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Kanazawa University research: Chromatin Accessibility: A new avenue for gene editing

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KANAZAWA, Japan, Feb. 16, 2024 /PRNewswire/ — In a study recently published in Nature Genetics, researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University explore chromatin accessibility, i.e., endogenous access pathways to the genomic DNA, and its use as a tool for gene editing.

Our DNA is protected from unwanted external modifications by forming structures called nucleosomes that consist of threads of DNA wound around chunks of special proteins known as histones. This unique coiled shape prevents the access of undesirable molecules to a cell’s DNA. However, for vital genetic functions—such as DNA repair—the right set of proteins require access to these DNA fragments. This phenomenon known as ‘chromatin accessibility’ involves a privileged set of protein molecules, many of which are still unknown.

Now, researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, led by Yusuke Miyanari, have used advanced genetic screening methods to unravel chromatin accessibility and its pathways.

For the investigation the team used a combination of two technologies—CRISPR screening and ATAC-see. While the former is a method to suppress the function of a desired set of genes, the latter is a means to identify which ones are essential for chromatin accessibility. Thus, using this method all genes playing a crucial role in chromatin accessibility could be pinned down.

With the help of these assays, novel pathways and individual players involved in chromatin accessibility were uncovered—some playing a positive role and some negative. Of these, one particular protein, TFDP1, showed a negative effect on chromatin accessibility. When it was suppressed, a significant increase in chromatin accessibility was observed, accompanied by nucleosome reduction. A deeper dive into the mechanism of TFDP1 revealed that it functions by regulating the genes responsible for production of certain histone proteins.

The team then focused their study towards exploring biotechnological applications of their findings. After suppressing TFDP1, two different approaches were tried. The first approach involved gene editing using the CRISPR/Cas9 tool. This revealed that deletion of TFDP1 made the gene editing process easier. Now, most chromatin accessibility occurs in nucleosome-depleted regions or NDRs. However, by suppressing TFDP1 chromatin accessibility occurred not only in NDRs but across other regions as well. Secondly, the depletion of TFDP1 aided the process of converting regular cells into stem cells, a massive step forward in cellular transformation.

This study identified new chromatin accessibility pathways and channels for exploring its potential even further. “Our study shows the significant potential to manipulate chromatin accessibility as a novel strategy to enhance DNA-templated biological applications, including genome editing and cellular reprogramming,” conclude the researchers.

Background

CRISPR screening: CRISPR screening is a large-scale tool used to find genes involved in a particular function. In this method, genes from the entire genome can be deleted one at a time to investigate which ones play a role in any target pathway. The mechanisms and roles of the genes narrowed down are then understood further using biological assays. In this study the genes identified by CRISPR screening were subjected to ATAC-see to confirm their involvement with chromatin accessibility.

ATAC-see: Transposase-Accessible Chromatin with visualization (ATAC-see) is a technique whereby accessible DNA locations can be visualized and quantified. ATAC-see involves using an enzyme to insert fluorescent proteins into the DNA at accessible sites. This technique works within nucleosome-depleted regions but also beyond these regions. Hence, when such sites were visualized after running CRISPR screening, the researchers could understand which genes were affecting chromatin accessibility directly.

Reference

Satoko Ishii, Taishi Kakizuka, Sung-Joon Park, Ayako Tagawa, Chiaki Sanbo, Hideyuki Tanabe, Yasuyuki Ohkawa, Mahito Nakanishi, Kenta Nakai, Yusuke Miyanari. Genome-wide ATAC-see screening identifies TFDP1 as a modulator of global chromatin accessibility. Nature Genetics, 2024. Published Feb 15, 2024

DOI :10.1038/s41588-024-01658-1

https://www.nature.com/articles/s41588-024-01658-1

Related figures

https://nanolsi.kanazawa-u.ac.jp/wp/wp-content/uploads/Fig.-1-1.png

Figure 1. a. Screening results of the players involved in chromatin accessibility analyzed by ATAC-see.

b. Successful reprogramming to stem cells (indicated by presence of TRA-1-60) after depletion of TFDP1 (right).

