innovative technological solutions. As of March 2025, Carro has started selling Brand New cars in Singapore.

Headquartered in Singapore, the unicorn startup has raised over S$700 million from Softbank Vision Fund and several sovereign funds. It recorded its best ever full-year positive EBITDA of S$43 million in FY2024. Together with its subsidiaries and business lines, Carro is supported by more than 5,000 employees across Asia Pacific:

Carro, Asia Pacific’s largest online used marketplace with a strong key presence Singapore, Malaysia, Indonesia and Thailand, and a recent expansion into Japan, Taiwan, and Hong KongCarro Care Powered by Jardine & Cycle, Carro’s in-house refurbishment and after-sales servicing capabilitiesGenie Financial Services, a next-generation fintech automotive financing provider in Singapore, Malaysia, Indonesia and ThailandMPM Rent, leading mobility solutions company in Indonesia specialising in leasing / fleet financing transportation servicesInnorithm, a next-generation fleet management solutions company leveraging state-of-the art IoT and machine learningKaidee, Thailand’s largest online shopping and classifieds platform

For more information, please visit: www.carro.co.

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SOURCE Carro

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Akamai Cloud Helps Eliminate Egress Costs for IRIAM

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Keeping real-time performance while lowering infrastructure costs

TOKYO, May 19, 2025 /PRNewswire/ — Akamai Technologies GK has succeeded in reducing the outbound communication costs (egress costs) for the streaming servers of IRIAM Inc. to almost zero through its cloud service, Akamai Cloud. The move to Akamai Cloud has also contributed to reducing the overall cost of the streaming servers from one-third to less than one-tenth of the total cost of the cloud infrastructure.

IRIAM’s key feature is its community-oriented structure, with close engagement between live streamers (who stream their content using the live-streaming platform) and listeners. To create streams that simulate talking face-to-face, IRIAM created a communication environment that prioritizes real-time performance and minimizes communication lag as much as possible. IRIAM aims to constrain lag to 0.1 seconds, and has independently developed and operates a communication method called the motion-live method.

As the number of users increases and the business grows, however, IRIAM’s network costs are increasing. Network costs accounted for more than one-third of the cost of using cloud infrastructure. These network costs were becoming an issue, and after Akamai started offering cloud services, IRIAM reviewed the Akamai Cloud offerings, and realized that Akamai was able to resolve the issue.

The result of migrating streaming servers to the Akamai Cloud that was most appreciated by IRIAM was the cost savings from Akamai’s proprietary pricing structure, which includes network usage fees as part of the server instance usage fees.

For example, an entry-class “Shared 4 GB” instance has no network transfer charge for up to 2 terabytes. In IRIAM’s case, outbound communication per server is limited to staying within 2 terabytes, so virtually all streaming servers can be operated with the only real cost being the server instance. Even if the limit is exceeded, the extra cost is extremely low, at US$0.005 per 1 GB (as of April 2025).

The amount of network traffic used on the previous cloud was 200 terabytes per month, costing hundreds of thousands of dollars a year. Moving to Akamai Cloud has removed these costs from IRIAM’s fees. Since then, network traffic has increased to approximately 300 terabytes per month as IRIAM’s services have grown, but all traffic still operates within the free quota that comes with each streaming service instance.

After the migration, the network costs as part of the entire infrastructure were reduced from one-third to almost zero, and IRIAM’s streaming server usage fees were reduced by approximately 50% on top of that.

In addition to the cost savings, IRIAM also highly praised the ease of migration and the service stability.

Akamai Cloud also supports API management, allowing the migration to be completed by simply switching the streaming server to the Akamai Cloud while maintaining the existing virtual machine management mechanism as is. CPU and memory utilization is stable and transmission errors on the network are rarely observed.    

IRIAM launched its service in the United States in November 2024. The attentive support and the fast response times are attractive features of the service, and its stability and reliability, coupled with the ease of global deployment, make it a great help for IRIAM’s future business developments in the United States.

Hirokazu Higuma, Managing Director of Akamai, said, “We’re pleased that IRIAM Inc., who have created a new culture on the internet, has adopted Akamai Cloud. We will continue to support IRIAM’s further business growth, starting with their global expansion. Akamai serves its customers more by delivering ever faster, safer, and more stable internet solutions, and by empowering and safeguarding people’s online lives.”

Read the Akamai Cloud product brief to learn more.

About Akamai
Akamai is the cybersecurity and cloud computing company that powers and protects business online. Our market-leading security solutions, superior threat intelligence, and global operations team provide defense in depth to safeguard enterprise data and applications everywhere. Akamai’s full-stack cloud computing solutions deliver performance and affordability on the world’s most distributed platform. Global enterprises trust Akamai to provide the industry-leading reliability, scale, and expertise they need to grow their business with confidence. Learn more at akamai.com and akamai.com/blog, or follow Akamai Technologies on X and LinkedIn.

CONTACT: Akamai PR, akamaiPR@akamai.com 

View original content:https://www.prnewswire.com/apac/news-releases/akamai-cloud-helps-eliminate-egress-costs-for-iriam-302458602.html

SOURCE Akamai Technologies, Inc.

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AnX Robotica Unveils NaviCam XS, NaviCam XST, and ESView 3.0 at DDW 2025 to Exceptional Industry Response

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PLANO, Texas, May 19, 2025 /PRNewswire/ — AnX Robotica, a leader in robotic capsule endoscopy and advanced GI diagnostics, proudly announced the successful launch of NaviCam XS, NaviCam XST, and ESView 3.0 during Digestive Disease Week (DDW) 2025. The unveiling drew exceptional interest, with clinicians, researchers, and industry professionals visiting the AnX Robotica booth to witness the next evolution in GI visualization technology.

AnX Robotica Showcases Breakthrough GI Technologies at DDW 2025

NaviCam XS, the latest addition to the NaviCam platform, introduces a capsule that is 44% smaller by volume than standard small bowel capsules, designed for enhanced patient comfort and easier ingestion without compromising on image quality or diagnostic reliability. This next-generation capsule further advances the possibilities of capsule endoscopy.

Alongside NaviCam XS, NaviCam XST made its debut, offering real-time esophageal visualization through a tethered capsule design. With ESView RT Display, clinicians can seamlessly navigate the esophagus without the need for sedation, providing an ideal solution for evaluating conditions such as reflux, and esophageal varices in real-time.

AnX Robotica also showcased ESView 3.0, the most advanced version of its software platform to date. With an intuitive interface, enhanced image clarity, and streamlined workflow, ESView 3.0 allows for faster interpretation, real-time annotation, and seamless report generation—enabling physicians to optimize diagnostic efficiency and patient outcomes.

“The response at DDW 2025 has been overwhelmingly positive,” said Stu Wildhorn, Vice President of Marketing and Product Management at AnX Robotica. “The enthusiasm from clinicians around NaviCam XS, XST, and ESView 3.0 underscores the market’s demand for non-invasive, high-resolution GI visualization. These innovations are not just advancing technology; they are setting a new standard for patient care.”

The high-traffic booth at DDW served as a launchpad for these technologies, with live demonstrations, hands-on sessions, and presentations that highlighted the precision, ease of use, and clinical impact of the new products. Attendees expressed strong interest in how these solutions can redefine both diagnostic efficiency and patient experience.

AnX Robotica remains committed to pushing the boundaries of capsule endoscopy and GI diagnostics, adding to its growing portfolio, which includes NaviCam SB with ProScan™, MotiliCap, NaviCam Colon*, IntraMarX, and VibraBot.

*Colon Capsule is not available in the United States

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SOURCE AnX Robotica

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