© 2024 Ishii, et al., Nature Genetics

Contact
Hiroe Yoneda
Senior Specialist in Project Planning and Outreach
NanoLSI Administration OfficeNano Life Science Institute (WPI-NanoLSI)
Kanazawa University
Kakuma-machi, Kanazawa 920-1192, Japan
Email: nanolsi-office@adm.kanazawa-u.ac.jp
Tel: +81 (76) 234-4555

About Nano Life Science Institute (WPI-NanoLSI), Kanazawa University

Understanding nanoscale mechanisms of life phenomena by exploring “uncharted nano-realms.”

Cells are the basic units of almost all life forms. We are developing nanoprobe technologies that allow direct imaging, analysis, and manipulation of the behavior and dynamics of important macromolecules in living organisms, such as proteins and nucleic acids, at the surface and interior of cells. We aim at acquiring a fundamental understanding of the various life phenomena at the nanoscale.

https://nanolsi.kanazawa-u.ac.jp/en/

About the World Premier International Research Center Initiative (WPI)

The WPI program was launched in 2007 by Japan’s Ministry of Education, Culture, Sports, Science and Technology (MEXT) to foster globally visible research centers boasting the highest standards and outstanding research environments. Numbering more than a dozen and operating at institutions throughout the country, these centers are given a high degree of autonomy, allowing them to engage in innovative modes of management and research. The program is administered by the Japan Society for the Promotion of Science (JSPS).

See the latest research news from the centers at the WPI News Portal: https://www.eurekalert.org/newsportal/WPI

Main WPI program site:  www.jsps.go.jp/english/e-toplevel

About Kanazawa University

As the leading comprehensive university on the Sea of Japan coast, Kanazawa University has contributed greatly to higher education and academic research in Japan since it was founded in 1949. The University has three colleges and 17 schools offering courses in subjects that include medicine, computer engineering, and humanities.

The University is located on the coast of the Sea of Japan in Kanazawa – a city rich in history and culture. The city of Kanazawa has a highly respected intellectual profile since the time of the fiefdom (1598-1867). Kanazawa University is divided into two main campuses: Kakuma and Takaramachi for its approximately 10,200 students including 600 from overseas.

http://www.kanazawa-u.ac.jp/e/

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Covet™ Unveils AI-Powered Estate Management Platform at Finovate, Captivating RIAs with Vision for Next-Gen Wealth Management

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SAN DIEGO, May 12, 2025 /PRNewswire/ — The future of wealth management arrived at Finovate as Covet.Life, a breakout platform harnessing the power of AI to advance estate asset management, took center stage. The live demonstration was met with resounding enthusiasm among Registered Investment Advisors (RIAs) eager to gain an unprecedented, holistic view of their clients’ complete estate landscape.

Covet is Advisors’ Bridge to the Next Generation

The Silent Threat to AUM: The Heirs’ Exodus

The wealth management industry faces a critical challenge: up to 80% of heirs transfer assets away from their parents’ advisor. This isn’t a reflection of service quality, but a generational disconnect. Advisors risk losing significant Assets Under Management (AUM) simply because they weren’t the inheritors’ trusted partner.

Covet is the Bridge to the Next Generation

Covet offers RIAs a powerful solution to not only mitigate this risk but to proactively cultivate lasting relationships with the next generation. This groundbreaking platform goes beyond traditional planning tools, acting as a dynamic management and continuity engine designed to:

Unlock Hidden Assets, Fuel AUM Growth: Covet’s AI diligently uncovers previously unseen assets, from held-away IRAs to dormant accounts, providing immediate opportunities to expand RIAs managed portfolio.Forge Unbreakable Multigenerational Bonds: By offering shared, transparent visibility into the entire estate, Covet empowers advisors to engage with the whole family, fostering trust and strengthening relationships across generations.Retain Heirs Before the Transfer: Positions the advisor as a vital resource for the entire family and beneficiaries, ensuring continuity and loyalty long before wealth transitions occur.

Beyond Vaults and Planning–Introducing the Covet Management Engine

Covet is purpose-built for advisors who are focused on organic growth and long-term client relationships. This isn’t just a static vault for documents or another planning tool. Covet leverages AI to actively manage all estate assets, visualize consolidated estate value and generate estate documents enabling you to:

Illuminate the Shadows: Effortlessly identify and catalog often-overlooked assets, including held-away retirement accounts and forgotten investments.Orchestrate Diverse Holdings: Seamlessly manage real estate, valuable possessions, and even digital assets within a unified platform.Elevate Advisor Value: Deliver true family-level planning, building profound trust and becoming an indispensable partner.

Experience the Covet Advantage

Covet isn’t just software; it’s a strategic advantage. It’s the key to deepening client relationships, achieving a comprehensive understanding of their wealth, and securing assets for generations to come.

Covet was recently added to Kitces 2025 AdvisorTech Map; yet, further validation of Covet’s market impact.

About – Covet’s mission is to help people take control of their personal asset management with dynamic valuation of their personal property and financial accounts by creating a living record–as fluid as their lives. Developed for digital-first customers, Covet is the destination for active management of all estate assets–including the often overlooked cataloging of personal property, valuables and digital files. Covet is SOC2 certified having met rigorous standards to assure confidentiality, integrity, and availability of an individual’s personal data. Website: Covet.Life Contact: Press Inquiries: Rob Buchner, rob.buchner@covet.life; Investor & Partnership Inquiries: Michael Larsen, michael.larsen@covet.life. Estate Lawyers & Advisors: Christy Wong, christy.wong@covet.life Covet™ is owned and operated by BQuest, Inc. Disclaimer: This press release is for informational purposes only and does not constitute legal or financial advice.

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SOURCE Covet

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E&R Showcases Advanced Packaging Innovations at IEEE ECTC 2025 in Texas

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KAOHSIUNG, May 12, 2025 /PRNewswire/ — E&R Engineering Corp. is excited to participate in the 75th IEEE Electronic Components and Technology Conference (ECTC), taking place from May 27–30, 2025 at the Gaylord Texan Resort & Convention Center in Texas.

This year, E&R will highlight its latest solutions in Advanced Packaging, including high-precision laser drilling for 2.5D/3D ICs, multi-beam laser application, and plasma systems with excellent uniformity and thermal stability. E&R will also showcase its comprehensive Flip Chip solution—featuring pre-die bond and pre-underfill plasma cleaning, as well as on-boat/tray laser marking for high-integrity traceability.

Our Marketing Director Kevin Chang and Sales Supervisor Leo Lee, both with extensive experience in the North American market, will be present to engage with partners and customers.

E&R will be co-exhibiting at the booth of our valued partner Scientech. We warmly invite you to visit us and explore how our advanced technologies can help shape the future of semiconductor packaging.

Booth Information
Booth Number: 438
Date: May 27–30, 2025
Location: Gaylord Texan Resort & Convention Center, Texas
Address:  1501 Gaylord Trail, Grapevine, Texas, USA, 76051
Visit us at Scientech’s Booth!

E&R Website: https://en.enr.com.tw/

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Ultra-Low-Power Microcontroller Market is expected to generate a revenue of USD 9.06 Billion by 2031, Globally, at 8.92% CAGR: Verified Market Research®

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LEWES, Del., May 12, 2025 /PRNewswire/ — Strategically, the Ultra-Low-Power Microcontroller Market presents high-growth opportunities in segments like IoT, wearables, and energy-harvesting devices, especially in innovation-driven regions like North America. While the market is fueled by rising demand for energy efficiency and edge computing, entry strategies must address challenges like limited processing power and integration complexity. Companies aiming to capture market share should focus on vertical-specific customization, invest in ecosystem partnerships, and offer development tools that reduce time-to-market. Targeting high-potential sectors with scalable, low-power solutions will be key to sustaining long-term growth.

The Global Ultra-Low-Power Microcontroller Market Size is projected to grow at a CAGR of 8.92% from 2024 to 2031, according to a new report published by Verified Market Research®. The report reveals that the market was valued at USD 4.57 Billion in 2024 and is expected to reach USD 9.06 Billion by the end of the forecast period.

The ultra-low-power microcontroller market is witnessing steady growth due to increased demand in wearable tech, smart home devices, and energy-efficient applications. These microcontrollers are crucial in enabling longer battery life and compact designs for next-gen electronic products.

Key Highlights of the Report:

Market Size & Forecast: Valuation, CAGR, and projected market size from 2024 to 2031Growth Drivers & Restraints: Clear breakdown of core enablers and roadblocks to adoptionSegment Analysis: Includes detailed breakdown by Peripheral Devices, Packaging Type, End-Use Industry, and Region.Competitive Landscape: In-depth profiling of major players, including their strategies, innovations, and market positioning.Regional Outlook: Comparative market share across North America, Europe, Asia Pacific

Why This Report Matters:

This report empowers B2B stakeholders to identify strategic investment areas, understand evolving end-user needs, and align product innovations with future market demands. It provides actionable data-driven insights for staying ahead in a rapidly changing tech ecosystem.

Who You Should Read This Report:

Semiconductor ManufacturersElectronics OEMs & ODMsIoT Product DevelopersIndustrial Automation FirmsVenture Capital & Investors in TechMarket Research Analysts & Consultants

For more information or to purchase the report, please contact us at: https://www.verifiedmarketresearch.com/download-sample?rid=261681

Browse in-depth TOC on ‘Global Ultra-Low-Power Microcontroller Market Size
202 – Pages
126 – Tables
37 – Figures

Report Scope

REPORT ATTRIBUTES

DETAILS

STUDY PERIOD

2021-2031

BASE YEAR

2024

FORECAST PERIOD

2024-2031

HISTORICAL PERIOD

2021-2023

UNIT

Value (USD Billion)

KEY COMPANIES PROFILED

Microchip Technology, Texas Instruments, Renesas Electronic Corporation, STMicroelectronics, Infineon Technologies AG, NXP Semiconductors, Silicon Laboratories, Panasonic Corporation, ON Semiconductor, and Intel Corporation.

SEGMENTS COVERED

By Peripheral Devices, By Packaging Type, By End-Use Industry, and By Geography

CUSTOMIZATION SCOPE

Free report customization (equivalent to up to 4 analyst working days) with purchase. Addition or alteration to country, regional & segment scope

Global Ultra-Low-Power Microcontroller Market Overview

Market Driver

Surge in IoT and Connected Device Deployments: The rapid increase in the implementation of IoT and interconnected devices across diverse sectors, such as smart cities, agriculture, and home automation, serves as a primary growth accelerator. These applications require extended battery longevity and reliable performance in challenging or isolated conditions. Ultra-low-power microcontrollers (ULP MCUs) provide optimal energy consumption, facilitating smooth integration into tiny, wirelessly connected devices where energy conservation is paramount.

Rising Demand for Wearable and Portable Medical Devices: The surge in wearable technology, especially in fitness trackers, medical monitoring devices, and portable diagnostic tools, is substantially propelling the demand for ULP MCUs. These devices necessitate ultra-low standby power, rapid wake-up periods, and real-time data processing—attributes exclusively offered by ULP microcontrollers. Original Equipment Manufacturers in the healthcare and consumer electronics industries depend on these components to provide small, high-performance solutions with prolonged battery life.

Integration with Energy Harvesting and Edge Computing Technologies: The transition to decentralized processing via edge computing and the demand for self-sustaining electronic systems have fostered an environment conducive to the development of ultra-low-power microcontrollers (ULP MCUs). These controllers are progressively integrated into sensor nodes and devices that employ solar, vibrational, or thermal energy harvesting. Their capacity to operate on limited power renders them optimal for predictive maintenance systems and industrial IoT applications, where uninterrupted functionality with minimal intervention is crucial.

To Purchase a Comprehensive Report Analysis: https://www.verifiedmarketresearch.com/select-licence?rid=261681

Market Restraint

Processing Power and Memory Limitations: Notwithstanding their energy efficiency, ULP MCUs generally have restricted processor speeds and limited memory capacity. This limits their applicability in computationally intensive or multifunctional domains such as edge machine learning, sophisticated image recognition, or AI-driven processing. Organizations may require the augmentation or substitution of ULP MCUs with higher-capacity controllers, hence negating the advantages of low power consumption in specific advanced applications.

Complex System Integration and Compatibility Challenges: ULP MCUs frequently exhibit incompatibility with established software ecosystems or older platforms, necessitating bespoke firmware development and particular design frameworks. This complicates integration into bigger systems, particularly when synchronization with numerous components is necessary. These complications increase engineering overhead and may extend time-to-market, discouraging enterprises pursuing expedited product development cycles.

High Initial R&D and Development Costs: Developing solutions with ultra-low-power microcontrollers can be cost-prohibitive, particularly during the prototyping and testing phases. Specialized development boards, simulation tools, and software frameworks are often essential. The employees must get training on power-optimized coding and hardware configurations. These preliminary investments may be considerable, especially for SMEs and startups, limiting broader market penetration.

Geographical Dominance

North America leads the Ultra-Low-Power Microcontroller Market, driven by improved IoT integration, strong semiconductor research and development, and a substantial presence of major technological firms. The region’s significant demand for energy-efficient solutions in healthcare, industrial automation, and smart home applications drives growth, positioning it as a pivotal hub for research and early technological adoption.

Key Players

The ‘Global Ultra-Low-Power Microcontroller Market’ study report will provide a valuable insight with an emphasis on the global market. The major players in the market are Microchip Technology, Texas Instruments, Renesas Electronic Corporation, STMicroelectronics, Infineon Technologies AG, NXP Semiconductors, Silicon Laboratories, Panasonic Corporation, ON Semiconductor, and Intel Corporation.

Ultra-Low-Power Microcontroller Market Segment Analysis

Based on the research, Verified Market Research has segmented the global market into Peripheral Devices, Packaging Type, End-Use Industry, and Geography.

Ultra-Low-Power Microcontroller Market, by Peripheral DevicesAnalog DevicesDigital DevicesUltra-Low-Power Microcontroller Market, by Packaging Type8-bit16-bit32-bitUltra-Low-Power Microcontroller Market, by End-User IndustryAerospace & DefenseAutomotiveServers and Data CentersConsumer ElectronicsTelecommunicationsHealthcareMedia and EntertainmentManufacturingOthersUltra-Low-Power Microcontroller Market, by GeographyNorth AmericaU.SCanadaMexicoEuropeGermanyFranceU.KRest of EuropeAsia PacificChinaJapanIndiaRest of Asia PacificROWMiddle East & AfricaLatin America

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Visualize Ultra-Low-Power Microcontroller Market using Verified Market Intelligence -:

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VMI provides a holistic overview and global competitive landscape with respect to Region, Country, Segment, and Key players of your market. Present your Market Report & findings with an inbuilt presentation feature saving over 70% of your time and resources for Investor, Sales & Marketing, R&D, and Product Development pitches. VMI enables data delivery In Excel and Interactive PDF formats with over 15+ Key Market Indicators for your market.

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With a team of 500+ Analysts and subject matter experts, VMR leverages internationally recognized research methodologies for data collection and analyses, covering over 15,000 high impact and niche markets. This robust team ensures data integrity and offers insights that are both informative and actionable, tailored to the strategic needs of businesses across various industries.

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